• Molecules and Cells
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• v.46 no.11
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• pp.675-687
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• 2023

Accumulation of pathogenic amyloid-β disrupts the tight junction of retinal pigment epithelium (RPE), one of its senescence-like structural alterations. In the clearance of amyloid-β, the autophagy-lysosome pathway plays the crucial role. In this context, mammalian target of rapamycin (mTOR) inhibits the process of autophagy and lysosomal degradation, acting as a potential therapeutic target for age-associated disorders. However, efficacy of targeting mTOR to treat age-related macular degeneration remains largely elusive. Here, we validated the therapeutic efficacy of the mTOR inhibitors, Torin and PP242, in clearing amyloid-β by inducing the autophagy-lysosome pathway in a mouse model with pathogenic amyloid-β with tight junction disruption of RPE, which is evident in dry age-related macular degeneration. High concentration of amyloid-β oligomers induced autophagy-lysosome pathway impairment accompanied by the accumulation of p62 and decreased lysosomal activity in RPE cells. However, Torin and PP242 treatment restored the lysosomal activity via activation of LAMP2 and facilitated the clearance of amyloid-β in vitro and in vivo. Furthermore, clearance of amyloid-β by Torin and PP242 ameliorated the tight junction disruption of RPE in vivo. Overall, our findings suggest mTOR inhibition as a new therapeutic strategy for the restoration of tight junctions in age-related macular degeneration.

• Journal of the Korean Applied Science and Technology
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• v.35 no.4
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• pp.1185-1196
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• 2018

The purpose of this study was to investigate the effects of 12-week aquarobics exercise on blood lipids, atherogenic index, and liver functions in elderly women. The subjects for the study were 25 healthy elderly women volunteers, aged 65 to 80 years, composed of the aquarobics exercise group (n=13) and control group (n=12). Twice a week for 60 minutes for 12 weeks. The exercise intensity was set to RPE 11-12 for 1 week to 4 weeks, RPE 13-14 for 5 week to 8 weeks and RPE 15-16 for 9 week to 12 weeks respectively. The test data were analyzed by two-way repeated measures ANOVA, paired t-test, and independent t-test. The alpha level of .05 was set for all tests of significance. The results of the study in the aquarobics exercise group were as follows; LDL-C (p<.05), AST (p<.05) had significantly decreased, with TC (p<.01), TG (p<.05), LDL-C (p<.05), LDL-C/HDL-C (p<.05), TG/HDL-C (p<.05), AST (p<.001) significantly lower than control group. Consequently, these findings suggest that regular aquarobics exercise will be effective for preventiy the metabolic syndrome and cardiovascular health in elderly women.

• Journal of Korean Critical Care Nursing
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• v.4 no.1
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• pp.65-73
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• 2011

Purpose: This study was to develop and evaluate stability and effects of an early exercise program for patients with open heart surgery. Methods: The subjects of this study were 30 patients who had either a coronary bypass surgery or a valvular heart surgery at a tertiary hospital in Seoul. The data was collected by observation and measurement from October 1, 2004 to November 15, 2004. Results: The early exercise program developed for this study consisted of range of motion exercise and walking. Intensity of walking was 1~3 METs and increased progressively to daily target distance. During exercise, the subjects were monitored heart rate, blood pressure and RPE (Rating of Perceived Exertion). The mean FIM (Functional Independent Measurements) score of subjects was significantly improved after the early exercise program. However, several complaints such as dizziness or pain were also reported. Most complaints were associated with chest tube and RPE. Conclusion: The early exercise program can help to recover patients' physical activities after surgery, and can be applied to most patients. Patients' RPE, dizziness and pain was possible limitations, therefore, active pain control and prevention of accidents for patients would be needed.

• Journal of the Korean Institute of Telematics and Electronics
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• v.27 no.4
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• pp.491-501
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• 1990

Recently, four speech coding techniques, namely, SBC-APCM(sub-band coding adaptive PCM), RPE-LPC(regualr pulse excitation linear predictive codec), MPE-LTP(multi-pulse excited long-term prediction) and CELP (code-excited linear prediction) are proposed for digital mobile radio applications. However, a performance comparison of these coders in the Rayleigh fading environment has not been made yet. In this paper, the performances of the four spech coders in the random bit error and burst error environment are investigated. For the channel coding of SBC-APCM, RPE-LPC and MPE-LTP, the sensitivity of output bit stream is measured and a bit selective forward error correction is provided acording to the measured bit sensitivity. And for an attempt to improve the performance of CELP, an optimum quantizer is applied for transmitting scalar quantities in CELP. However, an improvement over the conventional approach is found to be negligible. For the channel coding of CELP, Reed-Solomon code, Golay code, convolutional code of rate 1/2 shows the best performance. Finally, from the simulation results, it is concluded that CELP is the best candidate for digital mobile radio and is followed by MPE-LTP, SBC-APCM and RPE-LPC.

• Journal of Korean Physical Therapy Science
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• v.19 no.1
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• pp.47-54
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• 2012

Purpose : This study is to know the effect on muscle activity when people use mouse aid or not in computer working environment. Method : 11 people of both sex in their twentieth were tested. As a independent variable, the condition without mouse aid and the condition with movable mouse aid were selected, and as a dependent variable, MVC(%) on four muscles and inconvenience degree(RPE scale) on three body part(wrist, forearm, shoulder) were measured. Result : Analyzing the research, MVC(%) of extensor muscle of finger had notably higher muscle activity than other muscles, and there wasn't notable difference in muscle activity before and after using mouse aid. In case of using mouse aid, we tested by giving RPE questionnaire which segmentalized mental fatigue degree into hand, forearm, and shoulder, and resultingly, there wasn't notable differences perspectively. However, people felt less tiredness subjectively after they use the mouse aid. Conclusion : The usage of mouse aid seems to give comfort to computer users.

• The korean journal of orthodontics
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• v.49 no.2
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• pp.89-96
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• 2019

Objective: The purpose of this study was to assess the long-term stability of rapid palatal expansion (RPE) followed by full fixed edgewise appliances. Methods: This study included 67 patients treated using Haas-type RPE and non-extraction edgewise appliance therapy at a single orthodontic practice. Serial dental casts were obtained at three different time points: pretreatment ($T_1$), after expansion and fixed appliance therapy ($T_2$), and at long-term recall ($T_3$). The mean duration of the $T_1-T_2$ and $T_2-T_3$ periods was $4.8{\pm}3.5years$ and $11.0{\pm}5.4years$, respectively. The dental casts were digitized, and the computed measurements were compared with untreated reference data. Results: The majority of treatment-related increases in the maxillary and mandibular arch measurements were statistically significant (p < 0.05) and greater than expected for the untreated controls. Although many measurements decreased postretention ($T_2-T_3$), the net gains persisted for all of the measurements evaluated. Conclusions: The use of RPE therapy followed by full fixed edgewise appliances is an effective method for increasing maxillary and mandibular arch width dimensions in growing patients.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.327-332
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• 2015

Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries and identified mefloquine, an anti-malaria medicine, as a potent regulator of primary cilia in human retinal pigmented epithelial (RPE) cells. Not only ciliated cells but also primary cilium length was increased in mefloquine-treated RPE cells. Treatment with mefloquine strongly induced the elongation of primary cilia by blocking disassembly of primary cilium. In addition, we found that autophagy was increased in mefloquine-treated cells by enhancing autophagic flux. Both chemical and genetic inhibition of autophagy suppressed ciliogenesis in mefloquine-treated RPE cells. Taken together, these results suggest that autophagy induced by mefloquine positively regulates the elongation of primary cilia in RPE cells.

• Journal of the Ergonomics Society of Korea
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• v.32 no.6
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• pp.541-547
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• 2013

Objective: The aim of this study is to find the influence on muscle fatigue by changing an angle of neck while Shaker exercise. Background: Shaker exercise is commonly applied to dysphagia patients for strengthen suprahyoid muscle(SHM) and relaxing upper esophageal sphincter. Method: Experiments were conducted by measuring muscle fatigue with surface electromyography(SEMG) in case of neck $15^{\circ}$ and $50^{\circ}$ flexion, in addition to original method. For the study 30 undergraduate students were participated as subjects. Muscle fatigue was measured with variations of median frequency(MF) and median frequency slope(MFS) by attaching SEMG to 3 muscles. At the same time, perceived exertion was measured by using Borg's rating of perceived exertion(RPE). Results: A MF was increased when low angle in SHM, both male and female. It means that muscle fatigue was significantly decreased(p<.05). RPE was significantly increased when low angle(p<.01). Perceived exertion explained 15.2% of the variation of MF in SHM. And regression equation was, MF in SHM = 59.918 + (4,910 * RPE). Conclusion: The outcome shows that it is possible to use the efficient method which makes muscle fatigue decrease by reducing the angle of neck flexion. Application: The results might contribute to develop the effective Shaker exercise method.

• The korean journal of orthodontics
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• v.49 no.3
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• pp.150-160
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• 2019

Objective: This study aimed to analyze the effect of changing various parameters of the bone-borne rapid palatal expander (RPE) using the finite element method (FEM). Methods: In eight experimental groups, we investigated the effect of the number, position, and length of miniscrews; positional changes of the expander; and changes in the hook length on maxillary expansion. In finite element analysis, we compared the magnitude and distribution of stress, and the displacement changes following expansion of the bone-borne RPE. Results: When we compared the number and position of miniscrews, placing miniscrews in the anterior and posterior sides was advantageous for maxillary expansion in terms of stress distribution and displacement changes. Miniscrew length did not significantly affect stress distribution and displacement changes. Furthermore, anteroposterior displacement of the expander did not significantly affect transverse maxillary expansion but had various effects on vertical changes of the maxilla. The maxilla rotated clockwise when the miniscrews were placed in the anterior region. The hook length of the expander did not show consistent results in terms of changes in stress distribution and magnitude or in displacement changes. Conclusions: The findings of this study suggest that changes in the location and length of the miniscrews and displacement of the bone-borne RPE could affect the pattern of the maxillary expansion, depending on the combination of these factors.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.1766-1769
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• 1997

Fast and accurate distillation design requires a model that significantly reduces the problem size withour loss of accruacy is especially suitable for rela-time applicatoins. the reduced order model is obtained by use of Principal Component Anlysis(PCA). Then the extended Kalman filter and the Recursie Predictiuon Error(RPE) mehtod are appliced to identify the model parameters and the feed compostion form the measuremenets of the coumn. as a consequence it is found that the model reduction thechique can account for the dynamics of the rigorous distillation model and not only the model parameters, bu also the feed compostion can be identified efficiently. this technique is applied to industrial operation data verify the performance of reduced order model.