• Title/Summary/Keyword: Volume response

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Relationships between arterial and urinary $P_CO_2}, P{O_2}$ and acid-base balances (동맥혈 및 뇨 $P_CO_2}, P{O_2}$ 의 산-염기 균형 및 뇨량과의 관계)

  • Kim, Yong-Jin;Lee, Yeong-Gyun
    • Journal of Chest Surgery
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    • v.16 no.2
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    • pp.213-220
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    • 1983
  • Pulmonary function is the determinant of blood gas tension. However, Acid-Base disturbances can also alter partial pressures of oxygen and carbon dioxide in arterial blood. During respiratory acidosis $PO_2$ will be lowered and reverse changes will be produced during respiratory alkalosis. On the other hand, in metabolic acidosis $PO_2$ will be elevated and $PCO_2$ will be lowered by the respiratory compensation, and reverse response will be induced in metabolic alkalosis. Urinary gas tension has many influencing factors than arterial blood and difficult to estimate the tendency of its alterations. Urinary $PO_2$ and $PCO_2$ are not always identical level as venous blood. It is to be altered by blood gas tension, flow rate of urine, metabolic rate of kidney, and Acid-Base status of blood. Particularly countercurrent exchange of oxygen and carbon dioxide in the renal medulla will make larger alteration of gas tension than venous blood. After induction of Acid-Base disturbances [disturbances] arterial and urinary $PCO_2$, $PO_2$, urinary volume, and osmolarity were determined in dogs, and the relationships between arterial and urinary $PCO_2$ , $PO_2$ Acid-Base disturbances, urinary volume, and osmolarity were investigated. 1. During the acute Metabolic and Respiratory disturbances urinary pH did not respond on respiratory origin. However, there were immediate urinary response in pH on metabolic origin. 2. Urinary $PO_2$, $PCO_2$, did not always follow arterial or venous gas tension and Acid-Base disturbance. Urinary $PCO_2$, correlate well with the urinary volume. The larger the urinary volume, $PCO_2$ lowered to the venous level. The smaller the urinary volume, urinary $PCO_2$ tends to be higher. However urinary $PO_2$ did not have any particular correlation with urinary volume. 3. Correlation between urinary $PCO_2$ and $PO_2$ were inversely proportional to arterial blood. Differences of $PCO_2$ between arterial blood and urine also did not have any particular correlation with urinary volume. This may suggest that changes on blood gas tensions can influence on urinary $PCO_2$. 4. There were eminent clear inverse correlation between urinary $PCO_2$ and osmolar concentrations of urine. Above results strongly suggest that partial pressure of gas in urine primarily depend upon counter-current exchanges in renal medullary tissues.

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반응표면 분석법을 이용한 광학활성 styrene oxide의 생산조건 최적화

  • Lee, Eun-Yeol;Yun, Seong-Jun;Bae, Hyeon-Cheol;Gang, Jin-Hui
    • 한국생물공학회:학술대회논문집
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    • 2000.11a
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    • pp.593-596
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    • 2000
  • Chiral epoxides are useful chiral synthons in organic synthesis and various biological methods have been investigated for the production of chiral epoxides. In this work, enantioselective resolution of racemic styrene oxide was investigated using an isolated Aspergillus niger sp. for the production of optically pure (S) -styrene oxide. The enantioselectivity and initial hydrolysis rates of racemic substrate were highly dependent on the pH, temperature, and the volume ratio of cosolvent. The experimental sets of pH, temperature, and the volume ratio of cosolvent were designed using central composite experimental design, and the reaction conditions were optimized using response surface analysis. The optimal conditions of pH, temperature, and the volume ration of cosolvent were determined to be 7.78, $28.32^{\circ}C$, and 2.4 %(v/v), respectively, and optically pure (S)-styrene oxide (> 99% ee) could be obtained with the 35 % yield by microbial enantioselective hydrolysis reaction.

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Walsh Analysis of the State of Mixture in Heterogeneous Media and its Application (비균질체의 혼합상태에 대한 Walsh해석과 응용)

  • 박진무
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.10 no.1
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    • pp.164-169
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    • 1986
  • Walsh analysis is applied to the numerical specification of the volume distribution which is the key parameter in the formulation of the constitutive equations of heterogeneous media, indicating the geometrical state of the mixture. An example of two-dimensional volume distribution, its approximation, and the Walsh correlation coefficients are presented and the change of the information distribution in the operations is investigated. The phenomena of information concentration upon the large-scale Walsh coefficients are applied to the volumetric response of porous slids, clarifying the validity of the spherical-model calculation.

Comparative Numerical Analysis of Homogenized and Discrete-Micromechanics Models for Functionally Graded Materials (기능경사재를 위한 균질화와 이산화-미시역학 모델에 대한 비교 수치해석)

  • Ha, Dae-Yul;Lee, Hong-Woo;Cho, Jin-Rae
    • Proceedings of the KSME Conference
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    • 2000.04a
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    • pp.399-404
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    • 2000
  • Functionally graded materials(FGMs) involve dual-phase graded layers in which two different constituents are mixed continuously and functionally according to a given volume fraction. For the analysis of their thermo-mechanical response, conventional homogenized methods have been widely employed in order to estimate equivalent material properties of the graded layer. However, such overall estimations are insufficient to accurately predict the local behavior. In this paper, we compare the thermo-elastic behaviors predicted by several overall material-property estimation techniques with those obtained by discrete analysis models utilizing the finite element method, for various volume fractions and loading conditions.

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A Numerical Investigation on the Rule of Mixtures for the Mechanical Properties of Composites with Homogeneously Distributed Particles (입자가 균일하게 분포된 복합체의 기계적 성질과 혼합률에 관한 수치적 연구)

  • 김형섭
    • Transactions of Materials Processing
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    • v.10 no.5
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    • pp.396-401
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    • 2001
  • The concept of the mixtures can be used not only in the composites but also in the materials with precipitates and matrix. In this investigation, the finite element method of axisymmetric unit cell models and the rule of mixtures of the Voigt and the Reuss models are used to analyze the overall mechanical response of composites with homogeneously distributed particles. The calculations have been cameo out by taking the materials as i) hardening and ii) perfect plastic materials. The Plastic properties are predicted for various volume fractions of the soft and hard particles. The computational results are compared with the results of the rule of mixtures. It is found that the plastic flow curves agree well with the Voigt model when the volume fraction of the particles is high. On the other hand, the calculated flow curves exist between the Voigt model and the Reuss model when the volume fraction of the particles is low.

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NEW TECHNIQUE IN THE USE OF VIBRO-ACOUSTICAL RECIPROCITY WITH APPLICATION TO THE NOISE TRANSFER FUNCTION MEASUREMENT

  • Ko, K.H.;Kook, H.S.;Heo, S.J.
    • International Journal of Automotive Technology
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    • v.7 no.2
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    • pp.173-177
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    • 2006
  • A noise transfer function(NTF) is the frequency response function between an input force applied to an exterior point of a vehicle body and the resultant interior sound pressure usually measured at the driver's ear position. It represents the measure of noise sensitivity for the output force transmitted to the joints between the body and chassis. The principle of vibro-acoustic reciprocity is often utilized in the measurement of NTF. One difficulty in using the volume source is that most of the previously proposed methods require the knowledge of the volume velocity of the acoustic source in advance. A new method proposed in the present work does not require any calculation related with the volume velocity of the acoustic source, but still yields even more accurate results both in the amplitude and phase of the NTF. In the present work, the new method is applied to obtain NTF data for a midsize sedan.

Research on Assessment of Impact of Big Data Attributes to Disaster Response Decision-Making Process (빅데이터 속성이 재난대응 의사결정에 미치는 영향에 관한 연구)

  • Min, Geum Young;Jeong, Duke Hoon
    • The Journal of Society for e-Business Studies
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    • v.18 no.3
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    • pp.17-43
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    • 2013
  • This research is to assess the relationship Big Data attributes and disaster response process. The hypothesis are designed to form decision making between situation awareness and disaster response by defining major attribute of Big Data(Volume, Variety, Velocity, Complexity). It is proved whether there is a moderating effect in cause-and-effect relationship by visualizing Big Data. To test the hypotheses, it was conducted a questionnaire survey of civil servants in charge of disaster-related government employees, and collected 320 data(without 12 undependable responses). The research findings are suggested the attributes of accumulation, expandability, flexibility, real-time, analytical, combination of Big Data have a strong effect on disaster manager's situation awareness.

Optimization of Extraction Process for Total Polyphenols from Angelica Using Response Surface Methodology (반응표면분석법을 이용한 안젤리카로부터 폴리페놀 성분의 추출공정 최적화)

  • Lee, Seung Bum;Park, Bo Ra;Hong, In Kwon
    • Applied Chemistry for Engineering
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    • v.29 no.3
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    • pp.325-329
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    • 2018
  • In this study, polyphenols were extracted from Angelica, which are known to have a high antioxidant content and the extraction process was optimized using the response surface methodology. The extraction yield and the total polyphenols were set as response values for the methodology. Quantitative factors in the extraction process were the extraction time, volume ratio of alcohol/ultrapure water, and extraction temperature. When considering both the main and interaction effects, the greatest influence factor on the extraction yield and total polyphenols was the extraction time. The optimum extraction time and temperature and alcohol/ultrapure water volume ratio for angelica were 2.8 h, $56.6^{\circ}C$ and 64.0 vol% respectively. The extraction yield and total polyphenols when using the conditions were calculated to be 24.6% and 8.76 mg GAE/g. respectively. Determination coefficients of regression equations for the extraction yield and total polyphenols were 81.4 and 75.4%, respectively. Also the overall satisfaction level was found to be 0.80 and the significance was confirmed within 5%.

A Study on Nozzle Flow and Spray Characteristics of Piezo Injector for Next Generation High Response Injection (차세대 고응답 분사용 피에조 인젝터의 노즐유동 및 분무특성에 관한 연구)

  • Lee Jin-Wook;Min Kyoung-Doug
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.30 no.6 s.249
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    • pp.553-559
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    • 2006
  • Most diesel injector, which is currently used in high-pressure common rail fuel injection system of diesel engine, is driven by the solenoid coil energy for its needle movement. The main disadvantage of this solenoid-driven injector is a high power consumption, high power loss through solenoid coil and relatively fixed needle response's problem. In this study, a prototype piezo-driven injector, as a new injector mechanism driven by piezoelectric energy based on the concept of inverse piezo-electric effect, has been designed and fabricated to know the effect of piezo-driven injection processes on the diesel spray structure and internal nozzle flow. Firstly we investigated the spray characteristics in a constant volume chamber pressurized by nitrogen gas using the back diffusion light illumination method for high-speed temporal photography and also analyzed the inside nozzle flow by a fully transient simulation with cavitation model using VOF(volume of fraction) method. The numerical calculation has been performed to simulate the cavitating flow of 3-dimensional real size single hole nozzle along the injection duration. Results were compared between a conventional solenoid-driven injector and piezo-driven injector, both equipped with the same micro-sac multi-hole injection nozzle. The experimental results show that the piezo-driven injector has short injection delay and a faster spray development and produces higher injection velocity than the solenoid-driven injector. And the predicted simulation results with the degree of cavitation's generation inside nozzle for faster needle response In a piezo-driven injector were reflected to spray development in agreement with the experimental spray images.

The Response of Parenchymal Mass and Airway Obstruction from Lung Cancer to Radiation Therapy (단순 흉부 X-선 사진상 폐암 소견에 대한 방사선 치료의 효과 -단기 추적 조사를 중심으로-)

  • Kang, Cheol-Hoon;Shin, Sei-One;Kim, Myung-Se
    • Radiation Oncology Journal
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    • v.7 no.2
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    • pp.227-233
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    • 1989
  • From April 1986 to Dec 1988, fifty one patients with carcinoma of lung were treated by radiation therapy in Department of Therapeutic Radiology, Yeungnam University Hospital Of the 51 patients, $31(61\%)$ were squamous cell ca, $8(15.7\%)$ were small cell ca, and remained $4(7.9\%)$ were other cell types. Total radiation dose was average $64Gy (60\~75 Gy)$ for group A and 45Gy $(40\~59Gy)$ for group B. The mass regression and the response of airway obstruction to radiation therapy was established on the basis of follow up chest X-ray. The mass regression above $50\%$ of total volume was noted in 23 patients $(74.2\%)$ among 31 patients and the difference between two groups was not seen. In squamous cell ca, however, the mass regression rate (above $50\%$ of total volume) was $83.3\%$ (10/12) in group A compared to $50\%$ (3/6) in group B(p<0.05). The alleviation of airway obstruction was noted as follows. In group A, CR $42.9\%$, PR $35.7\%$, no response $21.4\%$ and in group B, CR $55.6\%,\;PR\;33.3\%$, no response $11.1\%$. But, in squamous cell ca, responsiveness is higher than group B. The study indicates that the importance of higher radiation dose in the management of primary tumor mass and airway obstruction caused by lung cancer especially squamous cell ca. So, meticulous treatment planning and multimodality combination therapy without increasing si.do elect or complication is recommended in management of inoperable bronchogenic carcinoma.

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