Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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Heritability and Familiality of MMPI Personality Dimensions in the Korean Families with Schizophrenia

  • Jeong, Hee Jeong (Department of Psychiatry, Pusan National University Hospital) ;
  • Lee, Byung Dae (Department of Psychiatry, Pusan National University Hospital) ;
  • Park, Je Min (Department of Psychiatry, Pusan National University Hospital) ;
  • Lee, Young Min (Department of Psychiatry, Pusan National University Hospital) ;
  • Moon, Eunsoo (Department of Psychiatry, Pusan National University Hospital) ;
  • Kim, Soo Yeon (Department of Psychiatry, Pusan National University Hospital) ;
  • Lee, Kang Yoon (Department of Psychiatry, Pusan National University Hospital) ;
  • Suh, Hwagyu (Department of Psychiatry, Pusan National University Hospital) ;
  • Chung, Young In (Department of Psychiatry, Pusan National University College of Medicine)
  • Received : 2017.12.28
  • Accepted : 2018.10.21
  • Published : 2018.12.31
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Abstract

Objective Categorical syndrome such as schizophrenia could be the complex of many continuous mental structure phenotypes including several personality development/degeneration dimensions. This is the study to search heritability and familiality of MMPI personality dimensions in the Korean schizophrenic LD (Linkage Disequilibrium) families. Methods We have recruited 204 probands (with schizophrenia) with their parents and siblings whenever possible. We have used MMPI questionnaires for measuring personality and symptomatic dimensions. Heritabilities of personality dimensions in total 543 family members were estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). Personality dimensions in total family members were compared with those in 307 healthy unrelated controls for measuring the familialities using ANOVA analysis. Results Seven of the 10 MMPI variables were significantly heritable and were included in the subsequent analyses. The three groups (control, unaffected 1st degree relative, case) were found to be significantly different with the expected order of average group scores for all heritable dimensions. Conclusion Our results show that the aberrations in several personality dimensions could form the complexity of schizophrenic syndrome as a result of genetic-environment coactions or interactions in spite of some limitations (recruited family, phenotyping).

Keywords

References

  1. McGuffin P, Asherson P, Owen M, Farmer A. The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia? Br J Psychiatry 1994;164:593-599. https://doi.org/10.1192/bjp.164.5.593
  2. Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Mol Neurobiol 2005;32:173-202. https://doi.org/10.1385/MN:32:2:173
  3. Bartels SJ, Clark RE, Peacock WJ, Dums AR, Pratt SI. Medicare and medicaid costs for schizophrenia patients by age cohort compared with costsfor depression, dementia, and medically ill patients. Am J Geriatr Psychiatry 2003;11:648-657. https://doi.org/10.1097/00019442-200311000-00009
  4. Bauer M, Unutzer J, Pincus HA, Lawson WB; NIMH Affective Disorders Workgroup. Bipolar disorder. Ment Health Serv Res 2002;4:225-229. https://doi.org/10.1023/A:1020968616616
  5. Shih RA, Belmonte PL, Zandi PP. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatry 2004;16:260-283. https://doi.org/10.1080/09540260400014401
  6. Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 2008;165:497-506. https://doi.org/10.1176/appi.ajp.2007.07101573
  7. Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-706. https://doi.org/10.1038/349704a0
  8. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71. https://doi.org/10.1126/science.7545954
  9. MacKinnon DF, Xu J, McMahon FJ, Simpson SG, Stine OC, McInnis MG, et al. Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data. Am J Psychiatry 1998;155:829-831.
  10. McMahon FJ, Simpson SG, McInnis MG, Badner JA, MacKinnon DF, DePaulo JR. Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder. Arch Gen Psychiatry 2001;58;1025-1031 https://doi.org/10.1001/archpsyc.58.11.1025
  11. Potash JB, Zandi PP, Willour VL, Lan TH, Huo Y, Avramopoulos D, et al. Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry 2003;160:680-686. https://doi.org/10.1176/appi.ajp.160.4.680
  12. Park N, Juo SH, Cheng R, Liu J, Loth JE, Lilliston B, et al. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 2004;9:1091-1099. https://doi.org/10.1038/sj.mp.4001541
  13. Willour VL, Zandi PP, Badner JA, Steele J, Miao K, Lopez V, et al. Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12. Biol Psychiatry 2007;61:725-727. https://doi.org/10.1016/j.biopsych.2006.05.014
  14. Raybould R, Green EK, MacGregor S, Gordon-Smith K, Heron J, Hyde S, et al. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biol Psychiatry 2005;57:696-701. https://doi.org/10.1016/j.biopsych.2005.01.018
  15. Schulze TG, McMahon FJ. Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping. Hum Hered 2004;58:131-138. https://doi.org/10.1159/000083539
  16. Walters GD. The MMPI and schizophrenia: review. Schizophr Bull 1983;9:226-246. https://doi.org/10.1093/schbul/9.2.226
  17. Carter JW, Parnas J, Cannon TD, Schulsinger F, Mednick SA. MMPI variables predictive of schizophrenia in the Copenhagen high-risk project: a 25-year follow-up. Acta Psychiatr Scand 1999;99:432-440. https://doi.org/10.1111/j.1600-0447.1999.tb00989.x
  18. Claridge G, Beech T. Fully and Quasi-Dimensional Constructions of Schizotypy. In: Raine A, Lencz T, Mednick SA, Editors. Schizotypal Personality. Cambridge University Press: New York, 1995, p.192-216.
  19. Matsui M, Gur RC, Turetsky BI, Yan M, Gur RE. The relation between tendency for psychopathology and reduced frontal brain volume in healthy people. Neuropsychiatry Neuropsychol Behav Neurol 2000;13:155-162.
  20. Haier RJ, Murphy DL, Buchsbaum MS. Paranoia and platelet MAO in normals and nonschizophrenic psychiatric groups. Am J Psychiatry 1979;136:308-310. https://doi.org/10.1176/ajp.136.3.308
  21. Haier RJ, Buchsbaum MS, Murphy DL, Gottesman II, Coursey RD. Psychiatric vulnerability, monoamine oxidase, and the average evoked potential. Arch Gen Psychiatry 1980;37:340-345. https://doi.org/10.1001/archpsyc.1980.01780160110013
  22. Ogura C, Hirano K, Nageishi Y, Takeshita S, Fukao K, Hokama H, et al. Deviate P200 and P300 in non-patient college students with high scores on the schizophrenia scale of the Minnesota Multiphasic Personality Inventory (MMPI). Int J Psychophysiol 1994;16:89-97. https://doi.org/10.1016/0167-8760(94)90045-0
  23. Haier RJ, Rieder RO, Khouri PJ, Buchsbaum MS. Extreme MMPI scores and the Research Diagnostic Criteria. Screening college men for psychopathology. Arch Gen Psychiatry 1979;36:528-534. https://doi.org/10.1001/archpsyc.1979.01780050038003
  24. Lenzenweger MF. Confirming schizotypic personality configurations in hypothetically psychosis-prone university students. Psychiatry Res 1991;37:81-96. https://doi.org/10.1016/0165-1781(91)90108-2
  25. Merritt RD, Balogh DW, DeVinney SE. Use of the MMPI to assess the construct validity of the revised social anhedonia scale as an index of schizotypy. J Pers Assess 1993;60:227-238. https://doi.org/10.1207/s15327752jpa6002_2
  26. Moldin SO, Gottesman II, Erlenmeyer-Kimling L. Psychometric validation of psychiatric diagnoses in the New York High-Risk study. Psychiatry Res 1987;22:159-177. https://doi.org/10.1016/0165-1781(87)90103-X
  27. Chapman LJ, Chapman JP, Raulin ML. Body-image aberration in schizophrenia. J Abnorm Psychol 1978;87:399-407. https://doi.org/10.1037/0021-843X.87.4.399
  28. Chapman LJ, Chapman JP, Raulin ML. Scales for physical and social anhedonia. J Abnorm Psychol 1976;85:374-382. https://doi.org/10.1037/0021-843X.85.4.374
  29. Greene RL. The MMPI-2/MMPI. An Interpretive Manual. Boston: Allyn & Bacon; 1991.
  30. Kim YH, Kim JH, Kim JS, Noh MR, Shin DG, Yeum TH, et al. The Main Principles for Minnesota Multiphasic Personality Inventory (MMPI). Seoul: Korea Guidance; 1989.
  31. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 1994;51:849-859; discussion 863-864. https://doi.org/10.1001/archpsyc.1994.03950110009002
  32. Maxwell ME. Family Interview for Genetic Studies (FIGS): Manual For FIGS. (Clinical Neurogenetics Branch, Intramural Research Program). Bethesda, MD: National Institute of Mental Health; 1992
  33. Walss-Bass C, Escamilla MA, Raventos H, Montero AP, Armas R, Dassori A, et al. Evidence of genetic overlap of schizophrenia and bipolar disorder: linkage disequilibrium analysis of chromosome 18 in the Costa Rican population. Am J Med Genet B Neuropsychiatri Genet 2005;139B:54-60. https://doi.org/10.1002/ajmg.b.30207
  34. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211. https://doi.org/10.1086/301844
  35. Green RL. Introduction. In: Green RL, Editor. The MMPI: Use with Specific Populations. Philadelphia, PA: Grune and Stratton, 1988, p.1-21.
  36. Matsui M, Sumiyoshi T, Niu L, Kurokawa K, Kurachi M. Minnesota Multiphasic Personality Inventory profile characteristics of schizotypal personality disorder. Psychiatry Clin Neurosci 2002;56:442-452.
  37. Walters GD. Schizophreia. In: Green RL, Editor. The MMPI: Use with Specific Populations. Philadelphia, PA: Grune and Stratton, 1988, p.50-73.
  38. Moldin SO, Gottesman II, Erlenmeyer-Kimiling L. Psychometric validation of psychiatric diagnosis in the New York high-risk study. Psychiatry Res 1987;22:159-177. https://doi.org/10.1016/0165-1781(87)90103-X
  39. Graham JR, Smith RL, Schwartz GF. Stability of MMPI configurations for psychiatric inpatients. J Consult Clin Psychol 1986;54:375-380. https://doi.org/10.1037/0022-006X.54.3.375
  40. Meehl PE. Schizotaxia, schizotypy, and schizophrenia. Am Psychol 1962;17:827-838. https://doi.org/10.1037/h0041029
  41. Gilberstadt H, Duker J. A Handbook of Clinical and Actuarial MMPI Interpretation. Philadelphia: W.B. Saunders Company; 1965.
  42. Koh SD, Kayton L, Berry R. Mnemonic organization in young nonpsychotic schizophrenics. J Abnorm Psychol 1973;81:299-310. https://doi.org/10.1037/h0034525
  43. Marks PA, Seeman W, Haller DH. The Actuarial Use of the MMPI With Adolescents and Adults. Baltimore: The Williams & Wilkins Company;1974.
  44. Golden RR, Meehl PE. Detection of the schizoid taxon with MMPI indicators. J Abnorm Psychol 1979;88:217-233. https://doi.org/10.1037/0021-843X.88.3.217
  45. Fine HK. Studying schizophrenia outside the psychiatric setting. J Youth Adolesc 1973;2:291-301. https://doi.org/10.1007/BF02213701
  46. Steronko RJ, Woods DJ. Impairment in early stages of visual information processing in nonpsychotic schizotypic individuals. J Abnorm Psychol 1978;87:481-490. https://doi.org/10.1037/0021-843X.87.5.481
  47. Koh SD, Peterson RA. Perceptual memory for numerousness in "nonpsychotic schizophrenics." J Abnorm Psychol 1974;83:215-226. https://doi.org/10.1037/h0036699
  48. Schulman SM. Cognitive deficit in students identified by the elevated 2-7-8 code of the MMPI. Diss Abstr Int 1976;37:3096B.
  49. Dahlstrom WG, Welsh GS, Dahlstrom LE. An MMPI Handbook: Vol. II. Research Applications. Minneapolis: University of Minnesota Press;1975.
  50. Sim M, Kim JH, Yim SJ, Cho SJ, Kim SJ. Increase in harm avoidance by genetic loading of schizophrenia. Compr Psychiatry 2012;53:372-378. https://doi.org/10.1016/j.comppsych.2011.05.004
  51. Smith MJ, Cloninger CR, Harms MP, Csernansky JG. Temperament and character as schizophrenia-related endophenotypes in non-psychotic siblings. Schizophr Res 2008;104:198-205. https://doi.org/10.1016/j.schres.2008.06.025
  52. Yoneyama E, Matsui M, Kawasaki Y, Nohara S, Takahashi T, Hagino H, et al. Gray matter features of schizotypal disorder patients exhibiting the schizophrenia-related code types of the Minnesota Multiphasic Personality Inventory. Acta Psychiatr Scand 2003;108:333-340. https://doi.org/10.1034/j.1600-0447.2003.00202.x

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