• Toxicological Research
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• 제17권
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• pp.257-261
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• 2001

Recently, a traditional medicine called Gouteng-san, which consists of eleven herbs, was reported to be effective in treating vascular dementia with a double-blind, placebo-controlled study. Gout-eng-san is also used for patients with vascular dementia in combination with Si-Wu-Tang. The effect of Gouteng-san and Si-Wu-Tang on deficit of learning behavior was investigated using step-down passive avoidance task in mice. Hot-water extract of Gouteng-san (1.5 and 6 g/kg, p.o.) significantly prolonged the step-down latency shortened by scopolamine. The extract of Uncaria hook (150 mg/kg, p.o.), one of the component herb of Gouteng-san, significantly prevented the decrease in the latency after scopolamine. Hot-water extract of Si-Wu-Tang (1.5 and 6 g/kg of dried herbs, p.o.) prevented dose-dependently scopola-mine-induced disruption qf learning behavior. Si-Wu-Tang also prevented the ischemia-induced deficit of learning behavior. Both hot water extract of peony and angelica (1.5 g/kg, p.o.), which are component herbs qf Si-Wu-Tang, prevented the scopolamine-induced learning behavior deficit. Scopolamine (10 uM) suppressed long-term potentiation (LTP) of population spike in the CA1 region of the rat hippocampal slices. Peoniflorin (0.1~ 1uM) extracted from paeony root significantly ameliorated scopolamine-induced inhibition of LTR These results suggest that improvement of deficit of learning behavior by Gouteng-san and Si-Wu-Tang is mediated by direct and/or indirect activation of the cholinergic system in the brain.

• 대한한의진단학회지
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• 제15권2호
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• pp.215-222
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• 2011

Objectives: The purpose of this study is to report the effect of Kamisamul-tang / Jia Wei Si Wu Tang / Augmented Four - Substance Decoction on a Menopausal Disorder Patient. This is a clinical report about a 49 year old female patient with a Menopausal Disorder treated by herb medicine, Kamisamul-tang / Jia Wei Si Wu Tang / Augmented Four-Substance Decoction without any other medicine or treatment. Methods: The patient was treated by herb medicine, Kamisamul-tang / Jia Wei Si Wu Tang / Augmented Four - Substance Decoction. The improvement of the patient was judged by Visual Analog Scale. Results The symptoms were gradually reduced and VAS became 1 after 8weeks of treatments, since then the symptoms were not reappearing for 3 months. Conclusions: Herb medicine, Kamisamul-tang / Jia Wei Si Wu Tang / Augmented Four - Substance Decoction is effective to improve a Menopausal Disorder Patient's symptoms. It is necessary to have more observation and many cases of patients with a Menopausal Disorder.

• 대한한의학원전학회지
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• 제20권3호
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• pp.33-48
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• 2007

Before the advent of febrile disease theory, people had used Sanghallon's theory to cure febril disease. Therefore, Wu-Tang both suggested new prescription and used the former prescription of Sanghallon(傷寒論) in curing febrile disease. However, he didn't use the original prescription of Sanghallon and modified the quantity and ingredients properly. Through this process, the fault of Sanghallon was supplemented and the method of curing febrile disease was advanced. To research about this, it will be much easier to understand prescription of Sanghallon and even the treatments and views of Wu-Tang about febrile disease. In this study, I researched the way Wu-Tang applied prescription of Sanghallon, focusing on Decoction for Purgation, White Tiger Decoction, Decoction for Restoring Pulse which was used by Wu-Tang in various ways and applied in treatment of febrile disease.

• 한국식품과학회지
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• 제30권4호
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• pp.888-894
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• 1998

한방 보혈제의 기본처방인 사물탕과 보기제의 기본 처방인 사군자탕의 방사선 조사 마우스에서의 방사선 방호 효과를 소장움 생존(고선량 방사선, 12 Gy), 조혈세포 생존(중간선량 방사선, 6.5 Gy), apoptosis 형성(저선량 방사선, 2 Gy) 실험법을 적용하여 관찰하였다. 방사선조사 전 사물탕투여군(경구투여: 음수 mL당 2 mg씩 7일간, 복강내주사: 마리당 1 mg씩 방사선 조사 24시간 전)에서 소장움의 생존이 증가되었으며 (방사선대조군: $38.48{\pm}4.34$, 복강내 주사군: $77.98{\pm}16.11$, P<0.005), endogenous spleen colony의 형성도 높게 나타났고(방사선대조군: $3.5{\pm}4$, 경구투여군: $10.7{\pm}7.730$, 복강내주사군: $8.667{\pm}5.244$, P<0.05), 소장움에서의 apoptotic cell의 발생율은 억제되었다(방사선대조군: $5.111{\pm}0.529$, 복강내주사군 $3.919{\pm}0.214$, P<0.01). 사군자탕 병행투여군에서는 이상의 실험에서 통계적으로 유의성 있는 효과는 없었다. 이상의 결과는 사물탕이 방사선방호 식품으로 활용될 수 있는 가능성을 제시하였으며, 각 구성약재 및 성분의 효과에 대한 연구가 계속되어야 할 것이다.

• 한국의사학회지
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• 제29권2호
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• pp.17-33
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• 2016

Objectives : The goal of this paper is to verify the hypothesis that the diagrams of liver from MingTangZangFuTu (明堂臟腑圖) were derived from ZangFu diagrams (臟腑圖) before northern Song Ages. Methods : The difference of form of liver was analyzed by means of 4 factors, e.g. shape, number, veins and a petiole of leafs, in diagrams from YanLuoZiNeiJingTu [煙蘿子內境圖], OuXiFanWuZangTu [歐希範五臟圖], CunZhenTu [存眞圖], MingTangZangFuTu and ones of liver from Taoism and MingTangZangFuTu. Results : Diagrams of whole body and liver from MingTangZangFuTu were first found in ZhenJiuJuYing (鍼灸聚英). Among them, lobed shape was first found in YanLuoZiNeiJingTu (in Wudai [五代]), a petiole in OuXiFanWuZangTu (northern Song Ages) and 7 leafs in WuZangLiuFuTu (五臟六腑圖. from Tang (唐) Ages to early northern Song Ages. unknown author.), one of references of UiBangNyuChwi (醫方類聚) (1455). However, veins of leafs were drawn in no diagrams. Conclusions : In diagrams of liver from MingTangZangFuTu, shape and a petiole of leafs were based on diagrams of ZangFu before northern Song Ages, but 7 leafs came from WuZangLiuFuTu. However, veins of leafs were not derived from any diagrams in same period.

• 동의생리병리학회지
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• 제29권1호
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• pp.1-10
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• 2015

This article is a study on palpitation of which disease cause, disease mechanism and formulas were analyzed with reference to annotations on "Shanghanlun" and "Jinkuiyaolue". And the scope of modern diseases related with palpitation was drawn by research on clinical papers. The source books are "Zhujieshanghanlun" and "Jinkuiyaoluefanglun" and the clinical papers are searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI). 13 clauses in "Shanghanlun" and 9 clauses in "Jinkuiyaolue" and 12 formulas are related with palpitation. Disease mechanisms of palpitation were classified as yang deficiency, yin deficiency, qi deficiency, blood deficiency, retained fluid, cold, etc and these days, qi stagnation, phlegm turbidity, blood stasis and fire heat are also considered as disease mechanisms. Modern diseases related with palpitation are arrhythmia(extrasystole, atrial fibrillation, bradycardia, tachycardia, sick sinus syndrome, atrioventricular block), vascular diseases(arterial occlusion, phlebothrombosis, Buerger's disease, coronary artery disease, vasculitis), blood pressure disorder(hypertension, hypotension) and heart diseases such as heart failure, angina pectoris, myocardial infarction, myocarditis, cardiomyopathy, pericardial effusion. And diseases related with psychological change(cardiac neurosis, anxiety neurosis, neurosis, depression, hyperthyroidism, hypothyroidism), pyrexia, anemia, drug intoxication, etc are also related with palpitation. Zhen Wu Tang showing an efficacy in dilating blood vessels and strengthening cardiac function, Wuling Powder with diuretic effect and Fried Glycyrrhizae Decoction acting on the ${\beta}$ receptor are applied to heart failure in different ways. Fried Glycyrrhizae Decoction(308 cases), Zhen Wu Tang(154), Wuling Powder(54), Xiao Chaihu Tang(34), Sini San(20) are reported to have been clinically applied to cardiovascular diseases and Zhen Wu Tang and Wuling Powder mainly applied to heart failure, Fried Glycyrrhizae Decoction, Lizhong Wan, Sini San and Zhen Wu Tang chiefly applied to arrhythmia related diseases. This study focuses on the general research and consideration on clinical applications and is a preliminary study to understand relations between Korean Medicine's symptoms and categories of modern diseases.

• Biomolecules & Therapeutics
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• 제9권1호
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• pp.1-6
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• 2001

Sa-Mul-Tang (Si-Wu-Tang, SMT), a kind of Chinese medicine, has been used for the hemato-deficient disease for hundreds of years. In this work, investigations on the anti-anemic activity of an aqueous extract of SMT were undertaken in order to find the pharmacological basis for the ethnomedical use of the formulation. Three kinds of Angelicase species, such as Angelica sinensis, Angelica acutiloba, and Angelica gigas, were used for preparing the water extracts of SMT. Anemic model rats were induced by the treatment of phenylhydrazine (40 mg/kg/day, i.p.) for 4 days. After the treatment of phenylhydrazine, rats were divided into several groups for their different treatment of three kinds of SMT. Red blood cell (RBC), hemoglobin (Hg), and hematocrit (Hct) were determined on the day 0, 3, 6, 10, 14 after the treatment of SMTs and erythrocytes deformabilities were also determined at the end of experiments. Oral administration of SMT (1g/kg/day) for 14 days did not ameliorate drug-induced anemic states evaluated by RBC counts, Hg contents, and Hct values. However, the erythrocyte deformabilities were improved in phenylhydrazine-treated group by the administragest that SMTs (p<0.05). Especially, these effects were high in the Angelica acutiloba group. These results suggest that SMTs have an ameliorative effect on blood rheology related to the blood stasis syndrome in oriental diagnostics not on the blood deficient states related to the anemic syndrome.

• 전기의세계
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• 제31권8호
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• pp.592-594
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• 1982

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2000년도 2nd Korea-China Congress of Nuclear Medicine and 39th Annual Spring Meeting if the Korea SOciety Nuclear Medicine
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• pp.66.2-66.2
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• 2000

• Journal of Ginseng Research
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• 제39권3호
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• pp.230-237
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• 2015

Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West. Methods: A genetically engineered $Apc^{Min/+}$ mouse model was used in this study. We analyzed the saponin composition of American ginseng used in this project, and evaluated its effects on the progression of high-fat-diet-enhanced CRC carcinogenesis. Results: After oral ginseng administration (10-20 mg/kg/d for up to 32 wk), experimental data showed that, compared with the untreated mice, ginseng very significantly reduced tumor initiation and progression in both the small intestine (including the proximal end, middle end, and distal end) and the colon (all p < 0.01). This tumor number reduction was more obvious in those mice treated with a low dose of ginseng. The tumor multiplicity data were supported by body weight changes and gut tissue histology examinations. In addition, quantitative real-time polymerase chain reaction analysis showed that compared with the untreated group, ginseng very significantly reduced the gene expression of inflammatory cytokines, including interleukin-$1{\alpha}$ (IL-$1{\alpha}$), IL-$1{\beta}$, IL-6, tumor necrosis factor-${\alpha}$, granulocyte-colony stimulating factor, and granulocyte-macrophage colony-stimulating factor in both the small intestine and the colon (all p < 0.01). Conclusion: Further studies are needed to link our observed effects to the actions of the gut microbiome in converting the parent ginsenosides to bioactive ginseng metabolites. Our data suggest that American ginseng may have potential value in CRC chemoprevention.