• 한국지반환경공학회 논문집
• /
• 제11권8호
• /
• pp.33-40
• /
• 2010

본 연구에서는 고속도로에서 발생되는 비점오염원 부하량 계산의 기초가 되는 비점오염물질의 원단위 산정을 위해 서해안 고속도로 매송지역 도로지점과 교각지점 두 지점을 대상으로 수문곡선과 농도분석을 하고 유량가중평균농도(Event Mean Concentrations, EMC)를 이용하여 원단위를 평가하였다. 중금속을 제외하고 대부분의 강우사상에서, 강우가 시작되고 유출이 시작된 이후 초기 30분 이내 오염물질의 농도는 급격히 줄어들었다. EMC 분석 결과 두 지점 모두 TSS, $BOD_5$, DOC가 하수처리수 방류수 기준보다 높게 나왔으며, T-N, T-P는 낮게 검출되었다. 중금속 변화에서는 두 지점 모두 Fe과 Pb 그리고 Zn 등이 다른 중금속에 비해 많이 검출되었다. 원단위 산정 결과 환경부 원단위와 비교하였을 때 $BOD_5$, T-N이 낮게 계산 되었으나, 중금속의 경우, 외국의 원단위와 비교하였을 때 Cu, Pb, Zn 이 약 10배 가량 높은 것으로 나타났다. 좀 더 신뢰성 있는 원단위 산정을 위해서는 현재까지 모니터링된 자료를 활용하고, 추가적인 자료의 획득을 위한 장기적인 모니터링 계획이 수립되어야 할 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권15호
• /
• pp.6015-6020
• /
• 2014

Background: Isolation and characterization of circulating tumor cells (CTCs) in patients suffering from a variety of different cancers have become hot biomarker topics. In this study, we evaluated the prognostic value of CTCs in pancreatic cancer. Materials and Methods: Initial literature was identified using Medline and EMBASE. The primary data were hazard ratios (HRs) with 95% confidence intervals (CIs) of survival outcomes, including overall survival (OS) and progression free survival/recurrence free survival (PFS/RFS). Results: A total of 9 eligible studies were included in this meta-analysis, published between 2002 and 2013. The estimated pooled HR and 95%CI for OS for all studies was 1.64 (95%CI 1.39-1.94, p<0.00001) and the pooled HR and 95%CI for RFS/DFS was 2.36 (95%CI 1.41-3.96, p<0.00001). The HRs and 95%CIs for OS and RFS/DFS in patients before treatment were 1.93 (95%CI 1.26-2.96, p=0.003) and 1.82 (95%CI 1.22-2.72, p=0.003), respectively. In patients receiving treatment, the HRs and 95%CI for OS and RFS/DFS were 1.37 (95%CI 1.00-1.86, p=0.05) and 1.89 (95%CI 1.01-3.51, p=0.05), respectively. Moreover, the pooled HR and 95%CI for OS in the post-treatment group was 2.20 (95%CI 0.80-6.02, p=0.13) and the pooled HR for RFS/DFS was 8.36 (95%CI 3.22-21.67, p<0.0001). Conclusions: The meta-analysis provided strong evidence supporting the proposition that CTCs detected in peripheral blood have a fine predictive role in pancreatic patients especially on the time point of post-treatment.

• Archives of Reconstructive Microsurgery
• /
• 제21권1호
• /
• pp.21-26
• /
• 2012

The radial artery superficial palmar branch free flap is based on the perforators of the superficial palmar branch of the radial artery and its venae comitantes. This flap can be used as a sensible flap including palmar cutaneous branch of the median nerve. Forty radial artery superficial palmar branch free flaps were performed at Centum Institute during October 2010 to December 2011. There were 32 males and 8 females and their mean age were 48 years (range 30 to 66 years). The thumb injured in 13 patients, the index finger in 16 patients, the middle finger in 4 patients, the ring finger in 2 patients, and the little finger in 5 patients. The mean size of the flap was $2.5{\times}3.5$ cm(range $2{\times}2.5$ to $3{\times}7$ cm). The donor site was always closed primarily. The overall survival rate was 90.2 percent. The flaps showed well-padded tissue with glabrous skin. All patients have touch sensation and showed 12 mm two point discrimination in an average(range 8 to 15 mm). Donor site morbidity was conspicuous. One patient showed unsightly scar. Early postoperative range of motion of the affected thumb showed slightly limited radial and palmar abduction. But it improved after postoperative 2 months, and patients did not complaint limitation of motion. In conclusion, the radial artery superficial palmar branch free flap can be used as an option for soft tissue reconstruction of finger defects where local or island flaps are unsuitable.

• 한국도서관정보학회지
• /
• 제2권
• /
• pp.23-59
• /
• 1975

Indexes has not devcloped as an independent branch in library science from the beginning, but it has gradually evolved in a clo~eas sociation with catalog and under the direct influence of the development of publishing pro cesses and of the rapid social changes. Historically, index in the West can be traced back to eariler concordance. On the other hand, index in the Bast does not show a continuous development. It started with book catnlog, but other types of indexing were later 'adopted from the West. Indexing in the West and in the East can be summarized as follows: 1) In the West, Taylor considers Gesner's Pandectae was the first index but the Concordance of the Bible in 1247 was the first true index. Indexing method was first established later in 1545 in Gesner's Partitiones which appeared in three volumes. Classified index appeared after Partitions, but alphabetically ordered index was not developed until th eseventeenth century. The pxiodical index of La France S~auante in 1683 proved -its value, and Poole's An Alphabetical Index in the nineteenth century became the turning point in the development of indexing. After Poole's Index appeared periodical index and book catalog gradually began to be treated separately, and subject index and cross reference were incorporated into indexing. Also dictionary arrangement of the indexed items was adopted in the second half of the nincteenth, century after Charles A. Cutter developed his theory of rules for dictionary catalog and systematic studies of indexing were carried out by many scholars. In the twentieth century, index was mainly developed in the United States of America, especially by Wilson publishing Company. The general trend is to move away from the gcncral index to subject index. Also the ncwspapcr indcx such as The Times I~zdcx is 21 landmark in the history cf indcxing. 2) In China, thcs arc somc cvidcnccs that $Bizgluh(&), $ was the first indcx, but unforlunatcly the book itsclf has not been found as yet.

• Journal of Acupuncture Research
• /
• 제19권2호
• /
• pp.221-230
• /
• 2002

Some studies report that electroacupuncture(EA) boost natural killer cell(NK cell) activity. And also it is well known that hypothalamus is deeply related to effects of EA on analgesia. Some reports said that especially lateral hypothalamic area(LHA) is related to splenic NK cell activity. In order to investigate the relation between hypothalamus and effects of EA at ST36 point on NK cell activity of Spraque-Dawley rats. Lesions were made bilaterally at lateral hypothalamic area(LHA). And NK cytotoxities of normal and lesioned rats were measured with 51Cr release immunoassay after EA stimulation for 2 and 14 days. NK cell activity of EA group was significantly higher than sham group at 2nd, 14th day in normal rats. And LHA lesions abolished effects of EA on NK cell activity at 2nd day. But LHA lesions did not affect the effects of EA at 14th days. We also had an evidence that the decrease of NK cell activity was almost recoverd at 14th day. These results strongly suggest that LHA is deeply related to increase of NK cell activity induced by EA.

• 대한한방내과학회지
• /
• 제31권2호
• /
• pp.395-400
• /
• 2010

Objective : To observe the effectiveness of Jayeumganghwa-tang on hot flush of a breast cancer patient who takes tamoxifen. Methods : For six weeks a dosage witch contained 13.92g of Jayeumganghwa-tang was administered 3 times (30 mins after meal) per day, for improvement of hot flush. No other therapies like hormone therapy or substituted therapy were done. Results : As a result of 6 weeks of Jayeumganghwa-tang therapy, the patient who suffered hot flush on taking tamoxifen showed improvement on several indices, including frequency, intensity and point of hot flush, Beck Depression Inventory-K (BDI-K) which shows uneasiness and sadness, and also Functional Assessment Cancer Therapy - Breast (FACT-B) which is an index of life quality of breast cancer patients. But no changes on female hormones like follicle-stimulating hormone (FSH) or luteinizing hormone (LH) were observed. Conclusion : This case demonstrates 6 weeks of Jayeumganghwa-tang taking had no effect on female hormones but can reduce the hot flush by tamoxifen. This shows minimum evidence of safety and efficacy of Jayeumganghwa-tang on hot flush of breast cancer patient. However this is a single case study so further case-series research should be compiled.

• Korean Journal of Acupuncture
• /
• 제19권1호
• /
• pp.25-33
• /
• 2002

Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. Injections of cocaine can produce one of the immediate-early gene, c-fos expression in the brain and behavioral activation. Acupuncture as a therapeutic intervention is widely used for the treatment of many mental disorders such as drugs of abuse. In order to investigate whether acupuncture has an influence on cocaine-induced reinforcing and behavioral effects, we examined the effect of acupuncture on cocaine-induced locomotor activity and c-Fos expression in the nucleus accumbens and the striatum using Fos-like-immunoreactivity(FLI). Male SD rats received acupuncture for 1 min after injection of cocaine hydrochloride(1 mg/kg, i.v.). The employed acupuncture point, Shenmen$(HT_7)$, has been clinically used to treat mental and psychosomatic disorders. Injections of cocaine produced a marked increase in locomotor activity and FLI in the nucleus accumbens and the striatum. Acupuncture at $HT_7$, but not at control points($PC_6,\;TE_4$ or tail), significantly attenuated cocaine-induced increase in locomotor activity and Fos-like immunoreactivity. These results demonstrated that reduction in locomotor activity by acupuncture may be reflected by reduction of postsynaptic neuronal activity in the nucleus accumbens and the striatum. Our results suggest that acupuncture may have a therapeutic effect on cocaine addiction.

• 한국의학물리학회지:의학물리
• /
• 제28권3호
• /
• pp.111-121
• /
• 2017

Verification of dose distribution is an essential part of ensuring the treatment planning system's (TPS) calculated dose will achieve the desired outcome in radiation therapy. Each measurement have uncertainty associated with it. It is desirable to reduce the measurement uncertainty. A best approach is to reduce the uncertainty associated with each step of the process to keep the total uncertainty under acceptable limits. Point dose patient specific quality assurance (QA) is recommended by American Association of Medical Physicists (AAPM) and European Society for Radiotherapy and Oncology (ESTRO) for all the complex radiation therapy treatment techniques. Relative and absolute point dose measurement methods are used to verify the TPS computed dose. Relative and absolute point dose measurement techniques have a number of steps to measure the point dose which includes chamber cross calibration, electrometer reading, chamber calibration coefficient, beam quality correction factor, reference conditions, influences quantities, machine stability, nominal calibration factor (for relative method) and absolute dose calibration of machine. Keeping these parameters in mind, the estimated relative percentage uncertainty associated with the absolute point dose measurement is 2.1% (k=1). On the other hand, the relative percentage uncertainty associated with the relative point dose verification method is estimated to 1.0% (k=1). To compare both point dose measurement methods, 13 head and neck (H&N) IMRT patients were selected. A point dose for each patient was measured with both methods. The average percentage difference between TPS computed dose and measured absolute relative point dose was 1.4% and 1% respectively. The results of this comparative study show that while choosing the relative or absolute point dose measurement technique, both techniques can produce similar results for H&N IMRT treatment plans. There is no statistically significant difference between both point dose verification methods based upon the t-test for comparing two means.

• 대한조선학회논문집
• /
• 제45권4호
• /
• pp.462-467
• /
• 2008

In this paper, we investigated the design method of mooring system in ultra deep sea and carried out the conceptual design for offshore West Africa oil field in ultra deep sea of 3000 meters. Recently, it was feasible to design and install the offshore floating structures in deep sea of up to 2000 meters. Due to the simplicity, two-point mooring design is fully utilized. Force-excursion curves are throughly examined to find out the feasibility of various combinations of mooring lines. Free length and pretension effects are discussed. It is found that composite materials including synthetic fiber rope may be good solution for ultra deep sea mooring design.

• Acta Via Serica
• /
• 제1권1호
• /
• pp.95-104
• /
• 2016

The Silk Route in ancient times served as a link between the World's greatest civilizations and as a source of knowledge, art, religion and philosophy. This network of ancient caravan paths formed the first bridge between East and West, where two different civilizations came in contact with their respective cultural traditions and religious beliefs, as well as their scientific and technological achievements. One of the main routes of the Great Silk Route passed through the Karakoram, linking Kashgar with Kashmir and the Gandhara regions. The Karakoram Highway connects the Chinese province with Pakistan and follows the ancient Silk Route, which connected the Heartlands of Asia with the Western fringes and further beyond the entire continent of Europe. Evidences of the history of humankind, ranging from Pre-historic times to the spread of Buddhism from South Asia to China and the Far East, is depicted in the rocky cliffs on the waysides and on rough boulders scattered in the upper valley of the Indus River and its tributaries. The ancient trade routes also carried scholars, teachers, missionaries and monks of different beliefs and practices, who met and exchanged ideas. The Buddhists as well as Zoroastrians and other missionaries all followed the Silk Route, leaving permanent footprints of their passage. The ancient greater Gandhara is situated in the North-West of the Indian Sub-continent, with the steep mountain ranges of the Karakoram, the Pamir and the Hindu-Kush bordering it and the dry areas of Central Asia to its rear. A number of races from Central Asia migrated to Gandhara because of its mild climate and plentiful farm products and fruits. This area was an entry point of Western Culture into India and at the same times the exit point of Indian Culture, including Buddhism, to the West. In Gandhara, the diffusion of different cultures developed an art form, during the 1-7th centuries CE commonly known after its geographic name as "Gandhara Art". The Buddhism's route of introduction into China originated in Gandhara, then reached in Korea and Japan and other countries. The fame of Gandhara however, rested on its capital, "Taxila" which was a great centre of learning. From the time of the Achaemenians, down through Muslim period, Gandhara continued to establish and maintain a link between East & West, as shown by material evidences recovered from Taxila and other Buddhist centres of Gandhara during the course of archaeological excavations.