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Influence of Age on The Adenosine Deaminase Activity in Patients with Exudative Pleural Effusion (연령의 증가가 삼출성 흉수 Adenosine Deaminase 활성도에 미치는 영향)

  • Yeon, Kyu-Min;Kim, Chong-Ju;Kim, Jeong-Soo;Kim, Chi-Hoon
    • Tuberculosis and Respiratory Diseases
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    • v.53 no.5
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    • pp.530-541
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    • 2002
  • Background : Pleural fluid adenosine deaminase (ADA) activity can be helpful in a differntial diagnosis of an exudative pleural effusion because it is increased in a tuberculous pleural effusion. The ADA activity is determined mainly by the lymphocyte function. Age-associated immune decline is characterized by a decrease in T-lymphocyte function. For that reason, the pleural fluid ADA level would be lower in older patients with exudative pleural effusion. This study focused on the influence of age on the pleural fluid ADA activity in patients with exudative pleural effusion. Methods : A total of 81 patients with exudative pleural effusion were enrolled in this study. In all patients, the pleural fluid ADA activity was measured using an automated kinetic method. Results : The mean age of the patients was $52.7{\pm}21.2$ years. In all patients with exudative pleural effusion, the pleural fluid ADA activity revealed a significant difference between young patients (under 65 years of age) and old patients (p<0.05), and showed a negative correlation with age (r=-0.325, p<0.05). In the 60 patients with a tuberculous pleural effusion, the pleural fluid ADA activity revealed a significant difference between the young and older patients : $103.5{\pm}36.9$ IU/L in young patients Vs. $72.2{\pm}31.6$ IU/L in old patients (p<0.05), and showed a negative correlation with age (r=-0.384, p<0.05). In the 21 patients with non-tuberculous exudative pleural effusion, the pleural fluid ADA activity of the young patients and old patients was similar : $23.7{\pm}15.3$ IU/L in young patients Vs. $16.1{\pm}10.2$ IU/L in old patients (p>0.05), and did not show any correlation with age (r=-0.263, p>0.05). The diagnostic cutoff value of pleural fluid ADA activity for tuberculous pleural effusion was lower in the older patients (25.9 IU/L) than in the younger patients (49.1 IU/L) or all patients (38.4 IU/L) with exudative pleural effusion. Conclusion : Tuberculous pleural effusion is an important possibility to consider in older patients with a clinical suspicion of a tuberculous pleural effusion, although no marked increase in the pleural fluid ADA activity is usually detected. For a diagnosis of a tuberculous pleural effusion in old patients, the cutoff for the pleural fluid ADA activity should be set lower.

A Comparison of the Designation Characteristics of Korean Scenic Sites Policies and National Park System in the United States (국내 명승 정책과 미국 국립공원 시스템의 지정 특성 비교)

  • Lee, Won-Ho;Kim, Dong-Hyun;Janet, R. Balsom
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.38 no.3
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    • pp.25-34
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    • 2020
  • This study examined the definition and major values, the designated procedures and types, and the designation trend in Korean scenic sites and national parks in the United States. Based on this, the analysis of the characteristics of the designation of the two natural heritages. The results are as follows; First, Scenic Sites has characteristics of complex heritage that includes academic, historical, and humanities values on the basis of landscape. As a natural heritage based on public nature, the U.S. National Park aims to contribute to the people's natural heritage and satisfy both ecological and historical values through the protection of the landscape. Second, the designation of a scenic sites are decided through deliberation by the Cultural Heritage Committee after the request of the owner, manager, or local government or by the authority of the head of the Cultural Heritage Administration. The designated survey is divided into basic resource surveys and resource surveys by type. Since the initial designation of the Sogeumgang Mountain in Cheonghakdong, Myeongju in 1970, the number of designated scenic sites was low until the 2000s, but the number of designated scenic sites has increased rapidly since 2006 due to the policy to promote the scenic site, and the proportion of natural and historical and cultural scenic sites has been balanced. The designation of the U.S. national park is decided by the Congress or the president, and the National Park Service makes a series of decisions on whether to conduct a special resource study of provisional resources through a preliminary inspection survey, whether to satisfy the criteria for designation of national parks based on the results of special resource research, and to prioritize them. The U.S. National Parks have been expanded not only by Congress but also by the president's empowerment to designate them as national monuments. With the integrated operation of the National Park Service, the number of designated cases increased as the national park included the heritage sites under the control of various ministries. In addition, a number of historical areas were designated by the enactment of the Historical Site Act, and recreational areas were designated to provide leisure space and classified and managed in a total of 18 units. Third, the comparison of the designation characteristics of the two heritage properties confirmed that the designation of natural heritage with complex value, the classification of types according to complementary designation system and resource characteristics, the establishment of the competent ministry and the balancing of the heritage according to the designation policy. The two heritages had the characteristics of complex natural heritages that met ecological, historical and academic values at the same time based on landscape and public nature. In addition, both countries have identified a system for deliberating the designation of heritage through a basic resource survey and an in-depth designation survey, and classified each type according to the characteristics of the resource. In addition, the policies for promoting scenic sites in Korea and the integrated operation of the National Park Service in the U.S. influenced the designated aspects of the two heritage sites, balancing natural heritage with historical and cultural heritage. Fourth, the resource types and conservation management methods of Scenic site and National Park were largely related. The natural areas of the U.S. National Park include types of natural monuments in Korea as major resources, and have characteristics similar to natural scenic sites. In addition, historical resources were similar to the criteria for designation of historical and cultural scenic sites in terms of landscape, and the aspects of war and celebrity-related relics were related to the types of historic sites. In terms of conservation management, the natural area of the U.S. national park has a way of keeping the original ecosystem intact, but the Korean natural heritage protection system is likely to be useful for focusing on the resource of viscosity. Meanwhile, historical resources include historical sites and historical and cultural scenic sites in the traditional era, but historical relics in the U.S. National Parks have set a time limit to modern times for war history and celebrity-related relics, and the active provision of entertainment programs based on existing resources was derived as a difference.

Effects of Temperature and Sunshine Hours During Grain Filling Stage on the Quality-Related Traits of High Quality Rice Varieties in Korea (우리나라 고품질 벼 품종의 쌀 품질 특성에 미치는 등숙기 단계별 기온과 일조시간의 영향)

  • Yang, Woonho;Choi, Kyung-Jin;Shon, Jiyoung;Kang, Shingu;Shin, Seong-Hyu;Shim, Kang-Bo;Kim, Junhwan;Jung, Hanyong;Jang, Jung Hee;Jeong, Jeong-Su;Lee, Chae Young;Yun, Yeo Tae;Kwon, Suk Ju;An, Kyu Nam;Shin, Jong-Hee;Bae, Sung Mun
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.60 no.3
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    • pp.273-281
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    • 2015
  • Relationship between grain quality-related traits and daily mean temperature/sunshine hours during grain filling stage was analyzed using eleven high quality rice varieties at 24 experimental sites through eight provinces of Korea in 2013~2014. In the data set pooled across varieties, experimental sites and years, grain quality-related traits such as percentage of head rice (PHR), head rice yield (HRY), protein in milled rice (PRO) and Toyo Mido Meter glossiness value (TGV) were higher at the temperature lower than $22.6^{\circ}C$ for 40 days after flowering (DAF), which was optimum for percentage of grain filling in this study. Optimum sunshine hours for 40 DAF were $6.0{\sim}6.1\;hr\;d^{-1}$when considered PHR, HRY and TGV. PRO was associated with daily mean temperature and sunshine hours for 40 DAF in more varieties than the other traits. PRO was closely correlated with daily mean temperature during early filling stage and sunshine hours during early to mid filling stage, compared to other stages during grain filling. It is concluded that general trend in the variation of grain quality-related traits could be explained by the changes in daily mean temperature and sunshine hours during grain filling. In addition, climate conditions during early grain filling stage played important roles to enhance grain quality.

The study of Breast Specific Gamma Imaging Protocol using Self-development Phantom (자체 제작된 팬텀을 적용한 Breast Specific Gamma Imaging 검사 프로토콜에 대한 고찰)

  • Lee, Hae-Jung;Lee, Juyoung;Lim, Kuen-Kyo;Park, Hoon-Hee
    • The Korean Journal of Nuclear Medicine Technology
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    • v.18 no.2
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    • pp.39-47
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    • 2014
  • Purpose As breast cancer patients continue to increase every year, cases of BSGI are on the rise with a heavier reliance on it. However, BSGI protocol in hospitals was not studied enough despite it was covered by hospital's condition and recommendation of manufacturers. The objective of the study was an examination of methods to be applicable to BSGI protocols, putting the self-development phantom to use in quality assessment of the images. Materials and Methods Dilon 6800 (Dilon Technologies Inc, Newport News, USA) was used in the study and five different sizes of sphere were distinctively produced in the phantom. The study used $^{99m}TcO_4$. The cases were classified in to three categories that background radioactivity to region of interest as ratio of 2: 4: 8, They were acquired images for 5, 7, 10mins. The acquired image was set region of interest according to the size of sphere, and We analyzed quantitative and qualitative analysis. The acquired data statistically analyzed with SPSS ver.18.0. Results As the result of quantitative and qualitative analysis, count rate of each sphere in accordance with difference of injection dose showed that higher count rate as injection dose and sphere size increased (P<0.005). Count rate of each sphere in accordance with difference of acquisition time showed that higher count rate as acquisition time and sphere size increased (P<0.005). Contrast noise ratio of each sphere in accordance with difference of injection dose showed that higher contrast noise ratio as injection dose increased. Particularly, Contrast noise ratio of eight times ratio images was the highest among. Contrast noise ratio of each sphere in accordance with difference of acquisition time showed that higher contrast noise ratio as acquisition time increased. And, Contrast noise ratio of seven minute image was the highest among (P<0.005). Conclusion There was significant change of Contrast noise ratio through quantitative and qualitative analysis. Moreover, We found usefulness of phantom. If Institutions identified image through the phantom study and they made BSGI protocol, We expected to help the improvement of diagnostic value of the images.

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Analysis of the Kinematic Characteristics at Entrance to the Straight Course from the Curvilinear Course in the 200m-Track Game (육상 200m 경기의 곡선주로에서 직선주로 진입 시 운동학적 특성분석)

  • Oh, Sei-Jin
    • Korean Journal of Applied Biomechanics
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    • v.12 no.2
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    • pp.51-63
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    • 2002
  • This study sought to identify the kinematic characteristics at entrance to the straight course from the curvilinear course in the 200m-track game. For this purpose, this study was conducted for 4 sprinters by setting the 10m-section combined from the curvilenear track to the straight course and shooting them with the camcorder. It was set up to include all the sections of analysis by using the framework of the control point knowing the coordinate of the space and actual analysis was conducted on the motion showing the best records by conducting it for each subject five times. As a result, the following conclusion was drawn: It was found that the subjects showed the average stride of 4.5${\pm}$0.41 times at the 10-meter section and the required time of 1.42${\pm}$0.04sec. They showed the ratio average stride to height of 1.25${\pm}$0.20% and the average speed of 7.06${\pm}$0.19m/s. The displacement in the center of gravity of the human body at the section combined from the curvilinear course to the straight course was moving along the inward course of the curvilinear course, and the displacement of the leg located at the outward direction(right) was found to be larger than that of the leg located at the inward direction(left). In the speed of the left and right hand segments, it was found that the speed of the right hand located in the outward direction was faster than that of the left hand located at the inward, and it was found that the subjects progressed in the curvilinear course. The subjects showed the larger angle of the shoulder joint when the upper arm was located in the forward direction than when the it was located in the backward direction. In the curvilinear course, they showed the lower value of the lateral angle of the trunk when the right foot located at the outward direction left the ground than when the left foot located at the inward direction left the ground. And it was found that the lateral angle of the trunk became lower with approaching the straight course.

Quantitative Assessment using SNR and CNR in Cerebrovascular Diseases : Focusing on FRE-MRA, CTA Imaging Method (뇌혈관 질환에서 신호대 잡음비와 대조도대 잡음비를 이용한 정량적평가 : FRE-MRA, CTA 영상기법중심으로)

  • Goo, Eun-Hoe
    • Journal of the Korean Society of Radiology
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    • v.11 no.6
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    • pp.493-500
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    • 2017
  • In this study, data analysis has been conducted by INFINITT program to analyze the effect of signal to noise ratio(SNR) and contrast to noise ratio(CNR) of flow related enhancement(FRE) and computed tomography Angiography(CTA) on cerebrovascular diseases for qualitative evaluations. Based on the cerebrovascular image results achieved from 63 patients (January to April, 2017, at C University Hospital), we have selected 19 patients that performed both FRE-MRA and CTA. From the 19 patients, 2 were excluded due to artifacts from movements in the cerebrovascular image results. For the analysis conditions, we have set the 5 part (anterior cerebral artery, right and left Middle cerebral artery, right and left Posterior cerebral artery) as the interest area to evaluate the SNR and CNR, and the results were validated through Independence t Test. As a result, by averaging the SNR, and CNR values, the corresponding FRE-MRA achieved were: anterior cerebral artery ($1500.73{\pm}12.23/970.43{\pm}14.55$), right middle cerebral artery ($1470.16{\pm}11.46/919.44{\pm}13.29$), left middle cerebral artery ($1457.48{\pm}17.11/903.96{\pm}14.53$), right posterior cerebral artery ($1385.83{\pm}16.52/852.11{\pm}14.58$), left posterior cerebral artery ($1318.52{\pm}13.49/756.21{\pm}10.88$). by averaging the SNR, and CNR values, the corresponding CTA achieved were: anterior cerebral artery ($159.95{\pm}12.23/123.36{\pm}11.78$), right middle cerebral artery ($236.66{\pm}17.52/202.37{\pm}15.20$), left middle cerebral artery ($224.85{\pm}13.45/193.14{\pm}11.88$), right posterior cerebral artery ($183.65{\pm}13.47/151.44{\pm}11.48$), left posterior cerebral artery ($177.7{\pm}16.72/144.71{\pm}11.43$) (p < 0.05). In conclusion, MRA had high SNR and CNR value regardless of the cerebral infarction or cerebral hemorrhage observed in the 5 part of the brain. Although FRE-MRA consumed longer time, it proved to have less side effect of contrast media when compared to the CTA.

The Effectiveness Evaluation of Reconstruction Method Using DFOV Position Changes for Reduction of Artifact Around Hotspot in PET/CT Images (PET/CT 검사에서 열소 주변 인공물 감소를 위한 DFOV 위치 변화 재구성 방법의 유용성 평가)

  • Han, Dong Chan;Hong, Gun Chul;Choi, Choon ki;Lee, Hyeok;Choi, Seong Wook
    • The Korean Journal of Nuclear Medicine Technology
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    • v.17 no.2
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    • pp.90-94
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    • 2013
  • Purpose: In the PET/CT images, various artifacts cause degradation of the quantitative assessment. Most hotspot generated by radiopharmaceutical injection errors cause an artifact and degrade the quality of the images as well as the accuracy of the quantitative evaluation. The purpose of this study is to assess effectiveness of the elimination of the hotspot at the injection sites using shifting the center of DFOV (Display Field of View, DFOV) method and evaluate the quantitative evaluation of result. Materials and Methods: GE Discovery STE 16 (GE Healthcare, Milwaukee, USA) and 1994 NEMA phantom were used for imaging acquisition. Phantom was filled with 0.005 MBq/mL of $^{18}F-FDG$. A hotspot was artificially placed on the outside of the phantom. The ratio of hotspot area activity to background area activity was regulated as 200:1. After image acquisition with routine protocol, all of the images were reconstructed using the shifting the center of DFOV method that wasn't overlapped with hotspot. Those images obtained before and after applying the shifting reconstruction method were compared. ROIs (Region Of Interests) were set in the hotspot areas, meanSUVs and standard deviations were calculated. Percentage differences were calculated with those meanSUVs and standard deviations. The evaluation on the effects of the shifting reconstruction method was done by comparison of the meanSUVs and the standard deviations, which were calculated for background areas unaffected by hotspot. Results: In the areas of unaffected by hotspot, meanSUVs before and after applying the shifting of center of DFOV method were $0.67{\pm}0.06g/mL$ and $0.65{\pm}0.06g/mL$, respectively. In the artifact areas affected by hotspot, meanSUVs before and after applying the shifting of center of DFOV method were $0.32{\pm}0.08g/mL$ and $0.56{\pm}0.12g/mL$, respectively. The percentage differences of the area adjacent to the hotspot and the area distant from the hotspot were 65.3% and 97.4%, respectively. Conclusion: In the PET/CT images, meanSUV was improved by 32.1% when the effect of artifact was removed with application of the shifting the center of DFOV methode. In other areas unaffected by artifacts, meanSUVs were not significantly different after applying DFOV center shift method. As shown in the result, adverse effects of hotspot made by swelling in the injection site can be reduced by applying DFOV center shift method. Therefore, DFOV center shift method can be applied for the more precise quantitative evaluation, and contribute to the increase of the diagnostic value of the images.

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Forest Structure in Relation to Altitude and Part of Slope in a Valley Forest at Keumsan, Hallyo-Haesang National Park (한려해상국립공원 금산지역 계곡부의 해발고와 사면부위에 따른 산림구조)

  • 박인협;임도형;류석봉;이석면
    • Korean Journal of Environment and Ecology
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    • v.12 no.4
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    • pp.373-380
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    • 1999
  • The Byokryon-Daejangbong valley forest in Keumsan area at Hallyo-Haesang National Park was studied to investigate forest structure in relation to altitude and part of the slope. Forty-eight quadrats were set up in the valley forest along altitude of 200m to 650m and part of the slope. Density, mean DBH, and basal area of the canopy trees were 820~1873trees/ha, 10.7~14.6cm, and 17.7~22.2$\m^2$/ha, respectively. With increasing elevation mean DBH and basal area of tree stratum increased while density of tree stratum decreased. As elevation increased the importance values of Quercus mongolioa, Styrax japonica, Acer pseudo-sieboldiannum, and Sorbus alnifolia increased while those of Pinus thunbergii, Pinus densiflora, Prunus sargentii, Cornus kousa, and Eurya japonica decreased. The importance values of Fraxinus sieboldiana, Quercus variabilis, and Sorbus alnifolia increased as going from lower part to upper part of the slope. However, the opposite trend was found for the importance values of Styrax japonica, Lindera erythrocarpa, and Zelkova serrata, With incresing elevation number of species, species diversity, and evenness incresed and it was suggested that man interference was relatively severe. The range of similarity indices between elevation belts and between parts of the slope were 42.0~71.8% and 74.8~76.8%, respectively. According to importance values and cluster analysis, the studied valley forest was classified into four forest communities of Quercus serrata-Pinus densiflora community in low elevation belt, Carpinus laxiflora-deciduous tree species community in high elevation belt and lower and middle parts at middle elevation belt, Quercus variabilis-Carpinus laxiflora community in upper part at middle elevation belt, and Quercus mongolica-Styrax japonica community in top area. There were significantly positive correlation among Quercus serrata, Pinus densiflora, Pinus thunbergii, and Eurya japonica and among Carpinus laxiflora, Zelkova serrata, and Cornus walteri.

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Estimation of the Freshwater Advection Speed by Improvement of ADCP Post-Processing Method Near the Surface at the Yeongsan Estuary (ADCP 표층유속 자료처리방법 개선을 통한 영산강 하구 표층 방류수 이류속도 산정)

  • Shin, Hyun-Jung;Kang, Kiryong;Lee, Guan-Hong
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.19 no.3
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    • pp.180-190
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    • 2014
  • It has been customary to exclude top 10-20% of velocity profiles in the Acoustic Doppler Current Profiler (ADCP) measurement due to side lobe effects at the boundary. To better understand the mixing in the Yeongsan estuary, the freshwater advection speed (FAS) was recovered from highly contaminated ADCP data near the surface. The velocity profiles were measured by using ADCP at two stations in the Yeongsan estuary during August 2011: one was located in front of the Yeongsan estuarine dam and the other was deployed near Goha Island. The FAS was recovered from the ADCP data set by applying rigorous post-processing methods and compared with the sediment advection speed (SAS). The SAS was determined by the peak time difference of suspended sediment concentration between two stations in the channel, divided by the distance of two stations. The FAS and the SAS showed very similar value when the freshwater discharge was greater than $2.0{\times}10^7$ ton and the SAS was a bit greater when the freshwater discharge was smaller. Since the FAS was on average about 0.8 m/s greater than the velocity at 0.8 of water depth from the bottom, the net discharge, estimated with recovered FAS and integrated over water depth and tidal cycle, was directed seaward during the high discharge contrary to the onshore direction of the net discharge estimated with 0.8 of water depth from the bottom. Moreover, the velocity shear and Richardson number changed when the FAS was used. Thus, the importance of the true FAS is appreciated in the investigation of the surface layer stability. If currents, temperature and salinity were observed for longer time in the future, it could be possible to more accurately understand the formation and decay of stratification as well as the suspended sediment transport processes.

Optimization for the Physical Properties of Steamed Foam Cakes Prepared with Single-stage Method by Response Surface Methodology (반응표면 분석법에 의한 단단계법 거품형 찜 케이크의 물리적 특성의 최적화)

  • Kwhak, Sung-Ho;Jang, Myung-Sook
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.4
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    • pp.557-566
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    • 2005
  • In preparation of steamed foam-cakes, effects of whipping time, amount of wheat flour, and amounts of emulsifier on physical properties of the steamed foam cakes were investigated using RSM (response surface methodology). The three independent variables selected for the RSM experiment were whipping time $(X_1)$, amount of wheat flour $(X_2)$, and amounts of wheat flour $(X_2)$, and concentration of emulsifier $(X_3)$ were set for single-stage mixing, respectively. A rotatable central composite design was used for treatment arrangement. The responses from the product for loaf volume, color values and textural properties were analysed. In the analysis of variance for the foam cakes prepared by single-stage method, significant interactions were observed between independent variables (experimental factors) and physical property like loaf volume (p<0.05); textural properties like hardness, gumminess, and chewiness (p<0.05). Among independent variables, concentration of emulsifier had the most effects on physical properties while whipping time. The ordinary points in surface response showed maximal points with physical property like colorimetric b value while other properties revealed saddle points. The 3-dimensional response surface graphs of the predicted regression models displayed decreasing loaf volumes with increasing whipping times and emulsifier concentrations beyond optimum levels. The optimum conditions for best loaf volume and textural property (hardness, gummimess and chewiness) of the products selected by extracting intersectional areas of the contour maps that commonly overlapped all characteristics were; $11\~13$ min whipping time, $470\~486\;g$ amount of wheat flour, and $19\~20\;g$ emulsifier concentration, in case of single-stage method. The median values extracted from the RSM experimental results for optimum manufacturing conditions for single-stage method, i.e., 12 min whipping time, 478 g amount of wheat flour, and 20 g emulsifier concentration were empirically proven to fit the predicted levels of physical properties from the final foam cakes.