• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10557-10563
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• 2015

It is well known that conventional chemotherapy and radiation therapy can result in toxicity to both normal cells and tumor cells, which causes limitations in the application of these therapeutic strategies for cancer control. Novel and effective therapeutic strategies for cancers with no or low toxicity for normal cells are a high priority. Therefore, natural products with anticancer activity have gained more and more attention due to their favorable safety and efficacy profiles. Pre-clinical and clinical studies have demonstrated that several representative natural compounds such as resveratrol, epigallocatechin-3-gallate, curcumin, allicin and ginsenosides have obvious anticancer potential. In this article, we summarize autophagy-associated targeting pathways of such natural products for inducing the death of cancer cells, and discuss the core autophagic pathways involved in cancer treatments. Recent advances in the discovery, evaluation and exploitation of natural compounds as therapeutic agents for cancers will provide references and support in pre-clinical and clinical application of novel natural drugs for the treatment of primary and metastatic tumors in the future.

• BMB Reports
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• v.44 no.1
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• pp.70-75
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• 2011

Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). Several lines of evidence indicate that NOLC1 plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes. In the present study, we examined the transcriptional regulation mechanisms that govern the expression of NOLC1. We first performed functional dissection of the NOLC1 promoter. We demonstrated that transcription factors NF-${\kappa}B$ and CREB could bind to the minimal NOLC1 promoter. This was demonstrated by electrophoretic mobility shift assays and chromatin immunoprecipitation. Mutagenesis and overexpression assays revealed that NF-${\kappa}B$ and CREB positively regulated the NOLC1 promoter. These findings may provide new insight into the mechanisms that regulate NOLC1 expression.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.2
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• pp.143-148
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• 2014

Arecoline is a major alkaloid of areca nuts which are widely chewed by southeast Asian and it manifests various toxic effects in different organs of human and animals. In this work, mature mice were treated by vitamins C plus E, arecoline, or both daily for four weeks. The results showed that arecoline significantly increased the levels of serum alkaline phosphatase (ALP), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and significantly decreased the levels of reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) in the liver tissues. Additionally, the body weight, testis weight, sperm counts, motility and normal sperms also were significantly decreased. The supplement of vitamins C and E can bring the activities of ALP and GPT to normal levels and partially restore the sperm counts compared to the arecoline-treated group but have no other positive effects. In conclusion, the vitamins C and E partially attenuated the arecoline-induced hepatotoxiciy but basically had on protective effects against the arecoline-induced testicular toxicity.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.10
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• pp.4080-4097
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• 2020

In recent years, convolutional neural network (CNN) has become the primary method for face detection. But its shortcomings are obvious, such as expensive calculation, heavy model, etc. This makes CNN difficult to use on the mobile devices which have limited computing and storage capabilities. Therefore, the design of lightweight CNN for face detection is becoming more and more important with the popularity of smartphones and mobile Internet. Based on the CPU real-time face detector FaceBoxes, we propose a multi-task lightweight face detector, which has low computing cost and higher detection precision. First, to improve the detection capability, the squeeze and excitation modules are used to extract attention between channels. Then, the textual and semantic information are extracted by shallow networks and deep networks respectively to get rich features. Finally, the landmark detection module is used to improve the detection performance for small faces and provide landmark data for face alignment. Experiments on AFW, FDDB, PASCAL, and WIDER FACE datasets show that our algorithm has achieved significant improvement in the mean average precision. Especially, on the WIDER FACE hard validation set, our algorithm outperforms the mean average precision of FaceBoxes by 7.2%. For VGA-resolution images, the running speed of our algorithm can reach 23FPS on a CPU device.

• Proceedings of the Korea Crystallographic Association Conference
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• 2003.05a
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• pp.12-12
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• 2003

초전도 선재로의 응용을 위하여 Pulsed laser deposition(PLD)법으로 고온 초전도 체 YBa₂Cu₃O/sub 7-δ/(YBCO) coated conductor를 제조하였다. coated conductor는 금속기판/완충층/초전도층의 구조를 이루고 있는데 완충층은 금속 기판의 집합조직을 초전도층까지 전달하는 역할과 금속기판의 금속이 초전도층으로 확산되어 초전도층의 전기적 특성을 열화시키는 것을 막아주는 확산장벽으로의 역할 등을 수행한다. 완충층의 박막 성장이 제대로 이루어지지 않으면 우수한 초전도 특성을 가지는 초전도층을 얻을 수 없다. 완충층은 금속기판과의 lattice match, thermal match등이 요구되고, 화학적으로 금속기판 및 초전도층과 반응하지 않아야 하며, 긍속기판의 산화없이 epitaxial하게 박막증착이 이루어질 수 있는 재료이어야 한다. 이러한 조건을 만족하는 YBCO, CeO₂, YSZ 등이 주로 사용되고 있다. 전기연구원에서 YBCO coated conductor 선재를 제조하기 위하여 사용하고 있는 다층 박막의 구조는 YBCO/CeO₂/YSZ/CeO₂/Ni(002)과 YBCO/CeO₂/YSZ/Y₂O₃/Ni(002)이며, 최적의 증착조건을 찾기 위하여 성장시 챔버의 산소분압, 완충층의 두께, 기판 온도 등을 변화시켰다. 증착된 완충층 및 초전도층의 집합 조직은 D8-Discover with GADDS(General Area Detector Diffraction System)로 XRD분석을 했고, 미세구조는 SEM으로 관찰하였으며 4단자법을 이용하여 초전도 특성을 측정하였다.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.1
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• pp.261-271
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• 2006

Purpose : Dysmenorrhea which repeat every menstrual phase give complaints like pain, vomiting, nasal bleeding and etc. But in many textbooks pathogenesis and treatment process of dysmenorrhea obscure. So the purpose of this study is to identify the conception, pathogenesis and treatment process of dysmenorrhea. Methods : After catching the limitations of preexistence theory about dysmenorrhea, I show a meaningful argument of dysmenorrhea. Results : The conception, pathogenesis and treatment process of dysmenorrhea are like this. Dysmenorrhea which occurs for menstrual phase can make deficiency of blood. There are intimate relations between uterine function and the five Zang-organs, especially heart, spleen and liver, so menstruation induces the weakness of those organs. And the insufficiency of kidney and conception-thorough vessel which have control over the uterine function can make dysmenorrhea. Conclusion : The deficiency of kidney which is responsible for holding Qi breaks down the balance of Zang-organs Yin-Yang, then dysmenorrhea appears through Zang-organs weakness of heart, spleen and liver. For the treatment of dysmenorrhea, we should consider preferentially the deficiency of kidney, afterward Bianzheng Lunzhi of the Zang-fu organs.

• Journal of Power Electronics
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• v.16 no.6
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• pp.2129-2138
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• 2016

The full-bridge inverter, widely used for single-phase photovoltaic grid-connected applications, presents a leakage current issue. Therefore, an AC bypass branch is introduced to overcome this challenge. Nevertheless, existing modulation strategies entail drawbacks that should be addressed. One is the zero-crossing distortion (ZCD) of the AC current caused by neglecting the AC filter inductor voltage. Another is that the system cannot deliver reactive power because the AC bypass branch switches at the power frequency. To address these problems, this work proposes an optimized hybrid modulation strategy. To reduce ZCD, the phase angle of the inverter output voltage reference is shifted, thereby compensating for the neglected leading angle. To generate the reactive power, the interval of the negative power output is calculated using the power factor. In addition, the freewheeling switch is kept on when power is flowing into the grid and commutates at a high frequency when power is fed back to the DC side. In this manner, the dead-time insertion in the high-frequency switching area is minimized. Finally, the performances of the proposed modulation strategy and traditional strategies are compared on a universal prototype inverter. Experimental results validate the theoretical analysis.

• Journal of the East Asian Society of Dietary Life
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• v.7 no.2
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• pp.247-255
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• 1997

The changes of mental activities and the normal life during the pregnancy have a direct and indirect influences not only on the maternal health but also on the physiological function of the fetus. In the oriental medicine, many attentions have been ordered during the pregnancy. And they called these attentions and managements during the pregnancy as 'Tia-jiao(胎敎)'. The Tia-jiao, that is the prenatal culture, means 'educations for the fetus', so it is a hygienic conception for the pregnacy and the delivery. About this, many oriental gynecologic texts contained various contents such as the prohibitions against food(Shi-ji 食忌), the attentions on the mental activities(Yang-xing-ging 養性情), the notions on the normal life(Qi-ju-ji 起居忌), the cautions against drugs(Yao-ji 藥忌), the instructions for the treatments, the preventions against abortion(Gu-tia-liang-fa 固胎良法). The Tai-jiao can be divided two categories. The one is the behaviors and mental attitudes which can induce the good characters, and the other is the intake of foods and drugs which can grow the healthy body. According to the transitions of the generation, the economies, the societies, and the cultures have been changed. Through the pursuits of the intelligent babies have been remained, all conceptions and recognitions have also been altered. Therefore the ways to the prenatal culture must be changed, The reviewing the old and learning now, and doing the appropriate Tia-jiao in the modern times may be the best way to get the good babies.

• Korean Journal of Acupuncture
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• v.25 no.4
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• pp.59-71
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• 2008

Objectives : The aim of this study was to show the rationale of point-selection for acupuncture and moxibustion in the Uterine section(in the Naegyeong Chapter) of the Dong-Ui-BO-Gam. Methods : We reviewed the causes of each disease in the Uterine section of the Dong-Ui-BO-Gam, and then explained the rationale of acupoint-selection for the treatment of those diseases referring to etiology and physiology of Oriental medicine, other applications of each acupoints in the Dong-Ui-BO-Gam, characteristic of each acupoints, flow of Gi (Qi) through meridian pathways and specific acupoints etc. Results : There are comments on acupuncture and moxibustion for abnormal menstruation, amenorrhea, metrorrhagia, leukorrhea, bleeding from uterus after menopause in the Uterine section of the Dong-Ui-BO-Gam. Conclusions : Acupoints of conception vessel, and three foot Yin meridians are preferably used for acupuncture and moxibustion in the Uterine section of the Dong-Ui-BO-Gam. Out of them, CV3 is most frequently used and SP6, CV6, BL23, LR2 are also used often.

• Journal of Power Electronics
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• v.19 no.6
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• pp.1413-1428
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• 2019

In this paper, a novel zero-voltage and zero-current switching (ZVZCS) interleaved two switch forward converter is proposed. By using a coupled-inductor-type smoothing filter, a snubber capacitor, the parallel capacitance of the leading switches and the transformer parasitic inductance, the proposed converter can realize soft-switching for the main power switches. This converter can effectively reduce the primary circulating current loss by using the coupled inductor and the snubber capacitor. Furthermore, this converter can reduce the reverse recovery loss, parasitic ringing and transient voltage stress in the secondary rectifier diodes caused by the leakage inductors of the transformer and the coupled inductance. The operation principle and steady state characteristics of the converter are analyzed according to the equivalent circuits in different operation modes. The practical effectiveness of the proposed converter was is illustrated by simulation and experimental results via a 500W, 100 kHz prototype using the power MOSFET.