• International Journal of Highway Engineering
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• v.10 no.4
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• pp.9-18
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• 2008

Curling is caused by the difference in the temperature and humidity by the depth of the slab in Jointed Plain Concrete Pavement. Slab curvature shape and size change due to curling exert a profound influence on the internal stress and roughness of the pavement, affecting structural and functional performance of the pavement. Direct measurement of the slab curvature entails many problems. Many measuring instruments have to be installed at the early-stage of the pavement construction, and the behavior of the slab curvature needs to be measured accurately from the early-stage. Moreover, the cost and technical difficulty are very formidable to measure the slab curvature. This study develops a measurement method for slab curvature in jointed concrete pavement at any given time by applying Power Spectrum Density Analysis and Inverse Fast Fourier Transformation to the profile data, that can be easily obtained at the construction field site. The effectiveness of this developed method is verified by measuring the profile data of the test road of jointed concrete pavement at an inland central expressway by the hour and by examining the result of extracting the slab curvature shape from this profile data. Additionally, the profile data of CRCP(Continuously Reinforced Concrete Pavement) sections on the same expressway were obtained and analyzed at the same time. The validity of the method developed for the slab curvature shape extraction is verified by comparing the result from the analysis of the profile data of CRCP sections with that from the analysis of the prof1Ie data of jointed concrete pavement sections.

• Journal of Korean Society of Environmental Engineers
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• v.22 no.6
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• pp.1037-1044
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• 2000

The objective of this study is the preparation of activated carbon for BAC(biological activated carbon). Prepared activated carbon was measured iodine adsorption(mg/g). methylene blue adsorption(mg/g), B.E.T($m^2/g$), PSD(Pore Size Distribution) and 'Picabiol' which in commercial activated carbon for BAC. Activation method for this study was a chemical activation used the phosphoric acid. In the method, two important factors affected activation characterized in preparation were temperature and impregnated phosphoric acid concentration. Activation temperature and impregnated phosphoric acid concentration were changed the $600{\sim}800^{\circ}C$ and 35~50wt% respectively. Activation time was fixed for 3 hour. Optimal activation temperature was $800^{\circ}C$ and impregnated phosphoric acid concentrations was about 50wt%. By the above condition specific surface area, iodine adsorption number and methylene blue adsorption number resulted $1643.3m^2/g$, 1093 mg/g, 445.6 mg/g, respectively.

• The Korean Journal of Pesticide Science
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• v.10 no.4
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• pp.272-278
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• 2006

Movement of pesticides applied for crop protection to the non-target environmental compartments has increasingly concerned in recent. A special review on groundwater leaching potential of pesticides registered in Korea was done by using the data submitted on half-life and adsorption of the pesticides in/on soil. Groundwater ubiquity score(GUS) of pesticides as a leaching potential was calculated by using domestic trial data on pesticide half-life in paddy or upland soils and Koc data bases of Oregon State University (OSU), British Pesticide Safety Directorate and Sweden. Of total 382 pesticides reviewed, domestic half-lives of 107 pesticides were for paddy soil and 297 pesticides for upland soil. And total 317 Koc values were collected 148 pesticides from OSU DB and 276 pesticides from UK/Sweden DB. Very highly leachable pesticides were 18 and highly leachable pesticides were 44 among 313 pesticides classified by GUS.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.665-675
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• 2021

Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer's disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still incompletely understood. Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence, western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used to examine postsynaptic density 95 (PSD95) expression, amyloid beta (Aβ) deposition, Tau and phosphorylated Tau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2 (NOX2) expression. Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronal damage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Aβ generation in APP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression in the hippocampus and cortex of APP/PS1 mice. Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Aβ deposition by inhibiting NOX2 activation in APP/PS1 mice.

• Journal of Ginseng Research
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• v.47 no.3
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• pp.458-468
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• 2023

Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect and mechanism in diabetes-associated cognitive dysfunction (DACD) deserve further investigation. Methods: After establishing the T2DM model with a high-fat diet and STZ intraperitoneal injection, Rg1 was given for 8 weeks. The behavior alterations and neuronal lesions were judged using the open field test (OFT) and Morris water maze (MWM), as well as HE and Nissl staining. The protein or mRNA changes of NOX2, p-PLC, TRPC6, CN, NFAT1, APP, BACE1, NCSTN, and Ab1-42 were investigated by immunoblot, immunofluorescence or qPCR. Commercial kits were used to evaluate the levels of IP3, DAG, and calcium ion (Ca²⁺) in brain tissues. Results: Rg1 therapy improved memory impairment and neuronal injury, decreased ROS, IP3, and DAG levels to revert Ca²⁺ overload, downregulated the expressions of p-PLC, TRPC6, CN, and NFAT1 nuclear translocation, and alleviated Aβ deposition in T2DM mice. In addition, Rg1 therapy elevated the expression of PSD95 and SYN in T2DM mice, which in turn improved synaptic dysfunction. Conclusions: Rg1 therapy may improve neuronal injury and DACD via mediating PLC-CN-NFAT1 signal pathway to reduce Aβ generation in T2DM mice.

• Korean Journal of Applied Biomechanics
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• v.26 no.2
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• pp.167-174
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• 2016

Objective: The purpose of this study was to determine the interrelationship between ranges of motion of the knee and ankle joints on the sagittal plane and the attenuation magnitude of impact shock at high frequency (9~20 Hz) in the support phase during downhill running. Method: Fifteen male heel-toe runners with no history of lower extremity injuries were recruited for this study (age, $25.07{\pm}5.35years$; height, $175.4{\pm}4.6cm$; mass, $75.8{\pm}.70kg$). Two uniaxial accelerometers were mounted to the tuberosity of tibia and sacrum, respectively, to measure acceleration signals. The participants were asked to run at their preferred running speed on a treadmill set at $0^{\circ}$, $7^{\circ}$, and $15^{\circ}$ downhill. Six optical cameras were placed around the treadmill to capture the coordinates of the joints of the lower extremities. The power spectrum densities of the two acceleration signals were analyzed and used in the transfer function describing the gain and attenuation of impact shock between the tibia and the sacrum. Angles of the knee and ankle joints on the sagittal plane and their angle ranges were calculated. The Pearson correlation coefficient was used to test the relationship between two variables, the magnitude of impact shock, and the range of joint angle under three downhill conditions. The alpha level was set at .05. Results: Close correlations were observed between the knee joint range of motion and the attenuation magnitude of impact shock regardless of running slopes (p<.05), and positive correlations were found between the ranges of motion of the knee and ankle joints and the attenuation magnitude of impact shock in $15^{\circ}$ downhill running (p<.05). Conclusion: In conclusion, increased knee flexion might be required to attenuate impact shock during downhill and level running through change in stride or cadence while maintaining stability, and strong and flexible ankle joints are also needed in steeper downhill running.

• Journal of the Korean Association of Geographic Information Studies
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• v.8 no.4
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• pp.33-43
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• 2005

China Coastal Waters(CCW) usually appeared from June through October every years, and it appeared very strong in August. In the harmonic analysis for Sea level anomaly (SLA), the annual amplitude of the eastern part (8~9.5cm) in Jeju Island was lower than those of the western part (over 13cm). In the harmonic analysis for Sea Surface Temperature (SST), the annual amplitude of the eastern part($7{\sim}8.5^{\circ}C$) in Jeju Island was lower than those of the western part($5.5{\sim}6^{\circ}C$). For the Power Spectrum Density (PSD), SLA and SST remarkablely peaked on the annual period, semi-annual period and 3-monthly period. In summer and autumn, SLA of 1996 to 1999 was high in comparison to other years, and then it should be considered that the appearance of CCW was closely related to heavy rainfalls. The path of CCW formed this boundary of temperature between the yellow sea and the east china sea.

• Journal of the Korean Society for Railway
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• v.17 no.5
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• pp.328-335
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• 2014

Numerical prediction methods were applied to investigate the turbulent air currents and air-conditioning efficiency in an underground subway station, and the results compared to experimental data. The Shin-gumho Station($8^{th}$ floor underground and 43.6m in depth) in Seoul was selected for the analysis. The entire station was covered for simulation and the ventilation mode was ordinary. The ventilation diffusers were modeled as 95 square shapes of $0.6m{\times}0.6m$ in the lobby and as 222 square shapes in the platform. Cooling air of $47,316m^3/h$ was supplied and the returned air of $33,980m^3/h$ is exhausted in the lobby and the cooling air of $33,968m^3/h$ is supplied and the returned air of $76,190m^3/h$ was exhausted in the platform which is the same as the experimental data. The cases of the screen-door-closed and open were respectively investigated. A total of 7.5million grids were generated and the whole domain divided into 22 blocks for MPI efficiency of calculation. Large eddy simulation (LES) was applied to solve the momentum and energy equation.

• Science of Emotion and Sensibility
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• v.8 no.1
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• pp.47-54
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• 2005

This study is aimed to inspect how the different sensitivities in Behavioral activation system(BAS) and behavioral inhibition system(BIS) modulate on the properties of physiological responses stimulated by positive or negative affective sound. We measured the electroencephalogram(EEG) and electrocardiogram (ECG) of 32 students, consisted of four groups depending on the BAS and BIS sensitivities, during listening to meditation music or noise. The EEG was recorded at Fpl and Fp2 sites and Power spectral density(PSD) of HRV was derived from the ECG, and the power of HRV was calculated for 3 major frequency ranges(low frequency[LF], medium frequency and high frequency[HF]). After listening to music or noise, subjects reported the affect induced by the sound. For EEG, the power in the alpha band at Fp2, especially in the alpha-2 band(9.0-11.0 Hz) increased during the subjects listening to music, while the power at Fpl increased during noise. During listening to meditation music, there is a tendency that the left-sided activation in prefrontal cortex(PFC) is positively correlated with the difference of BAS(Z)-BIS(Z). During listening to noise, there is a tendency that the right-sided activation in PFC is dominant in case any of the sensitivity of BAS or BIS is high. For HRV, we found that the index of MF/(LF+HF), during listening to music, was higher significantly in the individuals with a low BIS but high BAS than in the individuals with a low sensitivity both BIS and BAS individuals. With high BIS, regardless of the BAS sensitivity, the difference of this index values was not significant. From these results we suggest that the physiological responses of different individuals in BAS and BIS react differently under the same emotionally provocative challenge.

• Journal of Life Science
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• v.24 no.8
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• pp.820-826
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• 2014

The localization to specific subcellular sites and the regulation of cell surface receptors and channels are crucial for proper functioning. Postsynaptic density-95/Disks large/Zonula occludens-1 (PDZ)-domain is involved in recognition of and interaction between various proteins, by which the localization and the regulation are mediated. Multi-PDZ domain protein 1 (MUPP1) contains 13 PDZ domains. MUPP1 serves a scaffolding function for structure proteins and signaling proteins, but the mechanism how MUPP1 is stabilized and signalized has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with PDZ domains of MUPP1. We found an interaction between MUPP1 and Parkin. Parkin is an E3 ubiquitin ligase. Loss-of-function mutations of Parkin gene are known to cause an autosomal recessive juvenile parkinsonism. Parkin bound to the $12^{th}$ PDZ domain, but not to other PDZ domains of MUPP1. The C-terminal end of Parkin has a type II PDZ-association motif, which was essential for the interaction with MUPP1 in the yeast two-hybrid assay. When co-expressed in HEK-293T cells, Parkin co-localized with MUPP1. When co-expressed with ubiquitin in HEK-293T cells, MUPP1 has been strongly ubiquitinated by Parkin. These findings collectively suggest that MUPP1 is a novel substrate of Parkin and its function or stability could be modulated by Parkin-mediated ubiquitination.