• Journal of Microbiology and Biotechnology
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• v.34 no.2
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• pp.367-378
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• 2024

In this study we sought to elucidate the therapeutic effects of fenchone on constipation-predominant irritable bowel syndrome (IBS-C) and the underlying mechanisms. An IBS-C model was established in rats by administration of ice water by gavage for 14 days. Fenchone increased the reduced body weight, number of fecal pellets, fecal moisture, and intestinal transit rate, and decreased the enhanced visceral hypersensitivity in the rat model of IBS-C. In addition, fenchone increased the serum content of excitatory neurotransmitters and decreased the serum content of inhibitory neurotransmitters in the IBS-C rat model. Meanwhile, western blot and immunofluorescence experiments indicated that fenchone increased the expressions of SCF and c-Kit. Furthermore, compared with the IBS-C model group, fenchone increased the relative abundance of Lactobacillus, Blautia, Allobaculum, Subdoligranulum, and Ruminococcaceae_UCG-008, and reduced the relative abundance of Bacteroides, Enterococcus, Alistipes, and Escherichia-Shigella on the genus level. Overall, fenchone ameliorates IBS-C via modulation of the SCF/c-Kit pathway and gut microbiota, and could therefore serve as a novel drug candidate against IBS-C.

• The Korean Journal of Air & Space Law and Policy
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• v.31 no.2
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• pp.3-35
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• 2016

The United States Constitution gives power to the federal district courts to hear admiralty cases. 28 U.S.C. §.133, which states that "The district courts shall have original jurisdiction, exclusive of the Courts of the States, of any civil case of admiralty or maritime jurisdiction." However, the determination of whether a case is about admiralty or maritime so that triggers admiralty jurisdiction was not a simple question. Through numerous legal precedents, the courts have drawn a line to clarify the boundary of admiralty cases. This unique jurisdiction is not determined by the mere involvement of a vessel in the case or even by the occurrence of an event on a waterway. As a general rule, a case is within admiralty jurisdiction if it arises from an accident on the navigable waters of the United States (locus test) and involves some aspect of maritime commerce (nexus test). With regarding to the maritime nexus requirement, the US Supreme Court case, Executive Jet Aviation, Inc. v. City of Cleveland, held that federal courts lacked admiralty jurisdiction over an aviation tort claim where a plane during a flight wholly within the US crashed in Lake Erie. Although maritime locus was present, the Court excluded admiralty jurisdiction because the incident was "only fortuitously and incidentally connected to navigable waters" and bore "no relationship to traditional maritime activity." However, this historical case left a milestone question: whether an aircraft disaster occurred on navigable water triggers the admiralty jurisdiction, only for the reason that it was for international transportation? This article is to explore the meaning of admiralty jurisdiction over aviation accidents at US courts. Given that the aircraft engaged in transportation of passenger and goods as the vessels did in the past, the aviation has been linked closely with the traditional maritime activities. From this view, this article reviews a decision delivered by the Seventh Circuit regarding the aviation accident occurred on July 6, 2013 at San Francisco International Airport.

• Journal of the Korean Society of Groundwater Environment
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• v.5 no.3
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• pp.129-140
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• 1998

In this study two sites were selected to investigate groundwater contamination and spatial relationship between pollution level and its source. One is the Asan area, agricultural district where pollution sources are scattered. The other is the Gurogu area of Seoul city, industrial district where industrial complex and residential areas are located. Groundwater samples collected from these districts were analysis for chemical constituents. The attribute value files of the chemical constituents of groundwater and the spatial layers have been constructed and the pollution properties have been investigated to find out spatial relationships between the groundwater constituents and pollution sources using CIS. Relatively high contents of Si and HCO$_3$ in groundwater from the Asan area reflect the effect of water-rock interaction, whereas high contents of Cl, NO$_3$, SO$_4$and Ca in groundwater from the Gurogu area are due to the pollution of various sources. Pollution over the critical level of Korean Dinking Water Standard has been investigated from 15 sampling sites out of 40 in the Asan area, and 33 sampling sites out of 51 in the Gurogu area. There is pollution of NO$_3$, Cl, Fe, Mn, SO$_4$and Zn in groundwater from the Gurogu area, and that of NO$_3$, SO$_4$and Zn in groundwater from the Asan area. Principal pollution in both areas is NO$_3$contamination. Deep groundwater from the Asan area is not contaminated with NO$_3$except for one site and most of shallow groundwater near the potential point sources such as factory and stock farm is contaminated seriously. Groundwater from the Gurogu area has been already polluted seriously considering the fact of contamination of deep groundwater. This study reports a spatial relationship between the pollution level and pollution source using GIS.

• Economic and Environmental Geology
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• v.42 no.4
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• pp.289-300
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• 2009

The Geodo mine area, had been developed for Fe and Cu ores since 1963 and abandoned in recent decades, is located in the central part of the Taebaeksan mineralized district. This area comprises of the Jangsan, Myobong, Pungchon, Hwajeol, Dongjeom, and Dumugol Formations in ascending stratigraphic order. These Formations were intruded by the Cretaceous Eopyeong granitoids that appears to produce the Geodo skarn. Their compositions are relatively oxidized quartz monzodiorite to granodiorite (magnetite series, $Fe_2O_3/FeO=0.3{\sim}1.1$). Mineralizations related skarn deposit occur in the Myobong, Pungchon, and Hwajeol Formations. The proximal skarn is zoned from andraditic garnet ($Ad_{44-95}Gr_{1-53}$) predominant adjacent to the Eopyeong granitoids to diopsidic pyroxene ($Hd_{10-100}Di_{0-89}$) predominant away from the one. The differential proportion of garnet and pyroxene is generated by water/rock ratio and their source, such as magmatic and meteoric water. This is useful tool for assessment the overall oxidation state of the entire skarn system. Gold occurs in proximal red to brownish garnet skarn, and genetically associated with Bi- and Te-bearing minerals. Skarn deposit developed in the Geodo mine area is considered as oxidized Au skarn category, based on chemical composition of the Eopyeong granitoids, zonation of skarn, and gold occurrences. Garnet-rich skarn zone will be the main target for exploration of gold in the study area. However, it is needed to the detailed survey on vertical zonation of this area as well as lateral zonation. The result of this survey would provide an important basis for the exploration of the skarn Au deposit in the Geodo mine area.

• Economic and Environmental Geology
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• v.48 no.6
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• pp.509-523
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• 2015

This study introduces newly implemented geological well logs database for Jeju public water wells, built for a research project focusing on integrated hydrogeology database of Jeju Island. A detailed analysis of the existing 1,200 Jeju Island geological logs for the public wells developed since 1970 revealed six major indications to be improved for their use in Jeju geological logs DB construction: (1) lack of uniformity in rock name classification, (2) poor definitions of pyroclastic deposits and sand and gravel layers, (3) lack of well borehole aquifer information, (4) lack of information on well screen installation in many water wells, (5) differences by person in geological logging descriptions. A new Jeju geological logs DB enabling standardized input and output formats has been implemented to overcome the above indications by reestablishing the names of Jeju volcanic and sedimentary rocks and utilizing a commercial, database-based input structured, geological log program. The newly designed database structure in geological log program enables users to store a large number of geology, well drilling, and test data at the standardized DB input structure. Also, well borehole groundwater and aquifer test data can be easily added without modifying the existing database structure. Thus, the newly implemented geological logs DB could be a standardized DB for a large number of Jeju existing public wells and new wells to be developed in the future at Jeju Island. Also, the new geological logs DB will be a basis for ongoing project 'Developing GIS-based integrated interpretation system for Jeju Island hydrogeology'.

• Korean Journal of Ecology and Environment
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• v.41 no.2
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• pp.237-246
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• 2008

Filtration rates and fecal production of freshwater bivalve, Unio douglasiae on two kinds of hibernal diatom communities were measured simultaneously in a laboratory. One community is the Han River (HAN), which dominated by Asterionella Formosa. Stephanodiscus hantzschii (ca. 98% of total phytoplankton). The other community is the Ilgam Lake (IL), which dominated by Synedra ulna, Scenedesmus sp. Microcystis aeruginosa (ca. 82%). The HAN water has higher concentrations of nutrient (TN and TP) and chlorophyll $\alpha$ (Chl-$\alpha$), lower turbidity and conductivity than the IL water. Water sampling for the feeding experiment was conducted in the same day (Jan 15, 2008) and similar time (AM 10:00 for HAN, AM 11:00 for IL). Mussels with the similar size ($0.0{\pm}0.5\;cm$) were collected from the Gunsan and Okgu district (Jeonbuk), and starved in a laboratory for 2 days before the experiment. The experiment comprised CON (no addition of mussel), LOW (addition of mussel at 0.3 indiv. $L^{-1}$), MID (1.0 indiv. $L^{-1}$) and HIGH (2.0 indiv. $L^{-1}$), respectively. With the increment of mussel density and time, the concentration of Chl-$\alpha$ in two diatom communities were clearly decreased; Chl-$\alpha$ of HAN gradually decreased after 1 hour of mussel treatment, while that of IL decreased as soon as mussel introduction. In 7 hours of treatment, the former was removed finally up to about 90% of control, while the later was remained as about 50%. Under the presence of mussel, total phytoplankton density was shifted as the similar patterns to that of Chl-$\alpha$ (r=0.705, P<0.0001), however, there showed the drastic differences following a species. Based on the concentration of Chl-$\alpha$, filtration rate of U. douglasiae averaged 0.266 $L\;g^{-1}\;h^{-1}$ (0.115 to 0.442) on HAN and $0.577\;L\;g^{-1}\;h^{-1}$ (0.146 to 1.428) on IL water, respectively. There were no differences in feces production among the mussel density in the HAH water (ANOVA, P>0.5), while in IL water, including lots of seston, the HIGH mussel produced the higher fecal materials, over one hundred times of LOW. These results suggest that freshwater bivalve Unio douglasiae have the alternative potential, as a filter-feeder of seston in turbid lake, and a biological controller of diatom bloom in cold stream.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.2
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• pp.23-33
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• 2009

Satellite image is very usefully practiced to predict and analyze physical expansion and change of city. Physical expansion and change of city is closely related to the use of land, and continuous growth management focused on the use of land is essential for sustainable city growth. In this research, the change of land cover and land-use were analyzed with basic input data from 1985 to 2000 according to artificial satellite. Moreover, the land-use turnover rate was understood and expansion trend of urban sprawl in Busan metropolitan city and land-use characteristics of the expansion area. The results are, first, the area for urban region was expanded continuously but areas for agriculture area, forest area, and water area had different changes due to administrative district reform of Busan by each year. Second, the urbanization area in Busan was increased by 3.8% from $92.5km^2$ in 1985 to $167.5km^2$ in 2000. Third, the result of analysis on land-use turnover rate showed that agriculture area was turned into urbanized area the most, and forest area was followed by. Fourth, the result of analysis on database and overlay of buildings in Busan established in 2001 showed that agriculture area are had type 1 and 2 neighborhood living facilities (45.63%), apartment house in forest area (18.49%), and factory in water area (31.84%) with high ratio.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1383-1392
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• 2003

Apoptosis is a morphologically and biochemically district form of cell death that occurs in many different cell types in a wide variety of organisms. Albizzia julibrissin belonging the family Leguminosae has been used for the treatment of contusion, sore throat, amnesia, and insomnia in oriental traditional medicine. This study investigates whether the water extract of A. julibrissin induce apoptotic cell death in Jurkat T-acute lymphoblastic leukemia (ALL) cells. Jurkat cells were increased inhibitions of cell viability in a concentration-dependent manner by A. julibrissin. This herbal medicine also caused apoptosis as measured by cell morphology and DNA fragmentation. The capability of A. julibrissin to induce apoptosis was associated with proteolytic cleavage of specific target proteins such as poly (ADP-ribose)polymerase (PARP) and beta-catenin proteins suggesting the possible involvement of caspases. Our result showed that Bcl-2 and Bax protein levels were not changed in all A. julibrissin-treated groups compared to control group. These results suggest that A. julibrissin-mediated apoptosis is independent with Bcl-2 related signaling pathway in this cells. The purpose of the present study is also to investigate the Effect of A. julibrissin on cell cycle progression. Our results showed that G1 checkpoint related gene products (cyclin D1, cyclin dependent kinase 4, retinoblastoma, E2F1) were decreased in their protein levels in a dose-dependent manners after treatment of the extract. These results indicate that the increase of apoptotic cell death by A. julibrissin may be due to the inhibition of cell cycle progression in wild type p53-lacking Jurkat cells.

• Journal of Korea Water Resources Association
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• v.30 no.6
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• pp.777-785
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• 1997

This study was conducted to clarify the hydrological characteristics of subsurface flow through a soil matrix and macropores. The research facility was set up in a 20m-1ong trench excavated down to bedrock at the base of a hillslope in the Panola catchment under USGS Georgia district. 13 macropores were found on the trench face and 6 major macropores were monitored. Matrix and macropore flow were measured during 95.5mm rainfall on March, 6 to 7. 1996. Macropore flow had great influence on formation of peak flow because the delivery time to Peak flow of macropore flow were faster about 10hrs than those of matrix flow. Matrix flow continued to recess for 3 days. On the other hand, macropore flow stopped within 12hrs after the event ceased. This means that matrix flow controls the recession part. The spatial variations of matrix and macropore flow between each trough and collector were very large by a wide range of 8,655.3 $\ell$ to 17.8 $\ell$ . The bed rock surface topography relates closer with the spatial variations of the flow than the surface one.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.1519-1523
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• 2009

비상대처계획수립을 위한 홍수방어체계 구축은 방재적 측면에서 가능최대강수량 유입시 댐 붕괴 조건에 대한 하류지역의 침수범람지도와 대피경로 작성에 관한 내용이 주된 관심사였다. 그러나, 현재 국내에서 계획되고 있는 자연형하천 조성사업, 물순환시스템 조성공사 등에서는 기존의 비상대처계획수립과는 차별화된 홍수시 이용자 대피계획 및 각종 수리구조물의 운영에 대한 비상경보 발령체계 수립을 요구하고 있다. 본 연구는 청라지구 중앙호수와 공촌천, 심곡천 연결부의 하천 배수문 운영, 내부수로 수위조절을 위한 배수펌프 계획과 연계한 상황별 홍수조절 방안을 수립하고 강우, 수위 관측에 의한 비상시 경보발령 기준을 제시하였다. 하천배수문 운영에 따른 중앙호수 저류시설 활용효과 분석을 위하여 100년, 200년빈도 홍수 유입시 조위조건별 내수위 변화를 계산하였다. 수치모의는, 공촌천-중앙호수-심곡천을 연계운영을 위하여 HEC-RAS의 Full Network를 이용하였으며 심곡천, 공촌천과 중앙호수를 연결하는 하천배수문은 계획홍수위 El. 3.75m 이상인 경우 개별적으로 개방하도록 하였다. 모형 수행결과, 계획빈도 홍수시 하천배수문 개방을 통한 중앙호수 저류지 활용방안은 200년빈도, 약최고고조위 내습시에도 청라지구 전체의 치수안정성을 확보할 수 있다. 그러나, 200년빈도 고극조위 이상의 기상조건인 경우에는 심곡천 홍수위가 계획제방고 El. 4.55m를 넘어 비상대처계획 수립이 필요하다. 분석결과를 바탕으로 도시홍수방어체계 구축을 위하여 3단계의 치수안정성 확보 계획을 수립하였으며 하천배수문 개방 차단계획을 고려하여 계획빈도이하 홍수, 계획빈도이상 홍수, 비상상황시로 구분하여 상황별 홍수조절방안을 제시하였다. 또한, 500년빈도 홍수시 폭풍해일을 고려한 하천 수위 분석을 통하여 비상경보 발령체계를 정량적으로 분석하였다. 비상경보발령은 공촌천 수위 El. 3.85 m, 심곡천 수위 El. 3.73 m, 강우강도 39.7mm/hr 이상시이다. 본 연구는 홍수시 모니터링시스템에 의한 비상경보 발령체계 수립을 위한 수위 및 강우조건을 정량적으로 제시하여 차후 개발되는 신도시 물순환시스템의 상황별 홍수조절 방안 및 모니터링 시스템에 의한 경보발령 기준 수립시 활용가능 할 것으로 기대된다.