• 해양환경안전학회지
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• 제12권4호
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• pp.285-291
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• 2006

소리도와 욕지도 사이 해역의 유동 분포를 파악하기 위하여 2004년 5월, 6월, 10월 및 11월에 ADCP를 이용하여 정선관측 및 정점관측을 실시하였다. 25시간 정선관측에 따른 평균류의 연직분포는 욕지도 남서해역에서 북동류의 흐름이 우세하게 나타났다. 또한 25시간 정점관측 결과를 보면 상층과 하층의 경계수심이 $15\sim20m$에 존재함을 알 수 있었고, 상 하층으로의 유동분포가 다르고 상층과 하층의 변화폭이 작게 나타났다. 동서 성분 및 남북 성분에 대판 해수 수송량의 계산결과는 남서방향으로의 수송량보다 북동방향으로의 수송량이 더 크게 나타났다.

• 한국대기환경학회지
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• 제33권2호
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• pp.97-107
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• 2017

Columnar aerosol properties retrieved from solar radiation were investigated at the Yongin (YGN) SKYNET site over seven years from October 2008 to October 2015. Hourly averages were calculated when the data were available, and back trajectories were calculated to examine the effects of regional transport. Data recovery rate was low at 6.6%, primarily because solar radiation was measured only under daytime clear-sky conditions. Mean values of the fine-mode volume fraction (FMVF) as well as its seasonal variation were similar to those of $PM_{2.5}/PM_{10}$ although the coarse-mode fraction of column aerosols tended to be slightly larger. The values of single scattering albedo (SSA) and FMVF were lower in spring due to the effects of mineral dust, and higher in summer due to secondarily-formed inorganic ions. Back trajectories were grouped into five clusters according to the directions of transport paths. Aerosol loading was highest for Cluster 2 from the northwest, but SSA and FMVF were not particularly high or low because aerosols were composed of various materials with different properties. Aerosol loading was lowest for Cluster 5 from the Pacific Ocean passing through the south end of Japan, whose SSA and FMVF were highest as secondarily-formed inorganic ions were mixed.

• 한국해양공학회지
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• 제25권5호
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• pp.15-20
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• 2011

This study carried out a series of experiments involving impact tests (Drop Weight type & Charpy type with a standard specimen and newly designed I-type specimen), hardness tests, and fracture surface observations of French-made roll shell steel (F), abnormal roll shell steel (M), reheated roll shell steel (R), and S25C steel under heat treatment conditiAn experimental study was carried out to study the solid-liquid mixture upward hydraulic transport of solid particles in vertical and inclined annuli with a rotating inner cylinder. The lift forces acting on a fluidized particle play a central role in many important applications such as the removal of drill cuttings in horizontal drill holes, sand transport in fractured reservoirs, sediment transport, the cleaning of particles from surfaces, etc. In this study a clear acrylic pipe was used to observe the movement of solid particles. Annular velocities varied from 0.4 to 1.2 m/s. The effect of the annulus inclination and drill pipe rotation on the carrying capacity of a drilling fluid, particle rising velocity, and pressure drop in a slim hole annulus were measured for fully-developed flows of water and aqueous solutions of CMC (sodium carboxymethyl cellulose) and bentonite. The rotation of the inner cylinder was efficient at carrying particles to some degree. For a higher particle volume concentration, the hydraulic pressure loss of the mixture flow increased because of the friction between the wall and solids or between solids.

• 한국방재학회 논문집
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• 제8권2호
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• pp.59-63
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• 2008

지표수 흐름은 육지 물수지 계산에 중요한 요소중에 하나이다. 그러나, 기상변화의 예측과 그로 인한 방재대책수립을 위한 대규모의 기상모형과 연계되는 육지수문모형(Land Surface Model, LSM)들은 지표수 흐름을 토양수분수지로부터 간단하게 산정하고 있다. 침투계산에서 지표수 흐름깊이를 무시하는 것은 지표면 및 지표하 물흐름 모두에 계산상 오류를 초래할 수 있다. 그러므로, 육지수문모형에서 종합적인 물과 에너지 순환 예측을 하기 위해, 지표수 흐름을 위한 1차원 확산모형과 지표하 물흐름을 위한 계산망 체적평균 토양수분이송(Volume Averaged Soil-moisture Transport Model, VAST)모형을 연계하는 대규모 지표면 및 지표하 연계 물흐름 모형이 개발되었다. 이 논문에서는, 최첨단 육지수문모형중 하나인 CLM(Common Land Model)내의 지표수리수문 모의를 위한 주요부분을 비롯하여, 지형특성에 따른 지표수 흐름과 공간적 토양수분 분포의 예측개선을 위한 새로운 지표면 및 지표하 연계 물흐름 모형에 대해 기술하였다.

• Archives of Pharmacal Research
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• 제22권2호
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• pp.165-172
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• 1999

In the present work , the transport mechanism of a capsaicin derivative, DA-5018, through blood-brain barrier (BBB) has been investigated to evaluate the feasibility of potential drug development. The result of pharmacokinetic parameters obtained from the intravenous injection of plasma volume marker,$[3^H]RSA$ and $[{14}^C]DA-5018$, indicated that both AUC, area under the plasma concentration curve and VD, volume of distribution in brain of $[3^H]RSA$ agreed with those reported ($1620{\pm}10 $percentage injected dose minute per milliliter (%IDmin/ml) and $12.0{\pm}0.1{\mu}l/g$, respectively). Elimination half-life and AUC of $[{14}^C]DA-5018$is corrected by the PHLC analysis, 19.6$\pm$1.2 min and 7.69$\pm$0.85% IDmin/ml, respectively. The metabolic rate of $[{14}^C]DA-5018$was very rapid. The blood-brain barrier permeability surface area (PS) product of $[{14}^C]DA-5018$ was calculated to be 0.24$\pm$0.05 $\mu$l/min/g. The result of internal carotid artery perfusion and capillary depletion suggested that [14C]DA-5018 pass through BBB with the time increasingly. Investigation of transport mechanism of $[{14}^C]DA-5018$ using agonist and antagonist suggested that vanilloid (capsaicin) receptor did not exist in the BBB, and nutrient carrier system in the BBB has no effect on the transport of DA-5018. In conclusion, despite the fact that penetration of DA-5018 through BBB is significant, the intact drug found in the brain tissue is small because of a rapid metabolism. Therefore, for the central analgesic effect of DA-5018, the method to increase the metabolic stability in plasma and the brain permeability should be considered.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2020년도 추계학술대회
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• pp.169-170
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• 2020

부산항은 세계적인 환적중심항만이지만 지리적으로 이원화되어 있고, 환적 물동량의 지속적인 증가에도 불구하고 ITT 항만통합운영이 되고 있지 않아 항만운영 효율성을 저하시키고 있다. 또한, 이러한 운영방법이 환적운송 물동량 증가 및 이에 따른 환적운송비용 증가에 더불어 사회적 및 경제적 측면에서의 비효율에 대한 문제를 함께 야기하고 있다. 본 연구는 부산항 ITT 효율성 제고를 위해 추진 중인 ITT 공동배차를 수행할 통합운영조직 구성의 필요성과 부산항 ITT를 수행하는 운송사와 화물차주를 중심으로 한 조직 구성에 대해 다루며, 조직 설립한 후 관계당국과 컨소시엄 형태의 통합운영조직 설립과 지원방안에 대한 제안을 행하고자 한다. 아울러, 시사점 분석을 통하여 부산항 ITT 이해 당사자와 관계기관과의 역할에 대해서 다루도록 한다.

• Biomolecules & Therapeutics
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• 제25권4호
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• pp.441-451
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• 2017

Imperatorin, a major bioactive furanocoumarin with multifunctions, can be used for treating neurodegenerative diseases. In this study, we investigated the characteristics of imperatorin transport in the brain. Experiments of the present study were designed to study imperatorin transport across the blood-brain barrier both in vivo and in vitro. In vivo study was performed in rats using single intravenous injection and in situ carotid artery perfusion technique. Conditionally immortalized rat brain capillary endothelial cells were as an in vitro model of blood-brain barrier to examine the transport mechanism of imperatorin. Brain distribution volume of imperatorin was about 6 fold greater than that of sucrose, suggesting that the transport of imperatorin was through the blood-brain barrier in physiological state. Both in vivo and in vitro imperatorin transport studies demonstrated that imperatorin could be transported in a concentration-dependent manner with high affinity. Imperatorin uptake was dependent on proton gradient in an opposite direction. It was significantly reduced by pretreatment with sodium azide. However, its uptake was not inhibited by replacing extracellular sodium with potassium or N-methylglucamine. The uptake of imperatorin was inhibited by various cationic compounds, but not inhibited by TEA, choline and organic anion substances. Transfection of plasma membrane monoamine transporter, organic cation transporter 2 and organic cation/carnitine transporter 2/1 siRNA failed to alter imperatorin transport in brain capillary endothelial cells. Especially, tramadol, clonidine and pyrilamine inhibited the uptake of [$^3H$]imperatorin competitively. Therefore, imperatorin is actively transported from blood to brain across the blood-brain barrier by passive and carrier-mediated transporter.

• 한국ITS학회 논문지
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• 제20권5호
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• pp.113-129
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• 2021

최근 수도권 중심의 생활권역 확장과 대도시로의 인구 집중으로 도시 내의 교통 혼잡이 지속적으로 증가하고 있다. 도심지의 땅값 상승과 한정된 부지로 인해 새로운 도로 건설은 불가능하게 되었고, 데이터 기반의 효율적인 도로 운영의 중요성이 점점 부각되고 있다. 효율적인 도로 운영을 위해서는 교통상황의 변화에 따른 적절한 TOD 시간분할과 TOD 시간분할을 통한 최적의 신호 운영 방안이 필수적이다. 본 연구에서는 최적의 TOD 시간 분할을 위해 연속된 교차로에서 수집된 교통량과 속도 데이터에 시계열 데이터의 군집 분석을 위한 동적 타임 워핑 모델을 적용하였다. 시간 분할을 위해 활용된 데이터별 군집의 특성을 분석하여 최적의 신호 운영 시나리오를 구성하기 위한 시간 분할 방법론을 제안하고자 한다.

• 한국막학회:학술대회논문집
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• 한국막학회 1997년도 추계 총회 및 학술발표회
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• pp.69-70
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• 1997

Polyimides and related polymers, when synthesized from aromatic monomers, have generally rigid chain structures resulting in a low gas permeability. The rigidity of polymer chains reduces the segmental motion of chains and works as a good barrier against gas transport. To overcome the limit of use as materials of gas separation membranes due to low gas permeability, block copolymers with the incorporation of flexible segments like siloxane linkage and ether linkage have been studied. These block copolymers have microphase-separated structures composed of microdomains of flexible poly(dimethylsiloxane) or polyether segments and of rigid polyimides segments. In case of rigid-flexible block copolymers, the characteristics of both phases for gas permeation are of great difference. The permeation of gas molecules occurs favorably through microdomains of flexible segments, whereas those of rigid segments hinder the permeation of gas molecules. Accordingly the increase of content of flexible segments in a rigid polymer matrix will increase the gas permeability of the membrane linearly. However, this prediction does not satisfy enough many experimental results and in particular the drastic increase of the permeability is observed in a certain volume fraction. It was proposed that the gas transport mechanism is dominated by diffusion rather than gas solubility in a certain content of flexible phase if solution-diffusion mechanism is adopted. However, the transition from solubility-dependent to diffusion-dependent cannot be explained by the understanding of mechanism itself. Therefore, we consider an effective chemical path which permeable phase can form in a microheterogenous medium, and percolation concept is introduced to describe the permeability transition at near threshold where for the first time a percolation path occurs. The volume fraction of both phases is defined as V$_{\alpha}$ and V$_{\beta}$ in block copolymers, and the volume of $\beta$ phase in the threshold forming geometrically a traversing channel is defined as V$_{\betac}$. The formation mechanism of shortest chemical channel is schematically depicted in Fig. 1.

• 한국ITS학회 논문지
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• 제12권2호
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• pp.1-11
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• 2013

본 연구에서는 램프미터링과 요금소 본선미터링을 이용한 고속도로 통합교통관리 전략을 제시하였다. 램프와 본선의 통합 미터링을 위해 FREQ에서 램프미터링 진입허용 교통량의 최적화에 사용되는 Demand-Capacity 모형을 수정하여 최적 신호시간 산정모형을 제시하였다. 본 모형은 구간별 통과교통량을 최대화하는데 목표가 있으며, 본선 요금소 및 램프의 미터링 신호시간을 결정할 수 있다. 서울외곽순환선의 김포요금소~시흥요금소 구간을 대상으로 PARAMICS와 API를 이용하여 시뮬레이션 효과분석을 시행하였다. 시뮬레이션 분석결과, 본선미터링을 통해 램프미터링 단독 운영 대비 본선을 소통원활 상태의 속도로 유지할 수 있었으며, 정체구간에서 본선의 통과교통량이 14% 개선된 결과를 나타내었다. 또한 요금소에서의 신호운영으로 400m의 대기행렬이 발생되나, 정체의 분산으로 인해 본선과 램프 모두에서 보다 효율적 교통운영이 가능함을 확인하였다.