• Asian-Australasian Journal of Animal Sciences
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• 제18권12호
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• pp.1691-1695
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• 2005

The bovine lymphocyte antigen (BoLA)-DRB3 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to CD4 T helper cells. DRB3 is the most polymorphic bovine MHC class II gene which encodes the peptide-binding groove. Since different alleles favour the binding of different peptides, DRB3 has been extensively evaluated as a candidate marker for associations with various bovine diseases and immunological traits. For that reason, the genetic diversity of the bovine class II DRB3 locus was investigated by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). This study describes genetic variability in the BoLA-DRB3 in Iranian Golpayegani Cattle. Iranian Golpayegani Cows (n = 50) were genotyped for bovine lymphocyte antigen (BoLA)-DRB3.2 allele by polymerase chain reaction and restriction fragment length polymorphism method. Bovine DNA was isolated from aliquots of whole blood. A two-step polymerase chain reaction followed by digestion with restriction endonucleases RsaI, HaeIII and BstYI was conducted on the DNA from Iranian Golpayegani Cattle. In the Iranian Golpayegani herd studied, we identified 19 alleles.DRB3.2${\times}$16 had the highest allelic frequency (14%), followed by DRB3.2${\times}$7 (11%). Six alleles (DRB3.2${\times}$25, ${\times}$24, ${\times}$22, ${\times}$20, ${\times}$15, ${\times}$3) had frequencies = 2%. Although additional studies are required to confirm the present findings, our results indicate that exon 2 of the BoLA-DRB3 gene is highly polymorphic in Iranian Golpayegani Cattle.

• 건축역사연구
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• 제10권3호
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• pp.61-76
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• 2001

The purpose of this study is not only to evaluate the capacity of construction management but also to understand the capacity of construction productivity by analysing various information, mainly collected from the book, HwaSungSungYouk-EuGye. The book was made by ChungCho who was one of the great kings Choson Dynasty, which has lots of information about how to build HwaSung during the last of the eighteen century. It is true that previous researches have showed lots of limitation to study the HwaSungSungYouk-EuGye though it contained a plenty of construction data. The main reason would be the absence of study methods to analyze HwaSungSungYouk-EuGye systematically. That's why there have not been overall studies about the HwaSungSungYouk-EuGye. This study starts from the definition that the HwaSungSungYouk was one of the construction projects which is the concept for construction management today. The construction project can be defined in terms of its distinctive characteristics: a project is a temporary endeavor undertaken to create a unique product. Temporary means that every project has a definite beginning and a definite end. Unique means the product is different in some distinguishing way from all similar products. A project is also undertaken several kinds of organizations. They may Involve a single person or many thousands. This study is to show some of the effective methods. Firstly, the concept of the database system today can be applied to effectively control and classify the complicated data in the HwaSungSungYouk-EuGye. Secondly, on the basis of the database system, the concept of modern construction management will be also use to figure out the construction data of the HwaSungSungYouk-EuGye.

• 한국의료질향상학회지
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• 제23권1호
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• pp.69-90
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• 2017

Purpose: The purpose of this study was to analyze the impact of healthcare accreditation and to provide empirical evidence to validate positive effectiveness. Methods:Six electronic databases (KERIS, KoreaMed, NDSL, Ovid-medline, Embase, Cochrane library) were accessed in May 2016. Keywords used were 'accreditation' and 'Joint Commission on Accreditation of Healthcare Organization (JCAHO)'. Of the initially identified 3,008 articles, 60 studies on healthcare accreditation were selected based on inclusion criteria that are hospital accreditation, accreditation by disease and clinical center accreditation. These were retrieved and analyzed. Result: The 60 study results were on the impact of healthcare accreditation. Results were classified into four perspectives of Balanced Score Card (Financial, Customer, Internal Process, Learning & Growth). In internal process perspective, results revealed that healthcare accreditation has made a positive impact on "care process and procedure". In learning & growth perspective, healthcare accreditation has made a positive influence on "leadership", "organizational cultures" and "change mechanisms". However, it revealed that healthcare accreditation does not directly affect financial performance. It is also difficult to reach a definitive conclusion that healthcare accreditation programs affect patient satisfaction of customer and clinical outcome of the internal process. Conclusion: Healthcare accreditation programs provide positive impact on change of care process and building communication-oriented hospital culture. However, more rigorous and diverse research is needed on financial effects and clinical outcomes of healthcare accreditation.

• 한국전기전자재료학회논문지
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• 제28권7호
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• pp.467-472
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• 2015

Thermal batteries are primary power sources for military applications requiring high reliability, robustness and long storage life. Conventional electrodes for thermal batteries are prepared by compacting powder mixtures into pellets. Separator is composed of halide mixture, such as LiCl-KCl eutectic salt, blended with MgO to immobilize the molten salt. In order to increase the power density and energy density, the resistance of electrolyte should be reduced because the resistance of electrolyte is predominant in thermal batteries. In this study, wetting behaviors and impregnation weight of molten salts as well as the micro structures of ceramic felt were investigated to be applicable to thin electrolyte. Discharge performances of single cell with the ceramic separator impregnated by molten salt were evaluated also. Zirconia felt with high porosity and large pore outperformed alumina felt in wetting characteristics and molten salt impregnation as well as discharge performances. Based on the results of this study, ceramic felt separator impregnated with molten salt have revealed as an alternative of conventional thick MgO based separator with no conspicuous sign of thermal runaway by short circuit.

• Journal of Preventive Medicine and Public Health
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• 제43권1호
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• pp.9-17
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• 2010

Objectives: Parkinson's disease is one of the most common neurodegenerative diseases in the elderly population. In order to estimate the prevalence of Parkinson's disease in the community, the application of a good screening tool is essential. We evaluated the validity and reliability of a Parkinson's disease screening questionnaire and propose an alternative measure to improve its validity for use in community surveys. Methods: We designed the study in a three-phase approach consisting of a screening questionnaire, neurologic examination, and confirmatory examination. A repeated survey was administered to patients with disease detected in the community and on 150 subjects. We examined internal consistency using Cronbach's alpha test, test-retest reliability using the kappa statistic, and validity using sensitivity, specificity, and ROC curves. Unadjusted odds ratios were utilized for the estimation of weights for each questionnaire item. Results: The Cronbach's alpha of the questionnaire was 0.708. The kappa statistic for test-retest reliability was good to generally fair in most of the items. When newly proposed weighting scores were used, the optimum cut-off value was 7/8. When cut-off value was 5/6 for surveying prevalence in a community, the sensitivity was 0.98, and the specificity was 0.61, with simultaneous improvement in reliability. Conclusions: We recommend 5/6 as the ideal cut-off value for the survey of PD prevalence in community. This questionnaire designed for the Korean community could help future epidemiologic studies of PD.

• 한국간호교육학회지
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• 제3권2호
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• pp.207-213
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• 1997

Basic science teaching and clinical education should be integrated whenever appropriate, and the development of skills, values, and attitudes which are emphasized to the same extent as the acquisition of knowledge in nursing. Problem-based learning provides a students-centered learning environment and encourages an inquisitive style of learning. The purpose of this paper is to review and comment the role of tutors and students on problem-based learning. The use of problem-based learning places a high demand on faculty members' time and support. The role of tutors in Problem-based learning focuses primarily on issues of developing and teaching the curriculum and on organizational implementation and institutionalization. Tutors are an integral part of course planning. Tutors serve as a constant source of feedback on student needs and concerns to the course director and constitute an informal steering committee while the course is in progress. Tutors write cases, develop student evaluation methods, recommend resources, suggest modifications in lectures and laboratories. Students have a limited amount of time available to study what is traditionally defined as the core content of nursing. But, the role of students in Problem-based learning would be active, independent learners and problem-solvers rather than passive recipients of information. Students using a deep level approach attempt to integrate what they learn with what they already know, to understand the meaning underlying the material to be learned, and to look for explanations rather than facts. Students are encouraged, with appropriate guidance, to define their own learning goals, to select appropriate experiences to achieve these goals, and to be responsible for assessing their own learning progress. Problem-based learning is more flexible and meaningful, by encouraging student interaction, and by having a better emotional climate than the conventional learning.

• 패션비즈니스
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• 제20권6호
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• pp.32-51
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• 2016

KakaoTalk has become a reputed mobile social network and an inseparable part of people's lives by leading the mobile industry in South Korea. However, there is a lack of studies in academia regarding perception of the consumers and assessment toward the mobile marketing and services by KakaoTalk. Based on the theoretical orientation of Elaboration Likelihood Model (ELM: Petty & Cacioppo, 1986) and electronic service quality (E-S-QUAL: Parasuraman, Zeithaml, & Malhotra, 2005), this study investigates the effects of information sources (Charles & Richard, 1988), and examines the consumer perception toward the service quality of KakaoTalk. A total of 209 responses were collected, using a self-administered survey in Seoul and Gyeonggi province, South Korea from March 2015 to June 2015. A seven-point Likert scale survey was developed to measure the information sources (i.e., argument quality, post popularity, and post attractiveness), electronic service quality (i.e., efficiency, fulfillment, privacy, and system availability), attitude (i.e., usefulness, preference, and overall attitude), and behavioral intention (i.e., like intention, share intention, and purchase intention). This study reveals a consensus that an online environment is different from the traditional retail context in terms of information source and service quality. Specifically, the results indicate that argument quality greatly impacts the attitudes of the individuals and their behavioral intention toward mobile shopping via social media channel. The most powerful factor among E-S-QUAL is "efficiency." This dimension of service quality influences the customer perception of usefulness and preference as well as share and like intention toward mobile shopping on KakaoTalk.

• 한국축산식품학회지
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• 제40권4호
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• pp.541-550
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• 2020

The use of yeast assist kefir fermentation, but also can cause food spoilage if uncontrolled. Hence, in this study, the microbial composition of an existing commercial kefir starter was modified to produce a functional starter, where Lactobacillus acidophilus KCNU and Lactobacillus brevis Bmb6 were used to replace yeast in the original starter to produce non-yeast kefir-like fermented milk. The functional starter containing L. acidophilus KCNU and L. brevis Bmb6 demonstrated excellent stability with 10¹⁰ CFU/g of total viable cells throughout the 12 weeks low-temperature storage. The newly developed functional starter also displayed a similar fermentation efficacy as the yeast-containing control starter, by completing the milk fermentation within 12 h, with a comparable total number of viable cells (10⁸ CFU/mL) in the final products, as in control. Sensory evaluation revealed that the functional starter-fermented milk highly resembled the flavor of the control kefir, with enhanced sourness. Furthermore, oral administration of functional starter-fermented milk significantly improved the disease activity index score by preventing drastic weight-loss and further deterioration of disease symptoms in DSS-induced mice. Altogether, L. acidophilus KCNU and L. brevis Bmb6 have successfully replaced yeast in a commercial starter pack to produce a kefir-like fermented milk beverage with additional health benefits. The outcome of this study provides an insight that the specific role of yeast in the fermentation process could be replaced with suitable probiotic candidates.

• 한국학교보건학회지
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• 제15권1호
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• pp.141-150
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• 2002

The purpose of this study was to investigate the visual acuity and the degree of vision-related knowledge and behaviors of the 1st and 2nd graders of primary school and their parents in a city. The research design was a descriptive study and the subjects were 579 pupils and their parents in Namwon City, Chonbuk province. Children's vision screening was conducted with Han's test by author, school nurse according to the guidelines. The data were analyzed by frequency, percentage, mean, S.D., t-test, ANOVA, Pearson's correlation coefficient, $x^2$-test with SAS program. Subnormal visual acuity group (SVAG) in children was 17.3%, and was higher in girls and in the 2nd graders, but there were no significant differences statistically. The mean score of the vision-related knowledge in children was 6.8 points out of 10 points and that of vision-related behaviors was 23.5 points out of 33 points. The mean scores of the vision-related knowledge were significantly higher in 2nd graders (p= .02), in girls (p= .02) and SVAG (p= .01) and the group of high scores in vision-related knowledge presented significantly high scores in vision-related behaviors (p= .001). The mean score of the vision-related knowledge in parents was 6.4 points out of 10 points and that of vision-related behaviors was 28.4 points out of 33 points. The group with high scores of vision-related knowledge in parents presented significantly high scores in vision-related behaviors (p= .003). As SVAG were higher in 2nd graders and the group of high scores of vision-related knowledge showed also high scores in vision-related behaviors in both children and their parents, From the above results, the author suggests a school-based visual health program for them.

• 한국임상약학회지
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• 제7권1호
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• pp.17-21
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• 1997

Cefaclor is a second generation cephalosporin antibiotic that shows a potent antibacterial activity against both Gram-positive and Gram-negative bacteria, when it is orally administered. Due to its patent expiration, a number of generic drugs have been marketed, but not yet elucidated to ensure therapeutic equivalence. In this study, cefaclor capsules manufactured by Chong Kun Dang were bioequivallently assessed by comparing with $Ceclor^{TM}$ introduced originally by Daewoong Lilly. A total of 16 healthy male volunteers were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of cefaclor in plasma were measured upto 6 hours following a single oral administration of two capsules (500 mg of cefaclor) by high-performance liquid chromatography with UV detection. Although the plasma concentration at 6 hours was not detected, the computed half-life of cefaclor was approximately 0.5 hours. The area under the concentration-vs-time curve from 0 to 4 hours $(AUC_{0-4h})$ was calculated by the trapezoidal summation method. The differences in mean values of $AUC_{0-4h}$, peak plasma concentration $(C_{max})$, and time to peak concentration $(T_{max})$ between the two products were $4.63\%,\;1.84\%,\;and\3.28\%$, respectively. The least significant differences at $\alpha4= 0.05 for $AUC_{0-4h},\;C_{max},\;and\;T_{max}\;were\;6,53\%,\;4.05\%,\;and\;6.47\%$, respectively. In conclusion, the test drug was bioequivalent with the reference drug.