• The Korean Journal of Pharmacology
• /
• v.21 no.2
• /
• pp.128-141
• /
• 1985

To investigate the influence of phenobarbital sodium on the action of morphine and on the diurnal rhythms of both opiate receptor binding and ${\beta}-endorphin$ contents, the amount of specifically bound $(^3H)$-morphine and immunoreactive ${\beta}-endorphin$ were measured in the midbrain of phenobarbital-treated rats at 4h intervals in a day. Rats were housed and adapted to a controlled cycle of either 12 h light-12 h dark or 24 h constant dark. After 3 weeks of adaptation, 0.5 ml of physiological saline or phenobarbital sodium (20mg/kg/day, i.p.) were administered twice a day for 2 weeks. Highly significant diurnal rhythms of opiate receptor binding and ${\beta}-endorphin$ were present in rat midbrain. In control group, the peak of maximum $(^3H)$-morphine binding was observed at 22:00 h, whereas the peak of ${\beta}-endorphin$ content was found at 06:00 h. Even in the absence of time cues these diurnal rhythms persisted, but they were highly modified with respect to the wave form as well as differences in the timing of peak and nadir. In the phenobarbital-treated group, these diurnal rhythms were also modified in shape, phase and amplitude, as well as in timing of peak and nadir. In this group, 24 h mean of opiate receptor binding was significantly decreased, while the 24 h mean level of ${\beta}-endorphin$ content was highly increased. However, Kd values in all experimental groups did not change. This indicates that differences in binding were not due to changes in the affinity, but in the number of binding sites. Statistical analysis of regression line indicates that changes of receptor binding were closely correlated with the changes of ${\beta}-endorphin$ content. These results suggest that phenobarbital may influence the action of morphine by changing the number of opiate receptors and that the modification of diurnal rhythm of opiate receptor by the agent is possibly due to changes of ${\beta}-endorphin$ content.

• Korean Journal of Agricultural and Forest Meteorology
• /
• v.21 no.4
• /
• pp.327-336
• /
• 2019

Soybean is one of the most important crops of which the grains contain high protein content and has been consumed in various forms of food. Soybean plants are generally cultivated on the field and their yield and quality are strongly affected by climate change. Recently, the abnormal climate conditions, including heat wave and heavy rainfall, frequently occurs which would increase the risk of the farm management. The real-time assessment techniques for quality and growth of soybean would reduce the losses of the crop in terms of quantity and quality. The objective of this work was to develop a simple model to estimate the growth of soybean plant using a multispectral sensor mounted on a rotor-wing unmanned aerial vehicle(UAV). The soybean growth model was developed by using simple linear regression analysis with three phenotypic data (fresh weight, dry weight, leaf area index) and two types of vegetation indices (VIs). It was found that the accuracy and precision of LAI model using GNDVI (R²= 0.789, RMSE=0.73 ㎡/㎡, RE=34.91%) was greater than those of the model using NDVI (R²= 0.587, RMSE=1.01 ㎡/㎡, RE=48.98%). The accuracy and precision based on the simple ratio indices were better than those based on the normalized vegetation indices, such as RRVI (R²= 0.760, RMSE=0.78 ㎡/㎡, RE=37.26%) and GRVI (R²= 0.828, RMSE=0.66 ㎡/㎡, RE=31.59%). The outcome of this study could aid the production of soybeans with high and uniform quality when a variable rate fertilization system is introduced to cope with the adverse climate conditions.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2003.05a
• /
• pp.91-93
• /
• 2003

A comprehensive numerical study is carried out to investigate for the understanding of the flow evolution and flame development in a supersonic combustor with normal injection of ncumally injecting hydrogen in airsupersonic flows. The formulation treats the complete conservation equations of mass, momentum, energy, and species concentration for a multi-component chemically reacting system. For the numerical simulation of supersonic combustion, multi-species Navier-Stokes equations and detailed chemistry of H2-Air is considered. It also accommodates a finite-rate chemical kinetics mechanism of hydrogen-air combustion GRI-Mech. 2.11[1], which consists of nine species and twenty-five reaction steps. Turbulence closure is achieved by means of a k-two-equation model (2). The governing equations are spatially discretized using a finite-volume approach, and temporally integrated by means of a second-order accurate implicit scheme (3-5).The supersonic combustor consists of a flat channel of 10 cm height and a fuel-injection slit of 0.1 cm width located at 10 cm downstream of the inlet. A cavity of 5 cm height and 20 cm width is installed at 15 cm downstream of the injection slit. A total of 936160 grids are used for the main-combustor flow passage, and 159161 grids for the cavity. The grids are clustered in the flow direction near the fuel injector and cavity, as well as in the vertical direction near the bottom wall. The no-slip and adiabatic conditions are assumed throughout the entire wall boundary. As a specific example, the inflow Mach number is assumed to be 3, and the temperature and pressure are 600 K and 0.1 MPa, respectively. Gaseous hydrogen at a temperature of 151.5 K is injected normal to the wall from a choked injector.A series of calculations were carried out by varying the fuel injection pressure from 0.5 to 1.5MPa. This amounts to changing the fuel mass flow rate or the overall equivalence ratio for different operating regimes. Figure 1 shows the instantaneous temperature fields in the supersonic combustor at four different conditions. The dark blue region represents the hot burned gases. At the fuel injection pressure of 0.5 MPa, the flame is stably anchored, but the flow field exhibits a high-amplitude oscillation. At the fuel injection pressure of 1.0 MPa, the Mach reflection occurs ahead of the injector. The interaction between the incoming air and the injection flow becomes much more complex, and the fuel/air mixing is strongly enhanced. The Mach reflection oscillates and results in a strong fluctuation in the combustor wall pressure. At the fuel injection pressure of 1.5MPa, the flow inside the combustor becomes nearly choked and the Mach reflection is displaced forward. The leading shock wave moves slowly toward the inlet, and eventually causes the combustor-upstart due to the thermal choking. The cavity appears to play a secondary role in driving the flow unsteadiness, in spite of its influence on the fuel/air mixing and flame evolution. Further investigation is necessary on this issue. The present study features detailed resolution of the flow and flame dynamics in the combustor, which was not typically available in most of the previous works. In particular, the oscillatory flow characteristics are captured at a scale sufficient to identify the underlying physical mechanisms. Much of the flow unsteadiness is not related to the cavity, but rather to the intrinsic unsteadiness in the flowfield, as also shown experimentally by Ben-Yakar et al. [6], The interactions between the unsteady flow and flame evolution may cause a large excursion of flow oscillation. The work appears to be the first of its kind in the numerical study of combustion oscillations in a supersonic combustor, although a similar phenomenon was previously reported experimentally. A more comprehensive discussion will be given in the final paper presented at the colloquium.

• 한국노년학
• /
• v.38 no.3
• /
• pp.645-666
• /
• 2018

The purpose of this study is to investigate the characteristics of the elderly with disability focused on comparison between aging with disability and disability with aging in Korea. Disability in older age has been related to several psychosocial characteristics, including social support, self-esteem, life satisfaction and depression. However, the exact role of these characteristics in the disablement process remains uncertain and this study focused on comparison between aging with disability and disability with aging in Korea. This study analyzed the 12th wave (2017) KWPS(Korean Welfare Panel Study)and Disability Study which included 692 elderly with disability aged 65 and over. The data were processed by SEM and multi-group SEM analysis. The findings were as follows; First, family support and the significant others support showed direct effects on the life satisfaction of the elderly with disability. Second, family support and the significant others support reduced the level of depression and enhanced self-esteem and finally impact on the life satisfaction of the elderly with disability. The formal support enhanced the depression and reduced self-esteem and eventually reduced the life satisfaction. Third, the disability with aging group showed more higher perception and more experience of formal support and formal service and more higher depression than the aging with disability group. Forth, the significant others support on life satisfaction only showed significance in disability with aging group and depression had significance in disability with aging group. Finally, aging with disability group showed positive effects on the formal support of life satisfaction but showed negative effects on the depression and self-esteem. Based on these findings, practical implications of future directions for research are discussed.

• Sleep Medicine and Psychophysiology
• /
• v.26 no.1
• /
• pp.44-48
• /
• 2019

Objectives: Insomnia is one of the most prevalent sleep disorders. Recent studies suggest that cognitive and physical arousal play an important role in the generation of primary insomnia. Studies have also shown that information processing disorders due to cortical hyperactivity might interfere with normal sleep onset and sleep continuity. Therefore, focusing on central nervous system arousal and normalizing the information process have become current topics of interest. It has been well known that neurofeedback can reduce the brain hyperarousal by modulating patients' brain waves during a sequence of behavior therapy. The purpose of this study was to investigate effects of neurofeedback therapy on electroencephalography (EEG) characteristics in patients with primary insomnia. Methods: Thirteen subjects who met the criteria for an insomnia diagnosis and 14 control subjects who were matched on sex and age were included. Neurofeedback and sham treatments were performed in a random order for 30 minutes, respectively. EEG spectral power analyses were performed to quantify effects of the neurofeedback therapy on brain wave forms. Results: In patients with primary insomnia, relative spectral theta and sigma power during a therapeutic neurofeedback session were significantly lower than during a sham session ($13.9{\pm}2.6$ vs. $12.2{\pm}3.8$ and $3.6{\pm}0.9$ vs. $3.2{\pm}1.0$ in %, respectively; p < 0.05). There were no statistically significant changes in other EEG spectral bands. Conclusion: For the first time in Korea, EEG spectral power in the theta band was found to increase when a neurofeedback session was applied to patients with insomnia. This outcome might provide some insight into new interventions for improving sleep onset. However, the treatment response of insomniacs was not precisely evaluated due to limitations of the current pilot study, which requires follow-up studies with larger samples in the future.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.31 no.3
• /
• pp.101-114
• /
• 2019

In this study, we carry out the numerical simulation to trace the yearly shoreline change of Mang-Bang beach, which is suffering from erosion problem. We obtain the basic equation (One Line Model for shoreline) for the numerical simulation by assuming that the amount of shoreline retreat or advance is balanced by the net influx of longshore and cross-shore sediment into the unit discretized shoreline segment. In doing so, the energy flux model for the longshore sediment transport rate is also evoked. For the case of cross sediment transport, the modified Bailard's model (1981) by Cho and Kim (2019) is utilized. At each time step of the numerical simulation, we adjust a closure depth according to pertinent wave conditions based on the Hallermeier's analytical model (1978) having its roots on the Shield's parameter. Numerical results show that from 2017.4.26 to 2017.10.15 during which swells are prevailing, a shoreline advances due to the sustained supply of cross-shore sediment. It is also shown that a shoreline temporarily retreats due to the erosion by the yearly highest waves sequentially occurring from mid-October to the end of October, and is followed by gradual recovery of shoreline as high waves subdue and swells prevail. It is worth mentioning that great yearly circulation of shoreline completes when a shoreline retreats due to the erosion by the higher waves occurring from mid-March to the end of March. The great yearly circulation of shoreline mentioned above can also be found in the measured locations of shoreline on 2017.4.5, 2017.9.7, 2017.11.7, 2018.3.14. However, numerically simulated amount of shoreline retreat or advance is more significant than the physically measured one, and it should be noted that these discrepancies become more substantial for the case of RUN II where a closure depth is sustained to be as in the most morphology models like the Genesis (Hanson and Kraus, 1989).

• Journal of the Korean Institute of Landscape Architecture
• /
• v.47 no.5
• /
• pp.66-77
• /
• 2019

This study investigated the feasibility of wintering evergreen broad-leaf trees in the Incheon coastal area through a climate analysis. The coldest monthly mean air temperature ranged from $-2.9^{\circ}C{\sim}-1.6^{\circ}C$. The warmth index of the coastal area of Incheon ranged from $98.89^{\circ}C{\cdot}month-109.03^{\circ}C{\cdot}month$, while the minimum air temperature year ranged from $-13.9^{\circ}C{\sim}-3.6^{\circ}C$. This proved that the Incheon coastal area was not suitable for evergreen broad-leaf trees to grow as the warmth index ranges from $101.0^{\circ}C{\cdot}month{\sim}117.0^{\circ}C{\cdot}month$, and the temperature year-round is $-9.2^{\circ}C$ or higher. This suggests the coastal areas of Incheon is not suitable for the growth of evergreen broad-leaf trees, however some evergreen broad-leaf trees lived in some parts of the area. Wind speed reduction and temperature effect simulations were done using Landschaftsanalyse mit GIS program. As a result of the simulations of wind speed reduction and temperature effects affecting the evergreen broad-leaf trees, it was discovered that a coastal wind velocity of 8.6m/sec was alleviated to be 5m/sec~7m/sec when the wind reached the areas where evergreen broad-leaf trees were present. It was also discovered that species that grew in contact with buildings benefited from a temperature increase of $1.1^{\circ}C{\sim}3.4^{\circ}C$ due to the radiant heat released by the building. Simulation results show that the weather factors affecting the winter growth damages of evergreen broad-leaved trees were wind speed reduction and local warming due to buildings. The wind speed reduction by shielding and local warming effects by buildings have enabled the wintering of evergreen broad-leaved trees. Also, evergreen broad-leaved trees growing in the coastal area of Incheon could be judged to be gradually adapting to low temperatures in winter. This study reached the conclusion that the blockage of wind, and the proximity of buildings, are required for successfully wintering evergreen broad-leaf trees in the coastal area of Incheon.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.50 no.1
• /
• pp.68-77
• /
• 2022

The human thermal environment in an apartment complex located in Seoul was quantitatively analyzed to devise methods to modify human heat-related stresses in landscape and urban planning. Microclimatic data (air temperature, relative humidity, wind speed, and short- and long-wave radiation) were collected at 6 locations [Apt-center, roof (cement), roof (grass), ground, playground, and a tree-lined road] in the late spring and summer, and the data were used to estimate the human thermal sensation, physiological equivalent temperature (PET) and universal thermal climate index (UTCI). As a result, the playground location had the highest thermal environment, and the roof (grass) location had the lowest. The mean difference between the two locations was 0.8-1.1℃ in air temperature, 1.8-4.0% in relative humidity, and 7.5-8.0℃ in mean radiant temperature. In open space locations, the wind speed was 0.4-0.5 ms-1 higher than others. Also, a wind tunnel effect happened at the Apt-center location during the afternoon. For the human thermal sensation, PET and UTCI, the mean differences between the playground and roof (grass) locations were: 5.2℃ (Max. 11.7℃) in late spring and 5.4℃ (Max. 18.1℃) in summer in PET; and 3.0℃ (Max. 6.1℃) in late spring and 2.6℃ (Max. 9.8℃) in summer in UTCI. The mean differences indicated a level change in PET and 1/2 level in UTCI, and the maximum differences showed greater changes, 2-3 levels in PET, and 1-1.5 levels in UTCI. Moreover, the roof (grass) location gave 4.6℃ PET reduction and a 2.5℃ UTCI reduction in late spring, and a 4.4℃ PET reduction and a 2.0℃ UTCI reduction in the summer when compared with the roof (cement) location, which results in a 2/3 level change in PET and a 1/3 level in UTCI. Green infrastructure locations [roof (grass), ground, and a tree-lined road] were not statistically significant in the reduction of PET and UTCI in thermal environment modifying effects. The implementation of green infrastructure, such as rooftop gardens, grass pavement, and street tree planting, should be adopted in landscape planning and be employed for human thermal environment modification.

• Journal of Korea Entertainment Industry Association
• /
• v.14 no.3
• /
• pp.191-200
• /
• 2020

Companies are seeking to maximize profits through exports and imports in the ultra-fast, ultra-high-speed modern society. It is only possible to sustain its survival if it targets the global market, not based on any specific region. The K-POP group is also targeting overseas markets in a manner similar to the various global strategies used when companies make inroads into foreign markets, including exports, contracts and direct investment. The K-POP group is engaged in various forms of activities, ranging from simple forms of performance (export) that are visited and staged by an invitation from a certain foreign country to series performances (license) by an invitation from a local promoter and tour performances using its capabilities. The K-POP group is seeking to go beyond the art of single-stage performances and make a systematic plan and make inroads into foreign countries in the form of direct investment suitable for each foreign country. The K-POP group made inroads into overseas markets in the form of simple performances from the late 1990s to 2005, when 'Korean Wave' was first introduced. Group H.O.T., etc. are typical examples. Since then, it has sought to enter overseas markets in the form of franchises by accepting overseas members by 2018, starting with Super Junior in 2005. Since then, the K-POP group in the form of joint investment attempted as group IZ*ONE in 2018 appeared, and a voice story came out in September 2018 when South Korea's JYP Entertainment and Tencent of China joined forces. Unlike K-POP Group, which has entered foreign markets with a global strategy based on the existing export method (H.O.T.), 'Boystory' is a representative group that is made with joint investment, which is a direct investment method. In February 2020, RBW released 'D1Verse,' a five-member group selected by Vietnam's reality show, as a joint investment-type group. This shows the possibility that domestic and foreign companies will release a group in the form of joint investment in order to pursue both globalization and localization.

• Journal of the Korean Geotechnical Society
• /
• v.25 no.12
• /
• pp.87-105
• /
• 2009

Nonlinear dynamic deformation characteristics, expressed in terms of normalized shear modulus reduction curve (G/$G_{max}-\log\gamma$, G/$G_{max}$ curve) and damping curve (D-$\log\gamma$), are important input parameters with shear wave velocity profile ($V_s$-profile) in the seismic analysis of (new or existing) fill dam. In this paper, the reasonable and economical methods to evaluate the nonlinear dynamic deformation characteristics for core zone and rockfill zone respectively are presented. For the core zone, 111 G/$G_{max}$ curves and 98 damping curves which meet the requirements of core material were compiled and representative curves and ranges were proposed for the three ranges of confining pressure (0~100 kPa, 100 kPa~200 kPa, more than 200 kPa). The reliability of the proposed curves for the core zone were verified by comparing with the resonant column test results of two kinds of core materials. For the rockfill zone, 135 G/$G_{max}$ curves and 65 damping curves were compiled from the test results of gravelly materials using large scale testing equipments. The representative curves and ranges for G/$G_{max}$ were proposed for the three ranges of confining pressure (0~50 kPa, 50 kPa~100 kPa, more than 100 kPa) and those for damping were proposed independently of confining pressure. The reliability of the proposed curves for the rockfill zone were verified by comparing with the large scale triaxial test results of rockfill materials in the B-dam which is being constructed.