This study was conducted to identify the factors affecting the health-related quality of life(HRQOL) in married women according to their occupations. The study subjects were 2,555 married women in the 7th National Health and Nutrition Examination Survey, and the SPSS 25.0 program was used for data analysis. The results are as follows. In the case of office workers, the age, household income, obesity etc., were significant factors, and the explanatory power was 8.9% (p<.001). In the case of service workers, the age, education level, weight control, subjective health, and stress were significant factors, and the explanatory power was 16.1% (p<.001). In the case of simple labor, the age, education level, number of household members, hypertension, obesity, weight change, weight control, sitting time, subjective health, subjective body image, and stress were significant factors, and the explanatory power was 24.7(p<.001). In the case of unemployed, the age, household income, number of household members, number of days taking a walk per week, sleeping time, sitting time, subjective health, subjective body image, and stress were significant factors, and the explanatory power was 29.9% (p<.001). In the future, when developing a program to improve the HRQOL, the individual management programs considering the factors affecting the HRQOL according to occupation should be applied.