• 약학회지
• /
• 제45권1호
• /
• pp.93-100
• /
• 2001

Drug inetraction between of enalapril-induced angiotensin converting enzym) inhibitory effect and Ginkgo biloba Ext.-induced antioxidant action was evaluated in spontaneously hypertensive rats. Combination treatment of enalapril (20 mg/kg/day p.o.) and Ginkgo biloba Ext. (60 mg/kg/day, p.o.) for 6 weeks in drinking water to SHRs resulted the inhibition of ACE activity in lung tissue, angiotensin I-induced pressure response and plasma angiotensin II concentration as similar to enalapril alone treatment. But these effects were sustained after 1 week withdrawal of enalapril and Ginkgo biloba Ext. co-administeration. Also, coadministered group did not increase the concentration of bradykinin in lung tissue, which were different from enalapril alone treated group. Co-administration of enalapril and Ginkgo biloba Ext. inhibited the hemolysis induced by UV B type, even Ginkgo biloba Ext. alone treated group did not. These results suggested that Ginkgo biloba Ext. sustained ACE inhibitory effect and reduced the inhibitory effect of bradykinin inactivation induced by enalapril, meanwhile, enalapril increased the antioxidant effect of Ginkgo biloba Ext.

• Macromolecular Research
• /
• 제9권3호
• /
• pp.164-170
• /
• 2001

Recently in order to describe the complex rheological behavior of polymer melts with long side branches like low density polyethylene, new constitutive equations called the pom-pom equations have been derived by McLeish and Larson on the basis of the reptation dynamics with simplified branch structure taken into account. In this study mathematical stability analysis under short and high frequency wave disturbances has been performed for the simplified differential version of these constitutive equations. It is proved that they are globally Hadamard stable except for the case of maximum constant backbone stretch (λ = q) with arm withdrawal s$\_$c/ neglected, as long as the orientation tensor remains positive definite or the smooth strain history in the now is previously given. However this model is dissipative unstable, since the steady shear How curves exhibit non-monotonic dependence on shear rate. This type of instability corresponds to the nonlinear instability in simple shear flow under finite amplitude disturbances. Additionally in the flow regime of creep shear flow where the applied constant shear stress exceeds the maximum achievable value in the steady now curves, the constitutive equations will possibly violate the positive definiteness of the orientation tensor and thus become Hadamard unstable.

• 부모자녀건강학회지
• /
• 제6권2호
• /
• pp.103-114
• /
• 2003

This descriptive study was conducted to explore the mothers' perceived temperament of their preschoolers, and its related factors. Survey from 212 mothers of preschoolers residing in Seoul, Daejeon, and Suwon was performed, and Schaefer's MBRI(Maternal Behavior Research Instrument), and PTQ(Parent Temperament Questionnaire) by Thomas and Chess, Child-rearing burden instrument by Han were used to collect data from September 15 to October 31, 2002. Data was analyzed with SPSS 10.0 Win program. Summaries of results were as follows: 1. There was no significant difference in temperament type-easy or difficult child-depending upon the demographic characteristics. 2. In temperament subscale, boys showed higher activity level than girls, and in working mothers group, adaptability was significantly lower although mood was higher. Preschoolers with expanded families were higher in activity level and intensity of reaction than with nuclear families. 3. Approach-withdrawal, adaptability, and mood showed significant negative relationship with maternal childrearing burden. 4. Temperament showed significant positive or negative relationship with maternal childrearing attitudes. In conclusion, it determined preschoolers' temperament was affected by primary environment such as maternal attitude, childrearing burden, and family type as well as children's gender. It was suggested that parent education and counselling program in nursing would be needed to promote children's desirable temperament.

• 한국축산식품학회지
• /
• 제40권4호
• /
• pp.551-562
• /
• 2020

Beef fat was replaced with cold press pumpkin seed oil (PSO; 0%, 5%, 15%, and 20%) in the production of bologna-type sausages. A value of pH, water-holding capacity (WHC), jelly-fat separation, emulsion stability and viscosity values were determined in meat batters. Thiobarbituric acid reactive substances (TBARS), color, and textural characteristics (TPA, shear test, penetration test) were determined in end-product at 1, 7, 14, 21, and 28 days of storage at 4℃. The pH values were varied between 6.06 and 6.08. With the increase in the level of PSO in meat batters, there was a significant increase in WHC, jelly-fat separation and viscosity values (p<0.05) while a significant decrease in emulsion stability (p<0.05). TBARS values of sausages were found to be significantly higher than in the control group (p<0.05), and this trend continued during storage. Increasing of PSO level were caused a significant increase in L* and b* values while a decrease in a* value (p<0.05). Hardness, adhesiveness and chewiness values were significantly reduced whereas cohesiveness and resilience values increased (p<0.05). Maximum shear force and work of shear was significantly decreased as the level of PSO increased (p<0.05). Hardness, work of penetration and the resistance during the withdrawal of the probe values (penetration tests) increased significantly with the increase in the level of PSO (p<0.05). These results indicate that PSO has potential to be use as a replacement of animal-based fats in the production of bologna-type sausages.

• Biomolecules & Therapeutics
• /
• 제22권5호
• /
• pp.445-452
• /
• 2014

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study.

• 한국주조공학회지
• /
• 제33권5호
• /
• pp.193-203
• /
• 2013

The Ni-base superalloy CM247LC was directionally solidified (DS) using the Bridgman-type furnace to understand the effect of the chill plate on the microstructural evolution, such as dendrite arm spacing, microporosity, and MC-type carbide. The DS process was also modeled by the PROCAST to predict the solidification rate, thermal gradient, and resultant cooling rate in the entire length of the DS specimen. Due to the quenching effects of chill plate, four distinct areas were found to form in the specimen, in which the solidification rate was changed, during DS at a given withdrawal rate of 0.083 mm/s. Among the microstructural features investigated, the dendrite arm spacings and average size of the MC-type carbide near the chill plate were found to be influenced by the quenching effect of the chill plate. However, no significant influence was found on the size and volume fraction of microporosity, and the volume fraction of the MC-type carbide. The relationship between the microstructural features and the solidification variables was also analyzed and discussed on the basis of a combination of experimental and modeling results.

• Journal of Korean Biological Nursing Science
• /
• 제10권1호
• /
• pp.88-95
• /
• 2008

Purpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat. Method: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined. Result: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle. Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.

• 대한가정학회지
• /
• 제41권7호
• /
• pp.121-143
• /
• 2003

The purpose of this study was to show general trends in the psychological environment of family and problem behaviors perceived by adolescents and examine possible changes in such trends in accordance with the individual variables of adolescent, and then find out the effect of these variables on adolescents' problem behavior. The subject were 1374 adolescents of middle school in Busan(male 698, female 676). The main results were as follows : (1) General trends in the degree of parental monitoring showed that girls had more high than boys, and in the degree of family discord, boys showed more high than girls. In the degree of openness of parent-adolescent communication perceived by adolescents showed that girls had more open communication with mother than boys. Such trends in problem behaviors indicated that adolescents had the attention problem most. According to gender, girls had more problems in withdrawal, somatic complain, anxiety/depression, thought problems, attention problems, destructivity/identity, internalizing problems, total behavior problems in comparison to boys. Boys did delinquent behaviors more than girls. (2) For boys, the monthly income of their family, family discord, and the mother-adolescent communication have a significant direct effect on internalizing problems, externalizing problems and total behavior problems. Besides mother's employment and the type of family have a significant indirect effect on behavior problem. For girls, mother's employment, parental monitoring, family discord, and father-adolescent communication have a significant direct effect on internalizing problems. Mother's employment, family discord, mother-adolescent communication have a significant indirect effect on externalizing problems and total behavior problems. Bisides mother's employment, grade, the type of family, dating have a significant indirect effect on behavior problem. (3) The variables to have a significant influence on the parental monitoring showed as the monthly income of their family, dating, mother's employment, the type of family, the family discord showed as mother's employment on the parent-adolescent communication showed as the type of family. (4) Family discord was the most powerful predicator of problem behaviors of middle school students.

• Journal of the Korean Wood Science and Technology
• /
• 제31권5호
• /
• pp.96-103
• /
• 2003

국산 주요 침엽수재인 소나무, 잣나무, 낙엽송의 철물접합부 인장하중 특성 구명을 위하여 본 연구를 수행하였다. 철물 접합부의 최대 인장하중은 AA형의 경우 소나무가 3,612 kgf로 낙엽송, 잣나무에 비해 각각 1.2배, 1.7배, EA형의 경우 2,704 kgf로 1.1배, 1.5배 우수하였다. 또한 AA형은 EA형에 비해 3 수종 모두 약 1.2배 이상 높은 인장하중을 나타내었다. 철물접합부의 파괴모드는 주로 이의 빠짐, 철물의 인장파괴와 목재의 전단파괴로 이루어지며, 특히 소나무 접합부는 철물의 인장파괴를 나타내었다. 철물접합부재의 인장하중-변위 특성은 Foschi 모형으로 정확하게 추정할 수 있었으며, 철물접합부의 초기강성은 소나무 접합부재가 높게 나타났다. 국산 침엽수재의 철물접합부에 대한 설계하중은 소나무, 낙엽송, 잣나무의 순으로 높게 나타났으며, AA형의 경우 이당 설계하중이 소나무 25 kgf, 낙엽송 22 kgf, 잣나무 15 kgf이었으며, EA형의 경우 소나무 19 kgf, 낙엽송 17 kgf, 잣나무 13 kgf 이었다.

• 한국음향학회지
• /
• 제19권2호
• /
• pp.33-39
• /
• 2000

낮은 형상요소를 갖는 표면탄성파 대역통과 필터의 주파수 특성을 구현하기 위하여 35° Y-cut Quartz 표면에 빗살무늬 변환기를 형성시켜 모의실험을 수행하였으며, 전극재료로는 Al을 이용하였다. 이 모의실험에서 얻은 조건들로부터 필터를 설계하였으며, 필터의 입력단에는 apodization weighted형 빗살무늬 변환기를 이용하고, 출력단에는 withdrawal weighted형 빗살무늬 변환기로 필터를 구성하였다. 또한, 입·출력 빗살무늬 변환기의 전극 수는 리플의 영향을 최소화하기 위해 Kaiser-Bessel 창함수를 이용하였으며, 각각 2200쌍과 1000쌍으로 하였다. 그리고, 빗살무늬 변환기 전극의 폭은 6㎛, 간격은 5.75㎛ 및 두께는 표면탄성파 파장과의 비를 고려해 6000Å으로 할 때 최적의 결과를 얻을 수 있었으며, 구경은 임피던스 정합을 위해 2mm로 하였다. 제작한 표면탄성파 대역통과 필터의 중심주파수는 70MHz, 형상요소는 1.3이하, 1.5dB에서의 통과 대역은 1.3MHz, 저지대역은 -45dB, 삽입손실은 19dB, 통과 대역폭 내의 리플은 1dB정도로 측정되었다. 따라서, 제작한 필터의 주파수 응답과 특성은 설계조건과 잘 일치하였다.