Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

Involvement of LHA on the modulation of NK cell activity induced by electroacupuncture

외측 시상하부 파괴가 전침 유도 자연살해세포 활성의 변조에 미치는 영향

  • Oh, Sang-Deog (Department of East-West Medicine, Graduate School, Kyung-Hee University) ;
  • Choi, Gi-Soon (Department of East-West Medicine, Graduate School, Kyung-Hee University) ;
  • Han, Jae-Bok (Department of East-West Medicine, Graduate School, Kyung-Hee University) ;
  • Bae, Hyun-Su (Department of Physiology, College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Young-Wuk (Department of Physiology, College of Medicine, Kyung-Hee University) ;
  • Yun, Yeon-Sook (Laboratory of Immunology, Korea Cancer Center Hospital) ;
  • Lee, Won-Kyu (Department of Anatomy, Gachon Medical College) ;
  • Ahn, Hyun-Jong (Department of Microbiology, College of Medicine, Kyung-Hee University) ;
  • Min, Byung-Il (Department of East-West Medicine, Graduate School, Kyung-Hee University)
  • 오상덕 (경희대학교 대학원 동서의학과) ;
  • 최기순 (경희대학교 대학원 동서의학과) ;
  • 한재복 (경희대학교 대학원 동서의학과) ;
  • 배현수 (경희대학교 한의과대학 생리학교실) ;
  • 조영욱 (경희대학교 의과대학 생리학교실) ;
  • 윤연숙 (원자력병원 면역학연구실) ;
  • 이원규 (가천의과대학 해부학교실) ;
  • 안현종 (경희대학교 의과대학 미생물학교실) ;
  • 민병일 (경희대학교 대학원 동서의학과)
  • Received : 2002.03.09
  • Accepted : 2002.03.15
  • Published : 2002.04.20
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Abstract

Some studies report that electroacupuncture(EA) boost natural killer cell(NK cell) activity. And also it is well known that hypothalamus is deeply related to effects of EA on analgesia. Some reports said that especially lateral hypothalamic area(LHA) is related to splenic NK cell activity. In order to investigate the relation between hypothalamus and effects of EA at ST36 point on NK cell activity of Spraque-Dawley rats. Lesions were made bilaterally at lateral hypothalamic area(LHA). And NK cytotoxities of normal and lesioned rats were measured with 51Cr release immunoassay after EA stimulation for 2 and 14 days. NK cell activity of EA group was significantly higher than sham group at 2nd, 14th day in normal rats. And LHA lesions abolished effects of EA on NK cell activity at 2nd day. But LHA lesions did not affect the effects of EA at 14th days. We also had an evidence that the decrease of NK cell activity was almost recoverd at 14th day. These results strongly suggest that LHA is deeply related to increase of NK cell activity induced by EA.

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