• Title/Summary/Keyword: White Korean ginseng

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한국의 전통적 기능성 식품의 이용에 대한 역사적 고찰 (The Historical Study of Korean Traditional Funtional Food)

  • 한복진
    • 동아시아식생활학회지
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    • 제6권2호
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    • pp.235-255
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    • 1996
  • Natural substances, exploited in our daily life, have been applied to drugs to treat diseases and developed to functional foods by appropriate preparations, and these foods give beneficial effects on physical activities. In this paper, the utilization of traditional functional foods was studied with refer ring to old ancient writings published in the front-end of Chosun dynasty. The utilized vegetables were march mallow, turnip, radish, Chinese cabbage, lettuce, spinach, cucumber winter buds, flesh of a cabbage, eggplant, taro, burdock, Parsley, watershield plant, crown daisy, bamboo shoots, garlic, scallion, onion, acorn, bark of a tree, white goosefoot leaf, leaf of bean, pine mushroom, bracken. yam, mugwort, tea, ginseng, peppermint, fruit of the Maximowiczia chinensis, smartweed and pepper. The utilized fruits were chestnut, Chinese date, pine nuts, walnut, gingko nut, citrus. crab apple, pear, peach, grape, pomegranate, plum, Chinese quince, fig and watermelon. The utilized cereal were rice, barley, bean, buckweat and Job's-tears. The utilized sweetenings and seasonings were honey, wheat-gluten, sugar, oil, salt, soy sauce and vinegar. Our ancestors had a balanced diet using the various foods, and especially had a fundamental concept of "Foods have the efficacy of a remedy".edy".uot;.

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가례도감의궤(嘉禮都鑑儀軌)에 나타난 1600년대(年代)의 조선왕조(朝鮮王朝) 궁중(宮中) 가례상(嘉禮床)차림 고(考) -1651년(年) 현종(顯宗) 명성후(明聖后), 1696년(年) 경종(景宗) 단의후(端懿后) 가례동뢰연(家禮同牢宴)- (A Study of Wedding Feast Dishes in Gare Dogam Euigwae (1651, 1696))

  • 김상보;이성우
    • 한국식생활문화학회지
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    • 제5권1호
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    • pp.43-58
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    • 1990
  • To analyze wedding feast dishes of royal prince (1651, 1696) of Choson Dynasty, studied Gare Dogam Euigwae. Historic book 'Gare Dogam Euigwae' discribed wedding feast dishes of king‘s Choson Dynasty. The results obtained from this study are as follows. Dishes were arranged in four kinds of table, the first one called the main table, the second the right side table, the third the left side table, the fourth the confronting side table. Dishes of main table were oil and honey pastry, and fruits (pine nuts, orange, dried persimmon, torreya nuts, dried chestnut, jujube). Dishes of the second table and the third table were oil and honey pastry, and small cake made of honey and rice with patterns pressed in it. Dishes of the fourth table were cooked vegetable (wild ginseng, platy-codon, radish, white gourd melon, ginger), dried slices of meat seasoned with spices (abalone, octopus, shark, pheasant), cooked meat (wild goose, fowl, egg, pheasant, abalone), and fried fish (roe deer, fish, duck, pigeon, sparrow). The main table (同牢大宴床) and the second table (右挾床) stand as a symbol for integrity. The third table (左挾床) symbolize longerity. The fourth table (面挾床) symbolize bearing many young and connubial felicity.

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20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway

  • Xia, Ting;Zhang, Jin;Zhou, Chuanxin;Li, Yu;Duan, Wenhui;Zhang, Bo;Wang, Min;Fang, Jianpei
    • Journal of Ginseng Research
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    • 제44권5호
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    • pp.725-737
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    • 2020
  • Background: T-cell acute lymphoblastic leukemia (T-ALL) is a kind of aggressive hematological cancer, and the PI3K/Akt/mTOR signaling pathway is activated in most patients with T-ALL and responsible for poor prognosis. 20(S)-Ginsenoside Rh2 (20(S)-GRh2) is a major active compound extracted from ginseng, which exhibits anti-cancer effects. However, the underlying anticancer mechanisms of 20(S)-GRh2 targeting the PI3K/Akt/mTOR pathway in T-ALL have not been explored. Methods: Cell growth and cell cycle were determined to investigate the effect of 20(S)-GRh2 on ALL cells. PI3K/Akt/mTOR pathway-related proteins were detected in 20(S)-GRh2-treated Jurkat cells by immunoblotting. Antitumor effect of 20(S)-GRh2 against T-ALL was investigated in xenograft mice. The mechanisms of 20(S)-GRh2 against T-ALL were examined by cell proliferation, apoptosis, and autophagy. Results: In the present study, the results showed that 20(S)-GRh2 decreased cell growth and arrested cell cycle at the G1 phase in ALL cells. 20(S)-GRh2 induced apoptosis through enhancing reactive oxygen species generation and upregulating apoptosis-related proteins. 20(S)-GRh2 significantly elevated the levels of pEGFP-LC3 and autophagy-related proteins in Jurkat cells. Furthermore, the PI3K/Akt/mTOR signaling pathway was effectively blocked by 20(S)-GRh2. 20(S)-GRh2 suppressed cell proliferation and promoted apoptosis and autophagy by suppressing the PI3K/Akt/mTOR pathway in Jurkat cells. Finally, 20(S)-GRh2 alleviated symptoms of leukemia and reduced the number of white blood cells and CD3 staining in the spleen of xenograft mice, indicating antitumor effects against T-ALL in vivo. Conclusion: These findings indicate that 20(S)-GRh2 exhibits beneficial effects against T-ALL through the PI3K/Akt/mTOR pathway and could be a natural product of novel target for T-ALL therapy.

인삼 사포닌이 하부요로와 음경해면체 평활근의 이완작용에 미치는 효과 (The Effects of Ginseng Saponin on Relaxation of Smooth Muscle in the Lower Urinary Tract and the Corpus Cavernosum)

  • 정희창;오태희
    • Journal of Yeungnam Medical Science
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    • 제23권1호
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    • pp.52-61
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    • 2006
  • 이상의 결과를 종합하면, 인삼 총사포닌은 본 실험의 조건에서 배뇨개선 효과가 있으며 이에 관여하는 총사포닌의 주 효능은 근위부요도를 이완시킴으로써 이루어지는 것으로 생각된다. 그리고 인삼 총사포닌은 혈류역동학적으로 안전하게 음경해면체 평활근을 이완시켜 음경발기를 유발시키는 것으로 생각된다.

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Microwave를 이용한 한약재 중의 잔류농약 추출 (Extraction of pesticide residues in medical herbs by microwave)

  • 김택겸;김장억
    • 농약과학회지
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    • 제4권3호
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    • pp.60-67
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    • 2000
  • 건조된 한약재 시료인 백삼, 홍삼, 지황, 당귀 및 시호 중에 잔류되어 있는 tolclofos-methyl 및 quintozene의 추출에 microwave 추출법을 이용하고자 Soxhlet 추출법과 추출효율을 비교하여 최적의 추출용매, 추출시간 및 power supply의 강도 등에 대하여 조사하였다. 다섯 가지 한약재 시료에 잔류되어 있는 tolclofos-methyl 및 quintozene을 microwave로 추출하기 위한 용매는 acetone이 가장 효율적이었다. 추출효율은 Soxhlet 7시간 추출과 microwave로 45 watts에서 1분에서 10분 동안 추출한 결과를 비교하였는데 microwave 추출시간을 $3{\sim}5$분으로 한 결과와 Soxhlet 법으로 7시간 추출한 결과는 거의 같게 나타났다. 시료의 종류에 따른 microwave의 추출특성은 인삼은 5분, 다른 한약재들은 3분의 추출에서 Soxhlet추출과 거의 같은 추출 효율을 나타내었다. 잔류분석시 불순물의 방해를 고려한 최적 추출효율을 나타내는 microwave power는 $45{\sim}90$watts로 나타났다. 따라서 tolclofos-methyl 및 quintozene이 잔류되어 있는 다섯 가지 한약재 시료에서의 microwave를 이용한 추출의 최적 조건은 power $45{\sim}90$ watts, 추출용매 acetone, 추출시간 $3{\sim}5$분인 것으로 나타났다.

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Antineoplastic Natural Products and the Analogues(IX). A Review of the Series

  • Ahn, Byung-Zun;Kim, Shin-Il;Ryu, Sung-Ho;Kang, Kyu-Sang;Lee, You-Hui
    • 생약학회지
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    • 제17권2호
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    • pp.168-177
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    • 1986
  • Bioassay-directed isolation has yielded some cytotoxic substances against L1210 cell from the Korean traditional medicine. These include 5,2'-dihydroxy-6,7,8,6'-teramethoxyflavone $(IV,\;scutellaria\;root,\;ED_{50}\;=\;1.7\;{mu}g/ml)$, 7-geranyloxycoumarin $(XXXII,\;poncirus\;fruit,\;10.2\;{mu}g/ml) $and panaxydol $(I,\;white\;ginseng,\;0.03\;{mu}g/ml)$. IV, XXXII and their derivatives were synthesized in the purpose of in vivo tests and for observation of structure-activity relations. Among the flavone derivatives, 5,2',6'-trihydroxy-6,7,8-trimethoxy flavone (XVIII), 5-hydroxy-6,7,8-trimethoxy-6'-benzyloxyflavone (XVII) and 5,8-dihydroxy-6,7-dimethoxyflavone (X) showed the cytotoxicity which has no correlation to the flavone structures. Of the coumarins synthesized, 7,8-dihydroxycoumarin (XXVI), 6-7-dihydroxycoumarin (XXIX) and 6-hydroxy-5,7-dimethoxycoumarin (XXXI) showed considerable activities. Acetylated XXXI has moderate activity $(ED_{50}=17.2\;{mu}g/ml)$. Monobydroxycoumarins or their methyl and allyl ether were inactive. IV inhibits the growth of the solid form of S-180 by 70% at 40 mg/kg and shows T/C of 166% on the ascitic S-180 at 40 mg/kg. It strongly inhibits the activity of the membrane bounded ATPase from L1210 cell. The most cytotoxic fraction of the antitumor materials studied is the one from the trichosanthes root showing $ED_{50}=0. 0003\;{mu}g/ml$ against L1210 cell. This fraction, obtained from ethyl acetate extract, showed T/C of 130 and 135%, on ICR mice bearing S-180 and $BDF_1$ mice bearing L1210 at 10 mg/kg and 7.5 mg/kg, respectively.

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Production of the Rare Ginsenoside Rh2-MIX (20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3) by Enzymatic Conversion Combined with Acid Treatment and Evaluation of Its Anti-Cancer Activity

  • Song, Bong-Kyu;Kim, Kyeng Min;Choi, Kang-Duk;Im, Wan-Taek
    • Journal of Microbiology and Biotechnology
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    • 제27권7호
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    • pp.1233-1241
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    • 2017
  • The ginsenoside Rh2 has strong anti-cancer, anti-inflammatory, and anti-diabetic effects. However, the application of ginsenoside Rh2 is restricted because of the small amounts found in Korean white and red ginsengs. To enhance the production of ginsenoside Rh2-MIX (comprising 20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3 as a 10-g unit) with high specificity, yield, and purity, a new combination of enzymatic conversion using the commercial enzyme Viscozyme L followed by acid treatment was developed. Viscozyme L treatment at pH 5.0 and $50^{\circ}C$ was used initially to transform the major ginsenosides Rb1, Rb2, Rc, and Rd into ginsenoside F2, followed by acid-heat treatment using citric acid 2% (w/v) at pH 2.0 and $121^{\circ}C$ for 15 min. Scale-up production in a 10-L jar fermenter, using 60 g of the protopanaxadiol-type ginsenoside mixture from ginseng roots, produced 24 g of ginsenoside Rh2-MIX. Using 2 g of Rh2-MIX, 131 mg of 20(S)-Rh2, 58 mg of 20(R)-Rh2, 47 mg of Rk2, and 26 mg of Rh3 were obtained at over 98% chromatographic purity. Then, the anti-cancer effect of the four purified ginsenosides was investigated on B16F10, MDA-MB-231, and HuH-7 cell lines. As a result, these four rare ginsenosides markedly inhibited the growth of the cancer cell lines. These results suggested that rare ginsenoside Rh2-MIX could be exploited to prepare an anti-cancer supplement in the functional food and pharmaceutical industries.

결명(決明)의 파종기(播種期)와 피복재료(被覆材料)가 생육(生育) 및 수량(收量)에 미치는 영향(影響) (Effects of Planting Time and Mulching Materials on Growth Characteristics and Yield in Cassia tora L.)

  • 이희덕;김창영;노태홍;이종철
    • 한국약용작물학회지
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    • 제1권2호
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    • pp.158-161
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    • 1993
  • 본(本) 시험(試驗)은 1992년 충남(忠南) 농촌진흥원(農村振興院) 특작(特作) 시험포장(試驗圃場)에서 수행된 결명(決明) 적기파종(適基播種) 구명(究明)과 피복재료(被覆材料) 선발(選拔) 결과(結果)는 다음과 같다. 1. 대전 중부지역 결명 파종적기는 5윌 18일 파종이 가장 수량이 많았고, 6윌 하순도 10a당 273kg까지 생산이 가능하여 맥후작으로 이용할시 유리한 작물로 사료되었다. 2. 피복 재료 선발은 무피복대비 전구에서 수량성에 유의성이 인정되지 않았으나, 관행(무피복)보다 수량이 $20{\sim}53%$ 증수되었고 흑색 PE는 잡초제거 노력을 경감하여 생력화 할 수 있었다. 3. 결명은 조기파종시 결명 입고병이 조금 발생할뿐 파종기, 피복재료에 관계없이 농약사용없이 무공해 농산물이 생산 가능하였다.

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Sclerotinia sclerotiorum에 의한 잠두 균핵병 (Sclerotinia Rot of Broad Bean (Vicia faba) Caused by Sclerotinia sclerotiorum)

  • 권진혁;배영석
    • 식물병연구
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    • 제13권2호
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    • pp.115-118
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    • 2007
  • 2004년부터 2006년까지 3년 동안 경남농업기술원 잠두재배포장에서 지제부위의 줄기와 꼬투리가 수침상으로 물러지고 썩으면서 그 부위에 흰색 곰팡이와 균핵이 생기고 시들어 죽는 증상이 발생하였다. 감자한천배지 상에서 균총은 흰색에서 연한 회색을 띄었다. 균핵은 구형, 타원형 또는 불규칙하며 검은색이었다. 자낭반은 컵모양이며 크기는 $5{\sim}10\;mm$이었으며 자낭은 원통형이고 크기는 $90{\sim}180{\times}12\;{\mu}m$이었다. 자낭포자는 타원형이며 무색으로 크기는 $8{\sim}12{\times}4{\sim}6\;{\mu}m$이었다. 균사생육 최적온도는 $25^{\circ}C$, 균핵형성 적온은 $20^{\circ}C$이었다. 이상과 같이 잠두에 발생한 병징, 병원균의 균학적 특징 및 병원성 검정 결과를 토대로 병원균을 Sclerotinia sclerotiorum (Lib.) do Bary으로 동정하였으며, 이 병을 잠두 균핵병으로 명명할 것을 제안한다.

Fusarium solani f. sp cucurbitae에 의한 오이 근경썩음병 (Crown and Foot Rot of Grafted Cucumber Caused by Fusarium solani f. sp. cucurbitae)

  • 한경숙;이성찬;한유경;김동휘;김수
    • 식물병연구
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    • 제18권1호
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    • pp.57-61
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    • 2012
  • 2010년 3월 경기도 평택시 오이 시설재배농가에서 오이의 지제부 줄기가 썩으면서 시들어 죽는 증상이 발생하였다. 대목은 흑종호박을 사용하였으며, 대목줄기가 수침상으로 썩고 표면에 흰색 내지 분홍색의 곰팡이가 형성된 것을 확인할 수 있었으며, 병든 식물체 줄기에서 병원균을 분리하여 균학적 특징을 파악하고 배양적 특성을 검토한 결과 Fusarium solani f. sp. cucurbitae로 동정되었다. 따라서 본 연구에서 얻어진 결과를 가지고 이 병을 F. solani f. sp. cucurbitae에 의한 오이 근경썩음병(Crown and Foot Rot)으로 제안하고자 한다.