• Journal of KIISE:Databases
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• v.31 no.6
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• pp.641-649
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• 2004

The relationship between chemical structures and biological activities is researched briskly in the area of 'Medicinal Chemistry' At the base of these structure-based drug design tries, medicinal chemists search the existing drugs of similar chemical structure to target drug for the development of a new drug. Therefore, it is such necessary that an automatic system selects drug files that have a set of chemical moieties matching a user-defined query moiety. Substructure searching is the process of identifying a set of chemical moieties that match a specific query moiety. Testing for substructure searching was developed in the late 1950s. In graph theoretical terms, this problem corresponds to determining which graphs in a set are subgraph isomorphic to a specified query moiety. Testing for subgraph isomorphism has been proved, in the general case, to be an NP- complete problem. For the purpose of overcoming this difficulty, there were computational approaches. On the 1990s, a US patent has been granted on an atom-centered indexing scheme, used by the RS3 system; this has the virtue that the indexes generated can be searched by direct text comparison. This system is commercially used(http://www.acelrys.com/rs3). We define the RS3 system's drawback and present a new indexing scheme. The RS3 system treats substructure searching with substring matching by means of expressing chemical structure aspredefined strings. However, it has insufficient 'rerall' and 'precision‘ because it is impossible to index structures uniquely for same atom and same bond. To resolve this problem, we make the minimum-cost- spanning tree for one centered atom and describe a structure with paths per levels. Expressing 2D chemical structure into 1D a string has limit. Therefore, we break 2D chemical structure into 1D structure fragments. We present in this paper a new index technique to improve recall and precision surprisingly.

• Journal of Intelligence and Information Systems
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• v.14 no.1
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• pp.47-66
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• 2008

This study is aimed at proposing a new type of ubiquitous decision support system (u-DSS) portal which is embedded with two important mechanisms like an intelligent ontology management module (i-OMM) and multi-agent coordination mechanism (MACM). The proposed portal provides timely decision support to the involved decision entities (represented as agents) by taking advantage of the two mechanisms embedded on the portal. The most important virtue of the proposed portal is that it can resolve two problems such as semantic discordance and data confliction which are occurring very often in an ubiquitous computing environment. Frequent requests of revising the already established decision information due to the rapid changes in decision entities' requirements require the extremely flexible and intelligent u-DSS vehicle like theproposed mechanism. In this sense, the i-OMM is designed to provide support to solving the semantic discordance in the way that the i-OMM virtually integrates ontology view (IOV) to integrate heterogeneous ontology among the agents engaged inubiquitous commerce situations. Then the i-OMM sends the IOV to the MACM to resolve the conflicts among the involved agents. The proposed u-DSS portal was applied to the u-fulfillment problem in which all the involved decisionagents need their own requirements to be satisfied seamlessly and timely. The experimental results show that the proposed u-DSS portal is very robust and promising in the field of u-DSS and context modeling.

• Journal of the Korean Institute of Landscape Architecture
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• v.44 no.3
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• pp.79-93
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• 2016

The present study aimed to understand the taste of literati appearing in the Korean-Chinese garden by comparing "Yanghwasorok(養花小錄)" and "Zhangwuzhi(長物志)", which are one of the representative gardens in Korea and China. The main subject of comparison is plants; the research results are as follows. First, Gang Hui-an stated that the ultimate purpose of growing and appreciating the gardening plants is the completion of oneself, while Wen Zhen-heng(文震亨) used gardening plants as a means to practice a life of reclusiveness(隱逸). Second, Gang Hui-an claimed that growing plants is human's cultivation of virtue on the basis of Confucian view's gaining knowledge by the study of things(格物致知), whereas Wen Zhen-heng realized the taste of 'elegance(雅趣)' through form of plants or planting method. Third, although plant preference of literati of both countries is similar in many parts, there is a slight difference for putting gardening plants in pots and appreciating them. For example, even for selecting or placing pots, simplicity and lightness are characteristically reflected from Gang Hui-an while splendor and refinedness are characteristically shown from Wen Zhen-heng. Moreover, in light of the taste of appreciation of literati of the Song Dynasty(宋代), which is a sample of literati spirit, Gang Hui-an inherited the inner world of the spirit whereas Wen Zhen-heng expressed 'literati-ness' in visual images.

• Journal of the Mineralogical Society of Korea
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• v.20 no.4
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• pp.339-349
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• 2007

For various types of the Pungchon limestone, diverse mineral characters of the limestone including their size and morphology are investigated by using of ELS and SEM to examine the possibility of application as fillers to paper industry. Also, the measurement of zeta potential and the evaluation of coagulation properties in calcite suspension was made for fine powders of the limestone to examine the applicability and efficiency in wet-papermaking process. Fine powder of the Pungchon lime-stone, largely controlled by original mineral characters of ore in mineralogical aspects, exhibits some-what different trend in particle morphology according to ore types, and thereby, the size distribution, zeta potential and coagulation properties also become different. The examined whiteness, brightness, opacity and sheet strength in hand sheet also show remarkable differences according to ore types. These are seemed to be basically due to the results of combined effects of whiteness, site distribution, refractive index, and morphology of the limestone powder on the properties of hand sheet. Considering the investigated results, all types of the Pungchon limestone appear to be sufficiently applicable to paper industry. Especially, the mega-crystalline calcite type is evaluated to be overall suitable for the purpose of paper industry due to the higher values in whiteness and brightness. In addition the fine powder of micro-crystalline calcite type is assessed particularly to have a good quality in sheet strength by virtue of irregular particle shape.

• Journal of Korean Philosophical Society
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• v.139
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• pp.133-167
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• 2016

Happiness is no more than a pleasant mental state that we can feel everyday. How to seek happiness is the key subject of positive psychology, for which we also need a clear neural system so that our emotional life can be accomplished. This is an issue in people with neural problems (such as psychopathy or hypochondria) as they can not achieve such emotional clarity. In this sense neuroscience is thought of as a new approach that can replace the traditional rational insight which has been aimed at completing a virtual life. But there is also a limit: we can not reach a virtual life with only a confirmation of our transitive state. A practice of virtue which our moral ethos aims at, has been a problem of rational insight. Here is a gap between our emotional life and our rational insight in which an anguish of psychology results. So a task we should combine organically is band between neuroscientific fact and ethical practice; a new addition to psychology. But unfortunately psychology can not solve this problem by itself, for it is a meta-question arising beyond psychology. Thus an explication of this meta-question is, I believe, a new theory of moral philosophy; one that can only be explored using an interdisciplinary approach.

• Journal of Korean Philosophical Society
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• v.141
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• pp.133-166
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• 2017

The main aim of this paper is to show why justice is based on convention, not nature, in David Hume. Most philosopher, since Aristotle, have considered justice in relation to distribution. This understanding of justice continues up to modern times, and is handled especially in relation to ownership or private property in modern times. In modern times, private property is regarded as an absolute right that should not be violated in any case. Hume identifies this private property with justice. The absolute inviolability of private property is equivalent to never violate to justice. Hume is concerned with the question of where this justice originate. In other words, Hume is not concerned with the Kantian justification of justice, but rather with the psychological discussion of the genesis process of the idea of justice. Hume's answer is that "social utility" is its origin. Public societies are necessary conditions for human being. In other words, if public societies do not exist, humans can not exist. How then can a public society, which is a prerequisite for human being, exist or can be maintained? According to Hume, it is maintained by means of justice. So where is the ground for justice? Hume argues that the basis of justice is not nature, but human conventions. Man accepts justice tacitly and by doing so man can maintains his being. This is a rough insight of Hume. Hume uses a wide variety of concepts to carry out his argument. In this paper, we focus on how the idea of justice in human mind, based on these various concepts presented by Hume, is formed.

• Sijohaknonchong
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• v.24
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• pp.47-85
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• 2006

One of the famous Korean verses, Sijo 'In hemp clothes in winter(삼동에 베옷 입고)' is in thirty kinds of anthologies and ten kinds of Chinese writings. The major point in literary transmission of this work was the writer. The writer of this verse is Cho Sik(조식) in most anthologies. The writer of this work is recorded as Kil Jae(길재), Kim In-hoo(김인후), Kim Eung-jung(김응정), Lee Mong-gyu(이몽규) or Kim Ryung(김령) in Chinese writings. These people were famous for their studies and virtue, but they did not take office and retired from the world until they die. They were faithful to their principles serving their kings, though the country had wanted them to take a position in the government. Even though they did not in government service, they left some anecdotes and stories of lamentation after hearing their king's death. Because these stories and anecdotes can be easily connected with 'In hemp clothes in winter' which is about mourning over death of a king, they were known as the writer of this poem. Especially, their offsprings, juniors and followers often wrote these people as the writer of this work to represent their honor. Throughout the studies of several literary documents, this poem is written by Kim Eung-Jung, who lived in Kangjin(강진) in Jeonla province(전라도) and did not take office in all his life. He made this poem when he had heard the King Myoungjong(명종)'s death. Various transmission of literary documents with the records about 'In hemp clothes in winter' have a significance that can show the aspects of noble men's acceptance and transmission of Sijo.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.2
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• pp.1-15
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• 2011

Objective : Recently interest of fermented herb medicine has increased in Oriental medicine. Herb medicine fermented in a proper condition resultingly has better or new virtue by microbe. This study was designed to compare the anti-inflammatory effects of herbal decoction and fermented herbal decoction in Hwangnyeonhaedok-tang (Huanglian fiedu-tang; HHT). Methods : The effects of HHT and FHHT on anti-inflammation were measured by production of NO and pro-inflammatory cytokine productions including TNF-${\alpha}$ and IL-1${\beta}$, IL-6 in LPS induced RAW 264.7 cells. Results : 1. Cell viability in three doses of HHT extract (0.01, 0.05 and 0.10 mg/ml) and two doses of FHHT extract (0.01, 0.05 mg/ml) was more than 70％ and 80％ each. 2. In RAW 264.7 cells, LPS displayed significant stimulatory effects on the production of NO. However, both HHT, FHHT showed significant inhibitory effects on the production of NO. 3. Pre-treatment by HHT in a various concentrations (0.01, 0.05, 0.10, 0.50mg/ml) reduced the elevated production of TNF-${\alpha}$, IL-1${\beta}$, IL-1${\beta}$ mRNA, IL-6 mRNA. More than 0.05mg/ml concentrations of HHT reduced the production of IL-6. And TNF-${\alpha}$, IL-1${\beta}$ level of mouse serum reduced in a various dose(0.1, 0.5, 1.0g/kg). 4. Pre-treatment by FHHT in a various concentrations (0.01, 0.05, 0.10, 0.50mg/ml) reduced the elevated production of TNF-${\alpha}$. More than 0.05mg/ml concentrations of FHHT reduced the expression of TNF-${\alpha}$ mRNA. 0.1, 0.50mg/ml concentrations of FHHT reduced the production of IL-6. And IL-1${\beta}$ level of mouse serum reduced in a various dose(0.1, 0.5, 1.0g/kg). Conclusions : These results indicated that both HHT and FHHT could have anti-inflammatory capacity by inhibiting the production of NO and cytokines in vitro. But HHT has more strong anti-inflammatory effects than that of FHHT in broad outlines.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.1
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• pp.11-18
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• 2019

This paper explores desirable status of block chain electronic government in relation to the prevention of cybercrimes and corruption. After the research, we suggest four measures to establish desirable status of block chain electronic government. Eventually, transparency is ensured thanks to the core concept of block chain technology, sharing, not only allowing all of the participants to share information and but also preventing them from forging or falsifying information. Furthermore, a wide variety of participants can play a role as monitors in the horizontal structure of governance system, which also assures credibility and reliability on electronic government through trust on block chain itself. Electronic government aims at virtue of expanded electronic democracy which strengthens information democracy. Also, establishment of electronic governance, that emphasizes networking and guarantees, is a desirable image of the future of the fourth industrial revolution. Therefore, the establishment of future electronic government according to the four principles drawn from this paper can be the most suitable model.

• Journal of the Korea Convergence Society
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• v.10 no.7
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• pp.317-323
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• 2019

Amid the recent growing social demand for wellness culture and healing tourism, I, through a literature survey and case study, reviewed the conditions of healing tourism in Gangwon-do as a destination of healing tourism, and examined the development project of Gangwon-do type healing tourism and commercialization of the wellness perspective. According to the survey, it was found that the Yeongdong area in Gangwon Province had excellent healing-based conditions in virtue of abundant natural resources, but it was found that it was necessary for local governments to cooperate in order to prevent overlapping investments and create synergy effects by connecting with one another as development contents or business items of healing tourism projects overlap or remain in the planning stage. In the case of Goseong-gun, which was reviewed as the main site, it has high potential as a silver-healing tour and if the County seeks a wellness merchandising strategy for each healing tourism target based on a therapy program linked with local specialized resources, and effectively links and specializes regional strengths in Gangwon-do's Yeongdong region, it is expected to become a regional success story of operating the development of the local tourism for silver and health-oriented tourists.