• 대한한의학원전학회지
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• 제33권4호
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• pp.83-105
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• 2020

Objectives : This paper aims to examine the system, principle, and fundamentals of the great principle of pulse diagnosis in the 『Nanjing』. Methods : The system, principle, and fundamentals of pulse diagnosis in the 『Nanjing』 were examined within the book's description framework and logical structure in light of its relationship to the 『Huangdineijing』. Previous studies that follow pulse diagnosis of 『Nanjing』 and 『Wangshuhe Maijue』 were referenced. Results & Conclusions : The structure of pulse diagnosis in the 『Nanjing』 is systematically organized under the principle of the three positions and nine indicators as the great principle to which the yinyang and five viscera pulse theories are included. The great principle of the three positions and nine indicators is consisted of a system that allows for a multiple and comprehensive interpretation wherein the theories of yinyang and five elements are interweaved within the pulse diagnosis system, which is comprised of a great principle and particular principles. The theory follows that of the three yin three yang theory of the five circuits and six qi, its principles manifesting as the three positions and nine indicators and integration of pulse and symptoms.

• 대한한의학원전학회지
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• 제18권3호통권30호
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• pp.81-94
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• 2005

There appears 7 chapters about questioning and answering between Lei Gong - Huang Di in which includes many contents that do not appear in other chapters of Su Wen(${\ulcorner}$素問${\lrcorner}$) and Ling Shu(${\ulcorner}$靈樞${\lrcorner}$). Especially terms such as Kui Duo(揆度), Qi Heng(奇恒), Yin Yang(陰陽), Cong Rong(從容). Ci Xiong(雌雄), Wu Zhong(五中), Zhong Shi(終始), Bi Lei(比類), Ming Tang(明堂), Ren shi(人事) do not show what they implicate and are difficult to understand. However, from the context, we assume that they maybe terms related to diagnosis. Although the Yin Yang Mai Fa of Su Wen totally differs from Nan Jing, we will look for the orgin of it through Wu Zhong. Furthermore, we will look into the development of Ren Ying Cun Kou Mai(人迎寸口脈), which does not appear in the contents of questioning and answering between Lei Gong Huang Di. The term Bi Lei that only appears in questioning and answering between Lei Gong - Huang Di will be analyzed along with diagnostic skill and the co-explained term Ren Shi. A lot of Xe Zheng(虛證) provoked by a intrinsic factor, Ren Shi, and suitability of its development to Lei Gong - Huang Di 's Mai Fa will be more closely discussed.

• 한방비만학회지
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• 제16권2호
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• pp.109-115
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• 2016

Objectives: The all anti-obesity drugs currently approved by the US Food and Drug Administration work by reducing energy intake. In fact, no approved drug targets energy expenditure. In Korean medicine, it is known to Qi or Yang invigorating therapy could increase energy metabolism. Aconitum carmichaeli Debx (ACD) is a Yang invigorating herb, often used for treat obesity in Korean medicine. In the present study, the authors investigated the regulatory effects of ACD in energy metabolism and mitochondrial biogenesis in C2C12 skeletal muscle cells. Methods: The water extract of ACD (0.2, 0.5 and 1.0 mg/ml) were treated in differentiated C2C12 cells. The protein or mRNA levels of target genes were analyzed and mitochondrial mass were investigated. Results: ACD activated the expressions of peroxisome proliferator-activated receptor gamma coactivator 1-alpha ($PGC-1{\alpha}$), nuclear respiratory factor 1 and TFAM and increased mitochondrial mass. ACD also increased adenosin monophosphate-activated protein kinase (AMPK), and acetyl-CoA carboxylase. Conclusions: This study suggests that ACD has the potential to increase energy metabolism and mitochondrial biogenesis by activating AMPK and $PGC1{\alpha}$.

• 혜화의학회지
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• 제16권2호
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• pp.349-353
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• 2007

Hyperhidrosis is a condition characterized by excessive sweating. It can be generalized or focal. Generalized hyperhidrosis involves the entire body and is usually part of an underlying condition, most often an infectious, endocrine or neurologic disorder. Focal hyperhidrosis is idiopathic, occurring in otherwise healthy people. The condition carries a substantial psychological and social burden, since it interferes with daily activities. We treated two male patients who had hyperhidrosis on the head. In the point of Differentiation of Syndrom(辨證), these subjects were diagnosed as Bi-Wi-Gi-Her (Pi-Wei-Qi-Xu 脾胃氣虛) and was administered revised Bojungikgi-tang (reserved Buzhongyiqi-tang, 補中益氣湯加味方). All of two cases had anorexia, dyspepsia, fatigue. After treatment hyperhidosis and other symptoms improved.

• 동의생리병리학회지
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• 제20권5호
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• pp.1135-1148
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• 2006

The effect of heat on the cancer have been keen since ancient orint medic. Quantitative biologic techniques were applied to the investigation of heat, and the resulting studies have defined a firm rationale for the expectation that hypertherima will be useful in the treatment of cancer. This promise led to activity in developing physical means to produce and measure hyperthermia in patients. Hyperthermic treatments for cancer are grouped into two categories according two the amount of tissue bing heated during the treatments. The categories commonly used are localized, regional, and whole body hyperthermia. Hyperthermia is a situation referring to yang-heat. In orient medic, It refers to vital-qi and the driving force of life activities. Our paper reviewed the present state of the the hyperthemia, outline some major impediments to progress at this time, and suggest researching approches in order to define the role of hyperthermia in the treatment of cancer.

• 동의생리병리학회지
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• 제17권1호
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• pp.64-70
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• 2003

Jaeumgenby-tang(JGT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo caused by deficiency of qi(氣) and blood(血). Effect of Aurantii Fructus(AF) take off the phlegm by promoting the circulation of qi, Gastrodae Rhizoma(GR) has effects treating for headache, vertigo by calming the liver and suppressing hyperactivity of the liver-yang(陽). And, I designed to investigate whether injection of JGT adding AFㆍGR extract(JGTAG) affects cytotoxicity in vitro, cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD), mean arterial blood pressure(MABP)] in normal and cerebral ischemia rats by MCA occlusion method. The changes of rCBF and MABP were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video microscope and width analyzer. The results were as follows in normal rats; JGTAG was not cytotoxicity in brain cells. And JGTAG was significantly increased rCBF, PAD and MABP. This results suggest that JGTAG increased significantly rCBF by dilating PAD. And the results were as follows in cerebral ischemic rats; The changes of rCBF and PAD were increased stably by treatment with JGTAG(10mg/kg, i.v.) during the period of cerebral reperfusion, and pretreatment with propranolol and indomethacin were increased JGT AG induced increase of rCBF and PAD during the period of cerebral reperfusion. We suggest that JGTAG has an anti-ischemic effect through the improvement of cerebral hemodynamics.

• 동서간호학연구지
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• 제1권1호
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• pp.40-49
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• 1997

This study was done for understanding the desirable direction of eastern and western nursing by comparing the nursing practice for the Pyrexia patient occuring most commonly. Body temperature usually maintains around $37^{\circ}C$ owing to the thermoregulatory center but pyrexia is caused by exogenous pyrogen like infection, cancer or disturbances in body's homeostatic heat balance. Pyrexia is defined that body temperature rise above $37.2^{\circ}C$. It has chill phase, course of the fever, termination accompanied various symptoms. Oriental medicine explains that pyrexia comes from Yang's(陽) abundance and Yin's(陰) lack. Pyrexia mainly happens when body constitution is in bad condition by Six Dirty's(六陰) affection to Wi Area (偉分). It also occurs because of unbalance between Qi (氣) and Yin(陰) caused by the lack in Seven Emotions, labor, food. The Sanghanron(傷寒論), explains that pyrexia is categorized exogenous fever like Poong Han(風寒), Poong Yul(風熱), Sup Yul(濕熱) and endogenous fever due to the Qi and blood deficiency. Explained above, even though pyrexia has different meaning in oriental medicine and western medicine, but this study have compared the oriental and western medicine assuming that pyrexia is rise of body temperature. From this point of view, oriental and western nursing shows the similarity in the field of 1) use of antipyretic to control the body temperature 2) rest and comfort 3) watering 4) nutrition and case study was executed in nursing practice. From the above study, western nursing has superiority in decreasing the patient's risen body temperature using antipyretic and ice bag. But in case of empty heat, oriental nursing which recommends the patient's body keep warm and prevent the use of ice bag as the first step and helps patient's sweating by drinking of hot water was comparatively effective. In conclusion, it is desirable that oriental nursing emphasizing the supportive nursing and western nursing should be harmonized according to the status of pyrexia patient and it is needed to study the nursing method appropriate in our culture.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8225-8228
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• 2014

Glioma is one of the most common tumors in China and chemotherapy is critical for its treatment. Recent studies showed that benzyl isothiocyanate (BITC) could inhibit the growth of glioma cells, but the mechanisms are not fully understood. This study explored the inhibitory effect of BITC on invasion and angiogenesis of U87MG human glioma cells in vitro and in vivo, as well as potential mechanisms. It was found that BITC could inhibit invasion and angiogenesis of human glioma U87MG cells by inducing cell cycle arrest at phase G2/M. It also was demonstrated that BITC decreased expression of cyclin B1, p21, MMP-2/9, VE-cadherin, CD44, CXCR4 and MTH1, the activity of the telomerase and $PKC{\zeta}$ pathway. Microarray analysis was thus useful to explore the potential target genes related to tumorigenic processes. BITC may play important roles in the inhibition of invasion and angiogenesis of human glioma cells.

• 지역사회간호학회지
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• 제10권2호
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• pp.412-421
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• 1999

The purpose of current study was to investigate the effects of Ki-therapy which improves mood state and relieves pain on the elderly with chronic illness. The subjects were 42 elderly and convenience sampling(incidental sampling) was used to prevent contamination to the control group. Frequency, %, $X^2$, t-test, and repeated measure ANOVA by SPSS PC + program were used to analyze the data. The mean age of subjects was 72.95(Control group), 73.10(experimental group). Number of complains was 2.45(control group), 2.65 (experimental group). All of demographic characteristics of subjects. that is, age, weight. number of complains. educational background. family type. economic state, perceived health state were homogeneous. There are many difficulties in ADL & IADL. 14.2% in shopping, mode of transportation, ability to handle finances. 11.9% in ability to use telephone. continence, 7.1% in bathing, food preparation, transfer, and housekeeping. As the result of this study. slight improvement of mood state and pain relief were found. Although 3 improved items of 'clear-headed', 'lively', and 'nervous' were statistically significant. the pain relief was not statistically significant. It requires repeated treatment and measurement. And suggested case study or qualitative study in further studies because manufacturing of environment(i. e. rain) is very difficult in community people.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2307-2312
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• 2015

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.