• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.50-56
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• 2012

WIN-34B showed analgesic and anti-inflammatory effects in various animal models of pain and osteoarthritis. However, the molecular mechanism by which WIN-34B inhibits pain and inflammation in vivo remains to be elucidated. We investigated the molecular mechanisms of the actions of WIN-34B using various in vitro models using fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA FLSs), RAW264.7 cells and peritoneal macrophages. WIN-34B inhibited the level of IL-6, $PGE_2$, and MMP-13 in IL-$1{\beta}$-stimulated RA FLSs in a dose-dependent manner. The mRNA levels were also inhibited by WIN-34B. The level of $PGE_2$, NO, IL-$1{\beta}$, and TNF-${\alpha}$ were inhibited by WIN-34B at different concentrations in LPS-stimulated RAW264.7 cells. The production of NO and $PGE_2$ was inhibited by WIN-34B in a dose-dependent manner in LPS-stimulated peritoneal macrophages. All of these effects were comparable to the positive control, celecoxib or indomethacin. I${\kappa}B$B signaling pathways were inhibited by WIN-34B, and the migration of NF-${\kappa}B$ into the nucleus was inhibited, which is consistent with the degradation of $I{\kappa}B-{\alpha}$. Taken together, the results suggest that WIN-34B has potential as a therapeutic drug to reduce pain and inflammation by inhibiting the production of pro-inflammatory mediators.

• Journal of Acupuncture Research
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• v.29 no.5
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• pp.97-108
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• 2012

Objectives : To demonstrate the importance of syndrome differentiation in clinical research of herb medication, through the comparative study on efficacy and safety of herb medication according to cold-heat tendency of OA knee patients. Methods : During December 2010 to July 2011, 138 knee OA patients were randomly assigned to WIN-34B 600mg(300mg, b.i.d.), 1,200mg(600mg, b.i.d.) and placebo b.i.d. for 8 weeks. Patient were re-classified into cold-heat tendency group according to cold-heat questionnaires. To investigate efficacy and safety, we assessed the 100mm pain VAS at baseline and 8 weeks later, and we monitored adverse event of patients during treatment period. Results : 1. Efficacy study : In WIN-34B 1,200mg group, VAS mean changes of heat tendency group showed slightly increase than those of cold tendency, but no significant difference within two groups. In heat tendency group, WIN-34B 1,200mg group showed a significant decrease of VAS compared to placebo group. but there were no significant difference in cold tendency group. 2. Safety study; In WIN-34B 600mg group, incidence of adverse events of cold tendency group was higher than those of heat tendency, but not in WIN-34B 1,200mg group. Conclusions : This study suggests that WIN-34B tend to have more efficacy in heat tendency-knee OA patients and WIN-34B is safe drug relatively, regardless of cold-heat tendency. In further clinical research on efficacy and safety of WIN-34B, stratification using syndrome differentiation is required.

• Journal of IKEEE
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• v.24 no.4
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• pp.1093-1097
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• 2020

This work describes the design and characterization of a Ku-band monolithic microwave integrated circuit (MMIC) power amplifier (PA) for satellite communication applications. The device technology used relies on 0.25 ㎛ gate length gallium arsenide (GaAs) pseudomorphic high electron mobility transistor (PHEMT) of wireless information networking (WIN) semiconductor foundry. The developed Ku-band PHEMT MMIC power amplifier has a small-signal gain of 22.2~23.1 dB and saturated output power of 34.8~35.4 dBm over the entire band of 13.75 to 14.5 GHz. Maximum saturated output power is a 35.4 dBm (3.47 W) at 13.75 GHz. Its power added efficiency (PAE) is 30.6~37.83% and the chip dimensions are 4.4 mm×1.9 mm. The developed 3 W PHEMT MMIC power amplifier is expected to be applied in a variety of Ku-band satellite communication applications.

• International Commerce and Information Review
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• v.16 no.4
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• pp.3-34
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• 2014

Nowadays to thrive on the intensively competitive environments based on drastic and rapid technical evolutions, exporting manufacturing companies need to keep very stable relationship with suppliers. Thus, analyzing key factors of strengthening relationship with suppliers in a B2B environment is important. In this regard, this study develops a research model to deeply understand key antecedents of relationship strength between B2B companies. Relationship quality was considered as the key factor affecting to the relationship strength. This study considers relationship satisfaction, trust, and relationship commitment as the factors of relationship quality. Moreover, technical service quality and relational service quality were considered to be the antecedents of relationship satisfaction, while communication and information exchange, relationship policies and practices, and opportunistic behavior were regarded as the antecedents of trust. The PLS method was applied for the empirical analysis of 107 companies data. The results indicated that the relationship commitment has a significant impact on relationship strength. Moreover, relationship satisfaction and trust had indirectly impact on relationship strength through relationship commitment. Although the quality of technical service quality had a significant impact on relationship satisfaction, relational service quality did not have a significant impact. While communication and information exchange, relationship policies, and practices had positively significant impacts, opportunistic behavior had a negative impact.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.729-735
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• 2005

This study was to analyze the difference between blood type and blood constitution according to Sasang constitution. The subjects were 302 men who visited blood donation house. Data collection was performed by using questionnaire that included three types of Sasang constitution. The data were analyzed as frequency, percentage, ${\chi}$2-test and ANOVA using SPSS 10.0 WIN Program. There was significant difference statistically in frequency of blood type as per Sasang constitution(${\chi}$2 =53.254, p=.000). Soyangin got most number in B type(34.7%), O type(26.7%), A type(21.8%), AB type(16.8%) in order. Taewumin got most number in O type (45.8%), A type(31.3%), B type(22.1%) and AB type(0.8%) in order, and in case of Sowumin, most in A type(54.3%), B type(24.3%), O type (11.4%) and AB type(10.0%) in order. In weight, height, fatness, hemoglobin, Hematocrit, platelet, ALT, AST and cholesterol, it appears that there is significant difference according to Sasang constitution. If proper regimen according to Sasang constitution by grasping the special features as per Sasang constitution through analyzing the difference as per Sasang constitution based on the results of above study is applied.

• 한국노년학
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• v.29 no.2
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• pp.425-440
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• 2009

The purpose of this study was to understand the ability of the elderly to activity of daily living, assess their quality of sleep and level of depression at home and analyze how such relate health related quality of life. The subject was 223 senior over 65 years old who lived in B Metropolitan City. Descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation and stepwise multiple regression were performed using SPSS WIN 14.0. The major findings of this study are as follow: 1) 34.1% of the respondents experienced a degree of sleep disorder and 57.8% were vulnerable to depression. 2) Activity of daily living, quality of sleep and depression were related to health related quality of life to a statistically significant degree. quality of sleep, activity of daily living positively related to health related quality of life. level of depression related to health related quality of life. Stepwise multiple regression analysis revealed the most powerful predictor of health related quality of life was depression. While age, level of education and quality of sleep were also found as significant predictor variables. Based on these results, it is necessary to perform more studies on health related quality of life and related factors according to that in various settings. Especially, to develop a program intended to improve the health related quality of life of the elderly at home, we need to consider not only physical factors but also psychological factors.

• The Journal of the Convergence on Culture Technology
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• v.7 no.2
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• pp.1-7
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• 2021

The purpose of this descriptive study was to examine the degree and the relationship among empathy ability, sense of humor and communication ability of psychiatric nurses and to understand factors which influence on communication ability. Data were collected from 219 psychiatric nurses in B and G city and analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple regression using SPSS/WIN 22.0. The degree of communication ability in psychiatric nurses was 3.59±.43. There were significant differences in communication ability with respect to sense of humor(r=.53, p<.001), and also between communication ability and empathy ability(r=.39, p<.001), with an explanatory power of 34.4%(F=29.56, p<.001). In conclusion, these findings indicate that the higher sense of humor and empathy ability of psychiatric nurses, the higher communication ability. Accordingly, to improve the communication ability of psychiatric nurses, educational programs to improve sense of humor and empathy ability of psychiatric nurses should be developed and utilized

• Korean Journal of Occupational Health Nursing
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• v.32 no.2
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• pp.68-78
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• 2023

Purpose: This study aimed to determine the moderating effect of self-esteem on the perception of death and the meaning of life among hospital nurses. Methods: The participants were 167 nurses working in two tertiary general hospitals located in city B. Data were collected from September 8 to 21, 2022. SPSS/WIN 29.0 was used for analysis along with t-test, ANOVA, Pearson correlation coefficients, and hierarchical multiple regression. Results: The study showed that the meaning of life was significantly correlated with the perception of death (r=.34, p<.001) and self-esteem (r=.31, p<.001). Self-esteem significantly moderated the relationship between the perception of death and the meaning of life (F=16.00, p<.001). Conclusion: Self-esteem may moderate the relationship between the two factors. This means that nurses with higher self-esteem have a greater tendency for their perception of death to positively impact their meaning of life. Therefore, for hospital nurses to discover the meaning of life, it is necessary to develop and apply a self-esteem enhancement program specialized for each clinical career.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.417-424
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• 2020

There is increasing tension and anxiety about being evaluated by others such as anxiety, which is felt when others' evaluation is expected or actual, and this is called social interaction anxiety. The purpose of this study was to develop a nursing intervention program that can reduce social interaction anxiety among nursing college students by analyzing factors affecting social interaction anxiety in nursing college students. The subjects of this study were four nursing college students in B city and C city. The survey data were analyzed using frequencies, percentages, means, t-test, ANOVA, Pearson correlation coefficient, and stepwise multiple regression with the SPSS WIN 21.0 program. The results of this study show that social interaction anxiety was positively correlated with fear of negative evaluation (r=.67, p<.001), fear of positive evaluation (r=.56, p<.001), and intolerance of uncertainty (r=.44, p<.001). Factors affecting ambivalence over emotional expressiveness in terms of social interaction anxiety was interpersonal relationship (β=.19, p<.001), fear of negative evaluation (β=.43, p<.001), and fear of positive evaluation (β=.34, p<.001). The explanatory power of these variables was 58.1%. Therefore, it is thought that nursing college students need to provide a support system to maintain good interpersonal relationships, to reduce sensitivity to positive and negative evaluation, and to accept and positively evaluate their own ability.

• Journal of Digital Convergence
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• v.15 no.11
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• pp.395-405
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• 2017

This study was designed to examine the degree of empathic ability, gratitude disposition, and job satisfaction, and identify that the impact on job satisfaction of psychiatric nurses. Participants were 196 psychiatric nurses from 8 psychiatric hospitals in Korea. Data were collected from October 8 to 20, 2016 and were analyzed using independent t-test, one-way ANOVA, Pearson correlation coefficients and hierarchical multiple regression with the SPSS WIN 22.0 program. The mean score of job satisfaction was $3.3{\pm}0.34$, empathic ability was $3.5{\pm}0.28$, and gratitude disposition was $4.0{\pm}0.59$. The psychiatric nurses' empathic ability and gratitude disposition affected their job satisfaction, accounting for 18.5% of the total variance. Empathic ability influenced job satisfaction significantly (B=0.52, p<.001) for 17.0% of the variance. This study suggested that the development of training programs for improving job satisfaction needs to consider their empathic ability and gratitude disposition of psychiatric nurses.