• 인터넷정보학회논문지
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• 제25권1호
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• pp.29-37
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• 2024

본 논문에서는 환자와 같은 특정 객체의 움직임을 감지하고 추적하기 위한 효율적인 영상처리 시스템을 제안한다. 이진화된 차 영상에서 객체의 윤곽선추출을 위하여 기존 알고리즘대비 대비 정밀한 감지가 가능하고 혼성모드설계에 용이한 세선화 알고리즘을 적용하여 영역을 추출한다. 연산량이 많은 이진화와 세선화 단계를 RTL(Register Transfer Level) 기반으로 설계하여 논리회로 합성을 거쳐 최적화된 하드웨어 블록으로 대체된다. 설계된 이진화 및 세선화 블록은 표준 180n CMOS 라이브러리를 이용하여 논리회로로 합성한 후 시뮬레이션을 통하여 동작을 검증하였다. 소프트웨어기반의 성능비교를 위해 32bit FPGA 임베디드시스템 환경에서 640 × 360 해상도의 샘플 영상을 적용하여 이진 및 세선화 연산에 대한 성능분석도 실시하였다. 검증결과 혼성모드 설계가 이전의 소프트웨어로만 이루어지는 처리속도에서 이진 및 세선화 단계에서 93.8% 향상될 수 있음을 확인하였다. 제안된 객체인식을 위한 혼성모드 시스템은 인공지능 네트워크가 적용되지 않는 엣지 컴퓨팅 환경에서도 환자의 움직임을 효율적으로 감시할 수 있을 것으로 기대된다.

• 대한한의학방제학회지
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• 제31권4호
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• pp.361-371
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• 2023

Objectives : Gastric cancer is a malignant tumor of the digestive tract that not only has a high mortality rate, but also affects quality of life. In Traditional Korean Medicine, acupuncture and herbal medicines can increase the survival rate for Gastric cancer and improve the quality of life. Traditional Korean Medicine treatment played an important role when used alone or in combination with chemotherapy. However, there is still insufficient evidence to support the efficacy and safety of Traditional Korean Medicine in patients undergoing chemotherapy after surgery. Therefore, the purpose of this study is to systematically evaluate the effect of oriental medicine treatment on patients as a complementary therapy for Gastric cancer. Methods : 2 researchers will search using EMBASE, Pubmed, CNKI, Cochrane Library, CiNii, KMBASE, KISS, OASIS, RISS, ScienceON. The search period of the database is from inception until June 2022. This study will include a randomized controlled trial of GC for acupuncture and herbal treatment. Primary outcomes include anti-cancer effects. Secondary outcomes evaluate survival rates and improvements in quality of life. The data uses Review Manager Software 5.4. Results : This study will provide a systematic evaluation by synthesizing the anti-cancer effect, survival rate and quality of life of Gastric cancer when Traditional Korean Medicine is combined with chemotherapy. Conclusion : The conclusion of this study will provide a basis for determining whether Traditional Korean Medicine treatment for Gastric cancer treatment is an effective and safe treatment method in clinical practice.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9879-9884
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• 2014

Aim: The purpose of the current study was to conduct a systematic review of the published literature to evaluate the diagnostic accuracy of FDG-PET, PTE/CT, MRI and scintigraphy for multiple myeloma related bone disease. Methods: Through a search of PubMed, EMBASE, and the Cochrane Library, two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR), and two sample Z-tests were conducted to evaluate for differences in sensitivity, specificity, area under the curve (AUC), and the $Q^*$ index between any two diagnostic modalities. Results: A total of 17 studies were reviewed. The MRI had a pooled sensitivity of 0.88, specificity of 0.68, AUC of 0.897, and $Q^*$ index of 0.828, whereas for MIBI, the corresponding values were 0.98, 0.90, 0.991, and 0.962, respectively, and for bone scan, they were 066, 0.83, 0.805, and 0.740, respectively. The corresponding values of MIBI were 0.98, 0.90, 0.991, and 0.962, respectively. For PET and PET/CT, the values were 0.91, 0.69, 0.927 and 0.861, respectively. Statistically significant differences were not found in the sensitivity, specificity, AUC, and $Q^*$ index between MRI, scintigraphy, FDG-PET and PET/CT. Conclusions: On the condition that X ray is taken as a reference in our study, we suggested that FDG-PET, PTE/CT, MRI and scintigraphy are all associated with high detection rate of bone disease in patients with MM. Thus, in clinical practice, it is recommended that we could choose these tests according to the condition of the patient.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.539-549
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• 2020

The efficacy of P2Y12 reaction unit (PRU) of VerifyNow still remains as a controversial issue in neurointervention. So we investigated the usefulness of PRU of VerifyNow to predict the peri-procedural thromboembolic events (TE) and hemorrhagic events (HE). And we evaluated the safety of modified dual antiplatelet therapy (DAPT) or triple antiplatelet therapy (TAPT) for clopidogrel hyporesponders. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus on August 19 2018. Data was collected the 1) incidence of TE between clopidogrel responder and clopidogrel hypo-responder, 2) incidence of HE between clopidogrel hyper-responder and clopidogrel responder and hypo-responder, and 3) incidence of TE and HE between modified DAPT or TAPT and standard DAPT in clopidogrel hypo-responder. High cut-off value of PRU was defined as PRU >40% or <220. Fifteen studies were enrolled. Clopidogrel responder showed lower incidence of TE than hypo-responder (risk ratio [RR], 0.32; 95% confidence interval [CI], 0.17-0.61; p<0.001). With the high cut-off value of PRU, clopidogrel responder showed more lower incidence of TE than hypo-responder (RR, 0.11; 95% CI, 0.02-0.45; p=0.002). The incidence of periprocedural HE have higher on clopidogrel hyper-responder than clopidogrel responder and hypo-responder (RR, 4.26; 95% CI, 1.10-16.44; p=0.04; I²=66%). The incidence of periprocedural TE after changing regimen of DAPT for clopidogrel hypo-responder have a tendency to reduce, but there was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). The incidence of periprocedural HE after changing regimen of DAPT for clopidogrel hypo-responder was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). PRU is a useful tool as a predictor of peri-procedural TE or HE on neurointervention. PRU has a threshold effect of cut-off value to predict the peri-procedural TE. Modified DAPT or TAPT to prevent TE in clopidogrel hypo-responders could not reduce the incidence of TE. We should investigate the further research about modification of regiment on neurointervention.

• Tuberculosis and Respiratory Diseases
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• 제82권2호
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• pp.102-117
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• 2019

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia, which presents with a progressive worsening dyspnea, and thus a poor outcome. The members of the Korean Academy of Tuberculosis and Respiratory Diseases as well as the participating members of the Korea Interstitial Lung Disease Study Group drafted this clinical practice guideline for IPF management. This guideline includes a wide range of topics, including the epidemiology, pathogenesis, risk factors, clinical features, diagnosis, treatment, prognosis, and acute exacerbation of IPF in Korea. Additionally, we suggested the PICO for the use of pirfenidone and nintendanib and for lung transplantation for the treatment of patients with IPF through a systemic literature review using experts' help in conducting a meta-analysis. We recommend this guideline to physicians, other health care professionals, and government personnel in Korea, to facilitate the treatment of patients with IPF.

• 한국융합학회논문지
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• 제12권3호
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• pp.325-339
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• 2021

연구의 목적은 문헌고찰을 통해 스포츠 관련 인지기능과 이를 효과적으로 측정할 수 있는 검사도구를 제안하고, 스포츠 지능 연구의 기초를 마련하는 것이다. 문헌고찰은 체계적 문헌고찰과 메타분석 지침인 PRISMA 연구법에 근거하여 수행되었다. 게재년도 2008-2020년으로 검색기준 설정 후, 키워드를 통해 검색된 총 429편 중 본 연구의 문헌선택 기준을 충족한 45편이 최종 분석되었다. 고찰된 논문 결과를 요약하면, 선수들은 비선수보다 특정 인지기능이 우수하고, 스포츠 전문성이 높을수록 해당 인지기능이 더 높았으며, 종목에 따라 인지기능에 차이가 있는 것으로 나타났다. 45편에 대한 종합적 분석결과, 스포츠 수행과 관련된 주요 인지기능은 실행기능(억제능력, 인지유연성), 정보처리속도, 공간능력, 주의력으로 요약된다. 각 인지기능 측정을 위한 검사도구로 억제능력은 정지신호과제, 인지유연성은 설계유연성검사, 정보처리는 단순반응검사와 선택반응검사, 공간능력은 심적회전검사, 주의력은 주의연합검사가 적절하다.

• 대한조현병학회지
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• 제21권2호
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• pp.43-50
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• 2018

Objectives : Genome-wide association studies (GWASs) and meta-analyses indicate that single-nucleotide polymorphisms (SNPs) in the a-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) gene increase the risk for schizophrenia and bipolar disorders (BDs). We investigated the association between the genetic variants on CACNA1C and schizophrenia and/or BDs in the Korean population. Methods : A total of 582 patients with schizophrenia, 336 patients with BDs consisting of 179 bipolar I disorder (BD-I) and 157 bipolar II disorder (BD-II), and 502 healthy controls were recruited. Based on previous results from other populations, three SNPs (rs10848635, rs1006737, and rs4765905) were selected and genotype-wise association was evaluated using logistic regression analysis under additive, dominant and recessive genetic models. Results : rs10848635 showed a significant association with schizophrenia (p=0.010), the combined schizophrenia and BD group (p=0.018), and the combined schizophrenia and BD-I group (p=0.011). The best fit model was dominant model for all of these phenotypes. The association remained significant after correction for multiple testing in schizophrenia and the combined schizophrenia and BD-I group. Conclusion : We identified a possible role of CACNA1C in the common susceptibility of schizophrenia and BD-I. However no association trend was observed for BD-II. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

• Journal of Periodontal and Implant Science
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• 제37권3호
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• pp.465-478
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• 2007

Various periodontal barrier membranes used in many clinical and experimental fields, and many recent studies of membranes have reported good results. To improve clinical results, selection of barrier membranes is an important factor. So, we need not only to evaluate various barrier mem-branes, but also to understand the property of barrier membranes appropriate to defect characteristics. For this purpose, this study reviewed available literature, evaluated comparable experimental models, and compared various barrier membranes. From above mentioned methods, the following conclusions are deduced. 1. In i-wall periodontal defect models, new bone formation showed a consistent result, almost 30% of the defect size. New cementum formations measured mostly 40% of the defect size, but showed more variations than new bone formations. This seems to be resulted form difference in experimental methods, so standardization in experimental methods is needed for future studies. 2. Application PLGA barrier membrane to periodontal defect demonstrated improved healing in new bone and new cementum. 3. There was a minimal periodontal regeneration with calcium sulfate barrier membrane only. But, there was better healing pattern in combination of calcium sulfate membrane with bone graft material, such as DFDBA, 4. There was no significant difference between the experimental group that used chitosan mem-brane only and the control group. But, in combination with bone graft material for space maintanence, periodontal regeneration was improved. Overall, Space maintenance is a critical factor for Guided tissue regeneration using barrier membranes. Also, a barrier membrane itself that has difficulty in maintaining space, achieved better result when used with graft material.

• 산경연구논집
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• 제10권5호
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• pp.67-76
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• 2019

Purpose - The Korean child welfare services may have different feelings between providers and users. Few studies on the child welfare service quality have been conducted and research on the coorientation model of child welfare services are nonexistent. We compared the perceptions of Korean child welfare service providers and users in this study. It will have many applications in the service quality fields by applying a coorientation model. Research design, data, and methodology - In order to enhance user satisfaction with child welfare services, around 200 samples were carried out both in Busan and Kyungsangnamdo randomly. Seven point Likert scale was used in the questionnaire. Two measurements were made to evaluate the different positions on the part of child welfare service providers and users to assess their mutual orientation. Paired t-test verification was conducted for congruency analysis, and the verification of agreement and accuracy was analyzed by independent t-tests. Results - We empirically examined the differences between the providers and the users stance. The results are as follows. We have verified the statistical significance of the difference in perception between providers and users. We also confirmed a degree of agreement, a degree of congruency, a degree of accuracy and a degree of meta agreement in the study. In the Korean child welfare service quality, the coorientation model of process quality appeared in the form of semi-dissensus, the coorientation model of results quality were shown in the form of ignorances and the coorientation model of physical environment quality were investigated in the form of semi-dissensus. Conclusion - The study concluded that users need to understand more about the providers in order to enhance the coorientation model in process quality and physical environmental quality, and the providers need to persuade the users clearly about the positive factors. To enhance the coorientation model of the result quality, it can be misunderstood by guessing that the other party will positively evaluate it. Therefore, users believe that they need to talk more clearly to the provider about the results of the korean child welfare service quality to reduce misunderstandings and to understand each other about the resulting quality.

• 동양고전연구
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• 제54호
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• pp.155-182
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• 2014

이 논문은 "중용"의 "천명지위성(天命之謂性)"과 "시중(時中)", 그리고 "천지위만물육(天地位萬物育)"의 이슈가 진화생물학의 유전자, 자연선택, 종 다양성 문제와 대화 가능한지 그 가능성을 검토하고 있다. 이를 위해 먼저 성리학과 진화생물학의 유사점과 차이점을 살펴보고, "중용"과 진화생물학의 접점이 무엇인지 모색하고 있다. 이 논문은 세 가지 점에서 "중용"과 진화생물학 사이의 대화 가능성을 검토한다. 첫번째는 인간 본성에 대해 천명지위성과 유전자의 관점에서 대화 가능한지 살펴본다. 두 번째는 존재 이유의 타당성을 시중과 자연선택의 관점에서 살펴본다. 세 번째는 생물간 상호 유연 관계를 천지위만물육과 종 다양성이라는 관점에서 살펴본다. 첫 번째 모색의 소주제들은 <리와 기 vs 유전자와 운반체>의 구조적 연관성, <성선 vs 이기적 유전자의 이타성>의 판단기준, <인 의 예 지 vs 후성규칙>에서 '후천적 선험' 도출 가능성이다. 두 번째 모색의 소주제들은 <천리의 뒤집힘[번(?)] vs 돌연변이>, <변/화 vs 진화>의 시간관, <시중 vs 자연선택/적응>의 메타meta적 접근이다. 세 번째 모색의 소주제들은 <리일분수理一分殊 vs 부분과 전체>의 프랙탈 구조, < 일기一氣 vs 생물간 상호 유연>의 상동관계, <천지위 만물육 vs 생태계>와 치중화致中和의 과제이다. 이러한 모색과 제안들에 대한 후속연구는 "중용"을 둘러싼 성리학 연구의 지평 확대를 가져 올 수 있다.