• 한국식품과학회지
• /
• 제32권2호
• /
• pp.265-270
• /
• 2000

국내에서 살균, 살충의 목적으로 7kGy의 감마선이 허가된 백삼분말을 대상으로 $0{\sim}15\;kGy$의 전자선을 조사하고 screening을 목적으로 한 PSL측정과 신뢰성이 높은 것으로 여겨지는 TL 측정에 의해 방사선 조사여부를 확인하였다. PSL을 측정한 결과 비조사구는 threshold value$(T_1)$인 700보다 낮은 값을 나타내면서 negative로 표시되어 방사선 조사되지 않은 것으로, 2.5kGy이상 조사구는 threshold value $(T_2)$인 5000보다 높은 값을 나타내면서 positive로 표시되어 방사선 조사된 것으로 확인되었다. Density separation 추출법을 이용하여 시료로부터 mineral을 분리하여 TL 측정을 실시함으로써 glow curve가 나타나는 온도범위와 glow curve의 형태를 확인하고 TL ratio를 구한 결과, 방사선 조사되지 않은 시료는 $300^{\circ}C$ 부근에서 glow curve가 나타났고 이들의 intensity 또한 낮게 나타났다. 그러나 방사선 조사구는 $200^{\circ}C$ 부근에서 아주 강한 intensity의 glow curve를 보여주었다. 또한, normalization에 의한 TL ratio는 비조사구에서 0.01, 조사구에서 0.78 이상을 나타내어 방사선 조사여부 확인이 가능하였다.

• Food Science and Biotechnology
• /
• 제16권4호
• /
• pp.636-640
• /
• 2007

In order to investigate the major metabolite patterns of aged Panax ginseng C.A. Meyer roots, the ginsenoside contents for white ginseng roots of various ages were compared. The 1-year to 6-year old roots were extracted with methanol, and then the methanol-soluble metabolites were analyzed by high performance liquid chromatography (HPLC). The metabolite contents of the 1-year and 2-year roots, including the ginsenosides and minor components, were not different, but the $Rg_1$, Re, and Rc ginsenoside contents between the 2-year and 3-year roots showed significant differences. $Rg_1$ and Rc increased significantly in the 1-year to 2-year roots, and Re increased significantly from the 3-year root age. Rd increased slightly until the 2-year age and decreased from the 3-year age. Based on the ginsenoside distributions and contents at various root ages, we have suggested 2 biogenesis schemes using the ginsenosides that have been isolated from the roots of P. ginseng so far.

• Journal of Ginseng Research
• /
• 제9권2호
• /
• pp.186-192
• /
• 1985

In order to observe the effect of defatted ginseng which is made by extracting fat from ginseng using petroleum ether during the growth and the starvation, the powder of defatted ginseng was added to the basal diet by 25% and 50% respectively, and the mixtures were fed for 4 weeks to just weanling white female rat which weighed 78-82 g. As for the diet initake, there was not showed any meaningful difference between the defatted ginseng powder fed group and the control group (to which was fed just - the basal diet not including defatted ginseng powder), but the protein intake for the former group appeared to be reduced (P<0.02-0.01) compared to the control group. As for the growth rate, that of the defatted ginseng powder fed group appeared higher (P<0.02) than that of the control group in 1 week after feeding, but since after 2 weeks, there was not showed meaningful difference between the two groups. As for the weight-reduction rate by starvation, that of the 25% defatted ginseng powder fed group showed just 79.6% (P<0.05) of the control group's in 5 days after feeding, but the rate of the 50% defatted ginseng powder fed group appeared 119.3% of the control group's. As for the required time from the beginning of starvation to the death, it was resulted that the higher the rate of defatted ginseng addition is, the shorter the time becomes (P<0.05)

• 인삼문화
• /
• 제1권
• /
• pp.57-66
• /
• 2019

Ginseng has been recognized as a lifespan extending medicine which has been regarded as one of the medicines classified as top medicines, as the Boncho (medical herbs) study which is influenced by the idea of guidance's costume and food concept mainly in China is gaining its bona fide form. As the demand for ginseng has been expanded to other levels, the demand for ginseng has been increasing. Ginseng from the nature reached its supply chain limit due to its extinction and difficulty of picking, so it translated into ginseng cultivation of economy rather than harvesting in nature. After the start of ginseng cultivation, the ginseng cultivation was further enhanced by the rapid development of processing methods such as white-ginseng and red-ginseng, and the surge of consumption due to the traditional belief in ginseng drug efficacy and support of scientific research. In the Joseon Dynasty, the name Gasam (cultivated ginseng) had been created as ginseng was cultivated on farmland after the stage of SanYang (wild cultivated ginseng), the purpose of the new name Gasam is to differentiate from natural ginseng, and natural ginseng lost its firm position as the genuine ginseng as the Gasam replaced the genuine ginseng, and the natural ginseng got a new name of SanSam (wild ginseng). Because the real ginseng substance concept dissipated, and as Gasam is being called ginseng, the name Gasam was also disappeared. As a result, it was possible to grow large quantities according to the arrival of the Gasam era, and it was possible to supply the demand for ginseng, and it could become one agricultural industry. In this ginseng cultivation, in Japan where ginseng did not grow naturally, it was difficult to obtain ginseng from Joseon and faced with a shortage of ginseng at all times. Therefore, the shogun cultivated the Gasam systematically at the national level by the inside of the shogunate. However, since the natural ginseng is native to China and Korea, there is a concern about the deterioration of the quality of natural ginseng due to the incorporation of cultivated ginseng (Gasam). To protect the interests, the cultivation of ginseng was subject to control. For this reason, the lack of historical information on Gasam cultivation, which had to be started secretly, would be a natural result. In this paper, althouh not sufficient enough, the historical informations were used to summarize the history of ginseng cultivation in China, Japan and Korea.

• Journal of Ginseng Research
• /
• 제20권3호
• /
• pp.339-343
• /
• 1996

The effect of ginseng on the reactivity of penile corpus cavernosal smooth muscle strips of rabbits was investigated to support the clinical application of ginseng for the treatment of erectile dysfunction. New Zealand white rabbits were randomly divided into two groups, normal diet group (n=9) and ginseng saponin diet group (n=5). Then, each group was fed normal diet and Korean red ginseng saponin diet (50 mg/kg/day) for 10 weeks. We measured concentration dependent relaxation of corporal smooth muscle to acetylcholine (10-8 M to 10-4M) in organ chamber. The degree of relaxation was expressed as percentage of maximal relaxation obtained by papaverine (10-4M). Dose dependent relaxation of corpus cavernosal smooth muscle to acetylcholine, at the concentration of 10-8 M to 10-4M by half log increment, was 4.06$\pm$0.00, 4.30$\pm$1.30, 5.32$\pm$0.68, 11.64$\pm$1.74, 16.24$\pm$1.61, 23.33$\pm$ 2.29, 26.45$\pm$2.25, 30.43$\pm$2.40 and 33.41 $\pm$2.48 (%), respectively in normal diet group and 9. 83$\pm$4.15, 20.60$\pm$4.62, 24.1815.12, 35.75$\pm$5.71, 43.35$\pm$6.11, 51.30$\pm$6.22, 56.33$\pm$6.22, 54.30$\pm$4.17 and 51.98$\pm$3.92 (Vc), respectively in ginseng group. These data suggest that ginseng enhances ondothelium-dependent acetylcholine-induced relaxation of penile corpus cal.ernosal smooth muscle in rabbits.

• 한국약용작물학회지
• /
• 제19권6호
• /
• pp.456-463
• /
• 2011

The present study examined the effects of Korean white ginseng (WG, Panax ginseng C. A. Meyer) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered with saline or WG (WG 100 or 300 mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of WG on the amnesic rats, which was induced by TMT, was investigated by assessing the Morris water maze test and by performing immunohistochemistries on choline acetyltransferase (ChAT), acetylcholinesterase (AchE), cAMP responsive element binding protein (CREB) and brain derived neurotrophic factor (BDNF). The rats treated with TMT injection (control group) showed impaired learning and memory of the tasks, but the rats treated with TMT injection and WG administration produced significant improvement of the escape latency to find the platform in the Morris water maze at the 2nd and 4th days compared to that of the control group. In the retention test, the WG 100 and WG 300 groups showed significantly increased crossing number around the platform compared to that of the control group (p < 0.001). Consistently with the behavioral data, result of immunohistochemistry analysis showed that WG 100 mg/kg significantly alleviated the loss of BDNF-ir neurons in the hippocampus compared to that of the control group (p < 0.01). Also, treatment with WG has a trend to be increased the cholinergic neurons in the hippocampal CA1 and CA3 areas as compared to that of the control group. These results suggest that WG may be useful for improving the cognitive function via regulation of neurotrophic activity.

• Journal of Ginseng Research
• /
• 제34권4호
• /
• pp.336-341
• /
• 2010

One mechanism of inner ear damage by noise-induced hearing loss (NIHL) is the production of reactive oxygen species (ROS). Because Korean red ginseng (KRG) has an anti-ROS effect in various tissues, KRG may have a role in preventing NIHL. A window period exists in which ROS formations continue after noise exposure, and further damage can be prevented by antioxidants. In this study, we aimed to investigate the effects of KRG after exposure to noise. KRG (200 mg/kg) was fed to mice for 3 days after noise exposure. The change in hearing level was analyzed by measuring the auditory brainstem response. To induce a temporary threshold shift (TTS) of hearing, mice were exposed to 110 dB white noise for 3 hours. Fast recovery of hearing was observed in mice fed KRG 1 hour and 1 day after noise exposure for 3 days. The expression of 8-oxoguanine was not observed in the inner ears of mice fed KRG 1 hour after noise exposure, but was evident in the stria vascularis of mice in the control group (noise exposure only). From this study, we conclude that KRG acted as an effective inhibitor of NIHL in TTS cases.

• Journal of Ginseng Research
• /
• 제41권4호
• /
• pp.615-619
• /
• 2017

Background: Black ginseng has a more potent biological activity than non-steamed ginseng. We investigated the effects of long-term intake of dietary black ginseng extract (BG) on antioxidant activity in aged mice. We also compared the effects of BG on cognitive deficits with those of white ginseng extract (WG) and red ginseng extract (RG). Methods: Ten-month-old mice were fed an AIN-93G-based diet containing 10 g/kg (low dose, L) or 30 g/kg (high dose, H) WG powder, RG powder, or BG powder for 24 wk. We measured serum lipids, the activities of antioxidant enzymes, and malondialdehyde levels. Additionally, the protein expression levels of choline acetyltransferase and vesicular acetylcholine transporter, which are presynaptic cholinergic markers in the cortex and hippocampus of the brain, were measured by western blotting. Results: Triglyceride levels were reduced in all the extract-treated mice, except those in the LBG group. High-density lipoprotein cholesterol levels in the HBG group were higher than those in the control group. Total cholesterol levels were reduced in the LBG group. Additionally, glucose levels in the HBG group were significantly reduced by 41.2%. There were lower levels of malondialdehyde in the LBG group than in the control group. Furthermore, glutathione reductase activity increased in the HWG group and the HRG group. The protein expression levels of choline acetyltransferase and vesicular acetylcholine transporter significantly increased in all the ginseng-treated groups. Conclusion: The results suggest that supplementation with the tested ginseng extracts may suppress the cognitive decline associated with aging, via regulation of the cholinergic and antioxidant defense systems.

• 동아시아식생활학회지
• /
• 제24권3호
• /
• pp.335-350
• /
• 2014

Compared to the large numbers of studies on the diabetes, hyperlipidemia and cancer therpeutic effects of ginseng, the anti-obese effect and mechanisms of ginsengs have not been studied as much. To determine the effects of ginseng on obesity, 14 keywords (ginseng, ginsenoside, obesity, weight, fat, diet, overeat, appetite, lipid, 3T3-L1, adipocyte, food intake, adipogenesis and lipolysis) were combined in searching a database. Fifty-six articles published from 1983 to 2012 as well as 656 patents registered until Aug $17^{th}$, 2012, were screened for anti-obese effects of ginseng. In the classification of experimental methods, 16 papers on 3T3-L1 cells, 38 papers on animals and three papers on human were reviewed. In terms of obese mechanisms of action, the most commonly used biomarkers were in order of lipid profiles > weight change > blood glucose > adipocytokine. Most ginseng studies on obesity focused on AMPK, $PPAR{\gamma}$, GLUT-4, PI3K and SREBP-1. Korean white ginseng extracts and Re repressed the lipogenesis genes such as PPARc2, SREBP-1c, LPL, FAS and DGAT1. However, ginseng or ginsenosides, PD (Rb1) and PT (Re), showed different or contradictory results. Water and ethanol extraction of ginseng showed contradictory effects on the secretion of inflammatory cytokines, wheras IL-6 was repressed by ethanol extracts and TNF-${\alpha}$ repressed by Re in vitro. Based on the literature, further studies on anti-obese mechanisms of ginseng, such as the inflammation-related obesity or cross signals between the adipocytes and the environments, are needed, instead of more studies on its hypolipidemic and hypoglycemic effects.

• Journal of Biosystems Engineering
• /
• 제29권4호
• /
• pp.329-334
• /
• 2004

This study was conducted to investigate the characteristics of transmittance spectrum of Korean red ginseng using VIS/NIR spectroscopy. The results of this study were as follows; Light intensity affected the characteristics of the spectrum. For over 40% light intensity, the first and second peaks appeared at 700nm and 1,100nm, respectively. For the 20% light intensity, the first and second peaks appeared at 800nm and 1,100nm, respectively. Thus, the typical color characteristics of halogen lamp were similar to each other if over 40% of maximum light intensity power, otherwise it was not. Transmittance spectrum showed different characteristics at different portions of red ginseng. Normal red ginseng showed strong intensity at the first peak around 700nmbecause of reddish internal tissue. However, an internal white core red ginseng showed weak peak-intensity due to whitish internal tissue. There was no significant difference in the second peak at 800nm for the different internal qualities. Third peak at 900nm showed somewhat difference by internal qualities but it was difficult to find significant trend. To separate the differences of the internal qualities, intensity differences between peaks were used. It was possible to classify normal red ginseng by the differences of "peak 1 -peak 2" and "peak 1 - peak 3". In addition, shift of the first and the third peaks in the spectrum could separate normal red ginseng from others.ginseng from others.