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http://dx.doi.org/10.7314/APJCP.2013.14.1.355

Implication of Polymorphisms in DNA Repair Genes in Prognosis of Hepatocellular Carcinoma  

Yue, Ai-Min (Department of Surgical Oncology, Xinxiang Central Hospital)
Xie, Zhen-Bin (Department of Surgical Oncology, Xinxiang Central Hospital)
Guo, Shu-Ping (Department of Surgical Oncology, Xinxiang Central Hospital)
Wei, Qi-Dong (Department of Surgical Oncology, Xinxiang Central Hospital)
Yang, Xiao-Wei (Department of Surgical Oncology, Xinxiang Central Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.1, 2013 , pp. 355-358 More about this Journal
Abstract
XRCC1 genetic polymorphisms could be associated with increased risk of various cancer, including hepatocellular carcinoma (HCC), the fifth most common cancer. We here conducted a study to explore the role of selective SNPs of the XRCC1 and XPD genes in the prognosis of HCC. A total of 231 cases were collected, and genotyping of XRCC1 Arg194Trp, XRCC1 Arg399Gln, XPD Lys751Gln and XPD Asp312Asn was performed by duplex polymerase-chain-reaction with the confronting-two-pair primer method. Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes. The Cox's regression analysis showed individuals carrying XRCC1 399Trp/Trp genotype had 0.55 fold risk of death from HCC than Arg/Arg genotype. Similarly, XPD 751Gln/Gln had a strong decreasein comparison to XPD Lys/Lys carriers with an HR of 0.34. These results suggest that polymorphisms in XRCC1 and XPD may have functional significance in the prognosis of HCC.
Keywords
XRCC1; XPD; polymorphism; hepatocellular carcinoma; prognosis;
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