• Journal of Nutrition and Health
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• 제6권2호
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• pp.17-24
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• 1973

The function of the liver is so complicated and important that various Hepatic diseases are occured due to functional retardation of liver. Above all, the incidence of Hepatitis and liver cirrhosis among Koreans has shown an increasing tendency recently. 113 cases of Hepatitis and 125 cases of liver cirrhosis which had been admitted, more than 10 days, to KOREA Hospital between November, 1968 and July,1972, were studied through clinic charts. (A) Hepatitis 1) of the 113 cases; 54 cases (47.7%) were Infectious hepatitis; 40 cases (35.4%) were chronic hepatitis 2) of the 113 cases ; 80 cases (70.8%) were male and 33 cases (29.2%) were female; the sex ratio was 2.4 : 1 The ages of the onset of the disease was as follows; 34 cases (30.1%) were among $30{\sim}40$. 3) Patients had abdominal pain (77.9%) anorexia (66.4 %) and general weakness(82.3%) as symptom and jaundice (94.7%) hepatomegaly (76.1%) as sign 4) 57 cases of all had complication 26 cases (45.6%) were parasite, 12 cases (21.1%) were diabeties mellitus. 5) 99 casea (87.6%) of all were improved and recovered. (B) Liver Cirrhosis 1) Etiologic factors are hepatitis (56cases) and alcoholics (28 cases). 2) of the 125 cases, 84 cases (67.2%) were male and 41 cases (32.8%) were female; the sex ratio was 2 : 1 The age of the onset of the disease was as follows; 47 cases (37.6%) were among 41-50. 3) Patients had symptoms: indigestion (64.8%), Abdominal pain (60%), general wenkness (35.2%) and signs; Hepatomegaly (61.6%) Ascites (59.2%), Jaundice(56.8%). 4) 107 cases of all had complications; Hepatic coma was 20 cases (18.7 %), Ascites was 16 cases (15.0%). 5) 69 cases (55.2%) were improved. (c) Treatment of Hepatitis and cirrhosis. 1) Absolutely (bed) rest. 2) A well-balanced diet adequate in calorie value, showed be given (High Carbohydrate, High Protein, High vitamin diet) if the patient's appetite is good and easily digested. 3) Drugs; (1) Vitamins (2) Digestants (3) Tranquize

• 한국식품영양과학회지
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• 제29권1호
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• pp.99-105
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• 2000

The purpose of this study was to evaluat the Zn, Cu, Mn and Ni status and correlation of their concentrations in serum, urine, hair and fingernail in female college students. As the results are follows; The mean age of subjects was 22.5 years and height, weight and BMI were 160.1 cm, 51.0 kg and 20.0 respectively. The daily intake of energy 1769.5 kcal and the ratio of carbohydrate, fat and protein for energy is 60 : 20 : 15. The daily intake of energy (88.5%), vitamin B2 (86.1%), Ca (75.4%), Fe (58.3%) and Zn (63.0%) of subjects did not reach to Korean Recommended Dietary Allowance (RDA). The daily mean intake of Zn, Cu, Mn and Ni were 7.56 mg, 2.30 mg, 3.81 mg and 0.18 mg respectively. The concentrations of Zn in serum, urine, hair and nail were 85.6$\mu\textrm{g}$/dL, 391.2$\mu\textrm{g}$/day, 174.6$\mu\textrm{g}$/g and 102.4$\mu\textrm{g}$/g respectively and those Cu were 84.2$\mu\textrm{g}$/dL, 56.6 $\mu\textrm{g}$/day, 20.3$\mu\textrm{g}$/g and 4.3$\mu\textrm{g}$/g respectively. The concentrations of Mn in serum, urine, hari and nail were 0.2$\mu\textrm{g}$/dL, 1.1$\mu\textrm{g}$/day, 1.8$\mu\textrm{g}$/g and 1.6$\mu\textrm{g}$/g respectively and those of Ni were 0.6$\mu\textrm{g}$/dL, 24.5$\mu\textrm{g}$/day, 3.5$\mu\textrm{g}$/g and 3.1$\mu\textrm{g}$/g respectively. The daily intake of Mn showed the positive correlations with concentration of Mn in hair (p<0.05) and the daily intake of Ni was positively correlated with urinary exretion (p<0.05) and hair contents (p<0.001) of Ni. The more detailed studies about these trace mineral status should be required.

• 한국식품영양과학회지
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• 제21권6호
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• pp.677-680
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• 1992

저온발효 배추김치의 숙성도를 평가하기 위한 방법으로 $4^{\circ}C$에서 숙성과정중 자연적으로 유출되는 김치액의 색상변화를 색차계를 이용해서 측정하고, 성분분석에 의해 적숙기를 예측하였다. 김치액의 성분분석결과 숙성 30일째 김치의 숙성 적기 PH인 4.2, 산도 0.63%에 달하였으며 이때 비타민 C 함량도 최고치에 달하였다. 김치액의 양은 숙성 30일까지는 점진적으로 증가하다가 이후 변화가 없이 동일하였다. 김치액의 $L^*$, $a^*$, $b^*$ 색상값은 모두 숙성과 더불어 증가하여 적숙기인 숙성 30일째 최고치를 나타내고 이후 감소하였다. 김치액 색의 $a^*$/$b^*$ 비값은 담금 초기 0.82에서 적숙기시 0.98를 나타내고 과숙기로 접어들면서 다소 감소하여 0.94를 나타냈다. 따라서, 적숙기시 김치액의 $L^*$, $a^*$, $b^*$ 값 또는 $a^*$/ $b^*$ 비값을 단독 혹은 김치액의 양과 병용하여 이용함으로써 색차계에 의한 김치, 특히 포장김치의 품질을 간접적으로 평가할 수 있음을 시사해 준다.

• 생명과학회지
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• 제30권3호
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• pp.298-303
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• 2020

본 연구에서는 도깨비부채(Rodgersia podophylla)의 화장품 산업 적용 가능성을 확인하기 위해, 잎(RP-L), 줄기(RP-B), 뿌리(RP-R)의 에탄올 추출물을 조제하고 이의 항균, 항산화 및 항당뇨 활성을 평가하였다. 추출물의 총 폴리페놀 함량 분석 결과, RP-R 및 RP-L에서 382.5~387.7 mg/g의 높은 함량을 보였으며, RP-B의 경우 84.2 mg/g으로 RP-R에 비해 20% 수준을 나타내었다. 항균활성 평가에서는 RP-L 및 RP-R 추출물에서 매우 강력한 그람양성 세균에 대한 항균 활성을 확인하였으며, 특히 RP-R 추출물의 경우 제어가 어려운 그람음성의 대장균 및 P. vulgaris에 대해서도 우수한 항균활성이 확인되었다. 항산화 활성 평가 결과, 3종 부위별 추출물 모두에서 매우 강력한 DPPH 음이온 소거능, ABTS 양이온 소거능, 환원력 및 nitrite 소거능이 확인되었으며, RP-L 및 RP-R 추출물의 DPPH 음이온 및 ABTS 양이온 소거능에 대한 RC₅₀은 각각 23.0~29.7 및 15.0~18.2 ㎍/ml를 나타내어 vitamin C의 9.8 및 8.0 ㎍/ml 수준과 비교할 만 하였다. 또한 RP-R 추출물은 0.5 mg/ml 농도에서 α-glucosidase 및 β-amylase 활성을 각각 6.9% 및 48.5% 저해하여 우수한 항당뇨 활성을 나타내었다. 본 연구에서는 도깨비부채 잎 및 뿌리 추출물에서 강력한 항세균, 항산화 및 항당뇨 활성을 신규 확인하여, 향후 도깨비부채가 화장품 및 식의약품 산업에서 새로운 생물자원으로 이용 가능함을 제시하였다.

• Journal of Nutrition and Health
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• 제49권6호
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• pp.459-470
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• 2016

본 연구에서 국가 단위 대규모의 데이터를 활용하여 성인 남녀를 대상으로 연령대 (19~49세, 50~64세)로 구분 후 보건복지부에서 제시한 국민건강증진 종합계획 (Health Plan 2020)의 영양분야 중 건강식생활 실천 상태를 분석하고, 건강식생활 실천 여부에 따른 대사증후군 관련 위험 정도를 분석한 결과는 다음과 같다. 19~49세, 50~64세 연령층에서 모두 여성이 남성에 비해 건강식생활 실천율이 유의적으로 높았으며, 19~49세의 건강식생활 실천율은 40.46%였고, 50~64세에서는 37.07%로 나타났다. 또한 여성에서 나트륨 지표와 영양표시 지표를 목표에 부합하게 실천하는 비율이 남성에 비해 유의적으로 높게 나타났으며, 건강식생활 실천을 하는 대상자 (건강식생활 실천지표 2개 이상 충족)의 경우 건강식생활 비실천군에 비해 칼슘, 칼륨, 비타민 $B_1$, $B_2$, 비타민 C의 섭취 밀도가 유의적으로 높은 식사섭취를 보였다. 50~64세 여성에서 건강식생활을 실천하는 대상자 (건강식생활 실천지표 2개 이상 충족)의 경우 건강식생활을 실천하지 않는 대상자 (건강식생활 실천지표 1개 이하 충족)에 비해 교란인자를 보정 후 복부비만 및 대사증후군의 유병률이 유의적으로 낮게 나타난 의미있는 결과를 도출하였다. 이와 같은 결과는 지방, 나트륨, 과일채소의 섭취와 영양표시 활용 여부로 구성된 건강 식생활 실천율과 대사증후군 위험성을 의미하는 지표와의 관련성을 제안할 수 있는 근거자료가 될 수 있으며, 대사적 질환 예방 및 건강수명 연장을 위한 영양교육시 활용할 수 있는 기초자료가 될 수 있을 것으로 사료된다.

• Archives of Pharmacal Research
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• 제25권6호
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• pp.940-945
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• 2002

The present study was done to determine the effect of trolox C, a hydrophilic analogue of vitamin E, on hepatic injury, especially the alteration in cytochrome P-450 (CYP)-dependent drug metabolism during ischemia and reperfusion (I/R). Rats were subjected to 60 min of hepatic ischemia and 5 h of reperfusion. Rats were treated intravenously with trolox C (2.5 mg/kg) or vehicle (PBS, pH 7.4), 5 min before reperfusion. Serum alanine aminotransferase and lipid peroxidation levels were markedly increased after I/R. This increase was significantly suppressed by trolox C. Cytochrome P-450 content was decreased after I/R but was restored by trolox C. There were no significant differences in ethoxyresorufin O-dealkylase (CYP 1A1) and methoxyresorufin O-dealkylase (CYP 1A2) activities among any of the experimental groups. Pentoxyresorufin O-dealkylase (CYP 2B1) activity was decreased and aniline p-hydroxylase (CYP 2E1) activity was increased after I/R. Both these changes were prevented by trolox C. Our findings suggest that trolox C reduces hepatocellular damage as indicated by abnormalities in microsomal drug-metabolizing function during I/R, and that this protection is, in part, caused by decreased lipid peroxidation.

• 대한지역사회영양학회지
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• 제6권2호
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• pp.192-204
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• 2001

Osteoporosis and other related conditions pose a growing public health problem, especially in postmenopausal women. The main purpose of the study was to investigate the correlations among BMD, maternal factors, and life styles, and intake of nutrients in postmenopausal women. One hundred participants in Kyungge-do were divided into three groups according to their BMD measurements measured by DXA. Dietary analysis, anthropometric measurements, and questionares were administered to these women. The percentage of the osteoporosis, osteopenia(Osteopinia), and normal groups were 32%, 48%, and 20% respectively. The average age was significantly the highest in the osteoporosis group. The average age at menopause was 47.2. Osteoporosis group's age at menopause was significantly the lowest. The sleeping hours of the osteoporosis and osteopenia group were significantly longer than the normal group. The intake of vitamin B$_2$was positively correlated with the BMD of femoral neck. The BMD of these two sites was positively correlated with weight, BMI, waist, and hip size and negatively correlated with the length of the menstrual cycle, duration after menopause, the age at the last delivery, and sleeping hours. Spinal BMD positively correlated with hours of outdoor activity. Therefore, maternal factors, lifestyles, and intake of nutrients contribute to BMD.

• 한국식품영양과학회지
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• 제20권1호
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• pp.65-71
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• 1991

The purpose of this survey was to study Nutrition Status related to eating behabvior health status and nutrient intake. this survey was conducted for 100 students at Mokpo National University from semptember 25 to 29 in 1989. Average height and weight of students were found to be increased for last thirty years from 1957 to 1989. the average height of male and female were 172.0cm 160.1cm and the average weight of those were 63.4kg 48.2kg respectively. Health status showed fair. but most of students had symptoms such as stress cold and disorder of stomach. The main purpose of eating is to satisfy hungry and routinal work. Most students have had dietary problems such as irregularity of meal time and skipping meal. Most nutrients was intaken properly but some were under percentae of RDA. For the male the average intake of Calorie(84.5%) and Vitamin B2(93.3%) were lower than RDA for the frmale that of Calorie(81.7%) and Iron(80.6%) The ration of percent calorie of Carbohyd-rate : Protein : Fat from total calories in male was 65:15:20 and that of female was 64 : 15: 21 this result was properly approached to the Recommend Calorie Composition(Based on Recommended Allwances 5th ed. Korea FAO Assoc. 1989)

• Preventive Nutrition and Food Science
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• 제12권3호
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• pp.154-159
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• 2007

This study was conducted to find obesity, biochemical indices and nutrient intakes in type Ⅱ diabetes mellitus with hypertension in Gwangju area. Subjects were divided into two groups based on the status of hypertension. Duration of 139 normotensive type Ⅱ diabetes mellitus was $49.8{\pm}80.2$ months while that of hypertensive type Ⅱ diabetes was $79.7{\pm}95.5$ months. Anthropometric measurement revealed that subjects in both groups were in overweight determined by BMI, though there was no significant difference between two groups. Contrastingly, obesity rate and subscapular fat distribution were a good predictor to identify hypertensive group due to the significant differences between two groups, regardless of sex. Hypertensive type Ⅱ diabetes mellitus is significantly associated with more elevated cholesterol and fasting blood glucose level. Triglyceride level in the hypertensive female was prominent. Significant gender differences were shown in energy, carbohydrate, protein, Ca, Zn, vitamin $B_{6}$ and cholesterol intakes. Nutrient intakes of female normotensive group were higher than those of female hypertensive group except for riboflavin. However, different pattern on nutrient intakes in male was noted. Thus, sex is a great determinant to influence nutrient intakes in subject. Effective nutrition education program targeting type Ⅱ diabetes mellitus, especially hypertensive type Ⅱ diabetes mellitus should be developed and implemented to control blood glucose and lipidemia. It might be suggested to consider the importance different approaches of nutrition education program to both genders.

• BMB Reports
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• 제30권2호
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• pp.125-131
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• 1997

This work reports studies of the catalytic and structural properties of pyridoxal kinase (ATP: pyridoxal 5' -phosphotransferase, EC. 2.7.1.35), Pyridoxal kinase catalyzes the phosphorylation of vitamin $B_6$ (pyridoxal, pyridoxamine, pyridoxine) using ATP-Zn as a phosphoryl donor. The enzyme purified from brain tissues is made up of two identical subunits of 40 kDa each. Native enzyme was inhibited by a substrate analogue, pyridoxal-oxime. Limited chymotrypsin digestion of pyridoxal kinase yields two fragments of 24 and 16 kDa with concomitant loss of catalytic activity. These fragments were isolated by DEAE ion exchange chromatography and used for binding studies with fluorescent ATP and pyridoxal analogues. The spectroscopic properties of both fluorescent pyridoxal analogue and Anthraniloyl ATP (Ant-ATP) bound to the 24 kDa fragment are indistinguishable from those of both pyridoxal analogue and Ant-ATP bound to the native pyridoxal kinase, respectively. The small 16 kDa fragment, generated by proteolytic cleavage of the kinase, does not bind any of the substrate analogues. Binding characteristics of Ant-ATP were extensively studied by measuring the changes in fluorescence spectra at various conditions. From the results presented herein, it is postulated that the structural domain associated with catalytic activity comprises approximately one-half of the molecular mass of pyridoxal kinase (24 kDa). whereas the remaining portion (16 kDa) of the enzyme contains a regulatory binding domain.