• 한국임상수의학회지
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• 제20권2호
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• pp.245-247
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• 2003

4년령의 잉글리시쉽독이 4일간의 호흡곤란과 비출혈로 본 건국대학교 수의과대학 동물병원에 내원하였다. 항응고제인 살서제의 섭취는 vitamine K1의 재생을 방지하여 순환 응고인자의 활성을 감소시킨다. 따라서 살서제에 중독이 되었을 때, 빠르고 적절한 치료가 수행되지 않으면 심각한 출혈로 인해 의식불명에 빠지고 심지어는 생명을 위협하기도 한다. 본 증례에서는 의식혼탁과 후궁반장의 임상증상을 보이는 4년령의 중성화된 개의 성공적인 치료를 보고하고자 한다. 적절한 수혈요법과 vitamin K1를 이용한 효과적인 치료를 실시하여 임상증상의 현저한 개선을 보였으며, 환축은 현재 완치되어 건강한 삶을 살고 있다.

• Journal of Microbiology
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• 제40권2호
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• pp.119-124
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• 2002

Experiments for the characterization of inactivation were performed in a series of batch processes with the total coliform used as a general indicator organism based on the chlorine residuals as a disinfectant. The water samples were taken from the outlet of a settling basin in a conventional surface water treat- ment system that is provided with the raw water drawn from the mid-stream of the Han River, The inactivation of total coliform was experimentally analysed for the dose of disinfectants contact time, filtration and mixing intensity. The curves obtained from a series of batch processes were shaped with a general tailing-off and biphasic mode of inactivation, i.e. a sharp loss of bacterial viability within 15 min followed by an extended phase. In order to observe the effect of carry-over suspended solids on chlorine consumption and disinfection efficiency, the water samples were filtered, prior to inoculation with coliforms, with membranes of both 2.5$\mu$m and 11.0 $\mu$m pore size, and with a sand tilter of 1.0 mm in effective size and of 1.4 in uniformity coefficient. As far as the disinfection efficiency is concerned, there were no significant differences. The parameters estimated by the models of Chick-Wat-son, Hom and Selleck from our experimental data obtained within 120 min are: log(N/N$\_$0/)=-0.16CT with n=1, leg(N/N$\_$0/)=-0.71C$\^$0.87/ with n 1 for the Chick-Watson model, log (N/N$\_$0/)=-1.87C$\^$0.47/ T$\^$0.36/ for the Hom model, log (MHo)=-2.13log (1+CT/0.11) for the Selleck model. It is notable that among the models reviewed with regard to the experimental data obtained, the Selleck model appeared to most closely resemble the total coliform survival curve.

• 한국식품조리과학회지
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• 제1권1호
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• pp.65-73
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• 1985

In this study, we tried to compare and determine wat the effects will be to the sensory characteristics and textures of a meat balls when the proportion of the textu-rized soy protein (TSP) varies from 0, 10, 20, 30, and 40％. Evaluation was conducted through sensory evaluation and objective evaluation. The results are as follows: 1. As the level of 40％ TSP increased the meat ball maintained a better appearance. 2. Color, beef flavor, tenderness, juiciness and acceptability shelved the tendency to decrease as TSP proportion increased. (1) No significant change to the outside color revealed to the level of 20％. How-ever, inside color showed a significant change after the level exceeded 20％. (2) Soy flavor tended to increased and beef flavor tended to decrease as the TSP proportion increased. However up to the level of 30％ one could not taste the flavor of soy. (3) Tenderness tended to decrease as the TSP proportion increased however difference was not significant. (4) Juiciness decreased as TSP proportion increased. (5) Acceptability tended to decrease as the TSP proportion increased but to a 40％ addition, the level of TSP did not have much effect on the sensory characteristics as long as sufficient seasonings were added. 3. Instron measurement incidated that springiness, cohesiveness and shear force tended to dcrease as the TSP proportion increased but hardness increased and chewi-ness was the highest at 20％ TSP level. 4. Color and difference meter indicated that the figure L and b tended to increase and AE decreased as the TSP proportion increased. 5. Cooking retention tended to increase as the TSP proportion increased. From thiss tudy, we can conclude that the level of up to 40％ of TSP in making meat ball did not affect the preference.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.662-674
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• 2018

Purpose: Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, the effect of allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The aim of this study was to evaluate the levels of ILC subsets in allergic rhinitis (AR) patients in response to house dust mite (HDM)-specific immunotherapy. Methods: We enrolled 37 AR patients undergoing AIT (16 responders and 11 non-responders) for 2 years, 35 HDM AR patients and 28 healthy subjects. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry to identify ILC subsets. Stimulation of ILC2s with recombinant allergen-specific protein was used to determine ILC2's activation (CD69 expression). Results: Responder AIT patients and healthy subjects had a decreased frequency of circulating ILC2s compared to non-responder AIT and AR patients. Conversely, ILC1s from responder AIT patients and healthy subjects showed increased frequency compared to non-responder AIT and AR patients. The frequency of ILC3s natural cytotoxicity receptor $(NCR)^+$ and $NCR^-$ in responder AIT patients was significantly lower compared to AR patients and healthy subjects. The ILC1: ILC2 proportion in responder AIT patients was similar to that of healthy subjects. PBMCs from patients who were responders to AIT had a significantly lower expression of the activation marker CD69 on ILC2s in response to allergen re-stimulation compared to AR patients, but no difference compared to non-responder AIT patients and healthy subjects. Conclusions: We propose that AIT might affect ILC responses. The activation of ILC2s was reduced in AR patients treated with AIT. Our results indicate that a relative ILC1/ILC2 skewed response is a possible key to successful AIT.

• Journal of Applied Biological Chemistry
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• 제59권1호
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• pp.49-56
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• 2016

The current study investigated the anti-obesity effect of Cissus quadrangularsis extracts (CQR-300) and its molecular action mechanism on obese mice induced high-fat diet (HFD). To induce the obesity, mice were fed a HFD for 6 weeks and then fed HFD only or HFD with CQR-300 at 50 and 200 mg/kg. Then, body weight gain and white adipose tissue weights were measured. We investigated the reduction in body fat and the regulation of fatty acid synthesis was measured by dual energy X-ray absorptiometry and real-time PCR with Western blot, respectively. In vitro study, CQR-300 inhibited pancreatic lipase activity. The CQR-300 treatment was significantly decreased the body weight gain and adipocytes size as well as white adipose tissues weights in HFD-induced obese mice. Furthermore, CQR-300 reduced the body fat and fat mass with regulating of adipose tissue hormones as leptin. Treatment with 50 mg/kg CQR-300 showed effectively lower expression levels of adipogenesis/lipogenesis related genes and proteins such as CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$), peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), Sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS) in white adipose tissue (WAT) as compared with the HFD fed only mice. These results suggest that the CQR-300 has an anti-obesity effect via inhibition of lipase activity, decrease the body fat mass by regulating the adipogenesis and lipogenesis related genes and proteins in epididymal adipose tissue with evaluate body fat reduce in the HFD-induced obese mice.

• 한국식품과학회지
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• 제31권5호
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• pp.1171-1177
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• 1999

쌀전분으로부터 분리한 아밀로오스와 아밀로펙틴이겔을 형성할 수 있는 최저농도로 아밀로오스와 아밀로펙틴 혼합겔을 제조하여 주사전자현미경과 X-선 회절기를 이용하여 겔 구조를 관찰하였다. 겔을 형성할 수 있는 최저농도인 용해성 아밀로오스 1.08% 농도에 아밀로펙틴을 $1.5%{\sim}7%$ 첨가하면 겔 그물망구조가 잘 형성되었고, 아밀로펙틴을 2%와 3% 첨가한 겔은 저장에 따라 $2{\theta}\;=\;17.0^{\circ}$에서 피크가 커졌다. 15% 아밀로오스/아밀로펙틴 혼합겔을 저장했을 때 아밀로오스 함량이 높을수록 단단하고 안정된 그물망구조를 이루었으며 생전분에서의 겔형성 양상과는 달리 아밀로오스와 아밀로펙틴이 함께 겔메트릭스를 이루는데 참여하는 것으로 생각되었고, 아밀로오스 함량이 증가할수록 $2{\theta}\;=\;17.0^{\circ}$에서 피크의 크기와 결정강도는 커졌다.

• 지구물리와물리탐사
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• 제7권4호
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• pp.245-250
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• 2004

단일 채널 해양 탄성파탐사 자료의 2차원 탄성파 단면도에 수평거리 보정을 적용하여 탄성파 단면도의 수평축을 거리 단위로 표현하였다. 수평축을 거리 단위로 표시함으로써 탐사선의 운항 속력이 변할 경우 나타나는 수평 거리 왜곡 현상을 상당히 해소할 수 있었다. 수평거리 보정을 위하여 탄성파 자료의 각 트레이스에 저장된 GPS 위치 정보와 자료 취합 윈도우를 이용하였다. 자료 취합 윈도우의 최소 길이는 탐사선의 속력과 발파 간격에 의해 결정하였으며, 최대 길이는 1차 프레넬대 반경을 이용하여 결정하였다. 자료 취합 윈도우의 길이를 결정함에 있어 수평 해상도와 중합의 효과를 동시에 고려하였다. 수평거리 보정 과정을 적용하여 실제 지층구조와 유사하다고 생각되는 2차원 탄성파 단면도를 작성할 수 있었다.

• 원예과학기술지
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• 제33권3호
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• pp.340-348
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• 2015

Mowing turfgrasses, especially fast growing species like perennial ryegrass, is one of the most time and money consuming tasks of their management. Trinexapac-ethyl (TE) is a popular plant growth regulator used to reduce mowing requirements, improve stress tolerance, and enhance turf quality. This study was conducted to investigate the effect of TE rate and frequency of applications on growth response and traffic tolerance of perennial ryegrass. The experiment was a split-plot laid out in a randomized complete block (RCB) design with three replications. TE was applied to main plots at 0.00, 0.25, and $0.50kg\;a.i.\;ha^{-1}$. Application pattern included an initial application, followed by two sequential applications at 6-wk intervals. Traffic treatment was applied to subplots with a cleated roller. Results demonstrated that TE consistently reduced vertical shoot growth, clippings dry weight, with maximum growth reduction of 59% and 65%, for 0.25 and $0.50kg\;a.i.\;ha^{-1}$, respectively, occurring at 2 weeks after initial TE treatment (WAT). Traffic also dramatically reduced vertical shoot growth and clippings dry weight. Overall, quality of perennial ryegrass was enhanced by sequential TE applications, however, turf quality and surface coverage reduced greatly under traffic, regardless of TE treatment. Total chlorophyll, chlorophyll a and chlorophyll b and total carbohydrates (TC) contents were also positively influenced following sequential TE application. Our results indicated that TE reduces mowing frequency and enhances turf quality rather than influencing traffic resistance.

• Environmental Analysis Health and Toxicology
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• 제19권2호
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• pp.141-151
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• 2004

We exposed juvenile puffer fish, Takifugu obscurus(30 days after hatching) to various aqueous pollutants including 4 kinds of inorganic metals (Ag, Cd, Cu and Hg), 2 organotin compound.; (tributyltin ［TBT］ and triphenyltin［TPhT］) and 5 polycyclic aromatic hydrocarbon (PAH) compounds (chrysene, fluoranthene, naphthalene, phenanthrene and pyrene) to estimate median lethal concentrations (LC50s) of each pollutant after the 96-hour acute exposure. Among the inorganic metals, Hg (52 $\mu\textrm{g}$/L; 96-h LC50) was most toxic to test animals and followed by Ag (164 $\mu\textrm{g}$/L), Cu (440 $\mu\textrm{g}$/L) and Cd (1180 $\mu\textrm{g}$/L). Aqueous TBT was more toxic between the two organotins; the 96-h LC50 for TBT (5.1 $\mu\textrm{g}$/L) was 3 times lower than that of TPhT (17.3 $\mu\textrm{g}$/L). The acute toxicity of PAH compounds was highest for chrysene (1.5 $\mu\textrm{g}$/L; 96-h LC50) and decreased in the order of pyrene (65 $\mu\textrm{g}$/L) > fluoranthene (158 $\mu\textrm{g}$/L) > phenanthrene (432 $\mu\textrm{g}$/L) > naphthalene (8690 $\mu\textrm{g}$/L). The toxicity of PAH compounds wat closely related to their physico-chemical characteristics such as $K_{ow}$ and water solubility, and well explained by simple QSAR relationship. The sensitivity of puffer fish to various inorganic and organic pollutants was generally comparable to various fish species widely used as standard test species in previous studies and further evaluation should be conducted to develop adequate testing procedure for T. obscurus when used in various toxicity tests.

• 한국산학기술학회논문지
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• 제14권1호
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• pp.128-134
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• 2013

본 연구는 대학 체육계열 신입생을 대상으로 4주간의 동기유발 프로그램을 적용하고 이에 대한 효과를 알아보기 위해 학습동기와 자기효능감의 차이를 검증하였다. 연구대상자는 C도에 위치한 2개 대학 체육계열 학과를 편의 표본추출 방법에 의해 선정하여 각각 실험집단(37명)과 통제집단(29명)으로 분류하였으며 사전검사와 사후검사를 실시하였다. 학습동기 척도는 외적동기, 내적동기로 분류하였고 자기효능감 척도는 자신감, 자기조절효능감, 과제난이도로 구성하였다. 자료분석은 대음표본 t-검증, 일원변량분석, 공분산분석을 실시하였으며, 다음과 같은 결론을 얻었다. 첫째, 동기유발 프로그램 참여에 따른 학습동기를 분석한 결과 외적동기에서 집단간에 유의한 차이가 있었다. 사전검사와 사후검사에 대한 집단내 비교에서는 실험집단과 통제집단 모두 내적동기와 외적동기에서 유의한 차이가 없었다. 둘째, 동기유발 프로그램 참여에 따른 자기효능감을 분석한 결과 모든 하위요인에서 집단간에 모두 유의한 차이가 없었다. 사전검사와 사후검사에 대한 집단내 비교에서 실험집단의 자신감에 유의한 차이가 있었다.