• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.1
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• pp.98-111
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• 2005

Background and purpose: The Han(cold)-Yol(heat) patternization is one of the most usually used diagnostic methods in oriental medicine. This is preceding studies for compensating questionnaries on Han-Yol that were made by sook-kyeng Kim. Methods: Questionnaries on Han-Yol that will be worked out should be useful for clinical examination. So We selected symptoms based on Donguibogam that is regarded as a clinical textbook in Korea. Results: It is expected that not only Sil-Yol but also Hu-Yol and Yol combined with Han can be diagnosed by new questionnaries. Conclusion: These symptoms based on Donguibogam will be made into questionnaries that can diagnose not only Sil-Yol but also Hu-Yol and Yol combined with Han.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.10 no.1
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• pp.98-108
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• 2006

Background and Purpose: The Han(cold)-Yol(heat) patternization is one of the most usually used diagnostic methods in oriental medicine. This is studies for compensating questionnaries for Han-Yol that were made by Sook-Kyeng Kim. Methods: Questionnaries for Yol should be useful for clinical examination. So symptoms being chosen for questionnaries are based on Donguibogam that is clifnical textbook and 46 items are developed. By delphi panel and statistical analysis Items of questionnaries are choosen. Resultset: By delphi panel and statistical analysis 8 Items of questionnaries are choosen. Conclusion: Further research is necessary for improvement reliabilities and validities of the questionnaires for Yol pattemization.

• The Journal of Internal Korean Medicine
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• v.12 no.1
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• pp.155-165
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• 1991

On the treatment of C.V.A, I obtain the results through the bibliographic investigation in the method of Chong-Yol-Sa-Hwa as follows ; 1. The method of Chong-Yol-Sa-Hwa on the treatment of CVA. is used for the occation of flaming fire in the heart caused by fire emotions in excess (五志過極), difficiency of Yin, flaming up of excessive in liver and plegm-heat. 2. The representative symptoms which can be used by the method of Chong-Yol-Sa-Hwa are firerishness, redness on face, foul breath, fidgets, angry, high fever, constipation slimy and greasy yellow coat of the tongue, and the pulse shaped on full-rapid (洪數), tautsmaooth and rapid (弦滑血數). 3. The general prescription on the method of Chong-Yol-Sa-Hwa are Bang pung tong sung-San, Yangkyuk-San, Backho-Tang, Sosiho-Tang, Samhwa-Tang, Chibo-Tan and Woohwang chongsim-Hwan on excessive symptom-complex, Yookmichihwang-Tang-Kakam, Samool-Tang-Kakam and Youngyangkak-Tang on insufficency symptom complex. 4. The most frequently dosed medicinal plants are Seok-ko, Chi-mo, Dae-Hwang, Mang-cho, Hwang-kewm, Hwang-back, Chi-ja, Si-ho, Han-Su-Seok, Yong-Tam-Cho, Mok-Tan-Pi and Saeng-Chi-Hwang. 5. The method of chong-Yol-Sa-Hwa might be expressed good medicinal effects adopted on the symptoms or flaming evil fire (火旺) after awakend and ‘Yang’ occlusion of Chung-Chang-Pu (中臟脈) which is accompanied with the method of purgation, break through the plegm, resuscitate and nourishing the Yin.

• The Journal of Korean Medicine
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• v.15 no.2 s.28
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• pp.132-142
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• 1994

Paraquat has been widely used as a herbicide in Korea since 1970. Human ingestion results in transient impairment of liver and kidney function and a characteristically respiratory failure with a high mortality rate. Clinical investigation and Oriental Medical Treatment were done on 3 cases of paraquat poisoning admitted to the department of 1st Internal Medicine. Kyung San University Oriental Medical Hospital from August 1991 to December 1992. and following results were obtained. The symptoms of paraquat poisoning can be regarded as Sim hua chi song(心火熾盛), Kan hua sang yom(肝火上炎). um hu hua wang(陰虛火旺), Kan tam sup yol(肝膽濕熱), Yang myong yol tok(陽明熱毒) in Oriental Medicine. and the principle of treatment for paraquat poisoning can be applicable to Chong yol Ii sop(淸熱利濕), Chong yol hae tok(淸熱解毒). Sa ha hae tok(瀉下解毒). Ja um kang hua(滋陰降火) and so on. Three cases were treated by HuangYonHaeTokTang(黃蓮解毒湯) and KamDuTang(甘豆湯): all of them have survived without complications. According to the result above, it suggests that determination of treatment based on the differentiation of symptoms and signs(Pyon jung si chi ;辨證施治) of Oriental Medicine may prove to be helpful in saving lives of patients with paraquat poisoning.

• Journal of Microbiology and Biotechnology
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• v.25 no.11
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• pp.1810-1818
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• 2015

For the synthesis of various pharmaceuticals, chiral alcohols are useful intermediates. Among them, (R)-ethyl-4-chloro-3-hydroxybutanoate ((R)-ECHB) is an important building block for the synthesis of L-carnitine. (R)-ECHB is produced from ethyl-4-chloro-3-oxobutanoate (ECOB) by a reductase-mediated, enantioselective reduction reaction. The Saccharomyces cerevisiae YOL151W reductase that is expressed in Escherichia coli cells exhibited an enantioselective reduction reaction toward ECOB. By virtue of the C-terminal His-tag, the YOL151W reductase was purified from the cell-free extract using Ni²⁺-NTA column chromatography and immobilized onto Ni²⁺-magnetic microparticles. The physical properties of the immobilized reductase (Imm-Red) were measured using electron microscopy, a magnetic property measurement system, and a zeta potential system; the average size of the particles was approximately 1 μm and the saturated magnetic value was 31.76 emu/g. A neodymium magnet was used to recover the immobilized enzyme within 2 min. The Imm-Red showed an optimum temperature at 45℃ and an optimum pH at 6.0. In addition, Bacillus megaterium glucose dehydrogenase (GDH) was produced in the E. coli cells and was used in the coupling reaction to regenerate the NADPH cofactor. The reduction/oxidation coupling reaction composed of the Imm-Red and GDH converted 20 mM ECOB exclusively into (R)-ECHB with an e.e._p value of 98%.

• Journal of Microbiology and Biotechnology
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• v.20 no.9
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• pp.1300-1306
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• 2010

Ethyl (R, S)-4-chloro-3-hydroxybutanoate (ECHB) is a useful chiral building block for the synthesis of L-carnitine and hypercholesterolemia drugs. The yeast reductase, YOL151W (GenBank locus tag), exhibits an enantioselective reduction activity, converting ethyl-4-chlorooxobutanoate (ECOB) exclusively into (R)-ECHB. YOL151W was generated in Escherichia coli cells and purified via Ni-NTA and desalting column chromatography. It evidenced an optimum temperature of $45^{\circ}C$ and an optimum pH of 6.5-7.5. Bacillus subtilis glucose dehydrogenase (GDH) was also expressed in Escherichia coli, and was used for the recycling of NADPH, required for the reduction reaction. Thereafter, Escherichia coli cells co-expressing YOL151W and GDH were constructed. After permeablization treatment, the Escherichia coli whole cells were utilized for ECHB synthesis. Through the use of this system, the 30 mM ECOB substrate could be converted to (R)-ECHB.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1673-1674
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• 2008

화력발전소 보일러의 각종 공정은 대부분 비례 적분 미분 제어기에 의해 제어되어 왔다. 이러한 비례 미분 적분 제어기의 최적튜닝은 공정에 있어 가장 중요한 부분 중 하나라고 할 수 있다. 또한 보일러 제어는 다중의 입력과 루프로 구성되어져 있어 이를 튜닝하기가 어려워 현재까지의 최적튜닝은 튜닝전문가의 숙련도에 의해 결정되어져 왔다. 본 논문에서는 고급공정제어기(Advanced Process Control, APC)를 개발하는 과정과 이를 이용해 최종적으로 보일러 제어기에서 제어하고자 하는 대상에 대한 응답특성을 간단한 튜닝을 통해 구현하는 과정에 대하여 설명하고 그 결과를 시뮬레이터를 통해 시험함으로써 검증해 보이고자 한다.

• The Magazine of Kiice
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• v.10 no.1
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• pp.32-43
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• 2009

• Journal of the Korean Society for Precision Engineering
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• v.22 no.10 s.175
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• pp.7-16
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• 2005

• Bulletin of the Korean Chemical Society
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• v.26 no.8
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• pp.1274-1276
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• 2005