• BMB Reports
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• v.39 no.5
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• pp.492-501
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• 2006

Since differentiation therapy is one of the promising strategies for treatment of leukemia, universal efforts have been focused on finding new differentiating agents. In that respect, we used guanosine 5'-triphosphate (GTP) to study its effects on K562 cell line. GTP, at concentrations between 25-200 ${\mu}M$, inhibited proliferation (3-90%) and induced 5-78% increase in benzidine-positive cells after 6-days of treatments of K562 cells. Flow cytometric analyses of glycophorine A (GPA) showed that GTP can induce expression of this marker in more mature erythroid cells in a time- and dose-dependent manner. These effects of GTP were also accompanied with inhibition of DNA synthesis (measured by [$^3H$]-thymidine incorporation) and early S-phase cell cycle arrest by 96 h of exposure. In contrast, no detectable effects were observed when GTP administered to unstimulated human peripheral blood lymphocytes (PBL). However, GTP induced an increase in proliferation, DNA synthesis and viability of mitogen-stimulated PBL cells. In addition, growth inhibition and differentiating effects of GTP were also induced by its corresponding nucleotides GDP, GMP and guanosine (Guo). In heat-inactivated medium, where rapid degradation of GTP via extracellular nucleotidases is slow, the anti-proliferative and differentiating effects of all type of guanine nucleotides (except Guo) were significantly decreased. Moreover, adenosine, as an inhibitor of Guo transporter system, markedly reduced the GTP effects in K562 cells, suggesting that the extracellulr degradation of GTP or its final conversion to Guo may account for the mechanism of GTP effects. This view is further supported by the fact that GTP and Guo are both capable of impeding the effects of mycophenolic acid. In conclusion, our data will hopefully have important impact on pharmaceutical evaluation of guanine nucleotides for leukemia treatments.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.12C
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• pp.1154-1166
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• 2009

In this paper, we propose algorithms for generating high quality virtual intermediate views on the baseline or out of baseline. In this proposed algorithm, depth information as well as 3D warping technique is used to generate the virtual views. The coordinate of real 3D image is calculated from the depth information and geometrical characteristics of camera and the calculated 3D coordinate is projected to the 2D plane at arbitrary camera position and results in 2D virtual view image. Through the experiments, we could show that the generated virtual view image on the baseline by the proposed algorithm has better PSNR at least by 0.5dB and we also could cover the occluded regions more efficiently for the generated virtual view image out of baseline by the proposed algorithm.

• Journal of KIISE
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• v.44 no.2
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• pp.186-194
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• 2017

Depth-image-based rendering is a technique that can be applied in a variety of 3D-display systems. It generates the images that have been captured from virtual viewpoints by using a depth map. However, disoccluded hole-filling problems remain a challenging issue, as a newly exposed area appears in the virtual view. Image inpainting is a popular approach for the filling of the hole region. This paper presents a robust hole-filling method that reduces the error and generates a high quality-virtual view. First, the adaptive-patch size is decided using the color and depth information. Also, a partial filling method for which the patch similarity is used is proposed. These efforts reduce the error occurrence and the propagation. The experiment results show that the proposed method synthesizes the virtual view with a higher visual comfort compared with the existing methods.

• The Journal of the Korea Contents Association
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• v.16 no.6
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• pp.9-18
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• 2016

This paper proposes a multi-view Wyner-Ziv Video coding scheme based on spatio-temporal adaptive estimation. The proposed algorithm is designed to search for a better estimated block with joint bi-directional motion estimation by introducing weights between temporal and spatial directions, and by classifying effectively the region of interest blocks, which is based on the edge detection and the synthesis, and by selecting the reference estimation block from the effective motion vector analysis. The proposed algorithm exploits the information of a single frame viewpoint and adjacent frame viewpoints, simultaneously and then generates adaptively side information in a variety of closure, and reflection regions to have a better performance. Through several simulations with multi-view video sequences, it is shown that the proposed algorithm performs visual quality improvement as well as bit-rate reduction, compared to the conventional methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.5C
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• pp.632-641
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• 2004

In this paper, a new intermediate view reconstruction method employing a stereo image rectification algorithm by which an uncalibrated input stereo image can be transformed into the calibrated one is suggested and its performance is analyzed. In the proposed method, feature point are extracted from the stereo image pair though detection of the corners and similarities between each pixel of the stereo image. And then, using these detected feature points, the moving vectors between stereo image and the epipolar line is extracted. Finally, the input stereo image is rectified by matching the extracted epipolar line between the stereo image in the horizontal direction and intermediate views are reconstructed by using these rectified stereo images. From some experiments on synthesis of the intermediate views by using three kinds of stereo image; a CCETT's stereo image of 'Man' and two stereo images of 'Face' ＆ 'Car' captured by real camera, it is analyzed that PSNRs of the intermediate views reconstructed from the calibrated image by using the proposed rectification algorithm are improved by 2.5㏈ for 'Man', 4.26㏈ for 'Pace' and 3.85㏈ for 'Car' than !hose of the uncalibrated ones. This good experimental result suggests a possibility of practical application of the unposed stereo image rectification algorithm-based intermediate view reconstruction view to the uncalibrated stereo images.

• Journal of Broadcast Engineering
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• v.24 no.5
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• pp.743-754
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• 2019

System for three degrees of freedom plus (3DoF+) and 6DoF requires multi-view high resolution 360 video transmission to provide user viewport adaptive 360 video streaming. In this paper, we implement 3DoF+ 360 video compression system which removes the redundancy between multi-view videos and merges the residual into one video to provide high quality 360 video corresponding to an user's head movement efficiently. Implementations about 3D warping based redundancy removal method between 3DoF+ 360 videos and residual extraction and merger are explained in this paper. With the proposed system, 20.14% of BD-rate reduction in maximum is shown compared to traditional high-efficiency video coding (HEVC) based system.

• The Transactions of the Korea Information Processing Society
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• v.7 no.7
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• pp.2219-2228
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• 2000

Caches in a multiprocessing environment introduce the cache coherence problem. When multiple processors maintain locally cached copies of a unique shared-memory location, any local modification of the location can result in a globally inconsistent view of memory. Cache coherence protocols are important to operate a shared-memory multiprocessor system with efficiency and correctness. Since random testing and simulations are not enough to validate correctness of protocols, it is necessary to develop efficient and reliable verification methods. In this appear we present our experience in using VIS (Verification Interacting with Synthesis), a tool of formal method, to analyze a number of property of a cache coherence protocol, RACE (Remote Access Cache coherent Enforcement).

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 1998.04a
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• pp.120-127
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• 1998

It is very difficult to execute the vibration analysis of a huge strucutre, which takes up much time and expense. In this paper we intend to make the equivalent system of a local vibration system of a huge structure with a view to improving the dynamic characteristics and reducing time and expense. First of all, upper deck structure model is maded. And we perform the vibration analysis by the Substructure Synthesis Method and execute the exciting test for the upper deck structure model, and observe the coincidences of two results to confirm the reliability of the analyzing tools used. To make the equivalent system, we give boundary condition to sub-structure that want to be modified and execute the Sensitivity Analysis Method and the Optimum Structural Modification Method. And we execute the structural modification of the equivalent system.. The following can be found from this study. 1. The analytical results are generally coincident with each other. 2. The equivalent system of the superstructure model can be easily obtained using the sensitivity analysis metho and the optimum structural modification method. 3. The structural modification using the equivalent system can be obtained good results above 90% of object value.

• KSBB Journal
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• v.26 no.2
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• pp.119-125
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• 2011

In the synthesis of nanoparticles, much attention has been paid to regulating the particle size. There has been a possible evident that using the central cavity (core) of the protein ferritin has a greatly significant influence on it because the core can generate the nanometer-sized mineral particles of variable metal ions. In this report, recombinant human L-ferritins produced from Saccharomyces cerevisiae were purified and their molecular properties were characterized. The cDNA for human ferritin L chain was also expressed in another host such as Escherichia coli, and the properties of recombinant L-ferritins were compared. From isoelectric focusing experiment, the L-ferritin from the recombinant yeast showed no indication of N-glycosylation. Some post-translational modifications other than N-glycosylation were speculated in the L-ferritins from yeast. A difference was made in the L-ferritins in their iron uptake rates and the initial rate of the L-ferritin from yeast was slightly increased. The reconstitution yield and size distribution of the core minerals were analyzed in the L-ferritins by transmission electron microscopy. The L-ferritin from yeast with higher reconstitution yield (54.5%) showed slightly larger sizes (mean 6.92 nm) with narrower size distribution than the L-ferritin from E. coli. It is, in conclusion, speculated that L-ferritin from yeast is relatively superior to the other, in view of the size of nanoparticle and its relative homogeneity.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.46-46
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• 2007

There has been rapid progress in the portable electronics industry. which has led to a great increase for a demand of portable, lightweight power sources. Lithium 2'nd batteries have met these demand. and many studies on the cahtod materials for the lithium 2,nd batteries have been reported during the last decade. Possible candidates for the cathode materials for lithium 2,nd batteries are $LiCoO_2$, $LiNiO_2$, and $LiMn_2O_4$. Currently $LiCoO_2$ is widely used. but $LiMn_2O_4$ is an excellent alternative material in view of its several advantages such a low cost as well as the wasy availability of raw materials and environmental benignity. In this study, find the most suitable synthesis method that satisfied high capacitor and stability cycle character, etc in Li-Mn oxide for 2'nd batteries. And also made an experiment on doping the $LiMn_2O_4$ spinel with a small amount of metal ions has a remarkable effect on the electrochemical properties and characterics of powder, BET, PSA, Porosity, etc.