• Title/Summary/Keyword: Volume of distribution

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On the Analysis of Transportation System in Mokpo Port (목포항 운송시스템의 분석에 관한 연구)

  • Nam, M.U.;Lee, C.Y.
    • Journal of Korean Port Research
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    • v.11 no.2
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    • pp.321-337
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    • 1997
  • Rapid change in the technological environment of marine transportation and the development of the ocean shipping industry have fostered a revolution in the port system. This in turn has caused major changes in the function and use of port in Korea. Aside from this. Mokpo Port, however continues to decline, because the existing port facilities and related subsystem are already obsolete with no chance of regaining operational effectiveness and treatment for proper implementation. Although a few studies have been done on the Mokpo Port, has not been found, any reseach for the analytical approach to the transportation system of it. This paper aims to make an extensive analysis of the physical distribution system in Mokpo Port focusing on the coordination of subsystems such as navigational aids system, quay handling and transfer system, storage system and inland transport system. The base of introduced simulation tool here is the queueing theory. The overall findings are as follows; 1. Among those vessels called at Mokpo Port in 1994, the average size of oceangoing vessels is 4,922.1 G/T, and the domestic is 317.8 G/T. The average arrival interval and service time of the domestic vessels are 6.0 hours and 24.1 hours respectively marking the berth occupation rate over 100%. Those for oceangoing vessels are 34.5 hours, 120.0 hours and 37.2%. In order to maintainin the berth occupation rate to 70% the capacity considering the 1994 of domestic piers must be extended to 145% and oceangoing vessels must be increased to 165% year called. 2. The capacity of approaching channel is enough to handle the total traffic volume. 3. Tugs are sufficiently being provided to handle all ships requiring their services 4. The capacity of storage and inland transportation systems are sufficient to handle the throughput and the yard stroage utilization rate of No.1 $\cdots$ No.5 is 4.5% and No.6 1S 30% of 1993's. 5. The utilization rate of LLc(Level Looping Crane) and PNT(PNeumaTic) are 2.7% and 18.8%, respectively. Practical solution and proposal for improvement of Transportation System in Mokpo Port are as follows; 1. To avoid the congestion in domestic pier introduction of a new port operation system is necessary allowing the domestic vessel to use the oceangoing pier. 2. To establish the port management information system to improve the efficiency of port operation. 3. To build a new storage system for high valued cargos including modernization of the present storage and handling system. 4. To insure the safety of navigation in approaching channel, The Vessel Traffic System including separation scheme is introduced. 5. To interest enormously on public relation to ship owner's association, shippers and consignees by showing that they can save cost and ship turnaround time in order to promote the call to Mokpo Port. At last, to be strategically change the function of Mokpo Port to the Leisure, Fishing & Ferry as well as Maritime port.

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Metabolic impairment pattern analysis of the Alzheimer's disease (Alzheimer's Disease의 대사영상패턴 분석)

  • Juh, Ra-Hyeong;Lee, Chang-Uk;Chung, Yong-An;Choe, Bo-Young;Suh, Tae-Suk
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2004.11a
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    • pp.91-95
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    • 2004
  • Several MRI studies have reported reductions in temporal lobe volumes in Alzheimer's disease (AD). Measures have been usually obtained with regions-of-interest (ROI) drawn manually on selected medial and lateral portions of the temporal lobes, with variable choices of anatomical borders across different studies. We used the automated voxel-based morphometry (VBM) approach to investigate gray matter abnormalities over the entire extension of the temporal lobe in 10AD patients (MM5E 22)and 22 healthy controls. Foci of significantly reduced gray matter volume in AD patients were detected in both medial and lateral temporal regions, most significantly in the right and left posterior parahippocarmpal gyri. At a more flexible statistical threshold (P<0.01, uncorrected for multiple comparisons), circumscribed foci of significant gray matter reduction were also detected in the right amygdala/enthorinal cortex, the anterior and posterior borders of the superior temporal gyrus bilaterally, and the anterior portion of the left middle temporal gyrus. These VBM results confirm previous findings of temporal lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.

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Usefulness of serum cystatin C to determine the dose of vancomycin in neonate

  • Shin, Jeong Eun;Lee, Soon Min;Eun, Ho Seon;Park, Min Soo;Park, Kook In;Namgung, Ran
    • Clinical and Experimental Pediatrics
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    • v.58 no.11
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    • pp.421-426
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    • 2015
  • Purpose: The vancomycin dosage regimen is regularly modified according to the patient's glomerular filtration rate (GFR). In the present study, we aimed to assess the usefulness of serum cystatin C (Cys-C) concentration, compared with serum creatinine (SCr) concentration, for predicting vancomycin clearance (CLvcm) in neonates. Methods: We retrospectively analyzed the laboratory data of 50 term neonates who were admitted to the neonatal intensive care unit and received intravenous vancomycin, and assessed the pharmacokinetic profiles. Creatinine clearance (CLcr) and GFR based on Cys-C (GFRcys-c) were estimated using the Schwartz and Larsson formulas, respectively. Results: The mean CLvcm (${\pm}$standard deviation) was $74.52{\pm}31.17L/hr$, the volume of distribution of vancomycin was $0.67{\pm}0.14L$, and vancomycin half-life was $9.16{\pm}17.42hours$. The SCr was $0.46{\pm}0.25mg/dL$ and serum Cys-C was $1.43{\pm}0.34mg/L$. The peak and trough concentrations of vancomycin were $24.65{\pm}14.84$ and $8.10{\pm}5.35mcg/mL$, respectively. The calculated GFR based on serum creatinine concentration (GFR-Cr) and GFRcys-c were $70.2{\pm}9.45$ and $63.6{\pm}30.18mL/min$, respectively. The correlation constant for CLvcm and the reciprocal of Cys-C (0.479, P=0.001) was significantly higher than that for CLvcm and the reciprocal of SCr (0.286, P=0.044). GFRcys-c was strongly correlated with CLvcm (P=0.001), and the correlation constant was significantly higher than that for CLvcm and CLcr (0.496, P=0.001). Linear regression analysis showed that only GFRcys-c was independently and positively correlated with CLvcm (F=41.9, P<0.001). Conclusion: The use of serum Cys-C as a marker of CLvcm could be beneficial for more reliable predictions of serum vancomycin concentrations, particularly in neonates.

VOC/HAPs Emission Characteristics & Adsorption Evaluation for Paint Products in Busan Area (부산지역 페인트제조시설의 VOC/HAPs 배출특성 및 흡착능 평가)

  • Song, Bok-Joo;Lee, Seung-Min;Cho, Gab-Je;Cho, Jeong-Gu;You, Pyung-Jong;Kim, Gi-Gon
    • Journal of Korean Society of Environmental Engineers
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    • v.34 no.5
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    • pp.316-325
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    • 2012
  • In this study, we suggested adequate control technology by analyzing emission process and main chemical of VOC/HAPs generated from four paint factories in Busan area. And we estimated whether Kapok fiber, which is a natural material, can be commercially used for an absorbent by testing adsorption ability. As a result of this sturdy, above 60% of VOC/HAPs was volatilized and dispersed inside the working place without conducting control system of facilities during manufacturing paints. Concentration profile of VOC/HAPs, which is volatile naturally outside the factories, is surveyed above 70% at Toluene, Ethylbenzene, and Xylene. And a result of evaluation of odor attribution level about the component whose Odor Threshold is known, it is estimated that major cause material of A, B, C factories is Toluene and that of D factory is m/p-Xylene. And that result presented design arguments such as facilities specifications, activated carbon filling volume, and replace cycle of activated carbon as control technology. Also, that result presented emission process improvement such as adsorption of central-controlled ventilation device, installation of inlet flenge, and potable cleaning process. The rate of pollutant adsorption of Kapok fiber, which is natural material, is indicated about 91.9%, 66.7%. That result validated the possibility as replacement of activated carbon.

Seasonal Concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in Residential Areas Around Petrochemical Complexes and Risk Assessment Using Monte-Carlo Simulation (석유화학단지 주변 주거지역 다환방향족탄화수소(PAHs)의 농도와 Monte-Carlo 모의실험을 통한 위해성평가)

  • Park, Dong-Yun;Choe, Young-Tae;Yang, Wonho;Choi, Kil-Yong;Lee, Chae-Kwan
    • Journal of Environmental Health Sciences
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    • v.47 no.4
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    • pp.366-377
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    • 2021
  • Background: Polycyclic aromatic hydrocarbons (PAHs) are generated in petrochemical complexes, can spread to residential areas and affect the health of residents. Although harmful PAHs are mainly present in particle phase, gas phase PAHs can generate stronger toxic substances through photochemical reaction. Therefore, the risk assessment for PAHs around the petrochemical complex should consider both particle and gas phase concentrations. Objectives: This study aimed to investigate the concentration characteristics of particle and gas phase PAHs by season in residential areas around petrochemical complexes, and to assess the risk of PAHs. Methods: Samples were collected for 7 days by seasons in 2014~2015 using a high volume air sampler. Particle and gas phase PAHs were sampled using quartz filter and polyurethane foam, respectively, analyzed by GC-MS. Chronic toxicity and probabilistic risk assessment were performed on 14 PAHs. For chronic toxicity risk assessment, inhalation unit risk was used. Monte-Carlo simulation was performed for probabilistic risk assessment using the mean and standard deviation of measured PAHs. Results: The concentration of particle total PAHs was highest in autumn. The gas phase concentration was highest in autumn. The average gas phase distribution ratio of low molecular weight PAHs composed of 2~3 benzene rings was 85%. The average of the medium molecular weight composed of 4 benzene rings was 53%, and the average of the high molecular weight composed of 5 or more benzene rings was 9%. In the chronic toxicity risk assessment, 7 of the 14 PAHs exceeded the excess carcinogenic risk of 1.00×10-6. In the Monte-Carlo simulation, Benzo[a]pyrene had the highest probability of exceeding 1.00×10-6, which was 100%. Conclusions: The concentration of PAHs in the residential area around the petrochemical complex exceeded the standard, and the excess carcinogenic risk was evaluated to be high. Therefore, it is necessary to manage the air environment around the petrochemical complex.

A Study on the Auction Schemes of Fish Commodities in the Koheung Region (고흥지역 수산물 경매시장의 특성에 관한 연구)

  • 강연실
    • The Journal of Fisheries Business Administration
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    • v.29 no.2
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    • pp.111-141
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    • 1998
  • Why are auctions so prevalent in fisheries fields\ulcorner One answer is, perhaps, that fisheries products have no standard value. The price of any catch of fish (at least of fish destined for the fresh fish market) depends on the demand and supply conditions at a specific moment of time, influenced by prospective market developments and prices must be remade for each transaction. There are various auction schemes including written-bid method in Korea. It is difficult to make decision the application of auction selling in market distribution. One reason is the absence of adequate data on which to base firm statements. There is very little precise information about the relative volume handled by auction scheme as compared with other sales schemes Because of the paucity reliable data, one must depend largely on qualitative in attempting to above this problem. This paper is designed to examine which auction scheme is more efficient as a economic tool by introducing the three auctions, as samples, utilized in Koheung peninsula. Koheung coast with abundant fisheries resource, locates on the Middle-South part in Korea and has three auction firm operating by fisheries cooperatives. fur selling of dry fish included sea weed, live fish and fresh fish respectively, As a result, 1 found that there are three interesting auction schemes as follow : 1. More than one winners are selected as buyers. The highest bidder can at first get fishes he wants to buy, second winner can get surplus fishes after the highest bidder employes one's privilege with the highest pay, and next winner would be a buyer if fishes would be left in sequence after being sold with higher price. Every fisherman can sell one' s fishes with equal unit price if he delivery it to the winner within one day. Therefore, all the vendors feel they are equal members of fisheries cooperation. 2. Written-bid pricing on the cover of handy book. It is easy to write and to erase the figure more than on the small black board, and is convenient also to keep in the pocket. 3. Auctioning on the fixed platform with fixed fish tank is a very fast auction scheme in spite of short displaying time. Auctioneer presides bidding at one place on the fixed platform, instead of moving, vendors should carry a container of live fishes in the fish tank into showing table in front of would-be buyers and auctioneer. Although the applicability of the auction system to a marketing problem depends in part on subjective considerations by those making decision, basically it is a matter of comparative economic efficiency. In general, if the scheme maximizes returns in relation to the effort expanded by both buyers and sellers, it will be utilized. If it does not, a more efficiency may take place over a period of time, but, even more important, those making decisions may become aware of the potentialities of new schemes. Therefore, in order to applicate the three interesting auction schemes introduced in this paper to other fisheries market, it is necessary not only to analyze many other auction schemes but also to compare the economic efficiency those schemes utilizing in other fisheries market.

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Analyzing Thinning Effects on Growth and Carbon Absorption for Cryptomeria japonica Stands Using Distance-Independent Growth Simulations (거리독립 생장예측 시뮬레이션기법 적용에 의한 삼나무임분의 임분생장 및 탄소고정에 미치는 간벌시업 효과 분석)

  • Kwon, Kibeom;Han, Hee;Seol, Ara;Chung, Hyejean;Chung, Joosang
    • Journal of Korean Society of Forest Science
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    • v.105 no.1
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    • pp.132-138
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    • 2016
  • The objectives of this study were to infer the parameters of forest stand growth functions of STEMS for Cryptomeria japonica stands of Jeju Hannam Experimental Forest, Korea Forest Research Institute, and to investigate the effects of thinning regimes on the patterns of stand growth and carbon absorption. The forest stand growth functions for the potential diameter growth, modifier, crown ratio and mortality are the major ones composing the independent-tree/distance-free forest stand growth simulator, STEMS. The parameters were inferred using the sets of growth data obtained from stem analyses of 39 trees, chosen from 13 sample plots of the forest stands. The effects of thinning regimes on the patterns of stand growth and carbon absorption were investigated by simulating the stand growth patterns of the case study stand with 3 different thinning regimes: no-thinning, early thinning with low intensity and late thinning with high intensity using the simulator. According to the results of the analyses, the different thinning regimes cause significant effects on the growth patterns of average DBH, average height, diameter distribution and stand volume as well as the amount of carbon absorptions.

EFFECT OF SPHERICAL SILICA FILLER ON THE PHYSICAL PROPERTIES OF EXPERIMENTAL COMPOSITES (구상형 실리카 필러가 실험적 복합레진의 물성에 미치는 효과)

  • Kang, Seung-Hoon;Park, Sang-Jin;Min, Byung-Soon;Choi, Ho-Young;Choi, Gi-Woon
    • Restorative Dentistry and Endodontics
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    • v.24 no.1
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    • pp.88-99
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    • 1999
  • The purpose of this study was to investigate the physical properties of experimental composite resins made with the spherical and crushed fillers. The 14 experimental composite resins containing 0, 5, 10, 15, 20 and 25%(w/w) in spherical filler group and 0, 10, 20, 30, 40, 50, 60 and 70%(w/w) in crushed filler group, incorporated in a Bis-GMA matrix (Aldrich Co., USA), were made with 1% ${\gamma}$-methoxy silane treated fillers. The polymer matrix was made by dissolving 0.7%(w/w) of benzoyl peroxide(Janssen Chemical Co. Japan) in methacrylate monomer, whereupon 0.7%(v/v) N,N-dimethyl-p-toluidine(Tokyo Kasei Co. Japan) was added to the monomer. The weight percentage of each specific particle size distribution could be determined from a knowledge of the specific gravity, the weight(w/w), and corresponding volume %(v/v) of the filler sample in resin monomer. In crushed silica group and spherical silica group, the diametral tensile strengths and compressive strengths were measured with Instron Testing Machine(No.4467), and analyzed in 14 experimental composite resins made by filler fractions. The shear bond strength of 14 experimental composite resins to bovine enamel was measured with universal testing machine(Instron No.4467). The fracture surfaces were sputter-coated with a gold film and investigated by SEM. The results were as follows; 1. The diametral tensile strength was tendency to increase in crushed silica group, but not in spherical silica group. The highest diametral tensile strength was found in 20% filler fractions of two groups. 2. The compressive strength was higher in 15%(w/w) and 20%(w/w) in spherical silica group than in crushed silica group, but not in spherical silica group. 3. The significant correlation was noticed in increase in shear bond strength in crushed silica group, but not in spherical silica group. 4. The significantly highest shear bond strength was noticed in 50% filler concentration in crushed silica group, and in 15% filler concentration in spherical silica group, it was not significant in relation. 5. In crushed silica group, cut surface of resin matrix and the interface between resin and filler is obvious. In spherical silica group, fractures that occurred through the filler particles were round in shape.

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Pharmacokinetic Preformulation Study of rH IL-2 (인터루킨-2의 제제설계를 위한 체내 동태학적 연구)

  • Seo, Min-Seok;Shim, Chang-Koo;Kwon, Jong-Bum;Na, Do-Sun;Lee, Sun-Bok;Hahm, Kyung-Soo;Han, Moon-Hi
    • YAKHAK HOEJI
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    • v.34 no.4
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    • pp.238-243
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    • 1990
  • Pharmacokinetic characteristics of recombinant human interleukin-2 (rH IL-2) wre studied in the rat. First, different doses of rH IL-2 ranging from 6,400 to 1,600,000 U/kg were injected intravenously and the effect of dose size on the pharmacokinetics was examined. There was no dose dependency in the pharmacokinetics of rHIL-2 in the dose range of 6,400-40,000 U/kg. But at the dose of 1,600,000 U/kg, there was a severe hemolysis throughout the experiment and the pharmacokinetic parameters such as Vdss and CLt were significantly increased compared to those obtained from lower doses. It also showed that this drug is hardly distributed to the peripheral tissues and hardly eliminated from the body, since the valume of distribution (Vdss) and total body clearance (CLt) were 45-75 ml/kg and 1-2 ml/min/kg, respectively. The Vdss is close to the actual plasma volume and the CLt is less than glomerular filtration rate (GFR). Therefore it seemed that rH IL-2 is distributed only in the plasma pool and hardly filtered in the kidney due to its very large molecular weight. Second, rH IL-2 was administered to the rat via several routes such as hepatic portal vein (PV), intraperitoneal (IP), peroral (PO) and intranasal (IN) routes. The bioavailabilities (BA) of PV, IP, PO and IN routes were 96.8, 4.9, 0 and 0.1%, respectively. The addition of some nasal absorption enhancers such as taurocholate, taurodeoxycholate, glycocholate and glycodeoxycholate did not increase the BA of intranasaly administered rH IL-2. The result is contrast to the effect of these bile salts on the nasal absorption of ${\alpha}-inteferon$. Considering it together with the pharmacokinetic parameters, very large molecular weight of rH IL-2 seemed again to be the cause to very poor membrane permeability.

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Distribution And Abundance Of Copepods In The Gulf Of Alaska And The Bering Sea In Summer 1978 (하계(夏季) Alaska만(灣)과 Bering해(海)의 Copepods의 분포조성(分布組成))

  • Lee, Sam Seuk
    • 한국해양학회지
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    • v.15 no.1
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    • pp.17-33
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    • 1980
  • The materials were obtained in the eastern Gulf of Alaska and the south- eastern Bering Sea during the cruise of the research vessel, Ohdae San, from July to October 1978. A total of 76 samples were taken by NORPAC net from a depth of 200 meters or less in coastal areas. 1. The surface water temperature in the coastal waters, varing from 9 to 10$^{\circ}C$, was lower than that in offshore waters which varied from 10 to 12.9$^{\circ}C$ in the eastern Gulf of Alaska. Thermocline was formed in the 30∼50 meter layer. Salinity of the coastal waters of Kenai Peninsula and Kodiak was 30 which was slightly lower than that of offshore. 2. The water temperature of the surface layer down to 30 meters varied from 7 to 10$^{\circ}C$ and from 1 to 9$^{\circ}C$ in the layer below 30 meters in the south-eastern Bering Sea. Meandering thermal front spread from the Alaska Peninsula to St. Matthew Island by way of St. Paul, and a thermocline was found at the 30∼50 meter layer Salinity ranged from 31.0 to 33.0 and that of northern and coastal waters was little lower than that of offshore. 3. Zooplankton biomass fluctuated from 0.1 to 23.6cc/10㎥ in the eastern Gulf of Alaska and 2.0 to 26.1cc/10㎥ in the south-eastern Bering Sea. Plankton was rich in the following areas, the inshore Kodiak waters, the northern Bering Sea, the Coastal waters and waters adjacent to Alutian islands however, poor in the central Bering Sea. In general, the south-eastern Bering Sea has a higher concentration of plankton volume than the eastern Gulf of Alaska. 4. Twenty three species representing 17 genera of copepods were identified from the samples. These were mostly composed of the cold water species, such as Pseudocalanus minutus, Acartia longiremis, Metridia lucens and Eucalanus bungii var. bungii. 5. The cold oceanic species were composed of Calanus cristatus, C.plumchrus, Metridia lucens, Eucalanus bungii var. bungii and Scolecithricella minor. The cold neritic species were Centropages abdominalis, Pseudocalanus minutus, Acartia longiremis, Eurytemora herdmanii, Pontella pulvinata, P. longipedata and Tortanus discaudatus. On the other hand, the warm oceanic species were Calanus tenuicornis and Oithona plumifera. The cosmopolitan species were Calanus finmarchicus and Oithona similis. 6. It was suggested that the cold oceanic species, Eucalanus bungii var. bungii and Metridia lucens in the south-eastern Bering Sea can be recommended as a valuable indicator species for finding the fishing grounds of demersal fish such as pollock and yellowfin sole in this area.

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