• Animal cells and systems
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• v.7 no.2
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• pp.145-149
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• 2003

Adult periodontitis is a chronic inflammatory disease whose etiology is not well defined. Recent studies have shown that vitamin D receptor gene has been a candidate for the susceptibility of adult periodontitis. The purpose of this study is to investigate the frequency of Taq I restriction fragment length polymorphism (RFLP) in the vitamin D receptor gene in nan periodontically healthy controls and 28 adult periodontitis patients. Taq I RFLP in the vitamin D receptor gene was detected by PCR amplification, followed by restriction enzyme digestion and 2％ agarose gel electrophoresis. There was no significant difference in the distribution of Taq I RFLP between healthy controls and adult periodontitis group (P > 0.05). Thus, Taq I RFLP in the vitamin D receptor gene may not confer the susceptibility to adult periodontitis in Korean population. However, t allele distributions of this RFLP showed various frequencies among ethnic groups studied. Further studies in other ethnic groups will be required.

• Clinical Nutrition Research
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• v.12 no.1
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• pp.77-89
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• 2023

This study aimed to find out the effect of vitamins on respiratory-related viral infections, including coronavirus disease 2019 (COVID-19), through the literature reviews. From January 2000 to June 2021, the studies (cohort studies, cross-sectional studies, case-control studies, randomized control trials) related to vitamins (vitamin A, D, E, C, B₆, folate, and B₁₂) and COVID-19/severe acute respiratory syndrome/Middle East respiratory syndrome/cold/influenza were selected from the PubMed, Embase, and Cochrane libraries and analyzed. The relationship between vitamins and virus-related respiratory diseases was identified. Through the review, 39 studies were selected on vitamin D, one study on vitamin E, 11 studies on vitamin C, and 3 studies on folate. Regarding COVID-19, 18 studies on vitamin D, 4 studies on vitamin C, and 2 studies on folate showed significant effects of the intake of these nutrients in preventing COVID-19. Regarding colds and influenza, 3 studies on vitamin D, 1 study on vitamin E, 3 studies on vitamin C, and 1 study on folate demonstrated that the intake of these nutrients significantly prevents these diseases. Therefore, this review suggested the intake of vitamins D, E, C, and folate is important for preventing respiratory diseases related to viruses, such as COVID-19, colds, and influenza. The relationship between these nutrients and virus-related respiratory diseases should be continuously monitored in the future.

• Journal of Nutrition and Health
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• v.29 no.7
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• pp.758-771
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• 1996

This study attempted to define reference data for the distribution of vitamin d status and to explore the relationship between vitamin D status and related biochemical indices in Korean women. The vitamin D status of 179 Korean women aged from 20 to 75 years was analyzed by using HPLC(High Pressure Liquid Chromatography). Related biochemical indices such as iPTH, alkaline phosphatase, creatinine, albumin, Ca, Mg and P were also measured. The mean serum level of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were s25.8ng/ml and 89.8pg/ml, respectively. Low 25-hydroxyvitamin D (<25nmol/L) was found in 29 subjects(16.5%). There was a significantly progressive decrease in serum 25-hydroxyvitamin D with increasing age(p<0.05). After in their, there was a dramatical reduction in 25-hydroxyvitamin D(p<0.05). It was also significant in post-menopasusal women compared with pre-menopausal women(p<0.000). Serum alkaline phosphatase levels increased significantly with age(p<0.001). Whereas serum calcium and phosphorus levels remained constant with age. Serum 250-hydroxyvitamin D was invesely related to iPTH (p<0.05) and alkaline phophatase (p<0.001).

• Journal of Nutrition and Health
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• v.29 no.9
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• pp.981-990
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• 1996

To define the risk facots of subclinical vitamin D deficiency in postmenopausal women, circulating serum 25-hydroxyvitamin D levels, known to be the indicator of vitamin D status, were measured and risk faxtors affecting it were investigated in 27 women with low 25-hydoxyvitamin d level(ie, the study group : serum 25-hydroxyvitamin D<10ng/ml) by comparing to 55 age-matched control(the control group) were analyzed. The serum level of 25-hydorxyvitamin D was analyzed by HPLC(High Pressure Liquid Chor-matography) and analyzed biochemical parameter. The following information was obtained by interviews : sociodemographic charateristics, the intake of food containing vitamin D, proxy measure of sunlight exposure(time spent outdoors), and reprocuctive histpry of the subjects. The study group had significantly lower levels of serum calcium, increased levels of iPTH and alkaline phosphatase, Among the dietary determents, energy, protein, fat, calcium, phophorus, and vitamin D intakes were lower in the study group than the normal group. The time spent outdoors in a day was not significantly different between the two groups. However, during the day, a specific time of time spent out doors between 12:00 and 14:00 was significantly lower in the study group. Logistic analysis revealed that vitamin D and calcium intake were more important affecting factors than the time spent outdoors in post menopausal women.

• Food Science and Industry
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• v.55 no.3
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• pp.276-283
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• 2022

Vitamin D is a fat-soluble vitamin helps to retain calcium and phosphorus but also has shown to affect immune regulation and homeostasis. In humans, vitamin D3 and vitamin D2 and their metabolite has intensively studied in both innate and adaptive immune system that they are important to regulate overwhelmed inflammation. The vitamin D receptor is a nuclear hormone receptor which regulate various downstream target gene expressions as a transcription factor related to metabolism, immune regulation, etc. Vitamin D deficiency is a high-risk factor for inflammatory diseases like autoimmune disease and allergy. In addition, reduced vitamin D seem to correlate with susceptibility to the virus infection such as HIV and COVID-19. In this review, we will summarize up-to-date vitamin D's role in various immune cells, immune regulatory functions during autoimmune, allergic, and infectious diseases. We will also discuss about vitamin D supplement effects in human trial studies for COVID-19.

• 한국체육학회지인문사회과학편
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• v.54 no.5
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• pp.727-737
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• 2015

The study investigated the relationship between vitamin D status and lifestyle risk factors in office workers. A total of 515 office workers(336 men and 179 women) aged 30 years or older were voluntarily recruited from S-city. Along with serum vitamin D levels, lifestyle risk factors including obesity index, physical fitness, metabolic risk factors, lipids profile and sedentary behavior were measured using standardized protocols. Subjects were classified as deficiency (<20ng/mL), insufficiency (20-29ng/mL), and sufficiency (≥30ng/mL) based on serum vitamin D levels. Linear contrast analysis using one-way ANOVA showed significant linear decreases in mean body fat (p=.030) and sedentary behavior (p<.001) and significant linear increases in skeletal muscle (p=.037), cardiorespiratory fitness (p<.001) and HDL-C (p=.013) across incremental serum vitamin D levels. Compared with the low cardiorespiratory fitness group, the high cardiorespiratory fitness group had a significantly higher odds ratio (men OR=2.144, p=.042, women OR=1.971, p=.045) for having vitamin D insufficiency or deficiency even adjustment after age. Compared to the shortest sitting time group, the longest sitting time group had a significantly higher odds-ratio in a group of female office workers (OR=1.262, p=.043) for having vitamin D insufficiency or deficiency even adjustment after age. The current findings of the study showed that poor physical fitness and sedentary behavior were the risk factors of low serum vitamin D levels, implying the urgent need for a healthy lifestyle modification along with vitamin D supplementation.

• Journal of Nutrition and Health
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• v.41 no.2
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• pp.127-134
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• 2008

The effects of vitamin $D_{3}$ supplementation on bone mineral density and bone mineral content in ovariectmized rats were investigated. Forty female Sprague-Dawley rats (body weight 180 g) were divided into two group, ovariectomy and Sham groups, which were each randomly divided into two subgroups that were fed casein and casein supplemented with vitamin $D_{3}$ diets. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXlmus (GE Lunar Co, Wisconsin, USA) in spine and femur on 6 weeks after feeding. Osteocalcin and urinary DPD crosslinks value were measured as markers of bone formation and resorption. The body weight gain and food efficiency ratio (FER) were higher in OVX groups than in Sham groups regardless of diets. Serum Ca concentration and urinary Ca excretion were higher in vitamin $D_{3}$ supplemented group than in casein group in Sham and OVX. Crosslinks values were higher in OVX groups than in Sham groups. Spine BMD and femur BMD of ovariectomy group were significantly lower than Sham groups, however vitamin $D_{3}$ supplemented groups were significantly higher than control groups in Sham and OVX. In conclusion, dietary vitamin $D_{3}$ supplementation on ovariectimized rats were significantly increased bone mineral density and bone mineral content in spine and femur.

• Nutritional Sciences
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• v.9 no.1
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• pp.42-47
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• 2006

It has been reported that taking a proper amount of calcium and vitamin D helps to increase bone mineral density (BMD) and is effective in decreasing the risk of osteoporosis. This study investigated the supplementary effects of calcium and vitamin D on postmenopausal women who had osteoporosis and used calcium and vitamin D supplements. The study subjects consisted of osteoporotic postmenopausal women who were recruited from the Department of Orthopedics in a university-affiliated hospital. Sixty-seven study subjects were orally administrated 1,000 mg of calcium (calcium carbonate) and 2.5 mg of active vitamin D (1-$\alpha$ hydroxyvitamin D) (cholecalciferol 250 IU) twice a day for a year and a half. BMD and biochemical markers were evaluated and repeated every six months. One year after the intervention test, the bone mineral density of the lumbar spine was significantly increased as compared to the baseline. Six months after supplement administration, the level of serum alkaline phosphatase began to decrease, and afterwards a significant difference was maintained Concentration of 1, 25-dihydroxy-vitamin D at 1.5 years was higher than that of the baseline. In comparison with that of the baseline, the level of urinary hydroxyproline in the study subjects over six months was significantly decreased This study continued that effects such as BMD improvement and changes in biochemical markers appeared at least one year after administration of supplements.

• Korean Journal of Food Science and Technology
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• v.54 no.3
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• pp.327-333
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• 2022

An orally disintegrating film (ODF) based on hyaluronic acid (HA) containing vitamin D was developed. The vitamin D content in the ODF was set based on the adequate intake (AI) of vitamin D from 0 to 10 AI (0, 1, 4, 7, and 10AI). The control (0AI) had the highest thickness and showed the longest disintegration time among the samples. The moisture content of the ODFs was significantly lower in those with vitamin D compared to the control. As the amount of vitamin D increased, the water vapor permeability (WVP) of the ODFs decreased, and the opacity significantly increased. The tensile strength was higher in the films containing vitamin D compared to the control films. However, the elongation at the break showed no significant difference among the films. The vitamin D content in the film was reduced by 25.7-44.2% during processing compared to the amount that was originally added. Based on the above results, a new and convenient vitamin D delivery system, an ODF, could be successfully produced.

• Journal of Nutrition and Health
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• v.49 no.6
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• pp.437-446
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• 2016

Purpose: The purpose of this study was to estimate dietary intake of vitamin D and the relationship between serum 25-hydroxyvitamin D (25OHD) concentration and bone mineral density (BMD) in Korean adults using the 2011 data from the Korea National Health and Nutrition Examination Survey. Methods: Daily intake of vitamin D and ratio of subjects that consumed less vitamin D than adequate intake (AI) were estimated in 4,879 Korean adults. The relationship between daily intake of vitamin D and serum 25OHD and BMD were analyzed. Results: Average daily intakes of vitamin D were $3.84{\pm}0.23{\mu}g/day$ for men and $2.22{\pm}0.11{\mu}g/day$ for women. Approximately 72~97% of men and 80~99% of women consumed less than the AI of vitamin D for Koreans. Serum 25OHD concentration increased with age, and the ratios of serum vitamin D deficiency (< 20 ng/mL) were 47.8~81.1% for men and 59.4~92.8% for women. Average intake of vitamin D was higher in subjects aged < 50 yr than in those ${\geq}50yr$, but lower in serum 25OHD concentration. In subjects aged < 50 yr, serum 25OHD was higher in subjects that consumed $10{\mu}g/day$ of vitamin D than in those that consumed less than $5{\mu}g/day$. In female subjects aged ${\geq}50yr$, average intake of vitamin D was associated with higher bone mineral density. Conclusion: It was found that dietary intake of vitamin D could increase serum 25OHD concentration in young adults and bone mineral density in old women. Therefore, nutrition policies for enriched foods with vitamin D and nutrition education to consume more vitamin D-rich foods are needed to ameliorate vitamin D status of the Korean population. Adequate intake for Korean population aged < 50 yr might be adjusted upwardly up to $10{\mu}g/day$.