• 동의생리병리학회지
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• 제27권5호
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• pp.637-643
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• 2013

Daesiho-tang (DST), Yijin-tang (YJT), Gyeoneumjisil-hwan (GJH), Ukdam-hwan (UDH), and Sojojung-tang (SJT) have been used to treat hypertension. The aim of this study was to investigate whether five formulas were effective for improving obesity in high fat diet (HFD) induced obese mice. The mice were divided into seven groups: (1) a normal diet (ND), (2) a high fat diet (HFD) (3) a HFD plus DST (HFD + DST), (4) a HFD plus YJT (HFD + YJT), (5) a HFD plus GJH (HFD + GJH), (6) a HFD plus UDH (HFD + UDH), or (7) HFD plus SJT (HFD + SJT) at 150 mg/kg/day for 7 weeks. All five formulas treatments significantly lowered blood pressure, final liver weights, and serum total triglyceride levels. The four formulas (HFD+DST, HFD+YJT, HFD+UDH, and HFD+SJT) decreased body weights. Also, HFD+DST, HFD+YJT, and HFD+UDH groups reduced abdominal and epididymal fat weights. The serum LDL-cholesterol levels were decreased in HFD+YJT, HFD+UDH, and HFD+SJT groups compared to the HFD group. These results demonstrate that five formulas ameliorated obesity.

• 한방비만학회지
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• 제11권1호
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• pp.15-24
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• 2011

Objectives Our purpose of this study was to evaluate the association between depression, stress, and obesity indexes. Methods This study was performed in 110 healthy overweight and obese(BMI${\geq}23\;kg/m^2$) women in Korea. Subjects underwent abdominal CT(computed tomography) scanning and were asked to complete Beck depression inventory(BDI), social readjustment rating scale(SRRS), and stress response inventory(SRI) questionnaires. Weight, body-mass index(BMI), waist circumference(WC), and waist-hip ratio(WHR) were evaluated. Subjects were given written consent and this study was performed under permission of institutional review board of KyunHee University Hospital at Gangdong. Results 1. BDI and SRI were significantly correlated with VFA(visceral fat area)(p<0.05). However, other obesity indexes were not significantly correlated with BDI and SRI(p>0.05). 2. SRRS was not significantly correlated with all obesity indexes(p>0.05). Conclusions This study suggests that depression and stress might be correlated with visceral fat, and this result would be helpful for planning a treatment schedule of obese patients with depression or stress in the clinic.

• Toxicological Research
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• 제26권3호
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• pp.185-192
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• 2010

Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about 8 g/kg) of the feed for a period of 3 months and 6 months. The fatty acid composition profile as indicated GC-MS, showed significantly slight dose-dependent increases in the levels of unsaturated fatty acids, particularly, arachidonic acid (C20: 4n6), oleic acid, linoleic acid, eicosadienoic acid, eicosapentaenoic acid (EPA) (C20: 5) concentration in the the ad libitum IS-fed groups compared to the control group in SD abdominal fat over 6 month period. Over viewing of the SD and Ob mice treated Isaria sinclairii powder; there were increases in the single (mono) unsaturated fatty acids ratio but decreases in polyunsaturated fatty acid. In IS-fed groups in proportion to the treatment period, this Dongchunghacho also induced an increase in the level of same result of unsaturated fatty acid in C57BL/6 obese (ob/ob) mice over a 6-month period treatment compared to those given 10% dry mulberry leaf powder (ML) or silkworm powder mixed with the standard diet.

• 성인간호학회지
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• 제23권4호
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• pp.412-419
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• 2011

Purpose: The purpose of this study was to investigate the effects of a walking and resistance exercise on body composition and lipid profile in obese women. Methods: Fourty three women were assigned to experimental group (n=21) or control group (n=22). The walking and resistance exercise using elastic band was provided three times a week for 12 weeks. Weight, height, body mass index, body fat percentage, abdominal fatness, skeletal muscle mass, body fatness, total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured before and after the program. Paired and independent t-tests were performed using SAS program. Results: Weight (t=-5.35, p<.001), body mass index (t=-4.12, p<.001), body fat percentage (t=-2.33, p =.026), and body fatness (t=-4.32, p<.001) were significantly decreased and skeletal muscle mass (t=2.09, p =.044) was significantly increased after the walking and resistance exercise. Also, total cholesterol (t=-3.03, p =.006) and LDL cholesterol (t=-2.70, p =.011) were significantly decreased and HDL cholesterol (t=2.05, p =.046) was significantly increased after the exercise program. Conclusion: According to the study result, exercise led a positive outcome on obese women in their 30~40s. The walking and resistance exercise will contribute to the improving body composition and lipid profile in this population.

• 한방비만학회지
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• 제7권2호
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• pp.85-94
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• 2007

Objectives The purpose of this study was to investigate the clinical effect of oriental medical obesity therapy on obese patient with non-alcoholic fatty liver disease. We supposed to treat patient 21 years old that had non-alcoholic fatty liver with oriental medical obesity therapy. Methods The patient was treated from the 19th of July to the 22th of August for obesity treatment. And the patient had intensive care through admission treatment from the 19th of July to the 30th of July. Herbal medicine, low calorie and low cholesterol diet, electrolipolysis, auricular acupuncture, aerobic exercise was done during the treatment period. Results His body weight decreased from 107.10㎏ to 98.85㎏. The BMI decreased from 36.2㎏/$m^2$ to 34.5㎏/$m^2$. Abdominal visceral fat tissue decreased from 190.80$cm^2$ to 145.05$cm^2$. AST was decreased from 113 to 45. ALT was decreased from 145 to 40. r-GT was decreased from 123 to 51. Oriental obesity therapy could be effective to treat obese patient with non-alcoholic fatty liver disease. Conclusions The obese patient with non-alcoholic fatty liver disease had improved liver function after oriental obesity treatment.

• 대한통합의학회지
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• 제7권4호
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• pp.283-290
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• 2019

Purpose : The purpose of this study was to find out how changes in body shape of obese patients could be affected by the combined management of diet and psychotherapy along with exercise therapy to control energy imbalance, the cause of obesity. Methods : In this study, the aerobic exercise program was conducted on 12 industrial workers of "D" company for a total of eight weeks for obese patients with a high body mass index (25 kg/㎡ or higher). The experimental group did not apply the program three times a week. The body type analysis was carried out using the body analyzer (Inbody 770, Inbody, Korea) and blood test and psychological test were performed after 8 weeks of exercise before and after exercise. Results : The results of the group showed a change in weight loss of 6.03 kg (p=.000) on average, which is nearly 10 % of the change in weight. It was also shown that the BMI (body mass index) decreased by 1.76 kg/㎡ (p=.000). Abdominal fat (AO) is also 0.14 % (p=.000), waist circumference (WC, 12.72 cm, p=.000), internal fat (VF, 25.12 %, p=.000), liver function levels AST (5.47 U/L, p=.04), ALT (13.64 U/L, p=.000), total cholesterol, pTC -14.22. Conclusion : Based on the results of this study, the obesity management program will be able to maximize the effects of obesity control if exercise programs and psychotherapy are combined.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.621-626
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• 2013

Background Ever since lipoabdominoplasty was first developed to achieve better aesthetic outcomes and less morbidity, the rate of seroma formation, especially in obese patients, has disturbed plastic surgeons. The aim of this study was to evaluate the effect of fibrin sealant in the prevention of seroma formation after lipoabdominoplasty in obese patients. Methods Sixty patients with a body mass index (BMI) between 30 and 39.9 were assigned randomly to 1 of 2 groups (30 patients each). Group A underwent lipoabdominoplasty with fibrin glue, while group B underwent traditional lipoabdominoplasty; both had closed suction drainage applied to the abdomen. The patients' demographics and postoperative complications were recorded. Seroma was detected using abdominal ultrasound examinations at two postoperative periods: between postoperative days 10 and 12 and, between postoperative days 18 and 21. Results The age range was 31 to 55 years ($38.5{\pm}9.5$ years) in group A and 25 to 58 years ($37.8{\pm}9.1$ years) in group B, while the mean BMI was 31.4 to 39.9 $kg/m^2$ (32.6 $kg/m^2$) in group A and 32.7 to 37.4 $kg/m^2$ (31.5 $kg/m^2$) in group B. In group A, the patients had a complication rate of 10% in group A versus 43% in group B (P<0.05). The incidence of seroma formation was 3% in the fibrin glue group but 37% in the lipoabdominoplasty-alone group (P<0.05). Conclusions Lipoabdominoplasty with the use of autologous fibrin sealant is a very effective method that significantly reduces the rate of postoperative seroma.

• 패션비즈니스
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• 제22권5호
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• pp.96-112
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• 2018

This study developed the pants pattern, that improved appearance and gesture functions in clothes to resolve inconveniences in case of activities with being adequate in fitness of slim-fit pants for obese adolescents. The slim-fit pants pattern was developed through the fitting test after designing and making the pattern of the experimental clothing A(c/pu; 99/1%) with the primary commercial clothing as basic prototype, through the fitting test and implementation of the experimental clothing, modified and supplemented secondarily, and through the fitting test of the second experimental clothing, modified and supplemented tertiary. In terms of findings, first, as a result of analyzing the commercial slim-fit pants, it is interpreted to have projected an optical illusion, that appears to be slim due to being narrow in width of the front panel when observed from the front of the pants. Second, in the fitting test of the first experimental clothing, the prototype of commercial clothing was understood to have improved butt, crotch, waist and femoral regions. Third, pattern design of the second experimental clothing was allowed to decline abdominal pressure, in case of the sitting position, by making the crotch line in the front panel short and by handling it with a yoke belt, and was processed a difference between waist and hip circumference in the back panel, with a rubber band in the whole waist part. Fourth, in the gesture function test of the third experimental clothing, high evaluation was received in every item excluding the knee region.

• 비만대사연구학술지
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• 제1권2호
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• pp.78-82
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• 2022

Liraglutide (Saxenda^R) is prescribed to induce and sustain weight loss in obese patients. The starting dose of liraglutide is 0.6 mg/day for 1 week, which is increased by 0.6 mg/day every week until the full maintenance dose of 3 mg/day is achieved. Such dose titration is needed to prevent side effects, which primarily include gastrointestinal problems such as nausea, diarrhea, constipation, vomiting, dyspepsia, and abdominal pain. A 35-year-old, reportedly healthy obese man receiving liraglutide treatment for obesity visited the emergency room complaining of generalized weakness and dizziness accompanied by repeated diarrhea and vomiting. He reported over 20 episodes of diarrhea starting the day after liraglutide dose escalation from 1.2 mg/day to 1.8 mg/day. Laboratory findings suggested pre-renal acute kidney injury, including serum creatinine 4.77 mg/dl, blood urea nitrogen (BUN) 37 mg/dl, estimated glomerular filtration rate (eGFR) 15 ml/min/1.73 m², and Fractional excretion of sodium 0.08. After volume repletion therapy, his renal function recovered to a normal range with laboratory values of creatinine 1.08 mg/dl, BUN 14 mg/dl, and eGFR 88 ml/min/1.73 m². This case emphasizes the need for caution when prescribing glucagon-like peptide-1 receptor agonists, including liraglutide, given the risk of serious renal impairments induced by volume depletion and dehydration through severe-grade diarrhea and vomiting.

• Journal of Nutrition and Health
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• 제54권4호
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• pp.342-354
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• 2021

Purpose: Obesity is a serious public health issue for the modern society and is considered a chronic health hazard. There are many surgical and pharmacological approaches to treat obesity. However, various potentially hazardous side effects remain the biggest challenge. Therefore, diets based on foods derived from natural products have gained increasing attention compared to anti-obesity drugs. Recently, research on edible insects as a food source has been a topic of considerable interest in the scientific communities. This study examined the anti-obesity effects of ingesting an edible insect by feeding a high-fat diet (HFD)-induced obese mouse models with a diet containing Tenebrio molitor larvae powder (TMLP). Methods: Six-week-old female C57BL/6J mice were divided into 4 groups according to treatment: 100% normal diet (ND), 100% HFD (HFD), HFD 99% + TMLP 1% (TMLP), and HFD 97% + TMLP 3% (TMLP 3%). TMLP was added to the HFD for 6 weeks for the latter two groups. Results: Compared to the HFD group, mice in the TMLP group showed weight loss, and micro-computed tomographic imaging revealed that the volume of the adipose tissue in the abdominal area also showed significant reduction. After an autopsy, the fat weight was found to be significantly reduced in the TMLP group compared to the HFD group. In addition, the degree of fat cell deposition in the liver tissue and the size of the adipocytes significantly decreased in the TMLP group. Reverse transcription polymerase chain reaction analysis for the mRNA expression of adipogenesis-related genes namely CCAAT-enhancer-binding proteins (C/EBP-β, C/EBP-δ), and fatty acid-binding protein 4 (FABP4) showed that the expression levels of these genes were significantly reduced in the TMLP group compared to the HFD group. Serum leptin level also decreased significantly in the TMLP group in the comparison with the HFD group. In addition, total cholesterol, triglyceride, and glucose levels in mouse serum also decreased in the TMLP group. Conclusion: Taken together, our results showed that TMLP effectively inhibited adipocyte growth and reduced body weight in obese mice.