• Yonsei Medical Journal
• /
• v.59 no.9
• /
• pp.1015-1025
• /
• 2018

Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.12 no.1
• /
• pp.501-517
• /
• 2020

Three-dimensional numerical simulations were performed to study the effects of flow direction and flow velocity on the flow regime behind a curved pipe represented by a curved circular cylinder. The cylinder is based on a previous study and consists of a quarter segment of a ring and a horizontal part at the end of the ring. The cylinder was rotated in the computational domain to examine five incident flow angles of 0-180° with 45° intervals at Reynolds numbers of 100 and 500. The detailed wake topologies represented by λ2 criterion were captured using a Large Eddy Simulation (LES). The curved cylinder leads to different flow regimes along the span, which shows the three-dimensionality of the wake field. At a Reynolds number of 100, the shedding was suppressed after flow angle of 135°, and oblique flow was observed at 90°. At a Reynolds number of 500, vortex dislocation was detected at 90° and 135°. These observations are in good agreement with the three-dimensionality of the wake field that arose due to the curved shape.

• Journal of the Korean Society of Visualization
• /
• v.21 no.2
• /
• pp.24-33
• /
• 2023

This work is to observe the wake flow generated behind a ramp. We have conducted a large eddy simulation with two ramp models having different heights with two different inflow conditions. Reynolds number based on the height of the large ramp (LR) and small ramp (SR) are Re_h = 2.8×10⁴ and 1.4×10⁴ respectively. The wake flow visualization shows the formation of streamwise counter-rotating vortices pairs at the downstream of the obstacle. These primary vortices are stretched and lifted up when moving downstream. In order to observe the effect of the inflow condition on the wake transition, two different inlet flow conditions are given on the inlet section as an inlet boundary condition. Induced counter-rotating vortices pairs due to sharp-edged triangular ramp obstacles are developed and propagated downstream. In the result, the large ramp shows a more complicated wake structure of the boundary layer than the small ramp.

• Atmosphere
• /
• v.26 no.4
• /
• pp.635-647
• /
• 2016

The effects of sea surface temperature (SST) gradient induced by the previous typhoon on the following typhoon motion over East Asia have been investigated using Weather Research and Forecasting (WRF) model for the previous Typhoon Bolaven (1215) and following Typhoon Tembin (1214). It was observed that Typhoon Bolaven remarkably reduced SST by about $7^{\circ}C$ at Yellow Sea buoy (YSbuoy). Using the WRF experiments for the imposed cold wake over West of Tembin (WT) and over East of Tembin (ET), this study demonstrates that the effects of eastward SST gradient including cold wake over WT is much significant rather than that over ET in relation to unexpected Tembin's eastward deflection. This difference between two experiments is attributed to the fact that cold wake over WT increases the magnitude of SST gradient under the eastward SST gradient around East Asia and the resultant asymmetric flow deflects Typhoon Tembin eastward, which is mainly due to the different atmospheric response to the SST forcing between ET and WT. Therefore, it implies that the enhanced eastward SST gradient over East Asia results in larger typhoon deflection toward the region of warmer SST according to the location of the cold wake effect. This result can contribute to the improvement of track prediction for typhoons influencing the Korean Peninsula

• Wind and Structures
• /
• v.26 no.2
• /
• pp.57-68
• /
• 2018

Wind tunnel tests are conducted to investigate wake-induced vibrations of two circular cylinders with a center-to-center spacing of 4 diameters and attack angle varying from $0^{\circ}$ to $20^{\circ}$ for Reynolds numbers between 18,000 and 168,800. Effects of structural damping, Reynolds number, attack angle and reduced velocity on dynamic responses are examined. Results show that wake-induced vortex vibrations of the downstream cylinder occur in a wider range of the reduced velocity and have higher amplitudes in comparison to the vortex-induced vibration of a single circular cylinder. Two types of wake-induced instability phenomena with distinct dynamic characteristics are observed, which may be due to different generation mechanisms. For small attack angles like $5^{\circ}$ and $10^{\circ}$, the instability of the downstream cylinder characterizes a one-degree-of-freedom (1-DOF) oscillation moving in the across-wind direction. For a large attack angle like $20^{\circ}$, the instability characterizes a two-degree-of-freedom (2-DOF) oscillation with elliptical trajectories. For an attack angle of $15^{\circ}$, the instability can transform from the 1-DOF pattern to the 2-DOF one with the increase of the Reynolds number. Furthermore, the two instabilities show different sensitivity to the structural damping. The 1-DOF instability can be either completely suppressed or reduced to an unsteady oscillation, while the 2-DOF one is relatively less sensitive to the damping level. Reynolds number has important effects on the wake-induced instabilities.

• 한국전산유체공학회:학술대회논문집
• /
• 2010.05a
• /
• pp.115-121
• /
• 2010

Cavitating flow is widely shown in many engineering systems, such as marine propellers, pump impellers, nozzles, injectors, torpedoes, etc. The present work focuses on the numerical analysis of the multiphase flow around the underwater vehicle which was launched from a submarine. The governing equation is the Navier-Stokes equation with a homogeneous mixture mode. The multiphase flow solver uses an implicit preconditioning scheme in curvilinear coordinate. For the code validation, the results from the present work are compared with the existing experimental and numerical results, and a reasonably good agrements are obtained. The multiphase flow around an underwater vehicle is simulated which includes submarine wake effects.

• The KSFM Journal of Fluid Machinery
• /
• v.17 no.6
• /
• pp.59-63
• /
• 2014

Object of this study is to see whether the arc-groove on a D-shape bluff body effects the drag reduction or not. To this end, the changes of the boundary layer on the surface of the object, the downstream flow field and wake flow were found by experiments. The experiments are conducted by changing number and depth of the groove, angle of the first groove and Reynolds number(Re). Groove did not effect on the surface in the downstream boundary layer of the object and was minimal impact on the time mean velocity recovery of the wake flow. Also the effects of Groove did not have a significant impact on the structure of the wake and the wake frequency. Therefore it is found that the arc-groove of the drag reduction effect on the D-shape bluff body was smaller.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.53 no.4
• /
• pp.337-348
• /
• 2017

The tension of warp from trawler and sea-floor contact can generate tilt and wake turbulence around otter boards. Preliminary measurements of otter board tilt and 3-D flow velocity during bottom trawl operations were taken using a vector instrument to investigate the effects of wake turbulence at the trailing edge of the otter board. Tilt data (i.e., yaw, pitch, and roll) at 1 Hz and flow data (velocities in the towing, lateral, and vertical directions) at 16 Hz were analyzed to determine their periods and amplitudes using global wavelet and peak event analyses. The mean period (${\pm}standard$ deviation) of the tilt from the peak event analysis ($5{\pm}2s$) was longer or double than that of flow velocity ($3{\pm}2s$). The two periods also had a significant linear relationship. The turbulence rate of flow was 30-50% at the trailing edge and was closely related to roll deviation. The frequency of phase difference ratios (i.e., peak time differences between tilts and flow periods) was significantly different from random occurrence in two trials, possibly due to side tidal effects. However, in the other trials, flow peaks were random, as shown by the even peak times between tilts and flows. Future studies should focus on reducing tilt variation, wake turbulence, and bottom contact to stabilize otter board motion.

• The KSFM Journal of Fluid Machinery
• /
• v.19 no.4
• /
• pp.54-62
• /
• 2016

This study presents an approach of tidal farming optimization using a numerical modelling method to simulate tidal energy extraction for 1MW scale tidal stream devices around Jangjuk-sudo, South Korea. The utility of the approach in this research is demonstrated by optimizing the tidal farm in an idealized scenario and a more realistic case with three scenarios of 28-turbine centered tidal array (named A, B and C layouts) inside the Jangjuk-sudo. In addition, the numerical method also provides a pre-processing calculation helps the researchers to quickly determine where the best resource site is located when considering the position of the tidal stream turbine farm. From the simulation results, it is clearly seen that the net energy (or wake energy yield which includes the impacts of wake effects on power generation) extracted from the layout A is virtually equal to the estimates of speed-up energy yield (or the gross energy which is the sum of energy yield of each turbine without wake effects), up to 30.3 GWh/year.

• 유체기계공업학회:학술대회논문집
• /
• 1998.12a
• /
• pp.233-239
• /
• 1998

The effects of unsteady flow on gas turbine, particularly on a rotor blade surface are numerically investigated. The unsteady flow in a rotor blade passage as a result of wake/blade interaction is modeled by the inviscid flow approach, and solved by the Euler equations using a time accurate marching scheme, Numerical results show that for the case of $P_s/ P_r= 1.5$, the velocity and pressure distribution on the blade surfaces have much more complex profiles than those of $P_s/ P_r= 1.0$.