• Journal of Life Science
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• v.22 no.8
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• pp.1085-1091
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• 2012

The purpose of this study is to investigate the effects of indoor and outdoor exercise environments on bone mineral density and body composition in old women. A total of 26 old women were randomly divided into two groups: an indoor exercise group (IE, n=13) and an outdoor exercise group (OE, n=13). The exercise groups performed moderate exercise (HR max 50~70%; RPE 11-15) three times a week for 60 minutes over 20 weeks. After exercise training, bone mineral density was significantly improved in the OE group as compared with the IE group. Body fat mass was significantly decreased in the IE group. Weight, lean body mass, and body fat mass were significantly decreased in the OE group. Body mass index was significantly decreased in the outdoor exercise group as compared to the IE group. Our findings show that a 20-week program of outdoor exercise training improves bone mineral density and body composition in old women. As mentioned above, it has been found that engaging in an outdoor exercise program for 20 weeks has a positive effect on bone mineral density and body composition in old women. In conclusion, engaging in the outdoor exercise program, including aerobic and resistance exercises, for 20 weeks improved bone mineral density and inhibited bone loss in old women and had a positive influence on vitamin D levels, thereby potentially lowering the risk of osteoporosis.

• Journal of Life Science
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• v.26 no.11
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• pp.1330-1335
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• 2016

Sasa species leaves have been used in traditional medicine for their anti-inflammatory, antipyretic, and diuretic properties. Sasa quelpaertensis Nakai is a small bamboo grass that grows only on Mt. Halla on Jeju Island, Republic of Korea. This small bamboo grass has recently been the focus of much attention due to its potential biomass as well as its beneficial health effects. In this study, to promote the efficient utilization of the S. quelpaertensis leaf, we established a simple preparation method for phytochemical-rich extract (PRE) by comparing phytochemical contents and biological activities according to extraction methods. high performance liquid chromatography (HPLC) analysis revealed that the contents of two major phytochemicals such as, tricin (5.35 mg/g) and p-coumaric acid (44.10 mg/g) contained in PRE were higher than those in fresh hot water extract (SQH, p-coumaric 23.39 mg/g, tricin 0.18 mg/g) and ethanol extract (SQE, p-coumaric 10.8 mg/g, tricin 0.38 mg/g). The antioxidant activities [1,1-diphenyl-2-picrylhydrazy (DPPH) radical scavenging activity, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity, nitric oxide (NO) scavenging activity, and xanthine oxidase inhibitory activity] of PRE were higher than those of SQH and SQE. PRE effectively inhibited NO production in LSP- stimulation RAW 264.7 cells, and the growth of human promyelocytic leukemia (HL-60) cells. These results suggest that PRE has a potential as a promising antioxidant and anti-inflammatory agent.

• The korean journal of orthodontics
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• v.22 no.3 s.38
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• pp.509-529
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• 1992

Skeletal Class III malocclusion is one of the most difficult type to treat and stabilize. For a child with developing skeletal Class III malocclusion, the treatment objective would be to stimulate maxillary growth, particulary one who has markedly deficient maxilla, and to restrain excessive mandibular growth. In order to stimulate the maxillary growth, maxillary protraction appliance is the one of the effective orthopedic appliances in skeletal Class III. The purposes of this study were as follows ; evaluation of the skeletal and dental changes of the maxillary protraction in children with Class III Maxillary deficiency , comparison of the clinical effects between the group with RPE and labiolingual intraoral appliances , comparison of the clinical effects and stability related to the ages of the patients : stability of the maxillary protraction about 1 year after retention. The subjects consisted of 60 children between the ages of 8 and 13.4 who were diagnosed as Class III with maxillary deficiency and were treated with Face Mask (Delaire Type) from the Dept. of Orthodontics Yong Dong Severance Hospital, Yonsei University. 48 children wore the RPE and 12 children wore Labiolingual Appliance. Lateral Cephalograms were taken for each patient at before and after correction of anterior cross-bite in 60 children, and after an observation period of 10 to 14 months in 19 children. X and Y coordinate of 10 landmarks were analyzed using a horizontal line through sella and rotated $6^{\circ}$ down anteriorly as the horizontal reference axis, and a perpendicular verticual line through sella as the vertical reference axis. Each of the 31 measurents (10 verticals, 10 horizontals, 2 angles and 9 others) was statistically analyzed using SPSS/PC statistics. The results are as follows; 1. After maxillary protraction the maxilla and maxillary teeth moved downward and forward, while the mandible and mandibular incisor rotated downward and backward. 2. Maxillary protraction with rapid palatal expansion appliance was more effective than with labiolingual appliance. 3. More downward movement of the posterior palatal plane obserbed with maxillary protraction doing the midpalatal suture opening than with protraction after finishing the palatal expansion 4. The clinical effects of protraction and changes of the retention periods were not statistically significant among the age groups. 5. During the retention period, maxilla and maxillary teeth, and mandible and mandibular teeth moved downward and forward, however the mandibular changes were larger than the maxillary changes.

• Journal of Life Science
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• v.27 no.7
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• pp.817-825
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• 2017

This study investigated the effect of 12 weeks combined exercise and nutrition education program on body composition, liver function, serum lipids and insulin resistance in obese middle-aged women. The combined exercise program was performed for 55 minutes 3 times per week during which the intensity progressively increased from RPE 13 to 14, 60-70%HRR (1~5 weeks), RPE 15 to 17, 70-80% HRR (6~12 weeks) and nutrition education was conducted 20 minutes one day per week. The subjects were 21 obese middle-aged women were composed of the nutrition education group (A, n=7), combined exercise group (B, n=7), and the control group (C, n=7). The results of the study in the nutrition education group and combined exercise group were as follows; The A and B group had significantly lower body composition than did the control group. The A group had significantly lower liver function, TC, TG, HDL-C, and HOMA-IR than did the control group. Consequently, combined exercise and nutrition education program effective in preventing diabetes caused by obesity in obese middle-aged woman. On the basis of the results of this study, the following recommendations are made for further studies: additional studies are needed to confirm the results of this study and to compare the effects of combined exercise on these variables in obese and non-obese men and women by age or exercise type; they are also needed to develop effective nutrition education programs for different age groups or body types.

• Journal of the Korean Applied Science and Technology
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• v.39 no.6
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• pp.906-915
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• 2022

The purpose of this study was to investigate the effects of aquatic walking exercise on body composition, hs-CRP, HOMA-IR, and blood pressure in obese elderly women. Twenty, obese elderly women[percent body fat(%BF) < 30%] composed of aquatic walking exercise group(EX, n=10), the control group(CON, n=10). The variables of body composition, hs-CRP, HOMA-IR, and blood pressure were measured in all the subjects pre and post of 12 weeks aquatic walking exercise(RPE 11-14, 3 times per week, 50 mins). The test data were analyzed by paired t-test and repeated ANOVA, and the alpha level of p<.05 was set for all tests of significance. %BF (p<.05), insulin (p<.01), HOMA-IR (p<.01) and SBP (p<.05) were significantly decreased in EX group compared to CON group. These results suggest that 12 weeks of aquatic walking exercise improves %BF, HOMA-IR, and blood pressure. Thus, this proposed aquatic walking exercise modality can be a useful therapy to improve both obese and cardiovascular disease in obese elderly women.

• Journal of Digital Convergence
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• v.14 no.3
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• pp.489-497
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• 2016

The purpose of this study is to examine the effect of milk protein intake and band exercise on active fitness and metabolism risk factor of elderly women for 8 weeks. The two groups were classified into one group(TG) with milk protein intake and band exercise both, and the other group(CG) that was controled. The group of TG was applied doing milk protein intake 3 times for a day, and doing band exercise 4 times for 60 minutes a week. The intensity of the exercise was RPE<17. Each measurement variable was measured before and after 8 weeks to investigate the effect. This study got the result with this step. First, TG has shown small interaction with active fitness. Second, TG has shown small interaction with metabolism risk factor. Therefore, this study gives us the positive result of the effect of milk protein intake and band exercise on active fitness and metabolism risk factor of elderly women for 8 weeks. However, it has limitation to verify effect of milk protein intake and band exercise.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3405-3416
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• 2012

The purpose of this study was to find out the effects of music rope-skipping on health fitness, blood lipids and growth-related factors in male middle school students. For this purpose, twenty subjects were participated in this study and the participants were 'After School Class' boys in B middle school located in Gimhae City. They divided into exercise group(n=10) and control group(n=10). Exercise group conducted 45minutes per a day, four times a week for 12 weeks. And the control group continued their normal life. The results were as follows; First, in exercise group, lean body mass, muscular strength, muscular endurance, cardiovascular endurance and flexibility were all significantly increased after program execution. But %body fat was significantly decreased. In control group, muscular strength, muscular endurance and cardiovascular endurance were significantly increased. There were significant differences in lean body mass, %body fat, muscular strength and flexibility between two groups after program execution. Second, in exercise group, HDL-C was significantly increased after program execution. In control group, TG was significantly decreased. But HDL-C was significantly increased. There were no significant differences in all blood lipids(TC, TG, HDL-C and LDL-C) between two groups after program execution. Third, in exercise group, GH and IGF-I were significantly increased after program execution. In control group, IGF-I was significantly decreased. There were significant differences in IGF-I between two groups after program execution. These results indicate that music rope-skipping is effective to improve lean body mass, muscular strength, flexibility, GH and IGF-I in normal middle school male students.

• Parasites, Hosts and Diseases
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• v.56 no.2
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• pp.135-145
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• 2018

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little is known about the signaling events in RPE involved in Toxoplasma gondii infection and development. The aim of the study is to screen the host mRNA transcriptional change of 3 inflammation-related gene categories, PI3K/Akt pathway regulatory components, blood vessel development factors and ROS regulators, to prove that PI3K/Akt or mTOR signaling pathway play an essential role in regulating the selected inflammation-related genes. The selected genes include PH domain and leucine- rich-repeat protein phosphatases (PHLPP), casein kinase2 (CK2), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), glutamate-cysteine ligase (GCL), glutathione S-transferase (GST), and NAD(P)H: quinone oxidoreductase (NQO1). Using reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), we found that T. gondii up-regulates PHLPP2, $CK2{\beta}$, VEGF, GCL, GST and NQO1 gene expression levels, but down-regulates PHLPP1 and PEDF mRNA transcription levels. PI3K inhibition and mTOR inhibition by specific inhibitors showed that most of these host gene expression patterns were due to activation of PI3K/Akt or mTOR pathways with some exceptional cases. Taken together, our results reveal a new molecular mechanism of these gene expression change dependent on PI3K/Akt or mTOR pathways and highlight more systematical insight of how an intracellular T. gondii can manipulate host genes to avoid host defense.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.1
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• pp.47-51
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• 2009

The purpose of this study was to investigate the effects of vitamin C supplementation and yoga practice on total antioxidant status (TEAC), lipid peroxidation, and blood lipid profiles of middle-aged women. Thirty two women ($53.34{\pm}5.08$ years old) in B city volunteered and the signed consents were received before the study. Experimental groups were normal (n=8), vitamin C intake group (n=8), yoga group (n=8), and vitamin C intake with yoga group (n=8). Total experimental period was 12 weeks. Yoga group practiced yoga 3 times a week for 12 weeks with intensity of RPE $13{\sim}15$. Each practice was 60 minutes. Vt. C group was instructed to take 1 g of Vt. C every day after dinner meal. Changes in TEAC after 12 weeks were 28.23% for the normal group, 30% for Vt. C group, 26.58% for yoga group, and 43.66% for Vt. C with yoga group; the increases in TEAC among groups were not significantly different. Serum malondialehyde (MDA) concentration of the normal group increased by 10% during 12 weeks of experiment while that for the Vt. C, yoga, and Vt. C with yoga group were significantly decreased by 25%, 32.14%, and 33.87%, respectively (p<0.05) compared with the normal group. Neither yoga, Vt. C supplementation nor combined program for 12 weeks were effective enough to change the serum lipid profiles compared with the normal group. In conclusion, Vitamin C supplementation or regular yoga practice seems to have health promoting effects of retarding the oxidative stress by decreasing lipid peroxidation in middle-aged woman.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.329-340
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• 2024

Mangiferin is a kind of natural xanthone glycosides and is known to have various pharmacological activities. However, since the beneficial efficacy of this compound has not been reported in retinal pigment epithelial (RPE) cells, this study aimed to evaluate whether mangiferin could protect human RPE ARPE-19 cells from oxidative injury mimicked by hydrogen peroxide (H₂O₂). The results showed that mangiferin attenuated H₂O₂-induced cell viability reduction and DNA damage, while inhibiting reactive oxygen species (ROS) production and preserving diminished glutathione (GSH). Mangiferin also antagonized H₂O₂-induced inhibition of the expression and activity of antioxidant enzymes such as manganese superoxide dismutase and GSH peroxidase, which was associated with inhibition of mitochondrial ROS production. In addition, mangiferin protected ARPE-19 cells from H₂O₂-induced apoptosis by increasing the Bcl-2/Bax ratio, decreasing caspase-3 activation, and blocking poly(ADP-ribose) polymerase cleavage. Moreover, mangiferin suppressed the release of cytochrome c into the cytosol, which was achieved by interfering with mitochondrial membrane disruption. Furthermore, mangiferin increased the expression and activity of heme oxygenase-1 (HO-1) and nuclear factor-erythroid-2 related factor 2 (Nrf2). However, the inhibition of ROS production, cytoprotective and anti-apoptotic effects of mangiferin were significantly attenuated by the HO-1 inhibitor, indicating that mangiferin promoted Nrf2-mediated HO-1 activity to prevent ARPE-19 cells from oxidative injury. The results of this study suggest that mangiferin, as an Nrf2 activator, has potent ROS scavenging activity and may have the potential to protect oxidative stress-mediated ocular diseases.