• Journal of Pharmaceutical Investigation
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• 제28권2호
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• pp.87-92
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• 1998

Kojic acid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of the skin irritancy and the instability against the pH, temperature, and light. In order to overcome these problems, various topical gels and multiple emulsion creams which can control the release of active ingredient, KA, were formulated employing cream bases of mineral oil with caprylic capric triglyceride and hydrophilic polymers such as chitosan, carbopol. and pluronics. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12,000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solution. Drug release from chitosan-based gels (ChitoGel) obeyed to the first order kinetics with a rapid release especially in the initial period. However, pluronic-based gels (PluGel) and carbopol-based gels (CarboGel) revealed controlled release of drug to some extent, followed by the square root-time kinetics. Moreover, the release of KA was further controlled with the W/O/W multiple emulsion creams (MultiCream), showing the apparent zero order release kinetics by virtue of dynamic ratecontrolling membrane of the oil layer. The flux $(J,\;{\mu}g/cm^2/hr)$ of ChitoGel. CarboGel. PluGel. and MultiCream in the initial period of 6hr were 73.30, 28.67. 24.04 and 7.72, respectively. On the other hand, the skin irritancy score of ChitoGel and MultiCream were observed as 2.5 and 2.3 respectively, in the rabbit skin irritation test. Although there were insignificant differences at p<0.05 between those formulations, it was possible to conclude that the W/O/W multiple emulsion creams containing KA might be a good candidate for an antimelanogenic drug delivery system due to the controlled release of acidic drug molecules.

• 한국지역지리학회지
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• 제19권4호
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• pp.737-746
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• 2013

본 연구는 광릉 숲지역 지형을 유형화하여 산지 지형변화 관리 방안을 제시하고자 하였다. 지형요소는 축척별 계층적 체계에 따라 분류하였다. 지형유형화를 위한 축척은 4가지로 등급을 결정하였다. 등급0 요소는 4가지, 등급1은 6가지, 등급2는 12가지, 등급3은 27가지로 지형요소를 분류할 수 있었다. 지도화에 제약이 따르는 곡저미지형은 상부곡, 중간곡, 인공하도곡으로 분류하였다. 지표침식에 대한 지형관리 방안으로 저목통로, 암석과 자갈을 이용한 사면이나 다리 주변의 지형관리, 풍화층보다 안정된 기반암 지역에 관리 도로 건설, 하도벽 안식각 유지와 석축 쌓기, 마지막으로 산림 간벌시 완충구역 유지 등을 제안하였다. 본 연구결과는 산간지역 지형유형별 산림 관리에 필요한 정보를 제공해 줄 수 있을 것으로 본다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권4호
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• pp.1248-1266
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• 2012

This paper presents a multilevel reversible data hiding method based on histogram shifting which can recover the original image losslessly after the hidden data has been extracted from the stego-image. The method of prediction is adopted in our proposed scheme and prediction errors are produced to explore the similarity of neighboring pixels. In this article, we propose two different predictors to generate the prediction errors, where the prediction is carried out using the center prediction method and the JPEG-LS median edge predictor (MED) to exploit the correlation among the neighboring pixels. Instead of the original image, these prediction errors are used to hide the secret information. Moreover, we also present an improved method to search for peak and zero pairs and also talk about the analogy of the same to improve the histogram shifting method for huge embedding capacity and high peak signal-to-noise ratio (PSNR). In the one-level hiding, our method keeps image qualities larger than 53 dB and the ratio of embedding capacity has 0.43 bpp (bit per pixel). Besides, the concept with multiple layer embedding procedure is applied for obtaining high capacity, and the performance is demonstrated in the experimental results. From our experimental results and analytical reasoning, it shows that the proposed scheme has higher PSNR and high data embedding capacity than that of other reversible data hiding methods presented in the literature.

• 한국초전도ㆍ저온공학회논문지
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• 제17권1호
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• pp.21-24
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• 2015

New results of dependence of magnetic field, trapped by a stack of HTS tapes, on amount of tapes in a stack are reported. Commercial GdBCO tape 12 mm width and without Cu layer was used for the research. Tape was divided in square pieces $12{\times}12mm^2$ from which stacks were formed. Filling factor of the tape was about 1.4%. Measurements were carried out for stacks with height from 5 to 250 pieces and at wide temperature range from liquid helium to liquid nitrogen. Both FC (field cooling) and ZFC (zero field cooling) cooling methods were used in the research. These two methods show matching results with good accuracy. As a result dependences of trapped magnetic flux on amount of tapes for different temperatures were received. Research shows, that with increasing height of the stack trapped magnetic field value reach saturation at about 60 tapes in a stack for low temperatures. From 60 to 100 tapes increase of magnet flux is only 5%. Thus increase amount of tapes in a stack is not profitable. Also investigation of trapped magnet field relaxation was carried out. Relaxation speed decreases with increasing amount of elements. It means that the higher the stack is, the longer trapped flux will be held in cause of the same temperature.

• 해양환경안전학회지
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• 제17권2호
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• pp.167-172
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• 2011

표면조도에 의해 발생하는 난류유동은 공학적, 물리적 분야에서 매우 중요하게 다루어지고 있다. 표면조도는 선박에서도 설계, 용접, 도장 등 각각의 단계에서 다양한 측면으로 고려되어야 할 중요한 요소이다. 본 연구는 표면조도 형상을 일반화하여 PIV기법을 적용하여 수조실험을 수행하였다. 표면조도 조건은 거칠기 형상의 간격에 대해 변화를 주었으며, 실험유속은 Re = $1.1{\times}10^4$, Re = $2.0{\times}10^4$, Re = $2.9{\times}10^4$ 에서 시간평균에 대한 난류강도를 알아보았다. 거칠기 계수 증가에 따라 표면 거칠기 형상 근처에서 발생한 난류성분에 의해 난류강도는 강하게 나타났으며, 자유흐름 영역으로 갈수록 유동 방향의 변동이 전혀 없는 흐름이 나타났다. 실험유속 조건 변화에 대한 난류강도의 편차는 크게 영향을 받지 않았다.

• 지구물리와물리탐사
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• 제12권1호
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• pp.8-16
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• 2009

주파수 영역 항공 전자탐사 자료의 holistic 역산은 사전정보가 충분한 경우에 측정 자료의 보정, 처리 및 역산을 동시에 진행하는 역산법으로 개발되었다. 이 연구에서는 사전정보가 없는 경우에도 적응 가능하도록 holistic 역산을 발전시킨다. 이 역산에서는 수직방향으로 전기적 물성이 부드럽게 변화하는 다층 구조를 가정하고, 시스템 오차로 인한 편향 매개변수를 단순화하며. 고도에 따른 수평 방향의 평활화 조건을 적용하고, 클러스터를 이용하여 병렬 계산을 수행한다. 사전정보를 전혀 이용하지 않고 holistic 역산법으로 800만 개의 자료를 340만 개의 매개댄수에 대해 역산한 결과, 이와는 별개로 계산된 보정 계수, 다운홀 로깅 자료 및 지하수위 자료와 잘 일치하는 결과를 굴을 수 있었다. 이로부터 holistic 역산의 성공 여부가 정교하게 작성된 초기 모형이나 탐사 지역의 특별한 사전정보와는 무관함을 알 수 있었다. 또한. holistic 역산은 높은 고도에서의 원점 측정을 필요로 하지 않으므로 자료 획득에 필요한 비용을 상당히 절감할 수 있을 것이다.

• Journal of the Optical Society of Korea
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• 제16권2호
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• pp.141-144
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• 2012

A mobile Rayleigh Doppler wind LIDAR at an eye-safe wavelength of 355 nm incorporating double-edge technique with triple-channel Fabry-Perot etalon is developed for wind measurement from 5 to 40km. The structure of this LIDAR system is described. An intercomparsion experiment with rawinsonde is made, showing good agreement with expected measurement accuracy. A continuous observation of stratosphere wind field for several days with temporal resolution of 15 min and spatial resolution of 200 m from 5 to 40 km is presented, demonstrating the stability and robustness of the LIDAR. A stratospheric quasi-zero wind layer can be found at around 20 km with a direction change from east to west evident in the continuous observation.

• Journal of Magnetics
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• 제16권2호
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• pp.83-87
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• 2011

The vortex-driven magnetization process of micron-sized, exchange-coupled square elements with composition of $Ni_{80}Fe_{20}$ (12 nm)/$Ir_{20}Mn_{80}$ (5 nm) is investigated. The exchange-bias is introduced by field-cooling through the blocking temperature (TB) of the system, whereby Landau-shaped vortex states of the $Ni_{80}Fe_{20}$ layer are imprinted into the $Ir_{20}Mn_{80}$. In the case of zero-field cooling, the exchange-coupling at the ferromagnetic/antiferromagnetic interface significantly enhances the vortex stability by increasing the nucleation and annihilation fields, while reducing coercivity and remanence. For the field-cooled elements, the hysteresis loops are shifted along the cooling field axis. The loop shift is attributed to the imprinting of displaced vortex state of $Ni_{80}Fe_{20}$ into $Ir_{20}Mn_{80}$, which leads to asymmetric effective local pinning fields at the interface. The asymmetry of the hysteresis loop and the strength of the exchange-bias field can be tuned by varying the strength of cooling field. Micromagnetic modeling reproduces the experimentally observed vortex-driven magnetization process if the local pinning fields induced by exchange-coupling of the ferromagnetic and antiferromagnetic layers are taken into account.

• 한국자기학회지
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• 제19권4호
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• pp.152-155
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• 2009

Ba-ferrite 단결정을 제조하여 자기적 성질을 $M\"{o}ssbauer$ 분광법으로 연구하였다. 단결정 시료를 c-축 방향으로 얇게 절단하고 그 면에 감마선을 조사한 결과 Fe 이온의 스핀방향이 c-축과 일치하였고 시료 전체에 걸쳐 단일 결정체임을 확인하였다. 특히 감마선이 스핀과 나란한 경우 $M\"{o}ssbauer$ 흡수선 중에서 결정 내에 존재하는 Fe의 5개 자리 중에서 단지 4개 자리에서만 공명흡수선이 존재하였고 2b 자리에서는 전혀 공명흡수가 일어나지 않았다. 2b 자리에서의 공명흡수가 일어나지 않는 이유는 대칭성이 있는 2개의 우물 형 위치에너지의 중심 사이를 Fe 이온이 매우 빠른 속도로 c-축을 따라 진동하는 것으로 설명할 수 있다.

• Earthquakes and Structures
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• 제13권5호
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• pp.429-442
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• 2017

Dry bridges have been widely applied in the Qinghai-Tibet Railway (QTR) to minimize the thermal disturbance of engineering to the permafrost. However, because the Qinghai-Tibet Plateau is an area with a high potential occurrence of earthquakes, seismic action can easily destroy the dry bridges. Therefore, a three-dimensional numerical model, with consideration of the soil-pile interactions, is established to investigate the thermal characteristics and their impact on the seismic response of the dry bridge in permafrost region along the QTR. The numerical results indicate that there exist significant differences in the lateral displacement, shear force, and bending moment of the piles in different thermal conditions under seismic action. When the active layer become from unfrozen to frozen state, the maximum displacement of the bridge pile reduces, and the locations of the zero and peak values of the shear force and bending moment also change. It is found that although the higher stiffness of frozen soil confines the lateral displacement of the pile, compared with unfrozen soil, it has an adverse effect on the earthquake energy dissipation capacity.