• 한국동물생명공학회지
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• 제35권3호
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• pp.279-288
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• 2020

Changes of gonadal morphology and mRNA expression patterns of vitellogenin were investigated in Siberian sturgeon Acipenser baerii (Chondrostei) during its early gonadal maturation period. Early differentiations and morphological transitions of both ovaries and testes appeared to occur actively until the age of 3 years, however from then on, the maturation patterns to full maturity were largely gender-dependent, in which males showed a faster progression of maturation than did females while females experienced a steady-state progress with a lagged interval before entering the final maturation. Expression of vitellogenin mRNAs are closely correlated with transitional patterns of gonadal appearances. In both females and males, hepatic mRNA levels of vitellogenin exponentially increased in the earliest interval (up to 1-year-old). However, in subsequent periods, vitellogenin expression in females continued to increase with age, whereas in males, the expression stabilized at a younger age. Nevertheless, at the age older than or equal to 7-year-old, fully matured individuals showed a quite low level of vitellogenin expression in both females and males. Collectively, results from this study could be useful as a fundamental guideline to address the gonad maturation of this sturgeon species, which is helpful for making practical decisions about farming practices and management for caviar production on local sturgeon farms.

• 한국생활과학회지
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• 제15권2호
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• pp.209-225
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• 2006

The purpose of this study is to research the actual condition of environment and management of outdoor play at child care centers in Seoul, and to present a planning guideline for outdoor play environment. For this purpose, data were collected by a structured questionnaire and subjects were 164 directors of child care centers located in Seoul. The contents of the questionnaire were composed of general facts about the respondent and facility, environmental condition, managerial condition, and director's understanding about outdoor play. The data were then analyzed using the frequency, percentage, mean and crosstab. The major results have shown the following: 1) Most child care centers in Seoul had some space for outdoor play. 62% of them used front yard and 11 % a rooftop. 2) The space usually included fixed play instruments such as slide and complex unit structures, sand play area, and open area. It also had many natural elements as shrubs and earth. 3) 78% of the centers had a schedule for outdoor play. The schedule operates flexibly according to each center's own day schedule. Generally, a time for outdoor play was 21 to 30 minutes. 4) The directors of child care centers thought highly of outdoor play for it contributes to the balanced development of children. They answered that equipments and spaces, program devices, and teacher's understanding are some of the important factors for active outdoor play. 5) Most of them wanted wood-working area (construction activity area), water play area, and cages.

• 산업공학
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• 제23권4호
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• pp.311-318
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• 2010

In the daily multi-reservoir operating problem, monthly storage targets can be used as principal operational guidelines. In this study, we tested the use of a simple back-propagation Artificial Neural Network (ANN) model to derive monthly storage guideline for daily Coordinated Multi-reservoir Operating Model (CoMOM) of the Han-River basin. This approach is based on the belief that the optimum solution of the daily CoMOM has a good performance, and the ANN model trained with the results of daily CoMOM would produce effective monthly operating guidelines. The optimum results of daily CoMOM is used as the training set for the back-propagation ANN model, which is designed to derive monthly reservoir storage targets in the basin. For the input patterns of the ANN model, we adopted the ratios of initial storage of each dam to the storage of Paldang dam, ratios of monthly expected inflow of each dam to the total inflow of the whole basin, ratios of monthly demand at each dam to the total demand of the whole basin, ratio of total storage of the whole basin to the active storage of Paldang dam, and the ratio of total inflow of the whole basin to the active storage of the whole basin. And the output pattern of ANN model is the optimal final storages that are generated by the daily CoMOM. Then, we analyzed the performance of the ANN model by using a real-time simulation procedure for the multi-reservoir system of the Han-river basin, assuming that historical inflows from October 1st, 2004 to June 30th, 2007 (except July, August, September) were occurred. The simulation results showed that by utilizing the monthly storage target provided by the ANN model, we could reduce the spillages, increase hydropower generation, and secure more water at the end of the planning horizon compared to the historical records.

• Ecology and Resilient Infrastructure
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• 제3권4호
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• pp.263-271
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• 2016

본 연구에서는 호소 수체에 산소를 포기시켜 주는 마이크로 버블 발생장치를 충남 아산에 위치하고 있는 죽산호에 설치하여 수체에 미치는 수리학적 영향반경과 용존산소 (DO) 농도 분포를 조사하였다. 수체에 미치는 수리학적 영향반경은 로다민 염료를 이용한 추적실험을 하였으며, 마이크로 버블 제트류의 수평방향으로 총 160 m 길이의 가이드라인을 설치하여 10 m 지점마다 수심 1 m, 2 m, 3 m에서 로다민 농도, 수온, DO 등을 측정하였다. 죽산호의 로다민 배경농도는 $0.3-0.5{\mu}g/L$이었고, 용액 주입 후 15분 이내에 20-40 m 거리까지 확산되었으며, 거리 50-120 m의 수심 2 m 지점에서 로다민 농도가 $3.1-12{\mu}g/L$를 나타냈다. 본 연구결과로부터 마이크로 버블 발생장치의 제트류에 의한 직접적인 영향 범위는 40-50 m이고, 그 이후에는 이류 및 확산에 의한 영향으로 120 m까지 이동하는 것으로 나타났다. 수중 DO 농도는 경과시간과 이격 거리에 상관없이 7.4-12.6 mg/L의 농도를 유지하였고, 마이크로 버블 적용 전의 호소 바닥층 DO 0.2 mg/L에서 운영 후 8.0 mg/L 이상으로 DO가 개선되는 것으로 나타났다. 본 연구 결과에 의하면 마이크로 버블 포기 기술은 농업용 호소의 수질 관리와 개선에 기여할 것으로 기대된다.

• 대한환경공학회지
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• 제31권9호
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• pp.755-764
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• 2009

시화호 인공습지내 표층퇴적토에 의한 오염물질 제거효율을 평가하기 위하여 표층퇴적물내 물질함량과 퇴적토에 의한 오염물질의 용출여부를 조사하였다. 조사기간 동안 표층퇴적물의 COD, TOC, IL, TN, TP 함량은 각각 4.1~47.7 mg/g, 0.29~2.81%, 1.88~8.15%, 0.03~0.35%, 362~1,150 ${\mu}g$/g의 범위로 조사지점과 시기에 따라 차이를 보였다. 유기물과 TN 함량은 봄에 높고 시간이 지날수록 감소하는 경향을 보인 반면 TP 함량은 유의적인 차이를 보이지 않았다(3월${\geq}$5월${\geq}$7월${\geq}$9월, p=0.003 for COD, p=0.001 for TOC, p=0.017 for IL, p=0.015 for TN). 표층퇴적토의 중금속 함량은 As 3.5~13.9 ${\mu}g$/g, Cd 0.08~0.38 ${\mu}g$/g, Cr 51.8~107.0 ${\mu}g$/g, Cu 16.4~81.8 ${\mu}g$/g, Pb 26.8~81.8 ${\mu}g$/g, Zn 85~559 ${\mu}g$/g의 범위로 항목에 따라 상이한 시공간적인 분포를 보였다. 퇴적물환경기준으로 볼 때 유기물 함량은 대부분 기준 이하의 수준을 보인 반면 TN과 TP는 "중간오염" 또는 "심한 오염" 수준을 보였다. 그리고 중금속 함량은 Cd과 Pb을 제외한 모든 항목에서 퇴적물 환경기준으로 초과하는 것으로 나타났다. 퇴적토의 용출실험 결과로부터 TN, Pb, Zn은 퇴적토에 의해 제거되는 반면 TP, Cd, Cu는 퇴적토로부터 용출되는 경향을 보였다. 그러므로 시화호 인공습지에서 표층퇴적토의 수질정화기능을 향상시킬 수 있는 방안수립이 필요하다.

• 한국식품위생안전성학회지
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• 제37권5호
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• pp.310-316
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• 2022

본 연구에서는 수세미와 행주 재질별 항균 활성을 비교하고, 적합한 살균 방법을 제시하고자 건조, 열탕, 마이크로웨이브 살균을 실시하였다. 본 실험에 사용된 수세미는 은나노, 구리, 망사 수세미 3종을 사용하였으며 행주는 은나노, 대나무, 면 행주 3종을 실험대상으로 사용하였다. 건조 시간에 따른 수세미 중 대장균 저감화 효과는 은나노와 구리 수세미에서 높게 나타났으나 B. cereus에 대한 저감화 효과는 모두 미미하였다. 건조 시간에 따른 행주 중 대장균과 B. cereus에 대한 저감화 효과는 모두 미미하였다. 77℃에서 30초 이상 열탕 살균 후 수세미 중 대장균은 검출되지 않았고 100℃에서 1분 이상 열탕 살균 후 수세미 중 B. cereus는 검출되지 않았다. 77℃에서 30초 이상 열탕 살균 후 행주 중 대장균은 검출되지 않았으나 100℃에서 1분 이상 열탕 살균 후 행주 중 B. cereus가 검출되어 살균효과가 미약하였다. 700 W 마이크로웨이브로 3분간 살균 후 수세미 중 대장균은 검출되지 않았으나 B. cereus는 검출되었다. 700 W 마이크로웨이브로 1분 이상 살균 후 행주 중 대장균은 검출되지 않았으나 3분간 살균 후에도 면 행주에서 B. cereus는 검출되었다. 이러한 결과를 종합해 볼 때, 집단급식소에서 사용되는 수세미와 행주에 의한 집단식중독을 예방하기 위해 항균 수세미와 항균 행주 사용을 지양하고, 식품의약품안전처에서 제시하는 끓는 물에서 30초 이상 살균에 대한 재검토가 필요한 것으로 판단된다. 수세미와 행주의 위생관리를 위해 수세미는 100℃에서 1분 이상 열탕 살균, 행주는 700 W 마이크로웨이브로 3분 이상 살균을 제안한다.

• 한국임상약학회지
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• 제20권3호
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• pp.255-261
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• 2010

Cefprozil is a broad-spectrum oral beta-lactam cephalosporin consisting of cis- and trans-isomeric mixture whose ratio is approximately 90:10. Cefprozil is used to treat certain infections caused by bacteria such as bronchitis and ear, skin, and throat infections. The purpose of the present study was to evaluate the bioequivalence of two cefprozil tablets, $Cefzil^{(R)}$ tablet 250 mg (BMS Pharmaceutical Korea., Ltd.) and Procezil tablet 250 mg (Hanmi Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The in vitro release of cefprozil from the two cefprozil formulations were tested using KP VIII Apparatus I method with water dissolution media. Thirty five healthy male subjects, $24.00{\pm}1.53$ years in age and $69.77{\pm}9.99$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After four tablets containing 1000 mg as cefprozil were orally administered, blood samples were taken at predetermined time intervals and the concentrations of cefprozil in serum were determined using HPLC/UV detector. The dissolution profiles of two formulations were similar in water tested dissolution media. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ on the basis of total-cefprozil were calculated, and computer program (K-BE Test 2002) was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Cefzil^{(R)}$ tablets, were -0.81%, -3.00% and -6.83% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.9515~log 1.0454 and log 0.9613~log 1.0465 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Procezil tablet was bioequivalent to $Cefzil^{(R)}$ tablet.

• 한국습지학회지
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• 제16권1호
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• pp.61-72
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• 2014

높은 생산성을 위한 인공습지 조성 및 관리 방안 제시를 위해 세 가지 대형정수식물(갈대, 애기부들, 줄)을 두 가지 매질조건(개별 매질과 혼합 매질)과 두 가지 수위 조건(5 cm와 20 cm)에 식재한 뒤 3년간의 모니터링을 수행하였다. 그 결과 줄의 경우 조성 환경에 상관없이 첫 해 초기 생육(최대 초고, 약 200 cm; 최대 지상부 생산성 약 500 $g/m^2$)뿐만 아니라 3년경과 후 최종 생육(줄, 약 1,100 $g/m^2$; 애기부들, 770 $g/m^2$; 갈대, 450 $g/m^2$)에 있어, 전반적으로 갈대나 애기부들에 비해 월등하게 나타났다. 특히 초기 생육이 좋았던 줄은 자연적으로 유입돼 발생하는 잡초들에 의한 피해가 거의 없었던 반면 갈대나 애기부들의 경우 다년생 잡초를 포함한 여러 잡초와의 종간 경쟁으로 생육이 다소 부진하였다. 특히 얕은 수심환경과 moss peat를 포함한 혼합 매질 조건에선 식재종들의 생육이 전반적으로 부진하였으며, 그로 인해 잡초들의 생육이 상대적으로 좋았다. 높은 지상부 생산성을 위한 인공습지 조성을 위해선 줄과 같이 생육 환경에 크게 구애받지 않으며 초기 생육이 뛰어난 종의 선발을 통해 자연유입 잡초나 야생동물 등에 의한 피해를 최소화시켜야 할 것이다. 만약 줄이 아닌 갈대나 애기부들과 같은 종을 식재하고자 한다면 온실과 같은 환경에서 일정 수준 이상 생육시킨 뒤 식재함으로써 더욱 경쟁력을 제고시킬 수 있을 것이다. 더불어 높은 지상부 생산성을 위한 인공습지를 지속적으로 유지시키기 위해선 한두 가지 선택지가 아닌 제초와 관련된 최적의 관리방안들을 적시에 활용하는 통합적 잡초 관리 시스템의 적용을 제안하는 바이다.

• 한국토양비료학회지
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• 제43권3호
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• pp.384-389
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• 2010

Outbreak of contagious diseases to livestock animals is becoming prevalent worldwide and consequently, tremendous numbers of the infected or culled stocks are buried on the ground as the most common disposal method. The buried animals can generate a wide range of detrimental components such as leachate, nutrient salts, and pathogenic bacteria, consequently contaminating the surround environment. This implies that regular investigations are required to monitor any possible detrimental environmental aspect occurred around burial sites. Therefore, the current study was conducted to investigate whether the soil and groundwater nearby the burial sites had been contaminated by the substances originated from the burial sites, which can be applied for the establishment of the ideal burial site construction design and post management scheme. For this, two different burial sites located in Cheonan and Pyeongtaek were selected. Cheonan and Pyeongtaek sites were constructed in 2004 and 2008, respectively and both contained dead poultry infected by avian influenza (AI). Soil and groundwater samples were collected around the sites followed by determination of the nutrient concentrations and bacteria (Salmonella, Camphylobacter, and Bacillus) existence in both soil and groundwater. Some of the soil samples showed higher EC, $NH_4$-N, $NO_3$-N concentration compared to those of the background (control) soils. Also the concentration of $NH_4$-N in some of the groundwater samples appeared to exceed the USEPA guideline value for drinking water (10 mg $L^{-1}$). These results indicated that the soil and groundwater were influenced by the burial site originated nutrients. In the soil, Bacillus was isolated in most soil samples while there were no detections of Salmonella and Camplylobacter. Due to the Bacillus existing mainly as a spore in the soils, it was considered that the frequent detection of Bacillus in the soil samples was attributed to the nutrients originated from the burial sites.

• 한국농공학회논문집
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• 제62권6호
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• pp.85-95
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• 2020

According to the standard guidelines of design flood (MLTM, 2012; MOE, 2019), the design flood is calculated based on past precipitation. However, due to climate change, the frequency of extreme rainfall events is increasing. Therefore, it is necessary to analyze future floods' volume by using climate change scenarios. Meanwhile, the standard guideline was revised by MOE (Ministry of Environment) recently. MOE proposed modified Huff distribution and new CN (Curve Number) value of forest and paddy. The objective of this study was to analyze the change of flood volume by applying the modified Huff and newly proposed CN to the probabilistic precipitation based on SSP and RCP scenarios. The probabilistic rainfall under climate change was calculated through RCP 4.5/8.5 scenarios and SSP 245/585 scenarios. HEC-HMS (Hydrologic Engineering Center - Hydrologic Modeling System) was simulated for evaluating the flood volume. When RCP 4.5/8.5 scenario was changed to SSP 245/585 scenario, the average flood volume increased by 627 ㎥/s (15%) and 523 ㎥/s (13%), respectively. By the modified Huff distribution, the flood volume increased by 139 ㎥/s (3.76%) on a 200-yr frequency and 171 ㎥/s (4.05%) on a 500-yr frequency. The newly proposed CN made the future flood value increase by 9.5 ㎥/s (0.30%) on a 200-yr frequency and 8.5 ㎥/s (0.25%) on a 500-yr frequency. The selection of climate change scenario was the biggest factor that made the flood volume to transform. Also, the impact of change in Huff was larger than that of CN about 13-16 times.