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Influence of Chlorpromazine(CPZ) and Iproniazid on Acute Carbon Tetrachloride(CCl4) Poisoning (사염화탄소(四鹽化炭素)의 독성(毒性)에 미치는 Chlorpromazine 및 Iproniazid의 영향(影響))

  • Yang, Ki Chun
    • Korean Journal of Veterinary Research
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    • v.16 no.1
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    • pp.59-64
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    • 1976
  • In the sequence of carbon tetrachloride hepatotoxicity, increased serum levels of a number of enzymes have been demonstrated in experimental animals. These observations, therefore, have served to help in detecting hepatic injury. The serological influence of chlorpromazine (CPZ) and iproniazid on the acute $CCl_4$ poisoning was executed in this investigation taking use of 6 albino rabbits (around 2 kg b.w.) in each group. By measuring of blood sugar level (Nelson-Somogyi method), S-GOT and S-GPT activities (Reitman-Frankel method), the pharmacological effects of the drugs was evaluated setting pretreated groups against the control. The results obtained were summarized as follows: 1. The intramuscular injection of $CCl_4$ led to increase the blood sugar level in first 3 hours and, after that, to decrease reasonably. But CPZ-pretreated group showed a tendency of increasing in compare with the control, and iproniazid-pretreated group inhibited evidently. 2. In S-GOT activity, the increased level was induced by $CCl_4$ in control. And CPZ-pretreated group showed a increased level until first day and decreased rapidly. But this property inhibited inhibited significantly by pretreating with iproniazid. 3. Although a single dose of $CCl_4$ increased the S-GPT activity, the more increasing trend was observed in CPZ-pretreated group. But these tendencies depressed remarkably in the iproniazid-pretreated group. It seemed to be attributed not to defend the $CCl_4$ toxicity but to be suppressed the enzyme systems in the liver by iproniazid that the blood sugar level and serum transaminase activities was decreased significantly in pretreating with iproniazid.

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Preparation of Silica Particles by Emulsion-Gel Process Using Membrane Emulsification (막유화 에멀젼-겔 공정에 의한 실리카 입자의 제조)

  • Yeon, Song-Hee;Youm, Kyung-Ho
    • Membrane Journal
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    • v.20 no.2
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    • pp.87-96
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    • 2010
  • We prepared spherical silica particles by controlling various conditions of emulsion-gel procedure using a lab-scale membrane emulsification system equipped with SPG (Shirasu porous glass) membrane having pore size of 2.6 ${\mu}m$. We determined the effects of process parameters of membrane emulsification (dispersed phase pressure, stabilizer and emulsifier concentration in continuous phase, $H_2O$/TEOS ratio, ratio of dispersed phase to continuous phase) on the mean size and size distribution of silica particles. The increase of the dispersed phase pressure and ratio of dispersed phase to continuous phase led to the increase in the mean size of silica particles. On the contrary, the increase in stabilizer and emulsifier concentration and $H_2O$/TEOS ratio caused the reduction of the mean size of particles. Through controlling these parameters, monodisperse spherical silica particles with about 3 ${\mu}m$ of the mean size were finally prepared.

(A study on the Telemetry monitoring and control of the multi environment factor) (다중 환경요소의 원격감시 및 제어에 대한 연구)

  • Ju, Gwi-Yeong;Choe, Jo-Cheon
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.39 no.1
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    • pp.7-15
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    • 2002
  • This paper is concerned with remote environment monitoring & control for the breeding house as scattering far and wide. The environment data is detected in the breeding house that is collected to one processor. It's adapted to the PSTN(public switch tele-phone network) and multi-processing for exchange the environment data and the control data in between the manager and a breeding house by micro-processor. We have designed the algorithm of the communication sequence through the experimental research. This system is composed of sensor interface, FSK communications, LED display, data latch and MCS-51 single-chip. The S/W is composed with data acquisition by multi-processing, data communication and interrupt. And this paper is Proposed the DB structure algorithm concern to a mount scale using web design. The subject is a performance of effective management for the breeding house.

New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities

  • Gao, Xue-Mei;Li, Yun-Qi;Shu, Li-Dan;Shen, Yan-Qiong;Yang, Li-Ying;Yang, Liu-Meng;Zheng, Yong-Tang;Sun, Han-Dong;Xiao, Wei-Lie;Hu, Qiu-Fen
    • Bulletin of the Korean Chemical Society
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    • v.34 no.3
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    • pp.827-830
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    • 2013
  • Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with $EC_{50}$ 3.05 and 2.87 ${\mu}g/mL$, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with $IC_{50}$ values of 3.18 and 5.22 ${\mu}M$, respectively.

The analysis of knit design elements of men's knitwear (현대 남성 니트웨어에 나타난 니트 소재 활용 현황)

  • Lee, Younhee;Park, Jungin;Lee, Hanchul;Jang, Jung-im
    • Journal of the Korea Fashion and Costume Design Association
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    • v.20 no.3
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    • pp.79-98
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    • 2018
  • The purpose of this study is to analyze and document special design elements of the knit material, such as yarn, stitch, and gauge used in various types of knit in a collection of men's fashion, and to provide basic data for database design. The analysis covers 37 brand collections of men's clothing, used to collect a total of 1,954 men's knitwear photographs, and others were collected from 12 collections from F/W to 2017 S/S collection through www.vogue.com. The results of the analysis of the knit design elements of the contemporary men's collection since 2011 are as follows. First, there were 1,513 straight yarn (77%) and 440 decorative yarn (23%) types of yarn. There were many different kinds of decorative yarn, such as two tone and melange effect in three colors, and the emergence of hairy yarn, like mohair and angora shannell, which was much common in low gauge's knitwear designs. Second, the frequency was high with low and middle gauges. thin and light high-gauges were often found in S/S collections, but there were also thick types of yarn in low-gauge knitwear. Third, 794 (40.6%) items used basic stitches such as plain stitch, which was the most utilized. The plain stitch, which is the most basic of the knit stitches, appears to be in high demand for its use, along with the use of various decorators. The development of printing and dyeing technologies has led to many designs that utilize the printer for the plain stitch. 326 (16.7 %), of colored jacard stitch, and of 175 (0.9 %) of intasia stitch.

Preparation and Characterization of PEG-impregnated Aloe Gel through DIS Processing of Aloe vera Leaf Slice (DIS 공정에 의한 Polyethylene Glycol 함침 알로에 베라 겔의 제조 및 특성화)

  • Kwon, Hye Mi;Hur, Won;Lee, Shin Young
    • KSBB Journal
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    • v.28 no.6
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    • pp.356-365
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    • 2013
  • The novel Aloe gels were prepared with dewatering and impregnation by soaking (DIS) processing of Aloe vera leaf slice at four different temperatures (25, 35, 45 and $55^{\circ}C$), using dehydration solution of 40% (w/v) polyethylene glycol (PEG4000). The PEG-impregnation to Aloe vera leaf slice during DIS was observed depending on immersion temperature, and the PEG-impregnated Aloe vera gel (PEG-i-AVG) obtained was characterized using $^1H$ NMR, FT-IR, GPC, XRD and TGA. The PEG-i-AVG had the higher levels of Aloe bioactives (glucomannan and O-acetyl contents) and better quality indices by $^1H$ NMR and FT-IR spectroscopy than those of native Aloe gel. Also, the obtained Aloe gel maintained the bimodal patterns in higher molecular weight region by GPC indicating no degradation of polysaccharide from native Aloe gel. The result observed by SEM confirmed a surface modification by forming the porous structure, and TGA result exhibited better thermal stability than that of native Aloe gel. XRD result revealed that the crystalline structure in Aloe gel was led by incorporation of PEG. Significant decrease of %insolubility and high enhancement of water solubility index were observed, respectively, and highly ordered conformation such as a helix structure was also indicated by Congo red reaction. We concluded that the modification effect for enhancing function of native Aloe gel was successfully obtained by DIS process using PEG as a dehydrating agent. These results suggested that this DIS process had a high potential for developing a new minimally processed product from Aloe vera leaf.

Ga-doped ZnO nanorod arrays grown by thermal evaporation and their electrical behavior (수직 배향된 Ga-doped ZnO nanorods의 합성과 전기적 특성)

  • Ahn, C.H.;Han, W.S.;Kong, B.H.;Kim, Y.Y.;Cho, H.K.;Kim, J.J.;Kim, H.S.
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2008.11a
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    • pp.414-414
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    • 2008
  • Vertically well-aligned Ga-doped ZnO nanorods with different Ga contents were grown by thermal evaporation on a ZnO template. The Ga-doped ZnO nanorods synthesized with 50 wt % Ga with respect to the Zn content showed maximum compressive stress relative to the ZnO template, which led to a rapid growth rate along the c-axis due to the rapid release of stored strain energy. A further increase in the Ga content improved the conductivity of the nanorods due to the substitutional incorporation of Ga atoms in the Zn sites based on a decrease in lattice spacing. The p-n diode structure with Ga-doped ZnO nanorods, as a n-type, displayed a distinct white light luminescence from the side-view of the device, showing weak ultraviolet and various deep-level emissions.

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Effect of Waste Cooking Oil on Durability of High Volume Mineral Admixture Concrete (폐유지류가 혼화재 다량 치환 콘크리트의 내구성에 미치는 영향)

  • Han, Min-Cheol;Woo, Dae-Hoon
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.1 no.3
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    • pp.173-180
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    • 2013
  • This paper is to investigate an effect of waste cooking oil(WCO) on the engineering properties and durability of high volume admixture concrete. Fly ash with 30% and blast furnace slag with 60% were incorporated in OPC to fabricate high volume admixture concrete with 0.5 of W/B. Emulsified refining cooking oil(ERCO) was made by mixing WCO and emulsifying agent to improve fluidity. ERCO was replaced by cement from 0.25 to 1.0%. As results, the increase of ERCO resulted in decrease of slump and air contents. For compressive strength, the use of ERCO led to decrease the compressive strength at 28 days, while it had similar strength or much higher strength than plain concrete at 180 days. Resistance to carbonation and chloride penetration was improved with the increase of ERCO contents due to decreased pore distribution by saponification between ERCO and concrete, while freeze-thaw resistance was degraded due to air loss.

Osteogenic Potency of Nacre on Human Mesenchymal Stem Cells

  • Green, David W.;Kwon, Hyuk-Jae;Jung, Han-Sung
    • Molecules and Cells
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    • v.38 no.3
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    • pp.267-272
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    • 2015
  • Nacre seashell is a natural osteoinductive biomaterial with strong effects on osteoprogenitors, osteoblasts, and osteoclasts during bone tissue formation and morphogenesis. Although nacre has shown, in one study, to induce bridging of new bone across large non-union bone defects in 8 individual human patients, there have been no succeeding human surgical studies to confirm this outstanding potency. But the molecular mechanisms associated with nacre osteoinduction and the influence on bone marrow-derived mesenchymal stem cells (BMSC's), skeletal stem cells or bone marrow stromal cells remain elusive. In this study we highlight the phenotypic and biochemical effects of Pinctada maxima nacre chips and the global nacre soluble protein matrix (SPM) on primary human bone marrow-derived stromal cells (hBMSCs) in vitro. In static co-culture with nacre chips, the hBMSCs secreted Alkaline phosphatase (ALP) at levels that exceeded bone morphogenetic protein (rhBMP-2) treatment. Concentrated preparation of SPM applied to Stro-1 selected hBMSC's led to rapid ALP secretions, at concentrations exceeding the untreated controls even in osteogenic conditions. Within 21 days the same population of Stro-1 selected hBMSCs proliferated and secreted collagens I-IV, indicating the premature onset of an osteoblast phenotype. The same SPM was found to promote unselected hBMSC differentiation with osteocalcin detected at 7 days, and proliferation increased at 7 days in a dose-dependent manner. In conclusion, nacre particles and nacre SPM induced the early stages of human bone cell differentiation, indicating that they may be promising soluble factors with osteoinductive capacity in primary human bone cell progenitors such as, hBMSC's.

The Electromagnetic Properties in Uncoupled funnel-junction with Various Cr Seed Layer (비결합형 터널접합구조에서 Cr 하지층에 따른 전자기적 특성변화)

  • Park, J.W.;Jeon, D.M.;Yoon, S.Y.;Lee, J.Y.;Suh, S.J.
    • Journal of the Korean Magnetics Society
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    • v.13 no.3
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    • pp.91-96
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    • 2003
  • Cross-geometrical Cr/Co/Al-Ox/Co/Ni-Fe tunnel junctions were fabricated by magnetron sputtering. To form an insulating layer, The Al layer was oxidized in an atmosphere of oxygen-argon mixture at low power after deposition. To enhance the coercivity of the bottom Co layer, The Cr seed layer was deposited on the glass and it led to increase in coercivity. The coercivity increase is due to the increase of roughness through the Cr thickness. In over oxidation time, the oxidation of Co bottom layer and flat interface of insulator can increase the bottom Co coercivity. But TMR ratio gradually decrease. TMR ratio is relevant with Cr thickness, insulator thickness, and oxidation time. The maximum TMR ratio was 14% at room temperature and the TMR ratio was decreased to half at 0.51 V.