• Title/Summary/Keyword: a mixed data set

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Improved Long-term Survival with Contralateral Prophylactic Mastectomy among Young Women

  • Zeichner, Simon Blechman;Ruiz, Ana Lourdes;Markward, Nathan Joseph;Rodriguez, Estelamari
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.3
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    • pp.1155-1162
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    • 2014
  • Background: Despite mixed survival data, the utilization of contralateral prophylactic mastectomy (CPM) for the prevention of a contralateral breast cancer (CBC) has increased significantly over the last 15 years, especially among women less than 40. We set out to look at our own experience with CPM, focusing on outcomes in women less than 40, the sub-population with the highest cumulative lifetime risk of developing CBC. With an extended follow-up, we hoped to demonstrate differences in the long-term disease free survival (DFS) and overall survival (OS) among groups who underwent the procedure (CPM) versus those that did not (NCPM). Materials and Methods: We performed a retrospective review of all breast cancer patients less than age 40 diagnosed at Mount Sinai Medical Center between January 1, 1980 and December 31, 2010 (n=481). Among these patients, 42 were identified as having undergone CPM, while 195 were confirmed as being CPM-free during the observation period. A univariate and multivariate analyses were performed. Results: The CPM group had a significantly higher percentage of patients who were diagnosed between 2000 and 2010 (95.2% vs 40%, p=0.0001). The CPM group had significantly smaller tumors (0-2cm.: 41.7% vs 24.8%, p=0.04). Among the entire group of patients, the overall five- and 10-year DFS were 81.3% and 73.3%, respectively. CPM was significantly associated [HR 2.35 (1.02, 5.41); p=0.046] with 10-year OS, although a similar effect was not observed for five-year OS. Conclusions: We found that CPM has increased dramatically over the last 15 years, especially among white women with locally advanced disease. In patients less than 40, who are thought to be at greatest cumulative risk of secondary breast cancer, CPM provided an OS advantage, regardless of genetics, tumor or patient characteristics, and which was only seen after 10 years of follow-up.

Performance Analysis of MC-DS-CDMA System Using a Interference Suppression Method in a Multipath Fading Channel (다중 경로 페이딩 채널 환경에서 다중반송파 DS-CDMA 시스템의 간섭 제거 성능 분석)

  • Park Tae-Yoon;Choi Jae-Ho
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.27 no.8B
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    • pp.745-751
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    • 2002
  • The performance of existing CDMA-type multiple access data transmission systems is limited by interferences due to adverse mobile communication channel characteristics. Among them, the multi-user interference becomes one of the major performance degradation factors because the signal-to-signal orthogonality can be easily perturbed when numerous user signals are distorted by multipath fading channels and mixed together. In order to enhance the performance of CDMA-type systems by suppressing the multi-user interference, we have adopted chip-based cyclic prefix insertion along with adaptive one-tap DFE equalization into MC-DS-CDMA, which is known for its robustness in the frequency selective multipath fading channel environment. In order to assess the performance of the proposed system, a set of computer simulations is performed in the reverse link in which each user signal undergoes different multipath Rayleigh fading. The results show us a superior performance of our system over other CDMA systems in terms of SNR to BER measurements.

The Asymmetric Relationship between Output Volatility and Growth : Evidence from the U.K. Industrial Production (영국 산업생산 자료에 나타난 성장률과 변동성간의 비대칭적 관계)

  • Kim, Jan R.
    • International Area Studies Review
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    • v.14 no.3
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    • pp.86-107
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    • 2010
  • Prior research on the relationship between output volatility and growth has produced mixed results, failing to provide clear empirical evidence on the sign of the relationship. In this paper, we raise the possibility that such failure is due to misspecification in empirical models previously used, i.e., not taking into account the business cycle dependence of the volatility-growth relation. We set off with the conjecture that higher volatility exerts qualitatively different effect on growth depending on whether the economy is in expansion or contraction. We estimate a series of ARCH-type models with the monthly industrial production data of the U.K., and find strong evidence suggesting that the volatility-growth relation is positive when the economy is in expansion, while higher volatility lowers growth rate in the contraction phase. We also find evidence supporting that the volatility-growth relation estimated in the paper captures a a causal relation, not a bidirectional correlation.

Sensory Profiling of Commercial Korean Distilled Soju (시판 증류식 소주의 관능특성 분석)

  • Lee, Seung-Joo;Park, Cheon-Soo;Kim, Ho-Kyung
    • Korean Journal of Food Science and Technology
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    • v.44 no.5
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    • pp.648-652
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    • 2012
  • The sensory characteristics of nine commercially distilled soju samples were determined by sensory descriptive analysis. Eight aroma attributes, as well as four flavor/taste attributes, and six mouth-feel related attributes were evaluated by 9 judges. The descriptive data set was initially analyzed for a significant overall product effect by employing a three-way mixed model analysis of variance (judges, samples, and replications) as well as two-way interactions, with judges treated as random. In addition, correlations between mean attribute ratings were calculated, and a principal component analysis (PCA) of the mean attribute ratings employing the covariance matrix was conducted. Based on the PCA, distilled soju samples were primarily separated along the first principal component, which accounted for 66% of the total variance between the samples, with high intensities of 'alcohol taste' and 'alcohol aroma' versus 'yeast aroma'. The second principal component accounted for 14% of the total variance. Soju containing high alcohol showed stronger intensities of 'bitterness', 'alcohol taste', 'alcohol aroma', as well as all mouth-feel attributes.

The Buffer Capacity of the Carbonate System in the Southern Korean Surface Waters in Summer (하계 한국 남부해역 표층수의 탄산계 완충역량)

  • HWANG, YOUNGBEEN;LEE, TONGSUP
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.27 no.1
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    • pp.17-32
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    • 2022
  • The buffer capacity of southern Korean waters in summer was quantified using data set of temperature, salinity, dissolved inorganic carbon, total alkalinity obtained from August 2020 cruise. The geographical distribution and variability of six buffer factors, which amended the existing Revelle factor, are discussed their relationship with the hydrological parameters of temperature and salinity. The calculated results of six buffer factors showed the spatial variations according to the distributions of various water masses. The buffer capacity was low in the East Sea Surface Mixed Water (ESMW) and South Sea Surface Mixed Water (SSMW) where upwelling occurred, and showed an intermediate value in the Yellow Sea Surface Water (YSSW). In addition, the buffer capacity increased in the order of high temperature Tsushima Warm Current (TWC) and Changjiang Diluted Water (CDW). This means that the Changjiang discharge water in summer strengthens the buffer capacity of the study area. The highest buffer capacity of CDW is due to its relatively higher temperature and biological productivity, and a summer stratification. Temperature showed a good positive correlation (R2=0.79) with buffer capacity in all water masses, whereas salinity exhibited a poor negative correlation (R2=0.30). High temperature strengthens buffer capacity through thermodynamic processes such as gas exchange and distribution of carbonate system species. In the case of salinity, the relationship with buffer capacity is reversed because salinity of the study area is not controlled by precipitation or evaporation but by a local freshwater input and mixing with upwelled water.

Solvent Extraction of Light (Pr, Nd) and Medium (Tb, Dy) Rare Earth Elements with PC88A of Rare Earth Chloride Solution from Waste Permanent Magnet (폐 영구자석으로부터 회수한 염화희토류용액에서 PC88A를 이용한 경희토류(Pr, Nd)/중희토류(Tb, Dy) 용매추출)

  • Jeon, Su-Byung;Son, InJoon;Lim, Byung-Chul;Kim, Jeong-Mo;Kim, Yeon-Jin;Ha, Tae-Gyu;Yoon, Ho-Sung;Kim, Chul-Joo;Chung, Kyeong-Woo
    • Resources Recycling
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    • v.27 no.3
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    • pp.8-15
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    • 2018
  • Solvent extraction behavior of light rare earth elements (Pr, Nd) and medium rare erath elements (Tb, Dy) in the HCl-PC88A-kerosene extraction system was investigated in order to separate high-purity light rare earths (Pr, Nd) and medium rare earths (Tb, Dy) in the mixed rare earth chloride solution. In the batch test step, it was confirmed that the separation efficiency was good when the extractant concentration (PC88A) was 0.5 M, the equilibrium pH after extraction was 0.8 to 1.0 (initial pH 1.3 of the feed), the concentrations of hydrochloric acid in scrubbing solution was set as 0.1 M, the concentrations of hydrochloric acid in stripping solution was set as 2.0 M or more. Based on the experimental data obtained from the batch test, the mixer-settler was composed as follows; 4 stages of extraction, 8 stages of scrubbing, 4 stages of stripping, and 3 stages of pickling organic solution. The Mixer-settler was operated for 180 hours, and the operating conditions were continuously adjusted to obtain the high-purity light/medium rare earths. Finally, the purity of light (Pr, Nd) and medium rare earth elements (Tb, Dy) was reached as 3 N class.

Scanning Determination & Observation Features by Sex shown in the Process of Acquiring Visual Information - With the Object of Subway Station Hall Space - (시각정보획득과정에 나타난 주사판정과 성별 주시특성 - 지하철 홀 공간을 대상으로 -)

  • Kim, Jong-Ha;Choi, Gae-Young
    • Korean Institute of Interior Design Journal
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    • v.23 no.6
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    • pp.115-124
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    • 2014
  • This study has carried out scanning tests in order to figure out the features of scanning search by sex of space users, with the result of which the validity of data has been estimated. In this research, the scanning patterns were set up for verifying the typology of scanning paths and then the reason for determining scanning paths and the validity of estimation method were reviewed. Since the observation features depends on sex, the analysis of visual activities for acquiring any information in a space will reveal the intention and purpose of space users. The findings by analyzing the features of scanning pattern by sex which were found at the determination of scanning patterns can be defined as the followings. First, for estimating the process of space-information search, the movement distance at each point of continuative-observation data from the angle of eye-movement has been extracted, on the ground of which the fixation and movement of eye have been defined for the establishment of scanning-cut characteristics. Second, the scanning times were estimated for the extraction of effective observation data that would be used for comparative analysis, which showed that men had more data (3,398.2/64.4%) than women (2,998.2/55.6%). This enables the acknowledgment that the scanning cut of men was relatively less, which indicates that men will acquire more information on space than women in the process of observing any space. Third, men's scanning times (58.0 times/2.02 seconds) were less than those of women (71.9 times/1.39 seconds) while the scanning time of the former was longer than that of the latter, which shows the feature that it takes longer for men than women in scanning while the scanning times of the former is less than those of the latter. Fourth, the observation features can be determined that the combination of this result with the predominance character by sex for a general viewpoint to be employed indicates that while men employ mixed-scanning for observation activities to acquire space-information spending for longer time, women, by concentrated-scanning, focus on a single point for shorter time or stay at one location for a considerably long time for space-information acquirement.

Molecular Identification and Sequence Analysis of Coat Protein Gene of Ornithogalum mosaic virus Isolated from Iris Plant

  • Yoon, Hye-In;Ryu, Ki-Hyun
    • The Plant Pathology Journal
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    • v.18 no.5
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    • pp.251-258
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    • 2002
  • A potyvirus was isolated from cultivated Iris plants showing leaf streak mosaic symptom. Reverse transcription and polymerase chain reaction (RT-PCR) product of 1 kb long which encoded partial nuclear inclusion B and N-terminal region of viral coat protein (CP) genes for potyviruses was successfully amplified with a set of potyvirus-specific degenerate primers with viral RNA samples from the infected leaves: The RT-PCR product was cloned into the plasmid vector and its nucleotide sequences were determined. The nucleotide sequence of a CDNA clone revealed that the virus was an isolate of Ornithogalum moseic virus (OrMV) based on BLAST search analysis and was denoted as OrMV Korean isolate (OrMV-Ky). To further characterize the CP gene of the virus, a pair of OrMV-specific primers was designed and used for amplification of the entire CP gene of OrMV-Kr, The virus was easily and reliably detected from virus-infected Iris leaves by using the RT-PCR with the set of virus-specific primers. The RT-PCR product of the CP gene of the virus was cloned and its sequences were determined from selected recombinant CDNA clones. Sequence analysis revealed that the CP of OrMV-Kr consisted of 762 nucleotides, which encoded 253 amino acid residues. The CP of OrMV-Ky has 94.1-98.0% amino acid sequence identities (20 amino acid alterations) with that of other three isolates of OrMV, Two NT rich potential N-glycosylation motif sequences, NCTS and NWTM, and a DAC triple box responsible for aphid transmission were conserved in CPs of all the strains of OrMV. The virus has 58.5-86.2% amino acid sequence identities with that of other 16 potyviruses, indicating OrMV to be a distinct species of the genus. OrMV-Ky was the most related with Pterostylia virus Yin the phylogenetic tree analysis of CP at the amino acid level. This is the first report on the occurrence of OrMV in Iris plants in Korea. Data in this study indicate that OrMV is found in cultivated Iris plants, and may have mixed infection of OrMV and Iris severe mosaic virus in Korea.

Comparison of several criteria for ordering independent components (독립성분의 순서화 방법 비교)

  • Choi, Eunbin;Cho, Sulim;Park, Mira
    • The Korean Journal of Applied Statistics
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    • v.30 no.6
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    • pp.889-899
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    • 2017
  • Independent component analysis is a multivariate approach to separate mixed signals into original signals. It is the most widely used method of blind source separation technique. ICA uses linear transformations such as principal component analysis and factor analysis, but differs in that ICA requires statistical independence and non-Gaussian assumptions of original signals. PCA have a natural ordering based on cumulative proportion of explained variance; howerver, ICA algorithms cannot identify the unique optimal ordering of the components. It is meaningful to set order because major components can be used for further analysis such as clustering and low-dimensional graphs. In this paper, we compare the performance of several criteria to determine the order of the components. Kurtosis, absolute value of kurtosis, negentropy, Kolmogorov-Smirnov statistic and sum of squared coefficients are considered. The criteria are evaluated by their ability to classify known groups. Two types of data are analyzed for illustration.

CFD Simulation for Mixture Characteristic of DME-Propane Liquified Fuels (DME-Propane 액화연료의 혼합특성에 대한 CFD 시뮬레이션)

  • Kim, Cha-Hwan;Chun, Seuk-Hoon;Shin, Dong-Woo;Kim, Lae-Hyun;Lee, Hyun-Chan;Baek, Young-Soon
    • Korean Chemical Engineering Research
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    • v.50 no.2
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    • pp.328-333
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    • 2012
  • In this study, CFD simulation was performed with commercial CFD code FLUENT for the 3D mixing tank model (1 m in a diameter and 2.5 m in a height) of DME-Propane liquified fuels. Initial condition set-up with existence of DME 146 l at the upper side of mixing tank and Propane 770 l at the lower side of mixing tank. Characteristics of mixture and fluid flow were observed for 34 hours simulation. Two liquid fuel were uniformly mixed within range of 3 mol% after 24 hours, and range of 1 mol% after 34 hours. The simulation result following 4 hours was verified with KOGAS experimental data.