• Current Optics and Photonics
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• 제3권1호
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• pp.72-77
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• 2019

This study was performed to analyze the optical aberrations of the cornea induced by myopic refractive surgery. Corneal total higher-order aberrations, spherical aberration and coma for 4-mm and 6-mm pupils were measured using a wave-front analyzer. The amount of aberrations of the oblate corneal optics by the achieved correction was found to be larger than for the prolate corneal shape with complete eye, in an emmetropia control group. The change in corneal shape acts as an optical factor that degrades the quality of the retinal image; it seems to be one of the important factors related to quality of vision.

• 한국환경성돌연변이발암원학회지
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• 제17권1호
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• pp.17-22
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• 1997

We observed the frequency of chromosome aberrations induced by UVB irradiations, and the suppressing effect of tannic acid on chromosome aberrations induced by UVB irradiations in CHL cells, which is a phenolic compound, a hydrolysate of tannin and a components of green tea. UVB doses used for the frequency of chromosome aberrations were from 0.2 to 1.6 KJ/m$^2$ and tannic acid concentrations were from 1.16 $\mu$g/ml to 37.50 $\mu$g/ml. For the observation of suppressing effect of tannic acid on UVB-induced chromosome aberrations, UVB dose was 1.6 KJ/m$^2$ and tannic acid concentrations were 1.0, 2.0, 4.0 $\mu$g/ml. In our study, tannic acid was treated for 24 hours in CHL, cells after UVB irradiation without S9 mix or for 6 hours with S9 mix. From this study, we obtained the following results : (1) The frequency of chromosome aberrations UVB induced were dose-dependently increased. (2) The tannic acid did not induce chromosome aberrations in cultured Chinese hamster cells. (3) UVB-induced chromosome aberrations were suppressed by tannic acid at every concentration from 1.0 $\mu$g/ml to 4.0 $\mu$g/ml with or without metabolic activation. These results suggest that the tannic acid acts as an inhibitor to UVB-induced clastogenicity of the cultured cell.

• 한국환경성돌연변이발암원학회지
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• 제11권2호
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• pp.107-117
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• 1991

The effect of 3-aminobenzamide (3AB), an inhibitor of poly (ADP-ribose) polymerase, on ethyl methanesulfonate (EMS)-or bleomycin (BLM)-induced DNA repair synthesis and chromosome aberrations was examined during the cell cycle of Chinese hamster ovary (CHO)-K$_1$ cells. The synchronized cells were obtained by using thymidine double block method and mitotic selection method. Three assays were employed in this study: unscheduled DNA synthesis, alkaline elution and chromosome aberrations. 3AB alone did not induce DNA repair and chromosome aberrations in all phases. The post-treatment with 3AB inhibited DNA repair synthesis induced by EMS or BLM in G$_2$ phase, whereas 3AB did not affect chromosome aberrations induced by EMS or BLM in all phases. These results suggest that 3AB aggravates the cell cycle disturbance which occur after DNA damage, and leads to an accumulation of cells at G$_2$ phase, and inhibits DNA repair synthesis, while the effect 3AB on chromosome aberrations may need reevaluated.

• Current Optics and Photonics
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• 제8권2호
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• pp.151-155
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• 2024

Optical systems often suffer from optical aberrations caused by imperfect hardware, which places significant constraints on their utility and performance. To reduce these undesirable effects, a comprehensive understanding of the aberrations inherent to optical systems is needed. This article presents an effective method for aberration detection using Zernike polynomials. The process involves scanning the object plane to identify the optimal focus and subsequently fitting the acquired focus data to Zernike polynomials. This fitting procedure facilitates the analysis of various aberrations in the optical system.

• Clinical and Experimental Pediatrics
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• 제45권3호
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• pp.311-319
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• 2002

1974년 3월부터 1998년 8월까지 약 25년간 본 소아과에서 염색체 분석을 시행하였던 환아 중 염색체 이상증후군을 의심할 만한 임상증상을 가졌던 756례와 반음양, 경미한 성적 이상, 다발성 기형, 지능저하 및 성장장애 등이 있었던 424례의 결과를 종합한 총 1,180례의 결과를 비교 검토하였다. 1) 상염색체이상증후군의 남녀 비는 1.2 : 1이었다. 대상군의 연령분포는 상염색체이상군에서 1세 미만이 78.6%로 많았고, 성염색체이상군에서는 12세 이상이 89.8%로 많았다. 2) 전체 1180례 중 612례에서 염색체 이상을 보여 양성율이 51.9%였다. 그 중 상염색체이상증후군을 의심한 군의 경우는 597례 중 497례(83.2%)에서, 성염 색체이상을 의심한 군은 159례 중 93례(58.5%)에서, 기타 반음양, 경미한 성적 이상, 다발성 선천성 기형, 지능저하 및 성장장애에서는 424례 중 22례(5.2%)에서 이상소견을 보였다. 상염색체이상증후군 중 Down 증후군은 88.8%, E군 이상은 50%, D군 이상은 53.6%, 묘성 증후군은 71.4%의 양성율을 보였다. 성염색체이상증후군은 Turner 증후군은 63.3%, Klinefelter 증후군은 51.6%, Fragile X 증후군은 33.3%의 양성율을 보였다. 3) 염색체 이상의 핵형별 분포는 상염색체 이상이 514례로 83.8%, 성염색체 이상이 98례로 16.2%이었다. 성염색체 이상 중 Down 증후군이 86.8%로 가장 많았고 다음은 E군, D군, B군, A군, C군 이상 순이었다. 성염색체 이상은 Turner 증후군, Klinefelter 증후군, Fragile X 증후군이었다. 4) 가장 많았던 Down 증후군의 핵형별 빈도는 21 삼체성이 88.5%, 전좌형이 9.7%, mosaicism이 1.8%였다. 27례의 E군 이상 중 Edwards 증후군은 12례, 18p 단체성은 8례, 기타가 7례 였다. 15례의 D군 이상 중 Patau 증후군은 9례, 기타가 6례였다. 5) Turner 증후군은 57례 중 45,X가 19례로 33.3%였고 이형은 38례로 66.7%였다. Klinefelter 증후군은 32례 모두 47,XXY의 핵형이었다.

• 한국안광학회지
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• 제19권3호
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• pp.353-362
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• 2014

목적: 나이의 증가에 따른 고위수차의 변화를 분석하고, 근시도가 나이와 고위수차 변화와의 상관관계에 미치는 영향을 알아보고자 하였다. 방법: Hartmann-Shack 방식의 LADARWave 장비를 이용하여 20세에서 60세 931안의 고위수차를 분석하였고, 현성굴절검사를 통해 측정된 근시도가 고위수차에 미치는 영향을 분석하였다. 결과: 코마수차, 수직코마수차는 나이가 증가함에 따라 통계적으로 유의하게 감소하였으며, 수직난시수차는 통계적으로 유의하게 증가하였다. 코마수차, 수직코마수차, 구면수차, 수직트레포일수차, 수평트레포일수차, 수직난시수차, 수평난시수차, 수직테트라포일수차와 나이와의 상관관계는 근시도에 의해 영향을 받았으며 수평코마수차와 수평테트라포일수차는 영향을 받지 않았다. 결론: 본 연구에서는 근시도수가 나이에 따라 유발되는 고위수차의 변화에 영향을 줄 수 있음을 밝혔으며 시력교정술이나 시력교정용구 사용 시 시력의 질을 위하여 이의 고려를 제안하고자 한다.

• Molecules and Cells
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• 제24권1호
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• pp.105-112
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• 2007

Most neuroblastoma cells have chromosomal aberrations such as gains, losses, amplifications and deletions of DNA. Conventional approaches like fluorescence in situ hybridization (FISH) or metaphase comparative genomic hybridization (CGH) can detect chromosomal aberrations, but their resolution is low. In this study we used array-based comparative genomic hybridization to identify the chromosomal aberrations in human neuroblastoma SH-SY5Y cells. The DNA microarray consisting of 4000 bacterial artificial chromosome (BAC) clones was able to detect chromosomal regions with aberrations. The SH-SY5Y cells showed chromosomal gains in 1q12~ q44 (Chr1:142188905-246084832), 7 (over the whole chro-mosome), 2p25.3~p16.3 (Chr2:18179-47899074), and 17q 21.32~q25.3 (Chr17:42153031-78607159), while chromosomal losses detected were the distal deletion of 1p36.33 (Chr1:552910-563807), 14q21.1~q21.3 (Chr14:37666271-47282550), and 22q13.1~q13.2 (Chr22:36885764-4190 7123). Except for the gain in 17q21 and the loss in 1p36, the other regions of gain or loss in SH-SY5Y cells were newly identified.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.253-262
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• 1998

Ochratoxin A (OA) is a potent mycotoxin causing considerable health hazard and economic loss- e,i. OA is of concern as it is hepato-nephrotoxic, mutagenic, and carcinogenic to a great variety of animals. LDso of crude OA was 8.5 mgf kg.b.w., i.p. The clinical symptoms, mortalities and necropsy were recorded in rats injected with OA (LD5o, i.p.) during 10 days of daily treatment. Ginseng treatments (20 mg 1 kg. b.w., i.p.) : before, mixed with, or after OA dose, completely prevented the mortality in rats. OA-treated animals showed microcytic normochromic anaemia, lucocytosis, hypoproteinaemia and elevation of serum ALT, AST, AP, urea, and creatinine values. These findings were declined near the normal levels when ginseng injected with OA. OA (115 LDso) induced chromosomal aberrations (65.66%) compared to the control. When ginseng given 10 min before OA injection, chromosomal aberrations were reduced to be 31.66% compared to OA-treated animals. In conclusion: ginseng has a protective effect against ochratoxicosis, it has anti-genotoxic activity and it can repair the chromosomal damage induced by ochratoxin A. Key words Ochratoxicosis, Chromosomal aberrations, Mycotoxins, Ochratoxin A, Korean gin sting, Protective effect of Panax ginseng, Rat

• 한국임상보건과학회지
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• 제3권2호
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• pp.372-377
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• 2015

Purpose: The aim of this study is to compare total high order aberrations between surgery which uses TransPRK and general laser assisted sub-epithelial keratomileusis. Methods: The patients who had general laser assisted sub-epithelial and TransPRK laser assisted sub-epithelial by visiting ophthalmic clinic in Ulsan from January 2014 to August 2014 was researched. Results: When comparing total high order aberrations before and after operation, it was found that total high order aberration in general laser assisted sub-epithelial group increased to $0.222{\pm}0.078{\mu}m$ from $0.074{\pm}0.019{\mu}m$ while that in TransPRK assisted sub-epithelial group increased to $0.179{\pm}0.045{\mu}m$ from $0.076{\pm}0.032{\mu}m$. When comparing the increment in total high order aberrations between two groups after surgery, it was found that the increments of TransPRK assisted sub-epithelial group were statistically smaller than that of general laser assisted sub-epithelial group (p<0.05). Conclusions: This study made a comparative analysis of total high order aberrations between general laser assisted sub-epithelial and TransPRK assisted sub-epithelial which was introduced recently and the result showed a significant difference. The findings of this study suggest that TransPRK assisted sub-epithelial can be used widely in simply improving eye sight and quality of vision by reducing an increase in high order aberration caused by orthokeratology surgery. It is expected that TransPRK assisted sub-epithelial will be helpful for improving the understanding quality of eye sight which occurs by several methods of vision correction surgery.

• 한국광학회지
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• 제17권3호
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• pp.256-261
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• 2006

본 논문에서는 비축 포물 거울을 통과한 레이저 빔의 파면을 측정하는 방식으로 국내 및 국외에서 제작된 비축 포물 거울을 평가하였으며, 이로부터 비축 포물 거울의 집속 성능 및 정렬 민감도를 측정하였다. 국외에서 제작된 비축 포물 거울은 직경 약 34 mm의 레이저 빔에 대해 고차 파면 수차(higher-order aberration)의 rms 값이 $0.03{\mu}m$ 정도로 작아 광학적으로 좋은 품질을 갖는 것으로 판명되었다. 국내에서 제작된 비축 포물 거울은 같은 34 mm의 레이저 빔에 대해 고차 파면 수차의 rms 값이 $2.01{\mu}m$나 관측되어 아직 개선이 필요한 것으로 보인다. 또한, 비축 포물 거울의 회전 정렬 오차에 대한 비점수차(astigmatism)의 민감도를 측정한 결과 회전 정렬 오차에 대한 비점수차의 민감도는 $0.371{\mu}m/mrad$인 것으로 관측되었다. 이는 광선 추적 소프트웨어를 사용하여 계산한 값과 거의 같은 양으로 이러한 비점수차의 정렬 민감도 측정은 비축 포물 거울을 정렬하는데 도움을 줄 것으로 생각된다.