• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.317-318
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• 2009

• International Journal of Railway
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• v.3 no.1
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• pp.14-18
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• 2010

This paper describes design and characteristic analysis of long primary type linear synchronous motor (LSM) for high speed train system. LSM is designed using loading distribution method and magnetic equivalent circuit. For characteristic analysis of LSM, analytical and numerical methods are applied. Analytical method for solving the magnetic field distribution of the analytic model is based on the Maxwell’s equations. Using the characteristic equation and magnetic equivalent circuit, we analyze the effect of variation of parameters, and then we validate the result by comparing with numerical method by finite element method (FEM). We compare the analytical method with numerical method for analyzing the effect by variable parameters. This result will be useful of design and forecast of performance without FEM.

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.259-263
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• 2018

There are many treatment options for the malignant melanoma. Wide excisional surgery is one of the most acceptable treatments for locoregional treatment. Depending on the pathologic classification, however, some other treatment option can be included such as chemotherapy, radiotherapy and immunotherapy as adjuvant treatment. Small cell type malignant melanoma is a rare variant of malignant melanoma. It is known that melanomas manifesting this morphology are invariably in vertical growth phase and have an aggressive course. The authors encountered small cell type malignant melanoma and would like to share the experience of successful treatment with surgery plus immunotherapy as one of adjuvant treatment options.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.212.2-212.2
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• 2003

In the course of searching for BACE1 (${\beta}$-secretase) inhibitors from natural products, the ethyl acetate soluble fraction of green tea, which was suspected to be rich in catechin content, showed potent inhibitory activity. (-)-Epigallocatechin gallate, (-)-epicatechin gallate, and (-)-gallocatechin gallate ware isolated with IC$\_$50/ values of 1.6${\times}$10$\^$-6/ M, 4.5${\times}$10$\^$-6/ M, and 1.8${\times}$10$\^$-6/ M, respectively. Seven additional authentic catechins were tested for a fundamental structure-activity relationship. (-)-Catechin gallate, (-)-gallocatechin, and (-)-epigallocatechin significantly inhibited BACE1 activity with IC$\_$50/ values of 6.0${\times}$10$\^$-6/ M, 2.5${\times}$10$\^$-6/ M, and 2.4${\times}$10$\^$-6/ M, respectively. (omitted)

• Journal of the Earthquake Engineering Society of Korea
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• v.27 no.1
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• pp.49-57
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• 2023

This study investigated the rocking behavior of unreinforced masonry walls and wall piers under cyclic loading. Based on the benchmark tests, the characteristics of load-deformation relations in masonry walls with rocking failure were captured, focusing on observed deformation modes. The rocking strengths of masonry walls (i.e., peak and residual strengths) were evaluated, and the effects of opening configurations on the masonry wall strength were examined. The deformation capacity of the rocking behavior and the hysteresis shape of the load-deformation relations were also identified. Based on the results, modeling approaches for the rocking behavior of masonry walls were discussed.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.05a
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• pp.169-172
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• 2020

비프로파일링 부채널 분석은 프로파일링 장비가 없는 환경에서 부채널 정보를 이용해 비밀정보를 분석하는 방법이다. 기존에 알려진 Timon의 비프로파일링 분석은 학습 데이터 집합만을 이용해 공격하므로 전력 파형의 수가 제한된다면 과적합이 발생하여 키 분석 성능이 떨어질 수 있다. 본 논문에서는 비프로파일링 환경에서의 딥러닝 기반 부채널 분석 성능을 향상시키기 위해 학습 데이터 집합과 독립적인 검증 데이터 집합을 활용해야 하는 실증적 근거를 제시한다. 이에 대한 실험으로 기존 기법과 제시한 기법의 성능을 비교해 봤을 때, 검증 데이터를 활용하면 더 적은 데이터로 비밀키 추출이 가능함을 보인다.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.05a
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• pp.180-183
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• 2020

물리적 정보를 이용해 암호 알고리즘의 비밀정보를 분석하는 부채널분석 분야에서도 딥러닝을 접목한 분석방법들이 활발히 제안되고 있다. 본 논문에서는 소비전력이 시간축상으로 흐트러지는 현상인 지터가 있는 파형을 신경망의 특성을 기반으로 효과적으로 분석하는 방법을 제안한다. 제안한 방법을 실험적으로 검증하기 위해 지터가 있는 AES-128 파형을 Convolutional Neural Network와 Multi-Layer Perceptron을 기반으로 분석한 결과 제안한 방법을 적용한 신경망은 모든 바이트 키 분석에 성공했으나, 이외의 신경망은 일부 혹은 모든 바이트 키 분석에 실패했다.

• Journal of Oriental Neuropsychiatry
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• v.31 no.2
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• pp.63-76
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• 2020

Objectives: The purpose of this study was to verify the clinical effects of herbal medicines on patients with depressive disorder. Methods: A prospective observational study on patients with depressive disorder was conducted. The patients were treated with herbal medicines for eight weeks. The Korean Hamilton Depression Rating Scale (K-HDRS) was evaluated as the primary outcome and the Korean Beck's Depression Inventory (K-BDI), Instrument on Pattern Identification for Depression, Korean Symptom Checklist-95 (KSCL-95), Insomnia Severity Index (ISI), Korean State-Trait Anxiety Inventory (STAI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), EuroQol five-dimensional Questionnaire (EQ-5D), Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Heart Rate Variability (HRV) were measured as the secondary outcome. Adverse events were assessed for safety. Results: A total of 35 participants were observed for 12 weeks. The K-HDRS improved significantly in four, eight, and 12 weeks and the K-BDI showed significant differences in four, and eight weeks. There were no significant improvements in other evaluation scales. Gyejibongnyeong-hwan was the most frequently and continuously prescribed, showing significant improvements of K-HDRS after eight weeks of treatment. Conclusions: In our observational study, herbal medicine was effective for relieving the depression of patients with depressive disorder and Gyejibongnyeong-hwan showed the most significant effectiveness.

• Korean Journal of Medicinal Crop Science
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• v.17 no.6
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• pp.388-396
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• 2009

The present study investigated an ethanol extract (HS0608) of a mixture of three medicinal plants of Curcuma longae radix, Phellinus linteus, and Scutellariae radix for possible neuroprotective effects on neurotoxicity induced by amyloid $\beta$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to $10\;{\mu}M$ $A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $1-50\;{\mu}g/m{\ell}$, HS0608 inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with HS0608 (25, 50 and 100 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. From these results, we suggest that the antidementia effect of HS0608 is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that HS0608 may have a therapeutic role in preventing the progression of Alzheimer's disease.

• Korean Journal of Medicinal Crop Science
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• v.13 no.5
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• pp.219-226
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• 2005

Sanguisorbae radix (SR) from Sanguisorba officinalis L. (Losaceae) is widely used in Korea and China due to its various pharmacological activity. The present study aims to investigate the effect of the methanol extract of SR on amyloid ${\beta}$ Protein(25-35) $(A{\beta}\;(25-35))$, a synthetic 25-35 amyloid peptide, -induced neurotoxicity using cultured rat cortical neurons. SR, over a concentration range of $10-50\;{\mu}g/ml$, inhibited the $A{\beta}$ (25-35) $(10\;{\mu}M)-induced$ neuronal cell death, as assessed by a 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and the number of apoptotic nuclei, evidenced by Hoechst 33342 staining. Pretreatment of SR $(50\;{\mu}g/ml)$ inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced} elevation of cytosolic calcium concentration $([Ca^{2+}]c)$, which was measured by a fluorescent dye, fluo-4 AM. SR $(10\;and\;50\;{\mu}g/ml)$ inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}(25-35)$, which was measured by HPLC, and generation of reactive oxygen species. These results suggest that SR prevents $A{\beta}$ (25-35)-induced neuronal cell damage in vitro.