• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.96-102
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• 2019

This study proposes basic information to make effective environments for social welfare education, revealing the reasons why students choose the social welfare major at Konyang Cyber University. We conducted qualitative research with 41 students in the social welfare department at Konyang Cyber University. The result of this research is as follows. First, most students chose their major to get a certificate that can benefit them in the near future. Second, they chose their major as a way to achieve renown, and to enhance the quality of their lives. Third, they desired to contribute to society through their social work. Finally, individual experiences and family background were also motives. Based on the research, to improve learning outcomes in social welfare education, the necessary learning strategies are as follows. First, goal-oriented learning is necessary for students who want to get the certificate. A practical curriculum needs to contain both practical skills and professional knowledge applicable to the social work field. Second, education for students who choose the major to gain fame, and to develop their lives, requires generation-integrated education to help them review their lives and find their own meaning in life. Third, education for students who choose the major for a practical social contribution has to contain volunteer training that can lead them to be professional volunteers in society. Fourth, education for students who choose the major based on their personal experiences and their family background needs to deal with case management, which discovers the recipients who need help in society and the students who can achieve visible outcomes after all.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.651-657
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• 2019

Although smallpox was eradicated in 1980, it is still considered a potential agent of biowarfare and bioterrorism. Smallpox has the potential for high mortality rates along with a major public health impact, eventually causing public panic and social disruption. Passive administration of neutralizing monoclonal antibodies (mAbs) is an effective intervention for various adverse reactions caused by vaccination and the unpredictable nature of emerging and bioterrorist-related infections. Currently, vaccinia immune globulin (VIG) is manufactured from vaccinia vaccine-boosted plasma; however, this production method is not ideal because of its limited availability, low specific activity, and risk of contamination with blood-borne infectious agents. To overcome the limitations of VIG production from human plasma, we isolated two human single-chain variable fragments (scFvs), (SC34 and SC212), bound to vaccinia virus (VACV), from a scFv phage library constructed from the B cells of VACV vaccine-boosted volunteers. The scFvs were converted to human IgG1 (VC34 and VC212). These two anti-VACV mAbs were produced in Chinese Hamster Ovary (CHO) DG44 cells. The binding affinities of VC34 and VC212 were estimated by competition ELISA to $IC_{50}$ values of $2{\mu}g/ml$ (13.33 nM) and $22{\mu}g/ml$ (146.67 nM), respectively. Only the VC212 mAb was proven to neutralize the VACV, as evidenced by the plaque reduction neutralization test (PRNT) result with a $PRNT_{50}$ of ~0.16 mg/ml (${\sim}1.07{\mu}M$). This VC212 could serve as a valuable starting material for further development of VACV-neutralizing human immunoglobulin for a prophylactic measure against post-vaccination complications and for post-exposure treatment against smallpox.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.455-463
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• 2018

Skin elasticity has been known to be influenced by the change of dermal components such as collagen, elastic fiber, and glycosaminoglycans. However, it is unclear whether the uppermost epidermis may affect the mechanical characteristics of elasticity. In present study we tried to find the role of stratum corneum when determining the elastic property under skin bioengineering measurement with $Cutometer^{(R)}$. A total of 10 healthy volunteers aged 25-40 years were investigated by the parameters reflecting the skin elasticity from face and volar forearm. Within various ranges of suction pressure, R0 (=Uf), R7 (=Ur/Uf) and R8 (=Ua) were obtained to explore the depth-associated elasticity. In addition, these parameters were re-measured after the skin was fully hydrated. As results, we found that the measurement of depth-associated elasticity was possible as using various suction pressure. And the R7 parameter was significantly lower from face than those from forearm in before hydration (p < 0.05). Also, we found that the hydration of stratum corneum could affect skin elasticity. Especially, the R7 parameter at 300 mbar suction pressure of face skin showed significantly increased values than that of before hydration (p < 0.05). Interestingly, measured data from the face before and after hydration manifested relatively higher variation than from the forearm. These results suggest that it is possible to evaluate the skin elasticity considering the changes of stratum corneum and epidermis by using various suction pressure and skin hydration.

• Science of Emotion and Sensibility
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• v.21 no.4
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• pp.43-54
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• 2018

The aim of this study is to determine the effect of motion sickness on pupil rhythm. Sixteen volunteers of both genders (8 male, 8 female, mean age $25.67{\pm}2.43$ years) experienced VR contents in both 2D and HMD versions for 15 minutes, and their pupillary rhythms were compared. The irregular pattern of the pupillary rhythms, as demonstrated by increasing mean pupil diameter (mPD) and standard deviation of the pupil diameter (sPD), revealed motion sickness after experiencing HMD condition. The pupillary response is strongly related to the cognitive load, and the motion sickness can be interpreted as a change in the cognitive load caused by the increasing volume of visual information that must be processed and the conflict or inconsistency between different sensory modalities. The method proposed in this study could be a non-contact measurement method for the monitoring of motion sickness using a web-camera rather than previous sensor-based methods.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.30 no.3
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• pp.195-221
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• 2019

The purpose of this study is to suggest implications from the case of health information service for patients in overseas hospital libraries. A total of 89 overseas hospital libraries were selected, including general hospitals, specialized hospitals, women's hospitals, children's hospitals, and veterans' hospitals. The health information service that is provided in general and common in 89 hospital libraries was surveyed and the differentiated health information service was investigated next. As a result, first, it can be seen that the establishment of hospital libraries and the provision of health information services are common outside of Korea. Second, various human resources such as librarians, health information specialists, medical specialists, social workers, clinical librarians, health education specialists, and volunteers are utilized. Third, it provides not only print materials but also various information sources such as electronic materials, websites, pamphlets, brochures, and provides health information in various languages. Fourth, in providing health (information literacy) education and programs, services are provided through linkage with hospitals, local public libraries, and local communities. The implications for domestic hospital libraries are as follows: First, the change of awareness of the establishment of hospital libraries and the provision of health information services; second, the support of the curriculum and associations and the need for continuing education; third, it is necessary to link with related organizations for mandatory and diversification of health information services in hospital libraries.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.359-367
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• 2019

The purpose of this study was to investigate the effects of ingestion of rabies and ginseng fruit extracts on alcohol hangover, liver damage protection, fatigue recovery, and physical strength improvement. A total of 64 volunteers aged over 20 were participated in this study and the randomized and repeated measures design method was used to divide a group of participants with a random assignment. All participants were divided into 4 groups (n=16) treated with hoveni dulcis thunb extract + ginseng berry extract (ARI 1000), hoveni dulcis thunb extract, ginseng berry extract, and placebo. As a result of respiratory alcohol concentration change, the group treated with ARI 1000 was significantly lower than the group treated with hoveni dulcis thunb extract, ginseng berry extract, and placebo in 1 hour of drinking, and significantly lower than the placebo group in 2 hours and 3 hours of drinking (p<0.05). After 2 and 3 hours of alcohol consumption, blood alcohol concentration of the group treated with rabies ARI 1000 was significantly lower than those of the other 3 groups (p <0.05). In conclusion, ingestion of ARI 1000 before drinking may significantly reduce the respiratory and blood alcohol concentrations, which may induce an effect on the hangover effect.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.166-170
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• 2019

Objectives: Attentional and memory functions are important aspects of neural plasticity that, theoretically, should be amenable to pharmacopuncture treatments. A previous study from our laboratory suggested that quantitative electroencephalographic (qEEG) measurements of theta/beta ratio (TBR), an index of attentional control, may be indicative of academic performance in a first-semester medical school course. The present study expands our prior report by extracting and analyzing data on frontal theta and beta asymmetries. We test the hypothesis that the amount of frontal theta and beta asymmetries (fTA, fBA), are correlated with TBR and academic performance, thereby providing novel targets for pharmacopuncture treatments to improve cognitive performance. Methods: Ten healthy male volunteers were subjected to 5-10 min of qEEG measurements under eyes-closed conditions. The qEEG measurements were performed 3 days before each of first two block examinations in anatomy-physiology, separated by five weeks. Amplitudes of the theta and beta waveforms, expressed in ${\mu}V$, were used to compute TBR, fTA and fBA. Significance of changes in theta and beta EEG wave amplitude was assessed by ANOVA with post-hoc t-testing. Correlations between TBR, fTA, fBA and the raw examination scores were evaluated by Pearson's product-moment coefficients and linear regression analysis. Results: fTA and fBA were found to be negatively correlated with TBR (P<0.03, P<0.05, respectively) and were positively correlated with the second examination score (P<0.03, P=0.1, respectively). Conclusion: Smaller fTA and fBA were associated with lower academic performance in the second of two first-semester medical school anatomy-physiology block examination. Future studies should determine whether these qEEG metrics are useful for monitoring changes associated with the brain's cognitive adaptations to academic challenges, for predicting academic performance and for targeting phamacopuncture treatments to improve cognitive performance.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.460-474
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• 2019

Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

• Journal of the Society of Disaster Information
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• v.15 no.3
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• pp.358-366
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• 2019

Purpose: This paper aims to clarify the problems and to examine the improvement methods by investigating the management condition of local-designated cultural property of which management is relatively poor in comparison with state-designated cultural heritage. Method: In order to grasp the management situation of the local-designated cultural heritage, a research on cultural heritage management situation and problems will be carried out with 35 cultual heritages in Goryeong-gun. Also, the improvement methods about the property type vulnerability on the basis of interview with cultual property managers, fire-fighting officers and civil servants, etc. Results: Local cultural heritages were investigated to be very vulnerable to the fire of wooden buildings, the theft of movable cultural heritages, and the effects of wind and water damage. It is because cultural heritages are scattered over wide areas fundamentally. As the result, it has difficulty in the patrols of police officers and fire fighters, and in the situation that it lacks disaster monitoring and CCTV for countermeasures to replace them, electronic security including fire hydrant, sensors, etc and fire extinguishing facilities and so on. It is difficult for local governments managing local-designated cultural heritages to enhance their management systems directly due to their lack of budget and manpower. Conclusion: In order to strengthen disaster and safety management system for the cultural heritages designated by local governments, they have to clarify disaster countermeasure task of fire fighting, police, and cultural heritage managers prepare their manuals, and systematize them through disaster drill mainly in local autonomous governments. Also, so as to establish a surveillance system every day, they have to enhance the community for local cultural heritage manage consisting of local volunteer fire departments, local voluntary disaster prevention organizations, volunteers, etc.

• The Korean Journal of Archival Studies
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• no.44
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• pp.155-197
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• 2015

Disaster of Sewol took place in one year. Meanwhile, the victim's family and the call time record academics have tried to record it. Ansan activists have moved to objectives such as civil records committee also pivotal. The citizens committee under the dictation recording oral history team has a diverse group of people associated with the time issue. bereaved families were collected from the oral as well as volunteers, religious personnel, activists, Ansan citizens and various people. Disasters around the world is also an important event to remember and honor the people together, and one of the most effective means to record There it is establishing an oral history archive. Does not leave a lot of nature history of sudden disasters that occur, as well as a tribute record dictation telling people of diverse perspectives on events helps a lot closer to the reality of the event. Erected in the National September 11 Memorial Museum to honor the Sept. 11 attacks and provide a variety of programs to chaerok dictation of the people involved with 9/11. To remember the 2013 Boston Marathon bombing 'Our Marathon' of crowdsourcing digital archive was built. In the archives of the local universities and institutions were created to collaborate actively and gathering oral history. Pan Am Flight 103 pieces terror has established an archive from Syracuse University. Here, neither graduates, faculty, and to the victim's family and friends gather and oral hitory. Disaster-related Sewol neither should be able to be used as in the case of foreign well, and it should continue to honor the victims of the collection. It also ought to occasion again to avoid this disaster on earth.