• Korean Circulation Journal
• /
• 제53권9호
• /
• pp.581-593
• /
• 2023

In the catheterization laboratory, the measurement of physiological indexes can help identify functionally significant lesions and has become one of the standard methods to guide treatment decision-making. Plaque vulnerability refers to a coronary plaque susceptible to rupture, enabling risk prediction before coronary events, and it can be detected by defining a certain type of plaque morphology on coronary imaging modalities. Although coronary physiology and plaque vulnerability have been considered different attributes of coronary artery disease, the underlying pathophysiological basis and clinical data indicate a strong correlation between coronary hemodynamic properties and vulnerable plaque. In prediction of coronary events, emerging data have suggested independent and additional implications of a physiology-based approach to a plaque-based approach. This review covers the fundamental interplay between coronary physiology and plaque morphology during disease progression with clinical data supporting this relationship and examines the clinical relevance of physiological indexes in prediction of clinical outcomes and therapeutic decision-making along with plaque vulnerability.

• Journal of Information Processing Systems
• /
• 제16권1호
• /
• pp.61-82
• /
• 2020

The security risk management used by some service providers is not appropriate for effective security enhancement. The reason is that the security risk management methods did not take into account the opinions of security experts, types of service, and security vulnerability-based risk assessment. Moreover, the security risk assessment method, which has a great influence on the risk treatment method in an information security risk assessment model, should be security risk assessment for fine-grained risk assessment, considering security vulnerability rather than security threat. Therefore, we proposed an improved information security risk management model and methods that consider vulnerability-based risk assessment and mitigation to enhance security controls considering limited security budget. Moreover, we can evaluate the security cost allocation strategies based on security vulnerability measurement that consider the security weight.

• 생물정신의학
• /
• 제3권1호
• /
• pp.37-45
• /
• 1996

Recent studies on long-term outcome of schizophrenia revealed that schizophrenic symptoms recover in more than 50%, while it remains severe in less than 20% after 20 years or more from the onset. Psychopharmacological studies indicate that 75% of remitted schizophrenics may recur within 2 years after discontinuation of maintenance pharmacotherapy. In addition, family studies revealed that schizophrenic decompensation may occur significantly more frequent in discharged patients with high expressed emotion family than in low expressed emotion family. These findings strongly support a clinical validity of stress-vulnerability concept of schizophrenia which open a new viewpoint to two central problems in schizophrenia treatment, i.e. psychotic relapses and chronification of the fist episode schizophrenia. Moreover, recent psychopathological studies argue that schizophrenic symptoms are manifestations of psychological reaction secondary to a primary cognitive impairment(neurobiological vulnerability), which is originated in neurobiological changes in the brain. Recent approaches to the vulnerability to schizophrenic symptoms or schizophrenic decompensation are reviewed.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제5권3호
• /
• pp.139-144
• /
• 2016

소프트웨어 개발 시 보안을 고려한 개발방법의 적용은 추가비용을 발생시키고, 이러한 추가 비용은 많은 개발조직에서 보안을 고려하지 못하는 원인이 된다. 보안을 고려한 개발을 진행 하더라도, 주어진 비용 내에서 처리할 수 있는 취약점 처리량을 산출하는 방법이 부족한 실정이다. 본 논문에서는 보안 취약점 처리 비용을 효율적으로 사용하여 취약점 처리량을 산출하는 방법을 제안한다. 제안한 방법에서는 소프트웨어 개발단계 중 구현 단계에 중점을 두고, 정적 분석 툴을 활용하여 CWE TOP25에 대한 보안 취약점을 찾아낸다. 찾아진 취약점은 CWE의 정보를 활용하여, 각 취약점의 위험도, 처리 비용, 비용 당 위험도를 정의하고, 처리 우선순위를 정의한다. 정의된 우선순위를 통하여 탐지된 취약점 처리에 소모되는 비용을 산출하고, 투입 비용 내에서 취약점 처리량을 제어한다. 본 방법을 적용하면, 투입 비용 내에서 최대의 취약점의 위험도를 처리할 수 있을 것으로 기대된다.

• Membrane and Water Treatment
• /
• 제10권4호
• /
• pp.313-320
• /
• 2019

Increasing the concentration of nitrate ions in the soil solution and then leaching it to underground aquifers increases the concentration of nitrate in the water, and can cause many health and ecological problems. This study was conducted to evaluate the vulnerability of Meymeh aquifer to nitrate pollution. In this research, sampling of 10 wells was performed according to standard sampling principles and analyzed in the laboratory by spectrophotometric method, then; the nitrate concentration zonation map was drawn by using intermediate models. In the drastic model, the effective parameters for assessing the vulnerability of groundwater aquifers, including the depth of ground water, pure feeding, aquifer environment, soil type, topography slope, non-saturated area and hydraulic conductivity. Which were prepared in the form of seven layers in the ARC GIS software, and by weighting and ranking and integrating these seven layers, the final map of groundwater vulnerability to contamination was prepared. Drastic index estimated for the region between 75-128. For verification of the model, nitrate concentration data in groundwater of the region were used, which showed a relative correlation between the concentration of nitrate and the prepared version of the model. A combination of two vulnerability map and nitrate concentration zonation was provided a qualitative aquifer classification map. According to this map, most of the study areas are within safe and low risk, and only a small portion of the Meymeh Aquifer, which has a nitrate concentration of more than 50 mg / L in groundwater, is classified in a hazardous area.

• 토지주택연구
• /
• 제11권1호
• /
• pp.109-116
• /
• 2020

This study aims to establish an approach to assess urban flood vulnerability by identifying social characteristics such as the road transportation and the vulnerable groups. Assessment procedures comprise three steps as: (1) composing the assessment criteria to reflect the urban characteristics; (2) calculating the weight; and (3) evaluating the vulnerability. The criteria were adopted by Delphi survey technique. Four criteria as land cover, residents, vulnerable areas, and disaster response were adopted in the current study. To determine the weight set of criteria, subjective and objective methods were combined. The weight set was determined using the combined method which reflects the Delphi method and Entropy analysis. In the process of data-based construction, GIS tools wwere used to extract administrative unit materials such as land cover, road status, and slope. Data on population and other social criteria were collected through the National Statistical Office and the Seoul Metropolitan statistical data. TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) technique, which uses materials from cell units in order to rank the closest distance to the best case and the farthest distance from the worst case by calculating the distances to the area of assessment, was applied to assess. The study area was the Dorimcheon basin, a flood special treatment area of Seoul city. The results from the current study indicates that the established urban flood vulnerability assessment approach is able to predict the inherent vulnerable factors in urban regions and to propose the area of priority control.

• 대한한방소아과학회지
• /
• 제27권2호
• /
• pp.1-10
• /
• 2013

Objectives The aim of this study was to explore the effect of parental attitude on the behavioral problems in children who visited the traditional Korean pediatrics clinic. Methods The subjects were consist of 190 outpatients ($56.6{\pm}12.9$ months) and their mother. The Behavior problems of children were measured with Korean version of Child Behavior Checklist for Ages 1.5-5 (K-CBCL1.5-5) while parental perception of child vulnerability, parent overprotection, parenting stress were measured by Child Vulnerability Scale (CVS), Parent Protection Scale (PPS), Korean-Parenting Stress Index-Short Form scale (K-PSI-SF), respectively. Correlation and multiple regression were conducted for the analysis. Results Significant correlations between child total problems score and child vulnerability (r=.272, p<.001), parent overprotection (r=.243, p=.001), and parenting stress (r=.597, p<.001) were reported. Multiple regression analysis revealed that the parenting stress (${\beta}$=.548, p<.001) was a major predictor for the child behavior problems rather than child vulnerability and parent overprotection. Conclusions It was shown that the parenting stress has a significant influence on the emotional and behavioral development of children. These results can be useful for improving clinical diagnosis and treatment in traditional Korean pediatrics.

• 융합정보논문지
• /
• 제10권12호
• /
• pp.110-118
• /
• 2020

본 연구에서는 환경시설을 대상으로 침수피해에 대비한 재해 예방능력을 강화하고자 정량적인 부분뿐만 아니라 정성적인 부분을 고려한 홍수취약성 평가지표를 개발하고자 하였다. 이를 위해 환경시설의 침수에 취약한 시설물을 분석하고 구조적, 비구조적인 평가지표로 구분하여 개발하였다. 구조적 평가지표는 환경시설에 취약한 측면을 시설의 유형적인 측면에 대해 11개의 평가지표를 제시하였으며, 비구조적 평가지표는 내부인자와 외부인자로 구분하여 시설의 운영·상태 등 무형적인 측면에 대해 내부인자 8개와 외부인자 6개로 제시하였다. 본 연구에서 제시한 홍수취약성 평가지표는 기존 환경시설물의 침수피해 대비 홍수취약성에 대해 평가할 수 있도록 함으로써 홍수에 대한 대비할 수 있을 것으로 기대된다.

• 대한두경부종양학회지
• /
• 제39권2호
• /
• pp.1-6
• /
• 2023

The aging population, particularly those aged 65 and above, is on the rise, with projections indicating a substantial increase in the elderly demographic. This demographic shift brings challenges in managing age-related diseases, including head and neck cancers (HNCs). Frailty, often characterized by physiological decline and vulnerability to stressors, is a crucial factor affecting treatment outcomes of elderly cancer patients. Accordingly, the significance of assessing frailty in elderly HNC patients before their treatment should be emphasized, but current frailty assessment tools may not fully capture the unique challenges faced by HNC patients. Specific indicators, including respiratory and swallowing functions, are proposed for a more tailored assessment. This comprehensive review explores the impact of frailty on various treatment modalities, including surgery, radiation, and chemotherapy, highlighting the need for personalized interventions. Furthermore, it suggests avenues for future research to enhance frailty assessment tools and investigate interventions aimed at improving treatment outcomes in elderly HNC patients.

• Gut and Liver
• /
• 제12권6호
• /
• pp.623-632
• /
• 2018

Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor-${\alpha}$, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behçet's disease and inflammatory bowel diseases has been accumulating. Here, we review updated data on current experiences and outcomes after the administration of anti-tumor necrosis factor-${\alpha}$ for the treatment of intestinal Behçet's disease. In addition to infliximab and adalimumab, which are the most commonly used agents, we describe agents such as golimumab, etanercept, and certolizumab pegol, which have recently been shown to be effective in refractory intestinal Behçet's disease. This review also discusses safety issues associated with anti-tumor necrosis factor-${\alpha}$, including vulnerability to infections and malignancy.