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X-linked Agammaglobulinemia Assiociated with Bronchiectasis : A Case Report (기관지 확장증을 동반한 X연관 무감마글로불린혈증 1예)

  • Yu, Chang-Min;Koh, Won-Jung;Kim, Kyung Chan;Lee, Byoung-Hoon;Hwang, Jung Hye;Kang, Eun Hae;Suh, Gee Young;Chung, Man Pyo;Kim, Hojoong;Kwon, O Jung;Ki, Chang-Seok;Kim, Jong-Won
    • Tuberculosis and Respiratory Diseases
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    • v.54 no.6
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    • pp.628-634
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    • 2003
  • Bronchiectasis is defined as an abnormal, irreversible dilatation of the bronchi, which may result from a number of possible causes, and the recognition of these causes may lead to a specific management strategy. Immunodeficiency is known as one of the conditions associated with bronchiectasis. X-linked agammaglobulinemia is a rare inheritable immunodeficiency disorder, caused by a differentiation block, leading almost to the complete absence of B lymphocytes and plasma cells. The affected protein is a cytoplasmic protein tyrosine kinase, Bruton's tyrosine kinase. The early detection and treatment with immunoglobulin replacement are most important for the management of recurrent infections and for reducing severe complications. We report a 20-year-old male patient, with X-linked agammaglobulinemia associated with bilateral bronchiectasis, carrying a missense mutation(R520P) in the BTK gene.

Development for Penetrative Performance Improving Agent to In Prevent Deterioration of Concrete Structures (콘크리트 구조물의 내구성능 저하를 방지하는 침투형 성능개선제 개발)

  • Ryu Gum-Sung;Koh Kyoung-Taek;Kim Sung-Wook;Kim Do-Gyeum
    • Journal of the Korea Concrete Institute
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    • v.17 no.4 s.88
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    • pp.489-498
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    • 2005
  • Recently, the deterioration of concrete structures have been increased by the damage from salt, carbonization, freezing & thawing and the others. Therefore, the measures for the deterioration of concretes have been taken. Among them, it has been often used that surface treatment which cut off the deterioration factors of durability by protecting the surface of concrete. The water proof and repair materials for concrete mainly use organic materials such as epoxy, these materials excel in intial bonding force and resistance to chemical agents. But they cause difference in the modulus of elasticity and the rate of shrinkage and expansion of concrete, and thus result in such problems as scaling and spatting in the progress of time. Therefore in this study it develop the performance Improving agent of concrete surface that can block a deterioration cause such as $CO_2$ gas, chloride ion and water from the outside and enhance waterproofing ability by reinforcing the concrete surface when applying it to concrete structures.

Crack Source location Technique for nam Concrete Beam using Acoustic Emission (음향방출을 이용한 무근콘크리트 보의 균열 발생원 탐사기법)

  • 한상훈;이웅종;조홍동;김동규
    • Journal of the Korea Concrete Institute
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    • v.13 no.2
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    • pp.107-113
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    • 2001
  • This study was conducted preliminarily to develop the crack source location technique for plain concrete beam using acoustic emission(AE). Before the main experiment, the test of virtual An source location was achieved in plain concrete block. The sensor layout was mutually compared between triangular layout and rectangular layout. As the results of test, AE source location by triangular layout was evaluated more effective than that by rectangular layout. The specimen to apply he source location technique was man in total nine specimens (each three in 40 %, 50%, 60% of W/C ratio) which the experiment variable was the compressive strength level(W/C ratio). The bending loading method is selected by cyclic loadings to evaluate the degree of concrete damage. It is seen that Kaiser effect and Felicity effect exists through analysis of AE parameters in coming failure experiment. As a result of analyzing the felicity ratio(FR) values, it is shown that this values can be used for evaluating the degree of concerto damage. AE activity is started highly at the 70% of failure load without the compressive strength level. Thus considered by a index in constructing the system of the failure warning at application of the field structure. And the results compared the real cracking location with the source location has perceived by AE monitoring before it is appeared the primary crack by visual observation.

A Study on the Wearing Condition and Satisfaction of Pesticide Protective Clothing (농약방제복 착용실태 및 만족도에 관한 연구)

  • Oh, Young-Soon;Lee, Kyung-Suk;Chae, Hye-Seon;Kim, Kyung-Ran;Kim, Sung-Woo
    • Journal of the Korea Fashion and Costume Design Association
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    • v.16 no.4
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    • pp.217-228
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    • 2014
  • The purpose of this study is to grasp inconveniences and improvements by examining wearing condition and satisfaction of protective clothing targeting 114 Korean farmers and to suggest basic data for enhancement of pattern and wearing satisfaction of protective clothing by understanding problems of pesticide-proof clothing through comparative analysis on the size of its commercial products. Most of male subjects were in charge of spraying pesticide, whereas female were most likely to play an assistant role to hold the hose of pesticide applicator. Both of female and male subjects were very aware of the harmful effect of pesticide on human body and tried to take off the clothes immediately after spraying it to reduce possible damage caused by pesticide. As a result of examining wearing condition, the farmers avoided wearing protective clothing because that it feels hot, stuffy, and uncomfortable to move. This hesitant response of wearing the clothing was not shown significantly in case of female subjects who play an assistant role for spraying. Although the farmers wore protective equipments such as mask or gloves in a proper way as compared to protective clothing, they seemed to choose alternative way rather than best way to block pesticide completely. The satisfaction regarding to the fitting of protective clothing which the subjects showed low in all items of upper-lower clothes except waistline. It is necessary to improve the functionality such as relief from heat stress and convenience for movement rather than design or economic in protective clothing development. As a result of comparing the size of five kinds of commercial protective clothing, the farmers got confused to choose the product since designation method of size across companies showed a significant difference in an identical clothing size. In addition, the sizing system developed on a basis of a well-built man has become a hindering factor in wearing satisfaction of female farmers.

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Suggestion of Ocher Color Standards for Cement-Composites used on the Sidewalk (보도에 사용되는 시멘트복합체에 대한 황토색 표준의 제시)

  • Chung, Chul-Woo;Lee, Jae-Yong
    • Journal of the Korea Institute of Building Construction
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    • v.18 no.1
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    • pp.1-7
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    • 2018
  • This work aims to suggest the most proper Hwangtoh color(ocher) for sidewalks and walkways located at the central part of the city. The actual colors of Hwangtoh samples that were obtained from 3 different locations (mountain walkways) in Busan were measured. In addition, personal preferences of such Hwangtoh colors were evaluated through survey in order to provide a proper standard reference color for urban walkways and sidewalks. With respect to the chromaticity of Hwangtoh obtained in Busan, $a^*$ and $b^*$ values were found to range from 3.6 to 13.6 and 11.4 to 23.4, respectively. It was also found that $L^*$ (lightness) values of 3 different Hwangtoh samples were found to be similar. According to the results from survey, higher values of $+a^*$ (red type) and $+b^*$ (yellow type) were preferred, indicating the red and yellow color needs to be developed stronger from Hwangtoh. Based on these findings, the proper Hwangtoh color used for walkways in urban area was chosen. It was found to be $L^*$ for 32.2~45.8, $a^*$ for 5.2~13.6, and $b^*$ for 15.8~21.2, respectively.

PAPR Reduction Method of OFDM System Using Fuzzy Theory (Fuzzy 이론을 이용한 OFDM 시스템에서 PAPR 감소 기법)

  • Lee, Dong-Ho;Choi, Jung-Hun;Kim, Nam;Lee, Bong-Woon
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.21 no.7
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    • pp.715-725
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    • 2010
  • Orthgonal Frequency Division Multiplexing(OFDM) system is effective for the high data rate transmission in the frequency selective fading channel. In this paper we propose PAPR(Peak to Average Power Ratio) reduction method of problem in OFDM system used Fuzzy theory that often control machine. This thesis proposes PAPR reducing method of OFDM system using Fuzzy theory. The advantages for using Fuzzy theory to reduce PAPR are that it is easy to manage the data and embody the hardware, and required smaller amount of operation. Firstly, we proposed simple algorithm that is reconstructed at receiver with transmitted overall PAPR which is reduced PAPR of sub-block using Fuzzy. Although there are some drawbacks that the operation of the system is increased comparing conventional OFDM system and it is needed to send the information about Fuzzy indivisually, it is assured that the performance of the system is enhanced for PAPR reducing. To evaluate the perfomance, the proposed search algorithm is compared with the proposed algorithm in terms of the complementary cumulative distribution function(CCDF) of the PAPR and the computational complexity. As a result of using the QPSK and 16QAM modulation, Fuzzy theory method is more an effective method of reducing 2.3 dB and 3.1 dB PAPR than exiting OFDM system when FFT size(N)=512, and oversampling=4 in the base PR of $10^{-5}$.

Experimental Study on Engineering Characteristic of the Waste Landfill Soil Admixed Linear (폐기물매립지 토사계 혼합 차수재의 공학적 특성에 대한 실험적 연구)

  • Chang, Yongchai;Kim, Jinchun;Jeong, Ogki
    • Journal of the Korean GEO-environmental Society
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    • v.8 no.1
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    • pp.13-20
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    • 2007
  • Leachates resulting from the waste landfill of waste can possibly cause the second pollution, such as the underground water and environmental pollution. Accordingly, Liner layer has been installed in the reclaimed land of waste to block and purify permeation water to and prevent this second pollution. The material used as Liner layer should have water resistance and be less than permeability coefficient of $1{\times}10^{-7}$ cm/sec. As it is very difficult to get this kind of natural clay with low permeability around the field, the suitable way to get the low permeable material is to use blend with good watertighness by mixing it with natural soil which is spread in the site. While this mixed soil, which can resist water, is commonly used in the site, namely, bentonite and MCG cementious mateiral mixed soil, which is widely used as Liner layer in the reclaimed land of waste, is recognized in Liner and durability. The study was performed to find the effect of additive of the bottom liner in the waste landfill. The aim of this paper is to explain of the field application examples as well as the data of experimental research with the engineering properties of Liner layer of the reclaimed land.

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Behavior Analysis of Assembling Soil Nailed Walls through Large Scaled Load Test (대형파괴재하시험을 통한 조립식 쏘일네일 벽체의 거동분석)

  • Kang, Inkyu;Kwon, Youngho;Park, Shinyoung;Ki, Minju;Kim, Hongtaek
    • Journal of the Korean GEO-environmental Society
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    • v.9 no.4
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    • pp.23-36
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    • 2008
  • Soil nailing system can be mentioned to a method of supporting as the shear strength of in-situ soils is increased by passive inclusions. In the general soil nailing system, facing walls are used in two kind of a lattice concrete block or a cast in placed concrete wall. A case of lattice concrete blocks is used in slow slopes greater than 1(V):0.7(H). Also, a case of a cast in placed concrete wall is used in steep slopes less than 1(V):0.5(H). The cast in placed concrete walls are constructed to 30 cm thick together with a shotcrete facing. In this study, the assembling soil nailing method as a new soil nailing system will be proposed. This method is assembly construction using precast concrete panels with 20 cm thick. So, the ability of construction and the quality of facings can be improved more than a conventional soil nailing system. This method can be obtained the effects that a global slope stability increase, as precast concrete panels are immediately put on cutting face after excavating a slope. In this study, confining effects of concrete panels using the assembling soil nailing system were found out by large scaled load tests. In the tests, the load-settlement relationship to an assembling soil nailing system due to the stiff facings as concrete panels appeared to be better than a typical soil nailing system with shotcrete facings.

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Cytoprotective Effects of Polyamines Against Oxidative Stress (산화 스트레스에 대한 폴리아민의 세포보호 효과)

  • Ahn Seoni;Lee Ji Young;Chung Hae Young;Yoo Mi-Ae;Kim Jong-Min;Kim Byeong Gee
    • Journal of Life Science
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    • v.15 no.4 s.71
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    • pp.626-632
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    • 2005
  • The polyamines are essential components of all eukaryotic cells and absolutely necessary for cell growth. In the present study, the cytoprotective role of polyamine was characterized. When $Ac_2F$ rat liver cells were treated with 1M 2,2'-azobis (2-amidinopropane) dehydrochloride (AAPH), a water soluble free radical initiator, viability of the cells was noticeably decreased due to the increase of reactive oxygen species (ROS). The cytotoxic effect of AAPH as well as ROS generation were significantly inhibited by the treatment of polyamines. Among polyamines, especially spermine at $20{\mu}M$ concentration exerted over $45\%$ inhibition of AAPH-induced ROS generation. Western blotting was performed to determine whether superoxide dismutase(SOD) or catalase (CAT) expression was involved in oxidative stress. The AAPH treatment blocked both SOD and CAT protein expressions. Spermine could recover those protein expressions to the untreated control levels. According to the result of cycline E measurement, AAPH might block the entry of the cells into S phase of the cell cycle. The reduced expression of cyclin E protein could be fully recovered by the addition of spermine. The antioxidative effects of spermine was also further proved by the apopotitic morphological analysis using ethidium bromide and acridine orange.

Ridge and field tile aerodynamics for a low-rise building: a full-scale study

  • Tecle, Amanuel;Bitsuamlak, Girma T.;Suskawang, Nakin;Chowdury, Arindam Gan;Fuez, Serge
    • Wind and Structures
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    • v.16 no.4
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    • pp.301-322
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    • 2013
  • Recent major post-hurricane damage assessments in the United States have reported that the most common damages result from the loss of building roof coverings and subsequent wind driven rain intrusion. In an effort to look further into this problem, this paper presents a full-scale (Wall of Wind --WoW--) investigation of external and underneath wind pressures on roof tiles installed on a low-rise building model with various gable roofs. The optimal dimensions for the low-rise building that was tested with the WOW are 2.74 m (9 ft) long, 2.13 m (7 ft) wide, and 2.13 m (7 ft) high. The building is tested with interchangeable gable roofs at three different slopes (2:12; 5:12 and 7:12). The field tiles of these gable roofs are considered with three different tile profiles namely high (HP), medium (MP), and low profiles (LP) in accordance with Florida practice. For the ridge, two different types namely rounded and three-sided tiles were considered. The effect of weather block on the "underneath" pressure that develops between the tiles and the roof deck was also examined. These tests revealed the following: high pressure coefficients for the ridge tile compared to the field tiles, including those located at the corners; considerably higher pressure on the gable end ridge tiles compared to ridge tiles at the middle of the ridge line; and marginally higher pressure on barrel type tiles compared to the three-sided ridge tiles. The weather blocking of clay tiles, while useful in preventing water intrusion, it doesn't have significant effect on the wind loads of the field tiles. The case with weather blocking produces positive mean underneath pressure on the field tiles on the windward side thus reducing the net pressures on the windward surface of the roof. On the leeward side, reductions in net pressure to a non-significant level were observed due to the opposite direction of the internal and external pressures. The effect of the weather blocking on the external pressure on the ridge tile was negligible.