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Ellagic acid plays a protective role against UV-B-induced oxidative stress by up-regulating antioxidant components in human dermal fibroblasts

  • Baek, Beomyeol;Lee, Su Hee;Kim, Kyunghoon;Lim, Hye-Won;Lim, Chang-Jin
    • The Korean Journal of Physiology and Pharmacology
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    • v.20 no.3
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    • pp.269-277
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    • 2016
  • Ellagic acid (EA), an antioxidant polyphenolic constituent of plant origin, has been reported to possess diverse pharmacological properties, including anti-inflammatory, anti-tumor and immunomodulatory activities. This work aimed to clarify the skin anti-photoaging properties of EA in human dermal fibroblasts. The skin anti-photoaging activity was evaluated by analyzing the reactive oxygen species (ROS), matrix metalloproteinase-2 (MMP-2), total glutathione (GSH) and superoxide dismutase (SOD) activity levels as well as cell viability in dermal fibroblasts under UV-B irradiation. When fibroblasts were exposed to EA prior to UV-B irradiation, EA suppressed UV-B-induced ROS and proMMP-2 elevation. However, EA restored total GSH and SOD activity levels diminished in fibroblasts under UV-B irradiation. EA had an up-regulating activity on the UV-B-reduced Nrf2 levels in fibroblasts. EA, at the concentrations used, was unable to interfere with cell viabilities in both non-irradiated and irradiated fibroblasts. In human dermal fibroblasts, EA plays a defensive role against UV-B-induced oxidative stress possibly through an Nrf2-dependent pathway, indicating that this compound has potential skin antiphotoaging properties.

A Study on the Information Cultural and Creating Process (정보문화 창조과정에 관한 연구)

  • Chang, Woo-Kwon
    • Journal of the Korean Society for information Management
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    • v.21 no.4 s.54
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    • pp.295-314
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    • 2004
  • Information cultural is the compound of the physical and spirit livelihood mode in the knowledge and information age. They are the livelihood mode including obtained knowledge, belief, technology, and behaviour and so on shared members of the special boundary of land. The 21st century called people is the age to create the new added value of information and cultural. Thus information cultural is becoming the global. This study aims to propose model on the information cultural creating processes for information cultural magnification based on theory and the necessaries for the undertaking of a work in the side global.

On Mode Correlation of Solar Acoustic Oscillations

  • Chang, Heon-Young
    • Journal of Astronomy and Space Sciences
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    • v.26 no.3
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    • pp.287-294
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    • 2009
  • In helioseismology it is normally assumed that p-mode oscillations are excited in a statistically independent fashion. Unfortunately, however, this issue is not clearly settled down in that two experiments exist, which apparently look in discrepancy. That is, Appourchaux et al. (2000) looked at bin-to-bin correlation and found no evidence that the assumption is invalid. On the other hand, Roth (2001) reported that p-mode pairs with nearby frequencies tend to be anti-correlated, possibly by a mode-coupling effect. This work is motivated by an idea that one may test if there exists an excess of anticorrelated power variations of pairs of solar p-modes. We have analyzed a 72-day MDI spherical-harmonic time series to examine temporal variations of p-mode power and their correlation. The power variation is computed by a running-window method after the previous study by Roth (2001), and then distribution function of power correlation between mode pairs is produced. We have confirmed Roth's result that there is an excess of anti-correlated p-mode pairs with nearby frequencies. On the other hand, the amount of excess was somewhat smaller than the previous study. Moreover, the distribution function does not exhibit significant change when we paired modes with non-nearby frequencies, implying that the excess is not due to mode coupling. We conclude that the origin of this excess of anticorrelations may not be a solar physical process, by pointing out the possibility of statistical bias playing the central role in producing the excess.

A Study on the Selection Attributes of Convenience Store PB Lunch Box using IPA (IPA를 이용한 편의점 PB 도시락의 선택속성에 관한 연구)

  • Jin, Yang-Ho;Kim, Su-Oh
    • Culinary science and hospitality research
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    • v.23 no.8
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    • pp.17-26
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    • 2017
  • This study compared and analyzed the importance-satisfaction regarding the selection attributes of the convenience store focusing on PB lunch box for consumers of 20s and 30s. According to the research results, the importance of factors such as easy purchase, time reduction, convenient intake were found to be high among the selection attributes of the convenience store PB lunchbox and those of factors such as confirmation of food ingredients, nutrition, and new taste were found to be relatively low. In addition, factors with high satisfaction included easy purchase, convenient intake, time reduction, while factors with low satisfaction were confirmation of food ingredients, nutrition and hygiene. The results of the IPA analysis were as follows: The $1^{st}$ quadrant (Keep up the good work) included convenience, time reduction, easy purchase, convenient intake, convenient cooking method, and convenient packing container Etc. $2^{nd}$ quadrant (possible overkill) includes origin labeling and the 3rd quadrant (low priority) includes packing container design, convenient storage, consistency of quality and taste, good taste, moderate amount, new taste, one meal, moderate quantity and quality, inexpensive intake, and hygiene Etc. $4^{th}$ quadrant was found to include no corresponding factors.

Radiative Transfer Model of Dust Attenuation Curves in Clumpy, Galactic Environments

  • Seon, Kwang-il;Draine, Bruce T.
    • The Bulletin of The Korean Astronomical Society
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    • v.41 no.2
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    • pp.40.2-40.2
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    • 2016
  • The attenuation of starlight by dust in galactic environments is investigated through models of radiative transfer in a spherical, clumpy interstellar medium (ISM). We show that the attenuation curves are primarily determined by the wavelength dependence of absorption rather than by the underlying extinction (absorption+scattering) curve; the observationally derived attenuation curves cannot constrain a unique extinction curve unless the absorption or scattering efficiency is specified. Attenuation curves consistent with the Calzetti curve are found by assuming the silicate-carbonaceous dust model for the Milky Way (MW), but with the $2175{\AA}$ bump suppressed or absent. The discrepancy between our results and previous work that claimed the Small Magellanic Cloud dust to be the origin of the Calzetti curve is ascribed to the difference in adopted albedos; we use the theoretically calculated albedos whereas the previous ones adopted empirically derived albedos from observations of reflection nebulae. It is found that the model attenuation curves calculated with the MW dust are well represented by a modified Calzetti curve with a varying slope and UV bump strength. The strong correlation between the slope and UV bump strength, as found in star-forming galaxies at 0.5 < z < 2.0, is well reproduced if the abundance of the UV bump carriers is assumed to be 30-40% of that of the MW-dust; radiative transfer effects lead to shallower attenuation curves with weaker UV bumps as the ISM is more clumpy and dustier. We also argue that some of local starburst galaxies have a UV bump in their attenuation curves, albeit very weak.

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Primary Cutaneous Mucinous Carcinoma Treated with Narrow Surgical Margin

  • Choi, Jin-Hee;Kim, Seung Chan;Kim, Jiye;Chung, Yoon Kyu
    • Archives of Craniofacial Surgery
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    • v.17 no.3
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    • pp.158-161
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    • 2016
  • Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor of eccrine origin. Clinically, the carcinoma presents as a solitary, slow growing, and painless nodule. For this reason, this tumor is often considered to be a benign mass in the preoperative setting. The lesion is, however, malignant in nature and has a tendency for local recurrence and infrequent metastasis. Wide local excision is the treatment of choice. However, few reports exist with information regarding surgical margins and clinical outcomes. Herein, we report a case of PCMC excised with a narrow surgical margin and review the relevant literature. A 49-year-old man presented with a small cutaneous nodule of the right cheek. The mass was excised without any margin, but pathologic examination revealed histology of mucinous carcinoma. Because of this, the operative site was re-excised with a 5-mm margin, and the wound was closed using a V-Y advancement flap. Systemic work-up did not reveal other potential metastatic primary, for a final diagnosis of PCMC. We report this case of PCMC, treated with relatively narrow margin in a patient with good prognostic factors.

The Clinical study on the treatment of Frozen Shoulder (동결견 치료에 관한 임상적 연구)

  • Byun, Jae-Young;Ahn, Soo-Gi
    • Korean Journal of Oriental Medicine
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    • v.3 no.1
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    • pp.279-287
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    • 1997
  • Clinical studies were done on 80 persons who were treated with the acupuncture theraphy frozen shoulder. The following results are obtained. 1. Distribution of sex: male(28 persons), female (52 persons). 2. Causes of illness: work(40 persons), unknown origin(32 persons). 3. Duration of illness: less than 1 month(28 persons), 1-3 month(22 persons), 3-6 months(20 persons). 4. Distribution of occupational: housewife(30 persons), unemployed(22 persons), farmer(16 persons). 5. Distribution according to number of times of treatment rate: 3 weeks(32 persons), 2 weeks(14 persons), 4weeks(10 persons). 6. The classification of abduction disturbance before treatment were Gl group 14 persons, GII group 46 persons, GIII group 20 persons. After treatment were GI group 41 persons, GII group 30 persons, GIII group 9 persons. 7. The classification of HBST disturbance before treatment were GI group 10 persons, GII group 51 persons, GIII group 19 persons. After treatment were GI group 39 persons, GII group 28 persons , GIII group 13 persons. 8. The classification of MWT disturbance before treatment were GI group 25 persons, GII group 37 persons, GIII group 18 persons. After treatment were GI group 44 persons, GII group 25 persons, GIII group 11 persons.

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X-RAY FLUORESCENCE IN RESEARCH ON THE CULTURAL HERITAGE

  • Cechak, Tomas;Kopecka, Ivana;Musilek, Ladislav
    • Journal of Radiation Protection and Research
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    • v.26 no.3
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    • pp.321-326
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    • 2001
  • Radionuclide X-ray fluorescence analysis is a method, which has many advantages for analysing various historic artefacts, as it is relatively cheap, sensitive and non-destructive, and it allows measurements in-situ. However, this analysis has also certain limitations especially concerning sensitivity to chemical elements only, irrespective of the compounds or chemical forms in which these elements have been bonded. In addition, light elements emitting very soft X-rays cannot be measured, and in order to detect a wide range of elements, it is necessary to carry out repeated measurements with different radiation sources. Despite these limitations, valuable information can be obtained about the composition of historic materials and data about the origin and age of these artefacts can be derived. Analyses of wall paintings, ancient metal sculptures or other objects of art provide the basis for historic considerations documented in our results for some objects belonging to the Czech cultural heritage. The results are promising. Thus it is expected that our laboratory will expand its work into more fields of the fine and applied arts.

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New method development for position estimation of underground acoustic source using a passive SONAR system

  • Jarng, Soon-Suck;Lee, Je-Hyeong;Ahn, Heung-Gu;Park, Heun-Ho
    • 제어로봇시스템학회:학술대회논문집
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    • 1999.10a
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    • pp.149-152
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    • 1999
  • The aim of the work described in this paper is to develop a complex underground acoustic system which detects and localizes the origin of an underground hammering sound using an array of hydrophones located about loom underground. Three different methods for the sound localization will be presented, a time-delay method, a power-attenuation method and a hybrid method. In the time-delay method, the cross correlation of the signals received from the way of sensors is used to calculate the time delays between those signals. In the power-attenuation method, the powers of the received signals provide a measure of the distances of the source from the sensors. In the hybrid method, both informations of time-delays and power-ratios are coupled together to produce better performance of position estimation. A new acoustic imaging technique has been developed for improving the hybrid method. For each method the sound localization is carried out in three dimensions underground. The minimum distance between the true and estimated origins of the source is 28 m for a search area of radius 250m.

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Distributions of Amplitude and Phase Around C-points: Lemon, Mon-Star, and Star

  • Yu, Renlong;Ye, Dong;Xin, Yu;Chen, Yanru;Zhao, Qi
    • Journal of the Optical Society of Korea
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    • v.20 no.1
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    • pp.192-198
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    • 2016
  • The distributions of (or constraints for) amplitude and phase around C-points, including Lemon, Mon-Star and Star, are studied. A Cartesian coordinate system with origin at the C-point is established. Four curves, where the azimuthal angles of polarization ellipses are 0°, 45°, 90°, and 135° respectively, are used to determine the distributions. Discussions of these constraints illustrate why Mon-Star is rarer than Lemon or Star in experiments. The transformation relationships between these three polarization singularities (PSs) are also discussed. We construct suitable functions for amplitude and phase according to their constraints, and simulate several PSs of particular shapes. With the development of modulation techniques for amplitude and phase, it is clear that this work is helpful for generating arbitrarily shaped C-points in experiments.