• Journal of Korean Medicine for Obesity Research
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• v.24 no.1
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• pp.87-93
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• 2024

Objectives: Obesity is a globally prevalent public health issue. Hence, there is a need for the development of safer and more effective anti-obesity drugs. Lythrum salicaria, a traditional medicinal herb used for centuries, has been reported to improve lipid metabolism and fat accumulation. It also has a low toxicity profile. Therefore, its potential as a functional ingredient in health functional foods needs to be evaluated. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 90 participants will be randomly assigned to either the experimental or control group. Each subject will orally receive L. salicaria extract (1,350 mg/day) (500 mg L. salicaria+850 mg lactose as vehicle) or lactose (1,350 mg/day) as a hard capsule formula for 84 days (12 weeks). The primary outcome will be body fat mass (kg), which will be assessed using dual-energy x-ray absorptiometry (DXA) (performed only at visits 2 and 4). Secondary outcomes include body mass index, body weight, waist-to-hip ratio, body fat percentage (%) measured using DXA, lean body mass (kg) measured using DXA (assessed only at visits 2 and 4), lipids (total cholesterol, triglyceride, high-density lipoprotein cholesterol, and calculated low-density lipoprotein cholesterol), free fatty acid, high sensitivity C-reactive protein, adiponectin, and leptin. Conclusions: This protocol will be implemented after approval of Institutional Review Board of Pusan National University Korean Medicine Hospital (approval number: PNUKHIRB-2022-08-002) and registration with the Korean National Clinical Research Information Service (CRIS) (CRIS-KCT0008060). The results of this trial will provide potential of L. salicaria as a new anti-obesity functional food with fat-reducing effects and low toxicity.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.10
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• pp.1477-1483
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• 2014

This study investigated the anti-obesity effects of African mango (Irvingia gabonesis, IGOB $131^{TM}$) extract in leptin-deficient obese mice. Experimental groups were treated with two different doses of IGOB $131^{TM}$ (1% and 2% in each AIN93G supplement) for 8 weeks. Treatment of obese mice with both low and high dose of IGOB $131^{TM}$ significantly reduced body weight gain by 10.9% and 13.3%, respectively, compared to control obese mice. Subcutaneous adipose tissue weight of mice was significantly reduced by 18% by low-dose and 23% by high-dose supplementation. This result was supported by micro-CT analysis around the abdominal regions of mice, indicating that the adipose tissue area and volume were significantly reduced by treatment with IGOB $131^{TM}$. Serum levels of triglycerides in the low- and high-dose groups were reduced by 36.5% and 43.8%, respectively, upon treatment with IGOB $131^{TM}$, whereas total cholesterol levels were reduced by 31.8% and 35.4%. Interestingly, the serum LDL level decreased upon treatment with IGOB $131^{TM}$ while the serum level of HDL dramatically increased upon high-dose treatment with IGOB $131^{TM}$, resulting in a significant reduction in the LDL to HDL ratio of 59.2%. These results were supported by the expression levels of enzymes and proteins related to lipid metabolism assessed by real-time PCR. There was a significant increase of in adiponectin expression as well as significant decreases in the expression of FAS, LPL, and lipid regulatory transcription factors such as PPAR-${\gamma}$, C/EBP, and SREBP upon both low- and high-dose IGOB $131^{TM}$ treatment. However, there was no statistical difference between low- and high-dose treatments. These results suggest that IGOB $131^{TM}$ is able to regulate the serum lipid profiles by reducing triglyceride and increasing HDL levels as well as regulate expression of lipid metabolic factors, resulting in reduction of a weight gain in leptin-deficient obese mice.

• Fisheries and Aquatic Sciences
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• v.8 no.2
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• pp.65-69
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• 2005

We evaluated the effects of the partial dietary replacement of fish meal with squid liver $Meal^{TM}$ on the growth and body composition of juvenile olive flounder Paralichthys olivaceus during the winter season. Twenty-five fish with an initial body weight of 23 g per tank were distributed among 12,250 L flow-through tanks. The experimental diets, which were designated SLM5, SLM1O, and SLM15 diets, were prepared in triplicate along with control diet by replacing 5, 10, and $15\%$ of mackerel fish meal with squid liver $Meal^{TM}$, respectively. The weight gain and specific growth rate of flounder that were fed the control and SLM5 diets did not differ from those of the fish fed the SLM10 diet, but they were significantly (P<0.05) higher than those of the fish fed the SLM15 diet. The feed efficiency ratios for the flounder that were fed the control, SLM5 and SLM10 diets were significantly (P<0.05) higher than for the fish that were fed the SLM15 diet. However, the protein efficiency ratio for the flounder was not significantly affected by the experimental diets. The crude protein, crude lipid and ash content, and blood chemistry of the flounder were not significantly affected by the experimental diets. Therefore, the replacement of up to $10\%$ of dietary fish meal with squid liver $Meal^{TM}$ can be made without a reduction in growth or a deterioration of the feed efficiency of juvenile olive flounder during the winter season.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.48 no.6
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• pp.465-468
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• 2003

In order to find out the basic information for salt tolerance in vice (Oryza sativa L.), effects of NaCl treatment on absorption of inorganic components and growth were investigated in 6 japonica and 5 tongil varieties and compared to the salt tolerance variety, Annapurna. The absorption of N and $\textrm{P}_2\textrm{O}_5$ was less repressed than that of $\textrm{K}_2\textrm{O}$, MgO, CaO, and $\textrm{Si}\textrm{O}_2$ which were a little affected by NaCl treatment. $\textrm{K}_2\textrm{O}$ was the most highly repressed component in the absorption of inorganic components, followed by MgO, CaO, total-N, $\textrm{P}_2\textrm{O}_5$ and $\textrm{Si}\textrm{O}_2$. $\textrm{Na}_2\textrm{O}$ content was increased about twenty times to the control at 30days after NaCl treatment, and tonsil varieties more than absorbed japonica ones. Dry weight of japonica varieties by NaCl treatment was less reduced than that of tonsil varieties, followed by Seomjinbyeo, Sinseonchalbyeo, Nakdongbyeo, Daechoungbyeo, Dongjinbyeo and Chuchoungbyeo in japonica group, and Milyang30, Gayeabyeo, Jangseongbyeo, Chilseongbyeo and Taebackbyeo in tonsil group. The relationship between dry weight reduction and Na/K ratio showed positively significant correlation in rice.

• Journal of Korean Foot and Ankle Society
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• v.5 no.2
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• pp.112-119
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• 2001

Purpose: The purpose of this study is to analyze the clinical prognostic factors which may affect the postoperative clinical results of the unstable ankle fractures. Materials and Methods: This study is based on 62 unstable ankle fractures treated by open reduction and internal fixation from May 1994 to June 2000, with a minimum follow-up period of 12 months(range: 13 months-7 years 3 months). The 62 patients were average 39.1 years old with male: female ratio of 41:21. Based on Lauge-Hansen classification, the supination-external rotation type was the most common with 36 (58.1%) cases. The clinical results was assessed by American Orthopaedic Foot and Ankle Society(AOFAS) functional scale. The sex, age, body weight, trauma-operation interval, operation time, cause of injury, fracture type were statistically analyzed as the possible postoperative clinical prognostic factors. Results: Postoperative AOFAS functional scale was average 82.1 points with 22(35.5 %) cases excellent, 12(19.4%) good. 16(25.8%) fair and 12(19.4%) cases poor results. The age and the operation time were found to be statistically significant factors affecting the prognosis(p<0.001). The sex, weight, trauma-operation interval factors did not significantly affect the clinical results. The pronation-external rotation type showed better clinical tendency among the fracture types, but without the statistical significance. Conclusion: The surgically treated unstable ankle fractures in patients whose age was above 41 years old or operation time exceeding 90 minutes showed significantly poor clinical results.

• Journal of Korean Society of Steel Construction
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• v.24 no.6
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• pp.671-682
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• 2012

The use of sinusoidal corrugated web girder for the box-type girders and gable steel main frames has recently been increasing very much. The reasons are that the thin web of the girder affords a significant weight reduction compared with rolled beam and welded built-up girder, and that corrugation prevents the buckling failure of the web. Improvements of the automatic fabrication process makes mass production of the corrugated web and unit possible, and applications of this girder have been extended considerably. Thus, the research for the optimum design processer considering the production data is needed practically. For doing this research, we develope the discrete optimum structural design program in consideration of production list data for the research, and the program apply to the single girder under the uniform load and the concentrated load as numerical example. We consider objective function as minimum weight of the girder, and use slenderness ratio, stress of flanges and corrugated web, and the girder deflection as the constraint functions. And also the Genetic Algorithms is adopted to search the global minimum point by using the production list as a discrete design variable. Finally, to verify the optimality of the design, we conduct a comparison of the results of the discrete optimum design with those of the continuous one, and also analyze the characteristics of the optimum cross-section.

• Resources Recycling
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• v.9 no.1
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• pp.36-43
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• 2000

This study was carried out for treatment and reuse of inorganic sludge from Fenton process at B dyeing wastewater treatment plant. The parameters for pilot-scale treatment system were derived from the results of this study. It was found that $COD_{cl}$ of the treated effluent became lower than 100 mg/l approximately on the optimal reaction condition. 2nd sludge which was generated after redissolving sludge was analyzed, and it showed that reduction ratio of ash in 2nd sludge and total dry sludge weight in comparison with current sludge were 85% and 65%. Also Fe salt in sludge was redissolved about 90~95% of initial Fe by weight. It was estimated almost ￦350,000,000 for sludge reuse process. It was estimated saving of about ￦1,300,000 per day (￦420,000,000 per year) in operating cost based on 30,000 $m^3$/d treatment, which these were about ￦430,000 per day in chemical, ￦1,100,000 per day in sludge transportation and ￦200,000 per day in equipment maintenance. Payback period with interest charge for investment cost was estimated about 10.5 months. Also, net present value (NPV) was ￦792,000,000 and internal rat of return (IRR) was about 110%.

• Korean Journal of Environmental Agriculture
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• v.31 no.3
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• pp.229-234
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• 2012

BACKGROUND: The fruit quality and flowering characteristics of Kiwifruit (A. deliciosa cv. Hayward) in the following year is known to be affected by the extent and timing of defoliation of the current year. In korea, the production of kiwi, which is a perennial, straggling deciduous warm-temperate fruit, is often restricted by wind damage due to typhoons resulting to defoliation at the middle season of its growing period. In this paper, we report the effect of the different timing of defoliation and severities at the current season to the kiwifruit quality. METHODS AND RESULTS: Twenty seven-year-old 'Hayward' trees grown under polyethylene film rain-shelter were defoliated in different days from August to September at seven day-intervals. In each day, 0, 25, 50, 75 and 100% of leaves were removed from the trees. Fruits from each treatment were classified into four floating types (L: lying in bottom, S: standing on bottom, F: floating and SF: floating at the surface of water) by submerging them into tap water. Defoliation of kiwifruit trees in August and September caused air holes in locules of inner pericarp. Increased number of air hole in locules of a fruit was observed in floating types F and SF, and most of the air holes were located in stem end. The defoliation of trees in August significantly reduced the ratio of L-floating type fruits, which have the least number of locule air holes. The extent of defoliation also affected the distribution of the four types, the more leaves removed, the less L-floating type fruits harvested. The weight of fruits from trees defoliated in August was lower than that of fruits from September. Soluble solids content decreased as the number of locule air holes increased. Negative correlations were observed between the extent of defoliation and the weight and soluble solids content of fruits. CONCLUSION: Early defoliation effect on kiwifruit locule air hole occurrence and fruit quality were more severe in August than in September. And also if the defoliation severity is over 25%, severe fruit quality reduction expected to happen due to increase of fruit locule air hole in the inner pericarp.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.12
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• pp.1702-1710
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• 2017

Objective: The study examined the effect of condensed tannins (CT) containing Ficus infectoria and Psidium guajava leaf meal mixture (LMM) supplementation on nutrient metabolism, methane emission and performance of lambs. Methods: Twenty four lambs of ~6 months age (average body weight $10.1{\pm}0.60kg$) were randomly divided into 4 dietary treatments (CT-0, CT-1, CT-1.5, and CT-2 containing 0, 1.0, 1.5, and 2.0 percent CT through LMM, respectively) consisting of 6 lambs each in a completely randomized design. All the lambs were offered a basal diet of wheat straw ad libitum, oat hay (100 g/d) along with required amount of concentrate mixture to meet their nutrient requirements for a period of 6 months. After 3 months of experimental feeding, a metabolism trial of 6 days duration was conducted on all 24 lambs to determine nutrient digestibility and nitrogen balance. Urinary excretion of purine derivatives and microbial protein synthesis were determined using high performance liquid chromatography. Respiration chamber study was started at the mid of 5th month of experimental feeding trial. Whole energy balance trials were conducted on individual lamb one after the other, in an open circuit respiration calorimeter. Results: Intake of dry matter and organic matter (g/d) was significantly (p<0.05) higher in CT-1.5 than control. Digestibility of various nutrients did not differ irrespective of treatments. Nitrogen retention and microbial nitrogen synthesis (g/d) was significantly (p<0.01) higher in CT-1.5 and CT-2 groups relative to CT-0.Total body weight gain (kg) and average daily gain (g) were significantly (linear, p<0.01) higher in CT-1.5 followed by CT-1 and CT-0, respectively. Feed conversion ratio (FCR) by lambs was significantly (linear, p<0.01) better in CT-1.5 followed by CT-2 and CT-0, respectively. Total wool yield (g; g/d) was linearly (p<0.05) higher for CT-1.5 than CT-0. Methane emission was linearly decreased (p<0.05) in CT groups and reduction was highest (p<0.01) in CT-2 followed by CT-1.5 and CT-1. Methane energy (kcal/d) was linearly decreased (p<0.05) in CT groups. Conclusion: The CT supplementation at 1% to 2% of the diet through Ficus infectoria and Psidium guajava LMM significantly improved nitrogen metabolism, growth performance, wool yield, FCR and reduced methane emission by lambs.

• Journal of the Korea Concrete Institute
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• v.27 no.6
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• pp.651-659
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• 2015

Currently, social demands for long span building structures are increasing due to architectural planning purposes and economic efficiency. As a result, lighter board-type voiding materials were suggested. With the use of board-type voiding materials, a slab is able to become light weight and convenient. This process efficiently eliminates concrete where it is not required; considerably diminishing dead weight while maintaining the flexural strength of the slab. The reduction in concrete also allows for overall cost reductions and design flexibility. Also it can be ease with fixing the voided material that is composed of one body form. Although board-type voiding materials are ideal, the top and bottom concrete plates lack integrity. Because of this, test results show horizontal cracking towards the tops and bottoms of the concrete columns, or webs, connecting the slabs. The key to correcting this problem is to increase the shear strength. In order to increase the shear strength of the structure, horizontal shear area must increase. R70(100)-D-F has the largest horizontal shear area as it also shows stronger strength. As a result, shear strength ($V_{nh}$) is dependent on the horizontal shear area (N). $V_{nh}={\alpha}{\times}0.16{\sqrt{f_{ck}}}{\frac{{\pi}D^2}{4}}{\times}N({\alpha}=1.8125)$. The web columns have a shear span to depth ratio (a/d) that is less than 2; which classifies it as a deep beam. In this case, however, the shear strength of the deep beams may be as much as 2 to 3 times greater than that predicated conventional equations developed for members of normal proportions. As a result, ${\alpha}$ is suggested as an extra coefficient in the equation for shear strength ($V_{nh}$).