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http://dx.doi.org/10.23093/FSI.2022.55.3.276

Vitamin D in autoimmune, allergic, and infectious diseases  

Shim, Chae-Hyeon (Department of Life Science, College of Natural Sciences, Hanyang University)
Choi, Je-Min (Department of Life Science, College of Natural Sciences, Hanyang University)
Publication Information
Food Science and Industry / v.55, no.3, 2022 , pp. 276-283 More about this Journal
Abstract
Vitamin D is a fat-soluble vitamin helps to retain calcium and phosphorus but also has shown to affect immune regulation and homeostasis. In humans, vitamin D3 and vitamin D2 and their metabolite has intensively studied in both innate and adaptive immune system that they are important to regulate overwhelmed inflammation. The vitamin D receptor is a nuclear hormone receptor which regulate various downstream target gene expressions as a transcription factor related to metabolism, immune regulation, etc. Vitamin D deficiency is a high-risk factor for inflammatory diseases like autoimmune disease and allergy. In addition, reduced vitamin D seem to correlate with susceptibility to the virus infection such as HIV and COVID-19. In this review, we will summarize up-to-date vitamin D's role in various immune cells, immune regulatory functions during autoimmune, allergic, and infectious diseases. We will also discuss about vitamin D supplement effects in human trial studies for COVID-19.
Keywords
vitamin D; immune system; autoimmune; allergy; infection;
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1 Rastogi, A., Bhansali, A., Khare, N., Suri, V., Yaddanapudi, N., Sachdeva, N., Puri, G. D. & Malhotra, P. (2022). Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgrad Med J, 98, 87-90.   DOI
2 Rolf, L., Muris, A. H., Hupperts, R. & Damoiseaux, J. (2014). Vitamin D effects on B cell function in autoimmunity. Ann N Y Acad Sci, 1317, 84-91.   DOI
3 Siddiqui, M., Manansala, J. S., Abdulrahman, H. A., Nasrallah, G. K., Smatti, M. K., Younes, N., Althani, A. A. & Yassine, H. M. (2020). Immune Modulatory Effects of Vitamin D on Viral Infections. Nutrients, 12.
4 van der Aar, A. M., Sibiryak, D. S., Bakdash, G., van Capel, T. M., van der Kleij, H. P., Opstelten, D. J., Teunissen, M. B., Kapsenberg, M. L. & de Jong, E. C. (2011). Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J Allergy Clin Immunol, 127, 1532-40 e7.   DOI
5 Weir, E. K., Thenappan, T., Bhargava, M. & Chen, Y. (2020). Does vitamin D deficiency increase the severity of COVID-19? Clin Med (Lond), 20, e107-e108.
6 Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., Kamen, D. L., Wagner, M., Bals, R., Steinmeyer, A., Zugel, U., Gallo, R. L., Eisenberg, D., Hewison, M., Hollis, B. W., Adams, J. S., Bloom, B. R. & Modlin, R. L. (2006). Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science, 311, 1770-3.   DOI
7 Martineau, A. R. & Cantorna, M. T. (2022). Vitamin D for COVID- 19: where are we now? Nat Rev Immunol, 22, 529-530.   DOI
8 Murdaca, G., Pioggia, G. & Negrini, S. (2020). Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. Clin Mol Allergy, 18, 23.   DOI
9 Mirzakhani, H., Al-Garawi, A., Weiss, S. T. & Litonjua, A. A. (2015). Vitamin D and the development of allergic disease: how important is it? Clin Exp Allergy, 45, 114-25.   DOI
10 Peroni, D. G., Piacentini, G. L., Cametti, E., Chinellato, I. & Boner, A. L. (2011). Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol, 164, 1078-82.   DOI
11 Hsieh, E. & Yin, M. T. (2018). Continued Interest and Controversy: Vitamin D in HIV. Curr HIV/AIDS Rep, 15, 199-211.   DOI
12 Wang, H., Wang, Z., Cao, W., Wu, Q., Yuan, Y. & Zhang, X. (2021). Regulatory T cells in COVID-19. Aging Dis, 12, 1545-1553.   DOI
13 Yu, C., Fedoric, B., Anderson, P. H., Lopez, A. F. & Grimbaldeston, M. A. (2011). Vitamin D(3) signalling to mast cells: A new regulatory axis. Int J Biochem Cell Biol, 43, 41-6.   DOI
14 Zhou, L., Wang, J., Li, J., Li, T., Chen, Y., June, R. R. & Zheng, S. G. (2019). 1,25-Dihydroxyvitamin D3 Ameliorates Collagen-Induced Arthritis via Suppression of Th17 Cells Through miR-124 Mediated Inhibition of IL-6 Signaling. Front Immunol, 10, 178.   DOI
15 Sidbury, R., Sullivan, A. F., Thadhani, R. I. & Camargo, C. A., Jr. (2008). Randomized controlled trial of vitamin D supplementation for winter-related atopic dermatitis in Boston: a pilot study. Br J Dermatol, 159, 245-7.   DOI
16 Arora, J., Patel, D. R., Nicol, M. J., Field, C. J., Restori, K. H., Wang, J., Froelich, N. E., Katkere, B., Terwilliger, J. A., Weaver, V., Luley, E., Kelly, K., Kirimanjeswara, G. S., Sutton, T. C. & Cantorna, M. T. (2022). Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs. Nutrients, 14.
17 Cantorna, M. T., Hayes, C. E. & DeLuca, H. F. (1996). 1,25-Dihy- droxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A, 93, 7861-4.   DOI
18 Back, O., Blomquist, H. K., Hernell, O. & Stenberg, B. (2009). Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol, 89, 28-32.   DOI
19 Akamatsu, M., Mikami, N., Ohkura, N., Kawakami, R., Kitagawa, Y., Sugimoto, A., Hirota, K., Nakamura, N., Ujihara, S., Kurosaki, T., Hamaguchi, H., Harada, H., Xia, G., Morita, Y., Aramori, I., Narumiya, S. & Sakaguchi, S. (2019). Conversion of antigen- specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol, 4.
20 Heine, G., Hoefer, N., Franke, A., Nothling, U., Schumann, R. R., Hamann, L. & Worm, M. (2013). Association of vitamin D recep- tor gene polymorphisms with severe atopic dermatitis in adults. Br J Dermatol, 168, 855-8.   DOI
21 Kolls, J. K. & Garry, R. F. (2022). Role of the T cell vitamin D receptor in severe COVID-19. Nat Immunol, 23, 5-6.   DOI
22 Hollams, E. M., Hart, P. H., Holt, B. J., Serralha, M., Parsons, F., de Klerk, N. H., Zhang, G., Sly, P. D. & Holt, P. G. (2011). Vitamin D and atopy and asthma phenotypes in children: a longitu- dinal cohort study. Eur Respir J, 38, 1320-7.   DOI
23 Kongsbak, M., Levring, T. B., Geisler, C. & von Essen, M. R. (2013). The vitamin d receptor and T cell function. Front Immunol, 4, 148.
24 Chauss, D., Freiwald, T., McGregor, R., Yan, B., Wang, L., Nova- Lamperti, E., Kumar, D., Zhang, Z., Teague, H., West, E. E., Vannella, K. M., Ramos-Benitez, M. J., Bibby, J., Kelly, A., Malik, A., Freeman, A. F., Schwartz, D. M., Portilla, D., Chertow, D. S., John, S., Lavender, P., Kemper, C., Lombardi, G., Mehta, N. N., Cooper, N., Lionakis, M. S., Laurence, A., Kazemian, M. & Afzali, B. (2022). Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Nat Immunol, 23, 62-74.   DOI
25 Choi, J. M. & Bothwell, A. L. (2012). The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune dis- eases. Mol Cells, 33, 217-22.   DOI
26 Fabbri, A., Infante, M. & Ricordi, C. (2020). Editorial - Vitamin D status: a key modulator of innate immunity and natural defense from acute viral respiratory infections. Eur Rev Med Pharmacol Sci, 24, 4048-4052.
27 Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357, 266-81.   DOI
28 Hart, P. H., Gorman, S. & Finlay-Jones, J. J. (2011). Modulation of the immune system by UV radiation: more than just the effects of vitamin D? Nat Rev Immunol, 11, 584-96.   DOI
29 Wang, C., Wang, S., Li, D., Chen, P., Han, S., Zhao, G., Chen, Y., Zhao, J., Xiong, J., Qiu, J., Wei, D. Q., Zhao, J. & Wang, J. (2021). Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone. ACS Infect Dis, 7, 1545-1554.   DOI
30 Kim, G. R., Kim, W. J., Lim, S., Lee, H. G., Koo, J. H., Nam, K. H., Kim, S. M., Park, S. D. & Choi, J. M. (2021). In Vivo Induc- tion of Regulatory T Cells Via CTLA-4 Signaling Peptide to Con- trol Autoimmune Encephalomyelitis and Prevent Disease Relapse. Adv Sci (Weinh), 8, 2004973.   DOI
31 Laursen, J. H., Sondergaard, H. B., Sorensen, P. S., Sellebjerg, F. & Oturai, A. B. (2016). Vitamin D supplementation reduces relapse rate in relapsing-remitting multiple sclerosis patients treated with natalizumab. Mult Scler Relat Disord, 10, 169-173.   DOI
32 Lee, S. A., Hong, S., Kim, H. J., Lee, S. H. & Yum, H. Y. (2013). Correlation between serum vitamin d level and the severity of atop- ic dermatitis associated with food sensitization. Allergy Asthma Immunol Res, 5, 207-10.   DOI
33 Murdaca, G., Tonacci, A., Negrini, S., Greco, M., Borro, M., Puppo, F. & Gangemi, S. (2019). Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications. Autoimmun Rev, 18, 102350.   DOI
34 Trotta, E., Bessette, P. H., Silveria, S. L., Ely, L. K., Jude, K. M., Le, D. T., Holst, C. R., Coyle, A., Potempa, M., Lanier, L. L., Garcia, K. C., Crellin, N. K., Rondon, I. J. & Bluestone, J. A. (2018). A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med, 24, 1005-1014.   DOI