• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.8
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• pp.4025-4042
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• 2017

Session initiation protocol (SIP) is a kind of powerful and common protocols applied for the voice over internet protocol. The security and efficiency are two urgent requirements and admired properties of SIP. Recently, Hamed et al. proposed an efficient authentication and key agreement scheme for SIP. However, we demonstrate that Hamed et al.'s scheme is vulnerable to de-synchronization attack and cannot provide anonymity for users. Furthermore, we propose an improved and efficient authentication and key agreement scheme by using elliptic curve cryptosystem. Besides, we prove that the proposed scheme is provably secure by using secure formal proof based on Burrows-Abadi-Needham logic. The comparison with the relevant schemes shows that our proposed scheme has lower computation costs and can provide stronger security.

• Journal of Electrical Engineering and Technology
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• v.13 no.1
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• pp.240-249
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• 2018

Individual DC voltage balance problem is an inherent issue for cascaded H-bridge (CHB) based converter. When the CHB-based static synchronous compensator (STATCOM) is operating at zero current mode, the software-based individual DC voltage balancing control techniques may not work because of the infinitesimal output current. However, the different power losses of each cell would lead to the individual DC voltages unbalance. The uneven power losses on the local supplied cell-controllers (including the control circuit and drive circuit) would especially cause the divergence of individual DC voltages, due to their characteristic as constant power loads. To solve this problem, this paper proposes an adaptive voltage balancing module which is designed in the cell-controller board with small size and low cost circuits. It is controlled to make the power loss of the cell a constant resistance load, thus the DC voltages are balanced in zero current mode. Field test in a 10kV STATCOM confirms the performance of the proposed method.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09b
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• pp.926-927
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• 2005

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.6
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• pp.457-468
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• 2022

It has been demonstrated that APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) is involved in the regulation of several growth-related signaling pathways and thus closely associated with the development and progression of some cancers. Diallyl trisulfide (DAT), a garlic-derived bioactive compound, exerts selective cytotoxicity to various human cancer cells through interfering with pro-survival signaling pathways. However, whether and how DAT affects survival of human hepatocellular carcinoma (HCC) cells remain unclear. Herein, we tested the hypothesis of the involvement of APPL1 in DAT-induced cytotoxicity in HCC HepG2 cells. We found that Lys 63 (K63)-linked polyubiquitination of APPL1 was significantly decreased whereas phosphorylation of APPL1 at serine residues remained unchanged in DAT-treated HepG2 cells. Compared with wild-type APPL1, overexpression of APPL1 K63R mutant dramatically increased cell apoptosis and mitigated cell survival, along with a reduction of phosphorylation of STAT3, Akt, and Erk1/2. In addition, DAT administration markedly reduced protein levels of intracellular TNF receptor-associated factor 6 (TRAF6). Genetic inhibition of TRAF6 decreased K63-linked polyubiquitination of APPL1. Moreover, the cytotoxicity impacts of DAT on HepG2 cells were greatly attenuated by overexpression of wild-type APPL1. Taken together, these results suggest that APPL1 polyubiquitination probably mediates the inhibitory effects of DAT on survival of HepG2 cells by modulating STAT3, Akt, and Erk1/2 pathways.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5581-5585
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• 2012

Objective: To explore the relationship between computed tomography (CT) manifestations of thymoma and its WHO pathological classification. Methods: One hundred and five histopathologically confirmed cases were collected for their pathological and CT characteristics and results were statistically compared between different pathological types of thymoma. Results: Tumor size, shape, necrosis or cystic change, capsule integrity, invasion to the adjacent tissue, lymphadenopathy, and the presence of pleural effusion were significantly different between different pathological types of thymomas (P<0.05). Type B2, B3 tumors and thymic carcinomas were greater in size than other types. More than 50% of type B3 tumors and thymic carcinomas had a tumor size greater than 10 cm. The shape of types A, AB, and B1 tumors were mostly round or oval, whereas 75% of type B3 tumors and 85% of thymic carcinomas were irregular in shape. Necrosis or cystic change occurred in 67% of type B3 thymomas and 57% of thymic carcinomas, respectively. The respective figures for capsule destruction were 83% and 100%. Increases in the degree of malignancy were associated with increases in the incidence of surrounding tissue invasion: 33%, 75%, and 81% in type B2, type B3, and thymic carcinomas, respectively. Pleural effusion occurred in 48% of thymic carcinomas, while calcification was observed mostly in type B thymomas. Conclusions: Different pathological types of thymic epithelial tumors have different CT manifestations. Distinctive CT features of thymomas may reflect their pathological types.

• Structural Engineering and Mechanics
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• v.66 no.5
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• pp.583-594
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• 2018

A theoretical formulation based on the linearized potential theory, the Descartes' rule and the extremum optimization method is presented to calculate the critical distance of lifting points of the fully balanced hoist vertical ship lift, and to study pitching stability of the ship lift. The overturning torque of the ship chamber is proposed based on the Housner theory. A seven-free-degree dynamic model of the ship lift based on the Lagrange equation of the second kind is then established, including the ship chamber, the wire rope, the gravity counterweights and the liquid in the ship chamber. Subsequently, an eigenvalue equation is obtained with the coefficient matrix of the dynamic equations, and a key coefficient is analyzed by innovative use of the minimum optimization method for a stability criterion. Also, an extensive influence of the structural parameters contains the gravity counterweight wire rope stiffness, synchronous shaft stiffness, lifting height and hoists radius on the critical distance of lifting points is numerically analyzed. With the Runge-Kutta method, the four primary dynamical responses of the ship lift are investigated to demonstrate the accuracy/reliability of the result from the theoretical formulation. It is revealed that the critical distance of lifting points decreases with increasing the synchronous shaft stiffness, while increases with rising the other three structural parameters. Moreover, the theoretical formulation is more applicable than the previous criterions to design the layout of the fully balanced hoist vertical ship lift for the ensuring of the stability.

• Geomechanics and Engineering
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• v.11 no.4
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• pp.571-585
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• 2016

The crest of the Pubugou central core rockfill dam (CCRD) cracked in the first and second impounding periods. To evaluate the safety of the Pubugou CCRD, an inversion analysis of the constitutive model parameters for rockfill materials is performed based on the in situ deformation monitoring data. The aim of this work is to truly reflect the deformation state of the Pubugou CCRD and determine the causes of the dam crest cracks. A novel real-coded genetic algorithm based upon the differences in gene fragments (DGFX) is proposed. It is used in combination with the radial based function neural network (RBFNN) to perform the parameters back analysis. The simulated settlements show good agreements with the monitoring data, illustrating that the back analysis is reasonable and accurate. Furthermore, the deformation gradient of the dam crest has been analysed. The dam crest has a great possibility of cracking due to the uncoordinated deformation, which agrees well with the field investigation. The deformation gradient decreases to the value lower than the critical one and reaches a stable state after the second full reservoir.

• Structural Engineering and Mechanics
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• v.76 no.2
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• pp.153-162
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• 2020

Aiming at the mechanical and structural characteristics of the contact zone composite rock, the shear tests and numerical studies were carried out. The effects of the differences in mechanical properties of different materials and the normal stress on shear properties of contact zone composite samples were analyzed from a macro-meso level. The results show that the composite samples have high shear strength, and the interface of different materials has strong adhesion. The differences in mechanical properties of materials weakens the shear strength and increase the shear brittleness of the sample, while normal stress will inhibit these effect. Under low/high normal stress, the sample show two failure modes, at the meso-damage level: elastic-shearing-frictional sliding and elastic-extrusion wear. This is mainly controlled by the contact and friction state of the material after damage. The secondary failure of undulating structure under normal-shear stress is the nature of extrusion wear, which is positively correlated to the normal stress and the degree of difference in mechanical properties of different materials. The increase of the mechanical difference of the sample will enhance the shear brittleness under lower normal stress and the shear interaction under higher normal stress.

• Geomechanics and Engineering
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• v.12 no.4
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• pp.611-626
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• 2017

The research reported herein is concerned with the model testing of piles socketed in soft rock which was simulated by cement, plaster, sand, water and concrete hardening accelerator. Model tests on a single pile socketed in simulated soft rock under axial cyclic loading were conducted and the bearing capacity and accumulated deformation characteristics under different static, and cyclic loads were studied by using a device which combined oneself-designed test apparatus with a dynamic triaxial system. The accumulated deformation of the pile head, and the axial force, were measured by LVDT and strain gauges, respectively. Test results show that the static load ratio (SLR), cyclic load ratio (CLR), and the number of cycles affect the accumulated deformation, cyclic secant modulus of pile head, and ultimate bearing capacity. The accumulated deformation increases with increasing numbers of cycles, however, its rate of growth decreases and is asymptotic to zero. The cyclic secant modulus of pile head increases and then decreases with the growth in the number of cycles, and finally remains stable after 50 cycles. The ultimate bearing capacity of the pile is increased by about 30% because of the cyclic loading thereon, and the axial force is changed due to the applied cyclic shear stress. According to the test results, the development of accumulated settlement is analysed. Finally, an empirical formula for accumulated settlement, considering the effects of the number of cycles, the static load ratio, the cyclic load ratio and the uniaxial compressive strength, is proposed which can be used for feasibility studies or preliminary design of pile foundations on soft rock subjected to cyclic loading.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6435-6439
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• 2012

Chemoresistance to cancer therapy is a major obstacle to the effective treatment of human cancers with cisplatin (DDP), but the mechanisms of cisplatin-resistance are not clear. In this study, we established a cisplatin-resistant human ovarian cancer cell line (COC1/DDP) and identified differentially expressed proteins related to cisplatin resistance. The proteomic expression profiles in COC1 before and after DDP treatment were examined using 2-dimensional electrophoresis technology. Differentially expressed proteins were identified using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and high performance liquid chromatography-electrospray tandem MS (NanoUPLC-ESI-MS/MS). 5 protein spots, for cytokeratin 9, keratin 1, deoxyuridine triphosphatase (dUTPase), aarF domain containing kinase 4 (ADCK 4) and cofilin1, were identified to be significantly changed in COC1/DDP compared with its parental cells. The expression of these five proteins was further validated by quantitative PCR and Western blotting, confirming the results of proteomic analysis. Further research on these proteins may help to identify novel resistant biomarkers or reveal the mechanism of cisplatin-resistance in human ovarian cancers.