• Progress in Medical Physics
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• v.22 no.3
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• pp.117-123
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• 2011

Synchrotron radiation (SR) imaging enables us to observe internal structures of biologic samples without staining. In this study, we obtained X-ray microscopic images of human breast tissues with 11.1 KeV hard X-ray microscope of the Pohang light source and used zone plates and phase-contrast technique to get high resolution X-ray images. Hard X-ray microscopic images of fibrocystic change and breast cancer tissues with a spatial resolution of 60 nm were obtained and from these images, we could observe the micro-structures of human breast tissue. Also we analyzed and compared these images, which revealed distinct features of each condition. In conclusion, SR imaging with phase-contrast hard X-ray microscope for medical application, especially in breast disease can give some useful information for clinical research.

• Journal of Biomedical Engineering Research
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• v.22 no.2
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• pp.165-169
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• 2001

최근 포항 방사광 가속기 연구소에 미세구조 X-선 영상 실험을 위한 5C1 방사광(Synchrtoron Radiation) 빔라인이 건설되었다. 광대역의 에너지 스펙트럼을 가진 방사광 X-선이 물체를 투과한 후 CdWO$_{4}$ scintillator에 의해 가시광선으로 바뀌고, 그 빛을 CCD 카메라로 받아들여 영상을 획득하게 된다. 방사광 X-선은 일반 의료진단용 X-선에 비하여 위상이 일치하고, 평행하며, 그 양이 풍부한 특성들을 갖고 있다. 방사광 영상시스템과 X-선 유방촬영 시스템에서 영상을 획득하여 영상특성들을 비교, 분석하였다. 고-분해능 X-선 시험 패턴(20 line pairs mm$^{-1}$), 유방촬영 팬텀, 파라핀에 고정한 인체 유방암조직과 포르말린에 고정한 인체 유방암조직, 그리고 capillary tube내 micro-bubbles등의 방사광 영상은 기존의 X-선 유방촬영시스템에서 얻은 영상보다 분해능이 뛰어나고 영상질도 우수하였다. 방사광 X-선 영상시스템은 micrometer 공간 분해능 영상을 획득할 수 있어 많은 기초분야의 영상연구와 의료영상분야에서도 활발하게 활용될 것으로 기대된다.

• Journal of Biomedical Engineering Research
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• v.19 no.1
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• pp.1-8
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• 1998

Clustered microcalcifications on X-ray mammograms are an important sign for early detection of breast cancer. This paper proposes a computer-aided diagnosis method for the detection of clustered microcalcifications and marking their locations on digitized mammograms. The proposed detection method consists of the region of interest (ROI) selection, the film-artifact removal, the surrounding texture analysis method for the detection of clustered microcalcifications, which is based on the second-order histogram in two nested surrounding regions on the current pixel. This paper also describes the effectiveness of the proposed film-artifact removal filter in terms of the classification performance with the receiver operating-characteristics(ROC) analysis. A three-layer backpropagation neural network is employed as a classifier. The appropriate marking for the locations of clustered microcalcifications can be used to alert radiologists to locations of suspicious lesions.

• Progress in Medical Physics
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• v.12 no.1
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• pp.51-58
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• 2001

Synchrotron radiation (SR) has several advantages over convetional x-rays, including its phase, collimation, and high flux. A synchrotron radiation beamline 5C1 at Pohang Light Source (PLS) was recently built for imaging applications. We have shown that a SR imaging system is useful in imaging microscopic structures. SR with broad-band energy spectrum were adjusted to an object by Si wafers and their energy were approximately ranging from 6 keV to 30 keV. SR were passed through an object and finally transformed into visible lights by CdWO$_4$ scintillator screen. The visible lights which were reflected at an angle of 90 degrees by gold plated mirror were detected by a CCD camera and the image data were acquired using image acquisition system. A high-resolution phantom, capacitor, adult tooth, child tooth, cancerous breast tissue, and mouse lumbar vertebra were imaged with SR imaging system. The Objects were rotated within the field of view of the CCD detector, and their projection image data were obtained at 250 steps over 180 degrees rotation. Image reconstructions were carried out in a PC by using IDLTM(Research systems, Inc., US) program. The spatial resolution of the images acquired by the SR imaging system was measured with a high-resolution chart manufactured for several micrometer resolution. The specimens were also imaged with conventional x-ray radiography system to compare the image quality of radiography obtained with the SR imaging system. The results showed more structural details and high contrast images with SR imaging system than conventional x-ray radiography system. The SR imaging system may have a potential for imaging in biological researches, material applications, and clinical radiography.

• The Journal of the Korea Contents Association
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• v.16 no.12
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• pp.70-77
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• 2016

In this study, we aim to obtain the fundamental data needed for the objective analysis and bio-mimetics of leeches, using x-ray imaging with radiation that allows 3D analysis of the detailed anatomic structures of leeches. It was confirmed that through using radiation, detailed images of leeches can be obtained, allowing 3D analysis of leeches' anatomical structures. Also, since the data obtained through the radiation allows you to observe the micro-structure, it can serve as a good resource for component analysis, as well as physiological and functional research. More, it is hoped to contribute to further research in the areas of bio-mimetics using leeches.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.1744-1748
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• 2004

It is important to measure precisely the size and velocity of micro-bubbles used in various field. The synchrotron X-ray micro-imaging technique was employed to measure the size and velocity of micro-bubbles moving in an opaque tube simultaneously. Phase contrast images were obtained at interfaces of micro-bubbles between water and air due to their different refractive indices. The X-ray micro-imaging technique was found to measure an optical fiber with an accuracy of 0.2%. Micro-bubbles of $10{\sim}60{\mu}m$ diameter moving upward in an opaque tube (${\phi}=2.7mm$) were tested to measure bubble size and up-rising velocity. For DI water, the measured velocity of micro-bubbles is nearly proportional to the square of bubble size, agreed well with the theoretical result. In addition, the synchrotron X-ray micro-imaging technique can measure accurately the size and velocity of several overlapped micro-bubbles.

• Journal of the Korean Society of Radiology
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• v.2 no.2
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• pp.23-30
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• 2008

X-ray microscopy with synchrotron radiation(SR) might be a useful tool for novel x-ray imaging in the clinical and laboratory settings. Microscopically, it enables us to observe detailed structure of animal organs samples with a great magnification power and an excellent resolution. The phase contrast mechanisms in image by X-ray are described. The phase-contrast X-ray imaging with SR from in-vivo and in-vitro mouse tail, rat nerve and rat lung were obtained with an 8 KeV monochromatic beam. The visual image was magnified using 10x microscope objective lens and captured using an digital CCD camera. The results showed more structural details and high resolution images with SR imaging system than conventional X-ray radiography system. The SR imaging system may have a potential for imaging in biological researches, material applications and clinical radiography.

• Journal of the Korean Society for Nondestructive Testing
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• v.22 no.4
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• pp.377-385
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• 2002

Ultrasonic tests employing non-ionizing radiation are preferred in nondestructive examinations since they are safe and simple in use. The same principles of the techniques have been taken as valuable tools in medical area for the diagnoses of diseases, in other words, defects of the human body. The paper overviews the principles of the medical diagnosis based on nondestructive ultrasonic tests, and then evaluates experimentally the clinical potential of C scan images not popular in medicine, for detecting the micro fractures of the cortical bone. In the experiment the micro bone fractures were created on the femurs of porks by loading three point bending forces (2-4kN) with the speed of 1 mm/min. As the extent of the fracture was altered, not only X ray images but also ultrasonic C scan images using a focused ultrasonic probe resonated at 25 MHz were obtained. The results showed that ultrasonic C scan images were capable of detecting the micro bone fractures which were not possible to identify by conventional X ray images.

• Progress in Medical Physics
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• v.26 no.4
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• pp.215-222
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• 2015

In this work, we performed a proof-of-concept experiment for phase-contrast x-ray imaging (PCXI) based on a single antiscatter grid and a polychromatic x-ray source. We established a table-top setup which consists of a focused-linear grid having a strip density of 200 lines/inch, a microfocus x-ray tube having a focal-spot size of about $5{\mu}m$, and a CMOS-type flat-panel detector having a pixel size of $48{\mu}m$. By using our prototype PCXI system and the Fourier demodulation technique, we successfully obtained attenuation, scattering, and differential phase-contrast images of improved visibility from the raw images of several selected samples at x-ray tube conditions of $90kV_p$ and 0.1 mAs. Further, fusion image (e.g., the attenuation+the scattering) may have an advantage in displaying details of the sample's structures that are not clearly visible in the conventional attenuation image. Our experimental results indicate that single-grid-based approach seems a useful method for PCXI with great simplicity and minimal requirements on the setup alignment.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.82-83
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• 2012

본 논문에서는 세라믹을 비파괴 검사하여 얻어진 영상에서 세라믹의 결함을 검출하는 방법을 제안한다. 비파괴 검사를 통하여 얻어진 영상의 윤곽선을 추출하기 위하여 Prewitt 마스크를 적용한다. 그리고 비파괴 검사 영상의 잡음 비율을 최소화하기 위해 결함이 겹쳐진 윤곽선을 기준으로 감마 처리를 수행하고 임계치 이진화 기법을 적용하여 구간별로 결함을 검출한다. 구간별 결함을 통합하여 결함을 검출한다. 검출한 결함에 Grassfire 기법을 적용하여 미세한 잡음을 제거한다. 본 논문에서 제안된 방법의 성능을 평가하기 위해 비파괴 검사에 적용되는 영상을 대상으로 실험한 결과, 제안된 방법이 기존의 결함 검출 방법보다 결함 검출에 있어서 효과적인 것을 확인하였다.