• Journal of Radiopharmaceuticals and Molecular Probes
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• v.4 no.1
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• pp.32-35
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• 2018

Since utilization of metal is attractive research area applicable to medical applications, several metals have been studied by many scientists. Zr-89 is known as one of important radioisotopes nowadays. Novel ligands for Zr-89 have been developed, and Zr-89-based radiopharmaceuticals have been employed for positron emission tomography (PET) study. In this highlight review, recent advances on Zr-89 utilization for radiophramaceuticals are illustrated.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.105-111
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• 2021

⁸⁹Zr is a positron-emitting radioisotope, which has known as well-suited radioisotope for use in a monoclonal antibody-based imaging agent for immuno-PET. The purpose of this study was to quantitatively evaluate the diagnostic ability of general trastuzumab and thio-trastuzumab as HER2 positive receptors based on Df hexadentate iron chelator. Desferrioxamine-p-SCN (Df-Bz-NCS) and desferroixamine-maleimide (Df-Mal) were purchased from Macrocyclics (Dallas, TX, USA). The trastuzumab was purchased from Roche (Schweiz), and thio-trastuzumab was obtained from professor Hyo-Jeong Hong group (Kangwon National University). The radioisotope ⁸⁹Zr was produced by domestic purification system and KIRAMS using medical cyclotron (50 MeV, Scantronix). The conjugates of Df-trastuzumab and Df-thio-trastuzumab were prepared with Df-Bz-NCS and Df-Mal under basic aqueous solution (pH 8-9) at room temperature, respectively. The conjugates purified by PD-10 column were mixed with dried ⁸⁹Zr chloride. ⁸⁹Zr-labeled conjugates were purified and concentrated by Amicon ultra centrifugal filter. The preparation step and time of ⁸⁹Zr-labeled conjugates was shorted as 4 steps within 2 hours. ⁸⁹Zr-labeled conjugates showed the highly radiochemical purity of over 98%, and were very stable until 7 days by the analysis of radio-ITLC method. Each radio-labeled conjugates were also exhibited the highly stability in both PBS buffer and mouse serum. Immuno-PET imaging of ⁸⁹Zr-labeled conjugates in mice bearing gastric cancer xenograft tumors with HER2 expression showed high tumor uptake in the NCI-N87 HER2-expressing. However, ⁸⁹Zr-Df-Mal-thio-trastuzumab showed a relatively lower tumor-to-background ratio than ⁸⁹Zr-Df-Bz-trastuzumab, as well as whole-body distribution. In the results, ⁸⁹Zr-Df-Bz-trastuzumab was evaluated to have a relatively higher HER2 diagnostic ability than ⁸⁹Zr-Df-Mal-thio-trastuzumab.

• Korean Journal of Materials Research
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• v.10 no.10
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• pp.709-714
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• 2000

SAW 소자에 응용 가능한 자성박막재의 개발을 목적으로 RF 스퍼터링법으로 증착한 (Fe(sub)0.6Co(sub)0.4)(sub)89Zr(sub)11/Fe(sub)1-xCo(sub)x)Zr(sub)11(x=0, 0.6, 0.9)<원문잠조> 비정질 다층박막의 자기특성을 조사하였다. 수직자기장중열처리를 행하였을 때 상온에서 비자성 Fe(sub)89Zr(sub)11 층의 삽입에서만 다층박막화의 효과가 나타났다. 일 예로 (Fe(sub)0.6Co(sub)0.4)(sub)89Zr(sub)11(30${\AA}$)/Fe(sub)89-Zr(sub)11(40${\AA}$)<원문참조> 박막시편에 1kHz, 50 mOe의 여기자기장으로 평가된 최대 미분투자율${\mu}$(sub)d.max는 단층막의 750에서 1650으로 2배 이상 증가, 구동 바이어스자기장 Hw는 20 Oe에서 6Oe로 3배 이하로 감소하는 양호한 특성이 얻어졌다. 그러나 다른 중용 특성인 자왜는 34% 정도 감소하는 것으로 추정되었다.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.1
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• pp.43-50
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• 2016

$^{89}Zr$ with the favorable nuclear decay kinetics and chemical properties is an appealing radiometal for its application in immuno-PET using radiolabeled monoclonal antibodies. Rising demand of ultrahigh purity and high-specific activity $^{89}Zr$ has propelled the radiochemist worldwide to develop an overall efficacious method for its promising separation from the target matrix $^{89}Y$. The requirement of elevated radiochemical purity (${\geq}$ 99.99%) has accelerated the efforts since last two decades to achieve higher decontamination and separation factors of carrier free $^{89}Zr$ over $^{89}Y$ using several suitable separation techniques. However, each of the technique has its own pros and cons which prior to its actual medical application needs to be optimized and thoroughly scrutinized to avoid further complications during radiolabelling of the pharmaceuticals. In this short review article we will specifically consider as well focus on the historical development and the recent advances on the radiochemical separation of $^{89}Zr$ from $^{89}Y$ which will be helpful for the separation scientist involved in this area to understand the existing available means and plan the strategy to investigate and develop the novel techniques to overcome the problems involved in the present methods.

• Nuclear Engineering and Technology
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• v.56 no.7
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• pp.2683-2689
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• 2024

This work investigated the most suitable type of degrader (Cu, Al or Nb) and its thickness, taking into consideration the salient aspects of concrete activation for high-purity ⁸⁹Zr production by ⁸⁹Y(p,n)⁸⁹Zr nuclear reaction. The MCNP and FISPACT codes were used to determine the optimal degrader thickness and the radioactivity of shielding concrete by neutron activation, respectively. The results showed that the optimal thickness of the beam degraders was 1.16, 3.19, and 1.33 mm for Cu, Al, and Nb, respectively. The neutron production rate per proton and the energy and angular distributions of neutrons varied depending on the type of degrader. Considering the radioactivity of the target-room concrete and the amount of radioactive waste expected to be generated, the use of a 1.33-mm-thick Nb degrader for ⁸⁹Zr production was determined to be the best choice.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.11 no.6
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• pp.486-492
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• 1998

The amorphous Co-based magnetic films have a large saturation flux density, a low coercive force, and a zero magnetostriction constant. Therefore, they have been studied for application to magnetic recoding heads and micro magnetic devices. However, it was found that the magnetic anisotropy was changed for each film fabrication processes. In this study, we investigated how to control the anisotropy of sputtered amorphous $Co_{89}Nb{8.5}Zr{2.5}$ films. After deposition, the rotational field annealing ant the uniaxial field annealing were performed under the magnetic field of 1.5 kOe. the annealing was done at the temperature range from 400 to $600^{\circ}C$ for one hour. As-deposited amorphous $Co_{89}Nb{8.5}Zr{2.5}$ thin film had saturation magnetization ($4\piM_5$) of 0.8 T, coercive force($_IH_C$) of 1.5 Oe, and anisotropy field($H_k$) of 11 Oe. The amorphous $Co_{89}Nb{8.5}Zr{2.5}$ thin films annealed by rotational field annealing at $500^{\circ}C$ for one hour was found to be isotropy, and $4\piM_5$ of 0.9 T was obtained from these films, Also, the magnetic anisotropy of as-deposited films could be controlled by uniaxial field annealing at $400^{\circ}C$ for one hour. Anisotropy field($H_k$) of 17 Oe and $4\piM_5$ of 1.0 T were obtained by this method.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1265-1268
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• 2023

One important issue in using radiopharmaceuticals as therapeutic and imaging agents is predicting different organ absorbed dose following their injection. The present study aims at extrapolating dosimetry estimates to a female phantom from the animal data of ⁸⁹Zr radionuclide accumulation using the Sparks-Idogan relationship. The absorbed dose of ⁸⁹Zr radionuclide in different organs of the human body was calculated based on its distribution data in mice using both MIRD method and the MCNP simulation code. In this study, breasts, liver, heart wall, stomach, kidneys, lungs and spleen were considered as source and target organs. The highest and the lowest absorbed doses were respectively delivered to the liver (4.00E-02 and 3.43E-02 mGy/MBq) and the stomach (1.83E-03 and 1.66E-03 mGy/MBq). Moreover, there was a good agreement between the results obtained from both MIRD and MCNP methods. Therefore, according to the dosimetry results, [⁸⁹Zr] DFO-CR011-PET/CT seems to be a suitable for diagnostic imaging of the breast anomalies for CDX-011 targeting gpNMB in patients with TNBC in the future.

• Korean Journal of Materials Research
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• v.9 no.8
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• pp.831-836
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• 1999

Magnetic properties of (Fe(sub)1-xCo(sub)x)(sub)89Zr11 amorphous films fabricated by RF sputtering method have been investigated as a function of Co content x. By means of two step field annealing at 190~20$0^{\circ}C$ for 10 minutes in the magnetic field of 130 Oe, the film with x=0.4 among the samples shows the superior soft magnetic properties in spite of showing the high magnetostriction. For example, the obtained properties of coercivity and differential permeability measured in an exciting field of 10 mOe at the frequency of 8.7 MHz are 0.25 Oe and 280, respectively. It is confirmed that such behavior is due to the variation of magnetic anisotropies caused by a optimal compressive stress within the film.

• Korean Journal of Materials Research
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• v.11 no.6
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• pp.477-482
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• 2001

The velocity changes of magneto surface acoustic wave (MSAW) have been investigated in the MSAW devices composed of wedge type transducer and as-sputtered ($Fe_{1-x}$ $Co_{x}$ )$_{89}$ $Zr_{ 11}$ (x=0~1.0)amorphous films on glass substrates. The velocity changes of devices depended sensistively on exciting frequency of MSAW, applying the DC bias magnetic field. film thickness and film composition. Particularly. it was conformed that velocity changes increased with the increase of the exciting frequency of MSAW and the thickness of magnetic films. A device deposited x= 0.8 film along the MSAW propagation direction among the devices exhibited a large velocity change of 0.062% at 8.7 MHz for the applied field of 70 Oe.

• Korean Journal of Materials Research
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• v.12 no.4
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• pp.279-282
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• 2002

The effect of field annealing on the velocity changes of magneto surface acoustic wave (MSAW) devices has been investigated for deposited $(Fe_{1-x}Co_x)_{89}Zr_{11}$ (x = 0~1.0) amorphous films. By means of two step field annealing at $195^{\circ}C$ for 10 minute in the magnetic field of 130 Oe, the MSAW device with x=0.4 film among the devices showed the superior velocity change of 0.1 %. This gigantic value was obtained in the DC bias field of 40 Oe at the exciting frequency of 8.7 MHz. It was confirmed that such behavior was due to the variation of differential permeability caused by an optimal stress within the magnetic film.