• 대한수학회논문집
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• 제39권1호
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• pp.59-69
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• 2024

Let R be a commutative ring. An R-module E is said to be regular injective provided that Ext¹_R(R/I, E) = 0 for any regular ideal I of R. We first show that the class of regular injective modules have the hereditary property, and then introduce and study the regular injective dimension of modules and regular global dimension of rings. Finally, we give some homological characterizations of total rings of quotients and Dedekind rings.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.555-564
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• 2021

We investigated the effects of naringenin and morin on IL-5 and ROS production in PMA+ionomycin-treated EL-4 cells with the corroboration of their antioxidant and anti-inflammatory properties using an asthma-induced mouse model. The EL-4 cell line was used to study the outcomes of naringenin or morin, followed by cell viability studies. Western blot analysis and ELISA test were used to determine Th2 mediated cytokines. In vivo studies were carried out on BALB/c mice to induce allergic asthma using ovalbumin administered intraperitoneally. Intracellular ROS was determined using 2',7'-dichlorodihydrofluorescein diacetate, followed by serum enzymatic (AST and ALT) estimations and inflammatory cell count in the bronchoalveolar lavage fluid (BALF) and lung tissues. Histopathological studies were conducted to examine lung tissue-stained architecture. Our findings suggested that naringenin and morin significantly suppressed IL-5 and ROS production via various pathways. Interestingly, by reducing NFAT activity, naringenin and morin stimulated HO-1 expression, thereby suppressing IL-5 secretion due to regulating the transcription factor Nrf2 via P13/Akt or ERK/JNK signalling pathways in EL-4 cells, demonstrating the involvement of HO-1 expression in inhibiting asthmatic inflammation. The increased inflammatory cells in the BALF were substantially decreased by both naringenin and morin, followed by inhibition in the elevated Th-2 cytokines levels. The TNF-α protein levels in an allergic asthma mouse model were significantly reduced by suppressing Akt phosphorylation and eosinophil formation. Recent findings confirmed that naringenin and morin possess the potential to control asthma-related immune responses through antioxidant and anti-inflammatory properties, indicating potential therapeutic agents or functional foods.

• 동의신경정신과학회지
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• 제13권1호
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• pp.133-141
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• 2002

본 증례는 광장공포증 환자를 한방정신요법인 이정변기요법(移精變氣療法), 경자평지요법(驚者平之療法), 지언고론요법(至言高論療法) 등으로 약 8주간 치료한 예이다 .내원당시 환자는 혼자 외출할 수 없었으나, 치료받으면서 증상이 점차 호전되어, 대중교통수단 등도 이용하여 외출할 수 있게 되었다. 본 저자는 한방정신요법의 체계적인 적용이 광장공포증 환자의 증세를 호전시켰기에 보고하는 바이다.

• 대한한의학회지
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• 제30권6호
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• pp.53-68
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• 2009

Objectives: This study demonstrates the neurological effects of Bojungikki-tang and Bojungikki-tang-gamibang on the focal cerebral ischemia of rats with ischemic damage caused by middle cerebral artery occlusion (MCAO). Methods: Rats were treated with Bojungikki-tang and Bojungikki-tang-gamibang extracts for about five days after MCAO, and the size and volume of cerebral infarction and the ratio of cerebral edema were observed. From the immunohistochemical view, significant changes of outbreak of Bax, Bcl-2, c-Fos, HSP72, and iNOS were observed in the brain tissues. Results: Bojungikki-tang repressed only brain edema and iNOS revelation led by focal cerebral ischemia, when considering significance. In contrast, Bojungikki-tang-gamibang demonstrated significant suppression of cerebral infarction, brain edema, Bax, c-Fos, HSP72, and iNOS induced by focal cerebral ischemia. Conclusions: Bojungikki-tang is considered functional treatment for cerebral ischemic damage; it can be effective to relieve secondary brain edema and immune response. Bojungikki-tang-gamibang can have a direct function to alleviate brain infarct and to control the natural death of nerve cells which cerebral ischemic damage brings about.

• 대한한의학원전학회지
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• 제28권4호
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• pp.57-63
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• 2015

Objectives : Through the analysis of the harmonization(和) thought in Traditional Chinese culture, and then excavate the theory and application of Harmonization Method(和法) in Huang Di Nei Jing(黃帝內經) and Shanghan Zabing Lun(傷寒雜病論). Methods : We find the harmonization(和) means harmony and neutral in traditional Chinese culture, including the harmony of society, the harmony of the mind and the body, and so on. Results : Huang Di Nei Jing(黃帝內經) emphasized the health status is moderate, the disease state is unbalance, preserving our health should keep the yin-yang equilibrium, treating disease should reestablish the equilibrium status, which establish the foundation of the theory of Harmonization Method(和法). Shanghan Zabing Lun(傷寒雜病論) created the methods of settlement and harmony, which is a precedent for the wide application of Harmonization Method(和法) for future generations, including to reconcile the interior-exterior and yin-yang, to harmony the ying-wei and qi-blood, to reconcile the activities of qi of internal organs. Conclusions : The harmonization(和) is the ideological foundation of the theory system of TCM and the Harmonization Method(和法). The Harmonization Method(和法) is an important treatment method for clinical practice of Traditional Chinese Medicine.

• Structural Engineering and Mechanics
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• 제45권3호
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• pp.337-354
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• 2013

For shield TBM (Tunnel Boring Machine) tunnel lining, the segment joint is the most critical component for determining the mechanical response of the complete lining ring. To investigate the mechanical behavior of the segment joint in a water conveyance tunnel, which is different from the vehicle tunnel because of the external loads and the high internal water pressure during the tunnel's service life, full-scale joint tests were conducted. The main advantage of the joint tests over previous ones was the definiteness of the loads applied to the joints using a unique testing facility and the acquisition of the mechanical behavior of actual joints. Furthermore, based on the test results and the theoretical analysis, a mechanical model of segment joints has been proposed, which consists of all important influencing factors, including the elastic-plastic behavior of concrete, the pre-tightening force of the bolts and the deformations of all joint components, i.e., concrete blocks, bolts and cast iron panels. Finally, the proposed mechanical model of segment joints has been verified by the aforementioned full-scale joint tests.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.355-358
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• 2013

XRCC1 genetic polymorphisms could be associated with increased risk of various cancer, including hepatocellular carcinoma (HCC), the fifth most common cancer. We here conducted a study to explore the role of selective SNPs of the XRCC1 and XPD genes in the prognosis of HCC. A total of 231 cases were collected, and genotyping of XRCC1 Arg194Trp, XRCC1 Arg399Gln, XPD Lys751Gln and XPD Asp312Asn was performed by duplex polymerase-chain-reaction with the confronting-two-pair primer method. Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes. The Cox's regression analysis showed individuals carrying XRCC1 399Trp/Trp genotype had 0.55 fold risk of death from HCC than Arg/Arg genotype. Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34. These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in the prognosis of HCC.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5631-5635
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• 2013

Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini-review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death. Potential protectants, such as amifostine, N-acetylcysteine (NAC) and epicatechin (EC), are claimed to be effective at reducing radiation-inducedhair cell death. The RT dosage, selection and application of concurrent chemotherapy should be pre-examined in order to minimize the damage to cochlea hair cells.

• BMB Reports
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• 제44권1호
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• pp.70-75
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• 2011

Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). Several lines of evidence indicate that NOLC1 plays an important role in the synthesis of rRNA and the biosynthesis of ribosomes. In the present study, we examined the transcriptional regulation mechanisms that govern the expression of NOLC1. We first performed functional dissection of the NOLC1 promoter. We demonstrated that transcription factors NF-${\kappa}B$ and CREB could bind to the minimal NOLC1 promoter. This was demonstrated by electrophoretic mobility shift assays and chromatin immunoprecipitation. Mutagenesis and overexpression assays revealed that NF-${\kappa}B$ and CREB positively regulated the NOLC1 promoter. These findings may provide new insight into the mechanisms that regulate NOLC1 expression.

• Smart Structures and Systems
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• 제28권6호
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• pp.811-825
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• 2021

High-voltage isolating switches play a paramount role in ensuring the safety of power supply systems. However, their exposure to outdoor environmental conditions may cause serious physical defects, which may result in great risk to power supply systems and society. Image processing-based methods have been used for anomaly detection. However, their accuracy is affected by numerous uncertainties due to manually extracted features, which makes the anomaly detection of isolating switches still challenging. In this paper, a vision-based anomaly detection method for isolating switches, which uses the rotational angle of the switch system for more accurate and direct anomaly detection with the help of deep learning (DL) and image processing methods (Single Shot Multibox Detector (SSD), improved frame differencing method, and Hough transform), is proposed. The SSD is a deep learning method for object classification and localization. In addition, an improved frame differencing method is introduced for better feature extraction and a hough transform method is adopted for rotational angle calculation. A number of experiments are conducted for anomaly detection of single and multiple switches using video frames. The results of the experiments demonstrate that the SSD outperforms the You-Only-Look-Once network. The effectiveness and robustness of the proposed method have been proven under various conditions, such as different illumination and camera locations using 96 videos from the experiments.