• Title/Summary/Keyword: Y-Junction

Search Result 2,967, Processing Time 0.034 seconds

Role of Gap Junction in the Regulation of Renin Release and Intracellular Calcium in As 4.1 Cell Line

  • Han, Jeong-Hee;Hong, Bing-Zhe;Kwak, Young-Geun;Yuan, Kui-Chang;Park, Woo-Hyun;Kim, Sung-Zoo;Kim, Suhn-Hee
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.11 no.3
    • /
    • pp.107-112
    • /
    • 2007
  • Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of gap junction in renin secretion and its underlying mechanisms using As 4.1 cell line, a renin-expressing clonal cell line. Renin release was increased proportionately to incubation time. The specific gap junction inhibitor, 18-beta glycyrrhetinic acid (GA) increased renin release in dose-dependent and time-dependent manners. Heptanol and octanol, gap junction blockers, also increased renin release, which were less potent than GA. GA-stimulated renin release was attenuated by pretreatment of the cells with amiloride, nifedipine, ryanodine, and thapsigargin. GA dose-dependently increased intracellular $Ca^{2+}$ concentration, which was attenuated by nifedipine, nimodipine, ryanodine, and thapsigargin. However, RP-cAMP, chelerythrine, tyrphostin A23, or phenylarsine oxide did not induced any significant change in GA-stimulated increase of intracellular $Ca^{2+}$ concentration. These results suggest that gap junction plays an important role on the regulation of renin release and intracellular $Ca^{2+}$ concentration in As 4.1 cells.

Analysis for Difference of Water Surface Elevation at Cross Section in Pyungchang River Contained Junction Using Hydraulic Model (수리모형을 이용한 평창강 합류구간의 횡단면 수위차 분석)

  • Kim, Gee-Hyoung;Choi, Gye-Woon
    • Journal of the Korean Society of Hazard Mitigation
    • /
    • v.6 no.4 s.23
    • /
    • pp.57-65
    • /
    • 2006
  • In this study, hydraulic model same as natural channel with junction area and curved reach is constructed, and after that the variation of difference of the water surface elevation at cross section in junction area is analyzed using constructed hydraulic model. In junction area, the variation of maximum water level based on downstream section is more affected in discharge ratio at upstream than downstream. The maximum water level increased as closed to junction and the peak level appeared at just downstream of junction. The slope of water elevation at cross section is affected in section shape and decreased as discharge ratio is reduce. The expressed formulas developed in the channel consist of constant curvature and section shape showed difference of 60% with measured value, but the suggested formula in this study to compute difference of water surface elevation showed difference of 10% with measured value.

Micro-PIV Measurement of Water/Oil Two Phase Flow in a Y-Junction Microchannel (Y형 마이크로채널에서의 물/기름 2상 유동에 대한 Micro-PIV 측정)

  • Yoon,Sang-Youl;Ko, Choon-Sik;Kim, Kyung-Chun
    • Transactions of the Korean Society of Mechanical Engineers B
    • /
    • v.28 no.6
    • /
    • pp.682-687
    • /
    • 2004
  • Y-junction microchannels are widely used as a flew mixer. Fluids are entered from two branch channels and merged together at a combined channel. In this study, we suggest a simple method to create the fluid digitization using flow instability phenomena. Two immiscible liquids (water/oil) are infused continuously to each Y-junction inlets. Because of the differences in fluid and flow properties at the interface, oil droplet is formed automatically followed by flow instability. In order to clarify the hydrodynamic aspects involved in oil droplet formation, a quantitative flow visualization study has performed. Highly resolved velocity vector fields are obtained by a micro-PIV technique, so that detail flow structures around the droplet are illustrated. In this study, fluorescent particles were mixed with water only for visualization of oil droplet and velocity field measurement in water flow.

Realization of Primary Thermometer from Electrical Shot Noise in a Metal-Insulator-Metal Tunnel Junction (Metal-Insulator-Metal 터널접합의 산탄잡음을 이용한 일차 온도계 구현)

  • Park, J.H.;Rehman, M.;Choi, J.S.;Khim, Z.G.;Ryu, S.W.;Song, W.;Chong, Y.
    • Progress in Superconductivity
    • /
    • v.11 no.2
    • /
    • pp.96-99
    • /
    • 2010
  • We measured electrical shot noise in a metal-insulator-metal tunnel junction, which was made by using electron-beam lithography and double-angle evaporation technique. Since the dependence of the shot noise on bias voltage and temperature is theoretically well known, we can determine the temperature of the junction by measuring the noise as the voltage across the junction is changed. A cryogenic low noise amplifier was used to amplify the noise signal in the frequency range of 600-800 MHz, which enabled fast measurement of noise signal and thus temperature. With further study, this method could be useful for primary thermometry in cryogenic temperatures.

Simultaneous Measurement of Internal and External Flow Fields around the Droplet Formation in a Microchannel (마이크로 채널 내 Droplet 형성에 따른 내${\cdot}$외부 유동장 동시측정)

  • Kim Kyung Chun;Kim Jae Min;Yoon Sang Youl
    • 한국가시화정보학회:학술대회논문집
    • /
    • 2004.11a
    • /
    • pp.80-83
    • /
    • 2004
  • This experiment has been carried out to measure the process of droplet formation between water phase fluid$(PVA\;3\%)$ and organic phase fluid(oil), Internal and External flow fields measured by a Dynamic Micro-PIV method Water-in-oil(W/O) droplets successfully generated at a cross junction and Y junction. Internal and external flow fields were measured when the droplet grew up, stretched and separated.

  • PDF

NOTE ON THE GROUND STATES OF TWO-COMPONENT BOSE-EINSTEIN CONDENSATES WITH AN INTERNAL ATOMIC JOSEPHSON JUNCTION

  • Lu, Zhongxue;Liu, Zuhan
    • Bulletin of the Korean Mathematical Society
    • /
    • v.50 no.5
    • /
    • pp.1441-1450
    • /
    • 2013
  • In this paper, we consider two-component Bose-Einstein condensates with an internal atomic Josephson junction in the general case, i.e., 0 < p < $\frac{2}{(d-2)^+}$. We prove existence and uniqueness results for the ground states, and obtain some properties of the ground states with large parameters.

A study hot-carrier degradation on submicron devices (Submicron device에서의 hot-carrier 열화에 관한 연구)

  • 이용희;김현호;최영규;이천희
    • Proceedings of the IEEK Conference
    • /
    • 1998.06a
    • /
    • pp.867-870
    • /
    • 1998
  • In this paper we simulated 0.30um NMOS transitor to analysis hot carrier degradation depend on As, As+P, P LDD structure. As a result we obtained As+P LDD structure was good hot carrier immunity. Also we find that hog carrier life time improved a sincresing P dose due to P dose helps in grading the nLDD junction. However As-only junction was poor due to junction high peak position located near the surface.

  • PDF

Conductance Difference of Single Molecular Junctions between Experiments and Computational Simulations

  • Choi, Ji Il;Kim, Hu Sung;Kim, Young-Hoon
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • 2014.02a
    • /
    • pp.184.2-184.2
    • /
    • 2014
  • Recent advances in the synthesis and characterization of nanoscale objects provided us with the atomistic understanding of charge transport through single molecular junctions. The representative examples are the mechanically controlled break junction technique and STM or conducting AFM junction techniques. Theoretical studies have been reported on the dependence of electronic charge transport on the geometry of molecule-electrode contacts, the critical element toward the realization of molecular electronics. In this report, we will clarify the puzzling discrepancies between theoretical predictions and experiments.

  • PDF

Pd Shunt Resistor for Josephson Junction : Fabrication and Dynamic Simulation (Pd Shunt저항의 제작 및 동력학특성 조사)

  • 김규태;남두우;이규원;유광민
    • Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
    • /
    • 2003.02a
    • /
    • pp.143-145
    • /
    • 2003
  • External shunt resistor is used in Nb/AlOx/Nb Josephson junction which is basic component of RSFQ circuit. This is to increase damping and to make the so called 'self-reset' optimized for high speed operation. In this study, we fabricated and investigated sheet resistance of Pd and PdAu thin film, and simulated the inductance effect of the shunt resistor to the Josepshon junction dynamics.

  • PDF