• 대한한의학방제학회지
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• 제30권4호
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• pp.269-280
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• 2022

Objectives : In this study, it was investigated the effects of solid-phase fermentation extraction with Phellinus linteus of discarded Schisandra chinensis extract (PS) and its action mechanism on dexamethasone-induced muscle atrophy in mice. Methods : In mice, muscle atrophy model was induced by dexamethasone (5 mg/kg, I.p) once daily for 2 weeks and with PS extract administration (100 and 300 mg/kg, p.o.) as treatment groups. The changes in body weights, grip strength, Treadmill test, muscle weights, and the expression of atrophy-related genes were measured in muscle atrophy mice. The histological changes of gastrocnemius tissues were also observed by H&E staining with measurement of myofiber size. Results : The administration of PS extract increased significantly body weights, grip strength, treadmill test and muscle weights in muscle atrophy mice. PS extract administration increased significantly the area of myofibers and inhibited structural damages of muscle and increased significantly the expression of myogenin and decreased significantly the expression of MuRF1, Atrogin1 and phosphorylation of AMPK and PGC1α in muscle tissues of muscle atrophy mice. Conclusions : These results indicate that PS extract has a improvement effects on muscle atrophy with stimulation of myogenic differentiation and inhibition of mRNA degradation that could be related with the activation of AMPK and PGC1α signaling pathways in muscle. This suggests that PS extract can apply to treat muscle atrophy in clinics.

• 대한본초학회지
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• 제30권2호
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• pp.11-18
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• 2015

Objectives : Polygoni Multiflori Radix (Jeokhasuo in Korean) is a Oriental traditional herbs widely used in East Asian countries. Overconsumption of fructose results in hypertension, dyslipidemia, obesity and impaired glucose tolerance which have documented as a risk of cardiovascular diseases. This experimental study was designed to investigate the beneficial effects of an ethanol extract from Polygoni Multiflori Radix (PMR) in high-fructose (HF) diet-induced metabolic syndrome rat model. Methods : Sprague-Dawley (SD) rats were divided into three groups; Control group, receiving regular diet and tap water, HF group, and HF + PMR group both receiving supplemented with 65% fructose (n=10), respectively. The HF + PMR group initially received HF diet with PMR (100 mg/kg/day) for 8 weeks. Results : PMR significantly prevented the metabolic disturbances such as hyperlipidemia, hypertension and impaired glucose tolerance. Chronic treatment with PMR significantly decreased body weight, fat weight and adipocyte size, suggesting a role of anti-obesity effect. PMR led to improve the hyperlipidemia through the increase in HDL cholesterol level as well as the decrease in triglyceride and LDL cholesterol level. In addition, PMR suppressed adhesion molecules and endothelin-1 (ET-1) expression in aorta resulting in the decrease of hypertension. In muscle tissue, PMR significantly recovered the HF-induced insulin resistance through increase of insulin receptor substrate-1 (IRS-1), p-$AMPK{\alpha}1/2$, and p-Akt expression. PMR improved HF-induced metabolic disorders and its action was caused by energy metabolism-mediated insulin signaling activation. Conclusions : These results demonstrate that PMR may be a beneficial therapeutic for metabolic syndrome through the improvement of hyperlipidemia, obesity, insulin resistance and hypertension.

• Advances in nano research
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• 제12권1호
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• pp.73-79
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• 2022

Due to the extensive use of concrete structures in various applications, the improvement of their strength and quality has become of great importance. A new way of achieving this purpose is to add different types of nanoparticles to concrete admixtures. In this work, a mathematical model has been employed to analyze the vibration of concrete beams reinforced by graphene oxide (GO) nanoparticles. To verify the accuracy of the presented model, an experimental study has been conducted to compare the compressive strengths of these beams. Since GO nanoparticles are not readily dissolved in water, before producing the concrete samples, the GO nanoparticles are dispersed in the mixture by using a shaker, magnetic striker, ultrasonic devices, and finally, by means of a mechanical mixer. The sinusoidal shear deformation beam theory (SSDBT) is employed to model the concrete beams. The Mori-Tanaka model is used to determine the effective properties of the structure, including the agglomeration influences. The motion equations are calculated by applying the energy method and Hamilton's principle. The vibration frequencies of the concrete beam samples are obtained by an analytical method. Three samples containing 0.02% GO nanoparticles are made and their compressive strengths are measured and compared. There is a good agreement between our results and those of the mathematical model and other papers, with a maximum difference of 1.29% between them. The aim of this work is to investigate the effects of nanoparticle volume fraction and agglomeration and the influences of beam length and thickness on the vibration frequency of concrete structures. The results show that by adding the GO nanoparticles, the vibration frequency of the beams is increased.

• 대한통합의학회지
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• 제10권3호
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• pp.27-36
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• 2022

Purpose : This study was aimed to analyze the effects of cosmetics containing Persicaria perfoliata water extract (PPWE) on the skin moisturizing and improvement of skin condition in clinical trials. Methods : Clinical trial was conducted for five weeks after IRB approval at Dong-Eui University. Out of a total of 64 people, 15 people each were assigned to four groups as follows; control group A, B, C and the experimental group A that using cosmetic containing PPWE. Skin condition was measured two times, before and after clinical trial, by a professional skin analyzer, SDM (skin diagnosis system). Moisture and oil value of participants was analyzed twice, each morning and evening, using a portable device on their cheeks. In addition, the survey was investigated subjective satisfaction on change in skin condition and the satisfaction on the use of cosmetics. Result : The experimental group exhibited subjectively significant changes before and after clinical trials on skin its dryness (p=.039), blush (p=.017), and redness (p<.001). In addition, subjective evaluation was also the highest satisfaction in aspects of number of application (p=.003), amount of application (p=.002), moisture maintenance, and skin scratching frequency. The satisfaction on the use of cosmetics was the highest in the intention to repurchase (p=.045), recommendation willingness to others (p=.020), and intention to use various products (p=.001). Skin moisture of the clinical trial participants using the SDM, moisture level and elasticity of the experimental group increased by 12.94 and 10.28. Moisture level, which was measured by a portable device, was the most potently increased in the experimental group. Conclusion : Consequently, PPWE containg cosmetics exhibited the effects of moisturization and attenuated skin dryness in clinical trials, which might be utilized as a fundamental data to develop numerous lines of cosmetics.

• 한국축산식품학회지
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• 제43권5호
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• pp.901-913
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• 2023

This study aimed to investigate changes in the quality of meat aged using Jeju scoria earthenware. Water-holding properties, pH, color, tenderization, fatty acid composition, and free amino acid characteristics of aged pork loin were evaluated to determine the effects of wet and dry (normal and Jeju Scoria) aging methods and aging time (0, 10, 20, 30, and 40 days) on meat quality. The aging methods altered pH and CIE L^* after 10 days of aging. However, the aging method did not alter the pH and CIE L^* of the aged pork loin after 10 days of aging. The shear force was significantly lower in the Scoria aging method than in the wet aging method after 10 and 20 days of aging. Both the normal and Scoria aging methods increased aging loss compared to the wet aging method, which could be attributed to longer air exposure times of the two non-packaged aging methods than in the packaged aging method. The scoria aging method had significantly higher contents and ratios of saturated (SFA) to mono-unsaturated fatty acids but lower ratios of poly-unsaturated fatty acids to SFA than the wet aging method. The content of most free amino acids significantly increased with aging time, especially those related to the sweet, and umami categories. In summary, this study suggests that the Scoria aging method provides positive aspects of eating quality, such as improvement of meat tenderness and taste, including umami, with minimum changes in the overall meat quality.

• Journal of Animal Science and Technology
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• 제65권2호
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• pp.351-364
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• 2023

The experiment was carried out to study the effect of Korean wild ginseng adventitious root supplementation on the laying performance, egg quality, cytokine expression, ginsenoside concentration, and microflora quantity of Institut de selection Animale (ISA) brown laying hens at 24 weeks old. A total of 90 laying hens were subjected to a completely randomized design at three treatments, five repetitions and six laying hens per replicate. The experiments were divided by diets into the basic feed (CON), basic feed + 0.1% wild ginseng (WG1), and basic feed + 0.5% wild ginseng (WG2). The feeding trial was carried out over a duration of 12 weeks after an initial acclimation period of 2 weeks. Feeds and water were administered ad libitum in mash form, and light was available for 16 hours per day. At the end of study, henday egg production (HDEP), average egg weight (AEW), and egg mass (EM) were increased (p <0.05) in WG2 at week 12. Feed conversion ratio (FCR) was decreased (p < 0.05) in WG2 at week 12. The ginsenoside content in egg yolk was increased (p <0.05) in laying hens in the WG2 treatment at week 12. Relative expression of tumor necrosis factor alpha (TNF-α) was reduced (p < 0.05) in the WG supplemented diets at week 12. The fecal microflora quantity of Lactobacillus was increased (p < 0.05) in WG2 at week 8 to week 12, and Escherichia coli (E. coli) was significantly decreased (p < 0.05) in the WG2 at week 12. We concluded that the result observed in the HDEP, AEW, EM and FCR was due to an increase in ginsenoside content, leading to an improvement in the TNF-α, and fecal microflora quantity such as Lactobacillus and E. coli in the WG2 supplemented diets. We therefore recommend the use of WG at application level 0.5% per basal diet for optimum laying performance in layer hens.

• Clinical and Experimental Reproductive Medicine
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• 제50권1호
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• pp.19-25
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• 2023

Objective: Sleep deprivation (SD) is a common problem in today's stressful lifestyle and have physiological consequences, including reproductive dysfunction and infertility. As an antioxidant, olive oil may be effective in reducing testicular and spermatological damage by decreasing the production of free radicals. Methods: This study investigated the effects of olive oil on sperm quality and testicular structure using stereological methods to assess rats with SD. Results: When comparing SD group to grid floor+distilled water (GR) group, we found that the sperm count and motility, as well as the percentage of slow progressive sperm was significantly lower in SD group (p<0.05), but the percentage of immotile sperm was higher (p<0.01). However, no improvement was observed in sperm count or motility after concomitant treatment of SD group with olive oil. Stereological examinations revealed no significant change in the total volumes of the seminiferous tubules, interstitial tissue, and germinal epithelium in the study groups. Conversely, the total number of testicular cell types was significantly lower in SD group than in GR group. Although the total number of Sertoli and Leydig cells was significantly higher in the S +olive oil group than in the untreated SD group, no significant difference in the total number of other testicular cell types was observed between the two groups. Conclusion: SD potentially induced structural changes in testis that affected sperm count and motility. However, olive oil only improved the total number of Sertoli and Leydig cells in the animals with SD and did not improve sperm count and motility.

• 한국지반공학회논문집
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• 제24권12호
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• pp.93-101
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• 2008

본 논문에서는 연약지반 성토시 지반보강 공법으로 적용되는 지오그리드 감쌈 스톤컬럼공법의 하중지지 메카니즘에 대한 내용을 다루었다. 이를 위해 연약지반 성토 시공과정과 지오그리드 감쌈 스톤컬럼의 배수 및 보강 효과를 현실적으로 모사할 수 있는 3차원 응력-간극수압 수치해석 모델을 이용하여 다양한 시공조건에 대한 해석을 수행하고 그 결과를 분석하였다. 그 결과, 임의 시공조건에 있어 지오그리드 감쌈으로 발현되는 구속효과로 인해 스톤컬럼의 강성이 증가되어 상부 성토하중의 주변 연약지반으로의 하중분담율을 감소시키고 따라서 과잉간극수압 및 이에 따른 침하량이 감소되는 것으로 나타났다. 이러한 효과는 지오그리드 감쌈길이 및 강성 등 보강조건에 좌우되는 것으로 나타났으며 임의 시공조건에 있어 보강효과를 최대로 확보할 수 있는 임계감쌈길이와 임계강성이 존재하는 것으로 분석되었다.

• 대한토목학회논문집
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• 제28권3B호
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• pp.335-343
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• 2008

조간대 모의가 가능한 해수유동모형(ESCORT)을 개발하였다. 본 모형은 3차원 적용이 가능하도록 개발되었지만 본고에서는 우선 2차원적으로만 상용모형인 MIKE21모형과 함께 목포해역에 적용하여 모형의 타당성을 입증하였다. 여러 차례 목포해역에 적용된 바 있는 MIKE21모형을 기존과 유사한 영역으로 광역모형을 수립하였고 검증을 거친 후 주영역의 경계조건을 추출하였다. 격자간격이 일정한 광역과는 달리 주영역의 격자시스템은 ESCORT 모형과 MIKE21 모형 모두 가변격자를 채택하고 있다. 두 모형의 수행 결과 유속과 수위 모두 관측치와 유사한 결과를 나타내고 있으며 조간대 모의도 원활하게 수행되는 것으로 나타나고 있다. 그러나 아직까지 ESCORT 모형은 계산시간 측면에서 다소 비경제적인 측면이 있어 개선의 여지를 남겨두고 있다.

• 대한토목학회논문집
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• 제28권2C호
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• pp.75-81
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• 2008

본 연구에서는 연약지반을 목적에 맞게 개선하기 위한 방법으로 성토하중 및 멤브레인 등이 필요치 않은 석션드레인(Suction Drain)공법의 개량기간 및 적용 석션압에 따른 개량도를 파악하고 Hardening Zone의 영향을 파악하기 위한 일련의 실내 토조 실험을 실시하였다. 실험 조건은 석션압 적용기간을 4일, 8일, 12일, 16일, 20일, 적용 석션압을 -20kPa, -40kPa, -60kPa, -80kPa로 달리하여 실험을 실시하였다. 실험결과 침하량의 경우, 적용된 석션압 및 처리기간이 증가함에 따라 개량도는 증가하는 양상을 나타냈으며, 점차적으로 수렴하는 경향이 나타났다. 또한, 함수비로 역산된 투수계수 저하비와 변형된 Hansbo의 방사형 압밀이론에 의해 수치적으로 예측된 투수계수 저하비를 비교/분석한 결과 2~3으로 가정한 결과에서 실측치와 예측치에 가장 부합되는 결과가 나타났으며, Hardening Zone은 전체 영역 25cm 중 약 7~8cm 범위에서 발생됨을 파악할 수 있었다.