• 한국전문물리치료학회지
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• 제7권2호
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• pp.35-54
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• 2000

The purposes of this study were to assess variation of body sway prior to and after submaximal treadmill exercise; to determine the time course of the effects of a fatiguing performed on a treadmill on body sway; and to compare position sense prior to and after exercise in order to assess any variance in proprioception caused by submaximal treadmill exercise. The subjects were twenty-four healthy men in their twenties. They stood barefoot on the Kinesthetic Ability Training Balance Platform to measure body sway. Control trials were performed with eyes alternately open and closed. In the eyes open condition, they were asked to look at a target placed at eye level 1 m in front them. A total of 10 trials, each lasting 20 seconds, were performed. After this series of trials, position sense was measured. Subjects then exercised on the treadmill until 85% of each person's maximal heart rate was reached. The first series of postural sway measurements began immediately after this exercise. The second identical series of postural sway trials was performed at approximately 10 minutes after exercise. The third series was performed approximately 20 minutes after exercise. This allowed approximately 5 minutes of rest between each experimental series. Position sense was measured at approximately 15 and 25 minutes after exercise. The results were as follows: 1) There was a significant increase in body sway after submaximal treadmill exercise compared to pre-exercise values under both visual conditions (p<.05). 2) After submaximal treadmill exercise, under the eyes open condition, the mean value of body sway was significantly increased after both the first and second series (p<.05). Under the eyes closed condition, the mean value of body sway increased significantly after the first series but decreased significantly after the third series (p<.05). 3) Position sense, measured repeatedly after submaximal treadmill exercise, did not change significantly with respect to pre-exercise values (p>.05). These results suggest that fatigue induced by submaximal treadmill exercise produced an increase in body sway in young healthy subjects with or without visual input, but the increase appeared to be lasting less than 15 minutes. No significant change in position sense suggested that proprioception was unaffected by submaximal treadmill exercise-induced fatigue.

• Journal of Chest Surgery
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• 제43권6호
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• pp.663-668
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• 2010

배경: 자연성 종격동 기종은 드문 질환으로 세계적으로 보고된 환자도 적다. 주로 젊은 남자에서 발병하며 양성의 자연 치유 경과의 질환으로 어떤 특별한 이유 없이 일어난다. 폐기포 파열을 일으키는 흉강내 압력 변화 이후 나타나게 된다. 두 병원의 임상 경험을 분석하여 적정한 치료에 도움이 되고자 한다. 대상 및 방법: 후향적으로 2003년 3월부터 2010년 8월까지 자연성 종격동 기종 환자들을 연구하였다. 결과: 24명의 환자가 자연성 종격동 기종으로 진단되었다. 이들 24명의 환자는 18명의 남자와 6명의 여자로 구성되었고, 평균 나이는 18.9세였다(범위 10~33살). 초기 주요 증상은 흉부 통증(79.2%), 이후 통증(62.5%), 피하 기종(4 1.7%)이었고 유발 인자로 운동(16.7%), 기침(12.5%), 구토(12.5%) 등이었고 유발 인자가 없는 경우가 54.2%였다. 모든 환자에서 흉부 단순 촬영과 단층 촬영이 이루어졌으며, 25% 환자에서 진단을 위해 단층 촬영이 필요하였다. 백혈구 수치와 C반응 단백(CRP)가 측정되었는데 초기 평균 수치는 각각 $9,790{\pm}3,240/{\mu}L$와 $1.31{\pm}1.71mg/dL$, 최종 평균 수치는 $5,440{\pm}1,665/{\mu}L$와 $0.72{\pm}0.73mg/dL$이었다. 23명의 환자가 입원하였으며(평균 $5.0{\pm}1.8$일) 증상은 자연 치유되었으며 합병증은 없었다. 결론: 자연성 종격동 기종은 약한 염증성 증세를 보이는 양성 질환이며 종종 흉부 또는 인후 통증을 나타낸다. 바람직하지 못한 결과를 방지하기 위하여 비침습적인 검사로 이차성 원인이 배제되어야 한다. 합병증과 재발이 거의 없는 관계로 증상에 따라 외래 진료나 단기적인 입원이 합당하다고 하겠다.

• 농촌의학ㆍ지역보건
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• 제22권1호
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• pp.49-59
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• 1997

Backgrounds : There has been many studies investigating the causes of farmers' syndrome. In some studies, psychologic stress is related to farmer's syndrome. And the diagnostic criteria of farmer's syndrome is similar to those of generalized anxiety disorder. So we carried out this study to investigate the psychiatric causes of farmers' syndrome. Methods : This study was done in some rural and urban areas of Kyoungsangnam Province, July, August, October and November of 1996. Those who came to free medical service and completed interview, medical examination and laboratory examination and 20-59 years old were 150 persons. And those who came to health center for health examination and completed only interview and 20-59 years old were 94 persons. The questionnaire was composed of sociodemographic factors, health risk factors, farmer's syndrome, work load, BEPSI(inventory to measure stress), Spielberger's state-trait anxiety inventory, self-rating depression scale. To examine statistical significance, we used X2-test, Mantel-Haenszel test for linear association, t-test, ANCOVA, correlation, multiple regression, logistic regression. Results : The prevalence of farmer's syndrome, adjusted for age and sex with population of Kyungsangnam Province of 1993 was 208 per 1,000(90 per 1,000 in men and 329 per 1,000 in women). In bivariate analysis, farmer's syndrome was significantly related to age, sex, job, income, smoking, alcohol drinking, work load, BEPSI, state anxiety, trait anxiety, depression, body mass index, Hwa-Byung, hypertension, anemia. However, when age and sex were adjusted, job was not significantly related to farmer's syndrome. The score of farmer's syndrome was significantly related to age, sex, work load, BEPSI, trait anxiety by multiple regression. Farmer's syndrome was significantly related to increasing age(odd ratio 1.079, 95% C.I. 1.060 - 1.099), sex(odds ratio of male 0.434, 95% C.I. 0.349 - 0.540), and BEPSI(odds ratio 1.231, 95% C.I. 1.148 - 1.320) by logistic regression. Results of logistic regression analysis of the component symptoms of farmer's syndrome were as follows. Shoulder stiffness was significantly related to increasing age, female sex and BEPSI. Lumbago was significantly related to increasing age, female sex and trait anxiety. Numb limbs and nocturia was significantly related to increasing age and female sex. Breathlessness was significantly related to work load, sleeplessness was significantly related to depression, dizziness was significantly related to job and state anxiety, and abdominal fullness was significantly related to female sex. Conclusion : Farmers' syndrome was related to work load, but was more related to psychiatric factors such as BEPSI and trait anxiety. And the occupation was not risk factor of farmers' syndrome in this study, so further study is needed to investigate the cause of farmers' syndrome.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권3호
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• pp.281-289
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• 1994

This is a clinical study on 235 inpatients who sustained a total of 350 mandibular fractures and who were treated in our department during the period of Oug., 1989 through Dec., 1993. The results obtained are as follows : 1. The mumber of patients has not been increased year after year. In respect of incidence, there were the highest frequency as 67 patients(28.5%) in 1991 and the least frequency as 16 patients(6.8%) in 1989 and the highest frequency as 28 patients(11.9%) in October and the least frequncy as 12 patients(5.2%) in February. 2. The age frequency was the highest in the second decade(30.6%). The youngest patient was 8 months and the eldest patient was 80 years and mean age was 27.8 years. The ratio of men to Wemen was 4 : 1. 3. The most frequent cause was fall down as 86 patients(36.6%) and the next was fist blow 4 as 75 patients(31.9%), traffic accident as 56 patients(23.9%) in order. 4. The most common location was symphysis as 141 numbers(40.3%) and the next was condyle as 96 numbers(27.4%), angle as 94 numbers(26.8%), body as 14 numbers(4.0%) in order. The sum of fracture sites were 350 and there were 1.49 fracture sites per one patient and multiple fractures occured in 100 patients(40.5%) of the 235 patients. The ratio of Left to Right except for symphysis was 1.71 : 1. 5. Among the 333 associated injuries, facial laceration was 136(57.9%) and tooth injury was 58(24.7%) and extremity was 31(13.2%). 6. Among the 350 mandibular fractures, complications after treatment occured in 51(14.6%) and infection as 20(5.7%) was the most frequent complication. 7. In respect of treatment of mandibular fracture, close reduction was 64 patients(27.2%) and open reduction was 164 patients(69.8%) and other were 7 patients(3.0%) of all and so open reduction was the most common in type of treatment.

• 한국식품위생안전성학회지
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• 제34권6호
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• pp.595-600
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• 2019

본 연구는 아이스플랜트의 기능성 소금 대체제로서의 가능성을 조사하고자 천연 및 정제소금과의 NaCl, D-pinitol, 총 페놀, 총 플라보노이드 및 DPPH 라디칼 소거능에 대한 기초자료를 비교 조사하였다. 아이스플랜트 동결건조분말의 NaCl 함량을 분석한 결과 19%이었고 D-pinitol의 함량은 777 mg/100 g으로 천일염 및 정제염에 비해 NaCl 함량은 유의적으로 낮으나 D-pinitol을 함유하고 있어 건강기능성에는 도움이 될 것으로 사료된다. 또한, 아이스플랜트 동결건조분말의 총 페놀 및 플라보노이드 함량은 각각 115 mg/100 g 및 985 mg/100 g을 함유하고 있어 DPPH라디칼 소거능의 항산화효과를 갖는 것으로 나타났다. 따라서 아이스플랜트 분말의 bioactive compound을 함유한 대체 소금 천연소재로서 가능성을 확인한 기초 연구를 제공하였다.

• Parasites, Hosts and Diseases
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• 제47권3호
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• pp.205-212
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• 2009

Trichomonas vaginalis commonly causes vaginitis and perhaps cervicitis in women and urethritis in men and women. Macrophages are important immune cells in response to T. vaginalis infection. In this study, we investigated whether human macrophages could be involved in inflammation induced by T. vaginalis. Human monocyte-derived macrophages (HMDM) were co-cultured with T. vaginalis. Live, opsonized-live trichomonads, and T. vaginalis Iysates increased proinflammatory cytokines, such as TNF-${\alpha}$, IL-$1{\beta}$, and IL-6 by HMDM. The involvement of nuclear factor (NF)-${\kappa}B$ signaling pathway in cytokine production induced by T. vaginalis was confirmed by phosphorylation and nuclear translocation of p65 NF-${\kappa}B$. In addition, stimulation with live T. vaginalis induced marked augmentation of nitric oxide (NO) production and expression of inducible NO synthase (iNOS) levels in HMDM. However, trichomonad-induced NF-${\kappa}B$ activation and TNF-${\alpha}$ production in macrophages were significantly inhibited by inhibition of iNOS levels with L-NMMA (NO synthase inhibitor). Moreover, pretreatment with NF-${\kappa}B$ inhibitors (PDTC or Bay11-7082) caused human macrophages to produce less TNF-${\alpha}$. These results suggest that T. vaginalis stimulates human macrophages to produce proinflammatory cytokines, such as IL-1, IL-6, and TNF-${\alpha}$, and NO. In particular, we showed that T. vaginalis induced TNF-${\alpha}$ production in macrophages through NO-dependent activation of NF-${\kappa}B$, which might be closely involved in inflammation caused by T. vaginalis.

• 생명과학회지
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• 제18권8호
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• pp.1042-1048
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• 2008

전립선 암은 현대 남성에게 걸리기 쉬운 질환으로 매년 점점 증가하는 암 사망률 중 하나이다. 하지만 남성호르몬 비의존형 전립선 암 치료에 대한 효과가 거의 없어 이에 본 연구에서는 남성호르몬 비의존형 전립선 암세포인 PC-3 세포에서 감마선이 세포 성장 억제와 세포자멸사 기작에 대해 알아보고자 한다. 그리하여 본 연구에서는 5가지 방법으로 즉, 세포증식 억제, apoptotic cell의 형태학적 변화, DNA 분절 분석, AV/PI 염색, western blot 분석법을 사용하여 수행하였다. 본 연구의 결과로 감마선을 처리한 PC-3세포에서 형태학적(분절화) 변화와 DNA ladder가 관찰되었다. 또한 감마선을 처리한PC-3세포에서는 apoptosis와 관련된 Caspase3와 PARP cleavage가 유발되었고 Bax 단백질 증가도 보였다.

• Journal of Preventive Medicine and Public Health
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• 제34권3호
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• pp.284-290
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• 2001

본 연구는 지역사회 주민을 대상으로 코골이와 고혈압과의 연관성을 파악하고자 하였다. 일부 전남 농촌지역 역학조사에 참여한 1,763명을 연구대상으로 성별, 연령, 교육수준, 결혼상태, 직업, 흡연 및 음주여부, 고혈압의 유무, 코골이의 유무 등에 대해 직접면접법을 통해 설문조사 하였고 비만은 체질량지수(BMI)로 측정하였다. 고혈압은 측정된 수축기 혈압이 140 mmHg이상이거나 이완기 혈압이 90mmHg이상인 경우와 과거에 고혈압으로 진단 받고 현재 고혈압 치료 중인 경우로 하였다. 코골이 전체 유병률은 41.0%이었고 남자에서 42.7%, 여자에서 39.8%이었다. 연령에 따른 코골이 유병률은 45세-64세 중년층에서 44.3%로 젊은층(33.9%)과 노년층(38.7%)에 비해 높았다. 비만도에 따른 코골이 유병률은 체질량지수가 증가할수록 증가했고 흡연과 음주 여부에 따른 코골이는 유의한 차이가 없었다. 코골이 군에서 코골이가 없는 군보다 고혈압이 많았다(교차비: 1.25, 95% CI=1.01-1.55). 그러나 성별, 연령, 비만, 흡연 및 음주 등의 인자들을 보정한 후 고혈압에 대한 코골이의 유의한 영향은 없었다(교차비: 1.13, 95% CI = 0.90-1.41). 본 연구의 결과는 코골이가 고혈압과 직접적인 연관성이 있기보다는 비만과 같은 교란변수에 의한 효과일 수 있음을 나타낸다.

• 대한방사선기술학회지:방사선기술과학
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• 제26권1호
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• pp.63-70
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• 2003

상장간맥동맥 증후군은 일반적인 검사에서 매우 탐지가 어려운 십이지장 만성폐색의 원인으로 대두되고 있다. 그러므로, 십이지장의 횡행부가 상장간막동맥과 복부대동 사이를 지나가기 때문에 복부대동맥과 상장간맥동맥 사이의 각도가 좁아져 십이지장 폐색의 원인을 야기시킨다. 이 각도의 측정은 일반혈관촬영으로는 복잡하고, 종종 부정확한 결과를 초래한다. 또한 한국인을 기준으로 각도 측정에 관한 시도 및 자료가 없는 실정이다. 따라서 본 연구자는 3차원 영상재구성을 위하여 범용컴퓨터에서 실행 가능한 Rapidia S/W를 이용함으로써 복부대동맥으로부터 상장간막동맥기시부의 각도를 측정하였는데, 상장간막동맥증후군이 없는 일반 환자를 대상으로 복부전산화단층촬영의 3차원영상을 이용하였다. 이 실험의 결과 상장간막동맥과 복부대동맥의 평균각도는 $50.05{\pm}15.87^{\circ}$이고 남자의 평균각도는 $53.64{\pm}16.57^{\circ}$이고 여자는 $46.46{\pm}14.98^{\circ}$로 남자의 각도가 약간 더 크게 나타났다. 이러한 연구를 통하여 얻은 각도가 상장간막동맥 증후군의 진단하는데 매우 중요한 지표가 될 것으로 사료된다.

• 한국전문물리치료학회지
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• 제11권3호
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• pp.71-84
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• 2004

This study analyzes the factors involving clinical practice which have an influence on the satisfaction of students majoring in physical therapy at colleges or universities located in the Pusan and Kyungnam area. We investigated using a self-reporting method 305 students receiving a grade point average between 2.0 and 4.0 and who had finished their clinical practice. We also investigated the characteristics of clinical settings which make up the clinical practice, the general characteristics of the students involved and the characteristics of a clinical teaching method performed by physical therapists versus a teaching method by a professor of a university. The number of students divided according to educational background are as follows: 149 people (48.9% of the total group) were 4 year students, 156 people were 3 year students (51.1% of the total group). Sixty-nine students' or 22.6% of the group were men while women consisted of 236 persons or 77.4% of the group. Four year students had a longer clinical practice period than that of the 3 year students (p<.05). An average satisfaction score of students with their clinical practice was 3.84. The satisfaction scores showed no significant difference between genders, educational backgrounds, and grades. (p>.05). There were no significant differences in the satisfaction score of students with their clinical practice was 3.84. The satisfaction scores showed no significant difference between genders, educational backgrounds, and grades. (p>.05). There were no significant differences in the satisfaction scores regarding the student management system among varying gender or educational backgrounds between the 3 year and 4 year programs. The average satisfaction score with the environment of the physical therapy room was 3.35. And there were no significant differences in the physical therapy room satisfaction score based on sex or educational system (p>.05). The most influential factor of determining clinical practice satisfaction was a student management system of the clinical practice (p<.01). The next most influential factors were the clinical practice period (p<.05), size of facilities (p<.01) and relationship with physical therapists (p<.01) ($R^2$=.554).